2546 results about "Freckle" patented technology

The invention relates to the technical field of cosmetics, and particularly discloses a preparation method of multifunctional beauty concentrated liquor. Transparent, clear and golden yellow beauty concentrated liquor is obtained through the technological steps of fermentation of fructus hippophae juice and traditional Chinese medicine concentrated liquid raw materials, sedimentation of fermentation liquor, after-sedimentation extraction of liquor and the like. The beauty concentrated liquor can be applied in skincare products, has functions of being free of irritation, resisting allergy, whitening skin and fading freckles, resisting ageing and the like, and is stable in product property and outstanding in effect.

The invention discloses whitening and freckle-removing cream and a preparation method thereof. The whitening and freckle-removing cream comprises water, butanediol, caprylic / capric triglyceride, isohexadecane, glycerol, cyclopentasiloxane, butyrspermum parkii butter, trehalose, cetearyl olivate, sorbitan olivate, cetearyl alcohol, cetearyl glucoside, magnolia sieboldii extract, citrus peel extract, hydrogenated lecithin, phytosterol, bisabolol, tocopheryl acetate, glycyrrhiza glabra root extract, thymus serpyllum extract, panthenol, sodium hyaluronate and the like. The whitening and freckle-removing cream disclosed by the invention can be used for inhibiting tautomerase activity of tyrosinase and dopachrome and hindering polymerization of DHI; the formation of melanin in a body is inhibited, the regeneration capability of pigment cells is improved, the pigment deposition is reduced and pigment cell detachment is promoted; the self-immunity of the cells is enhanced, and the skin elasticity and a metabolism function are improved; and the self-protection capability of skins is improved and the safe whitening and freckle-removing effects are realized.

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

The invention discloses whitening and freckle-removing cream. The cream is mainly prepared from glycerin, ethylhexyl palmitate, caprylic / capric triglyceride, isononyl isononanoate, polydimethylsiloxane, 1,2-pentanediol, butyrospermum parkii butter, 1,2-hexanediol, caprylyl glycol, cetostearyl alcohol, carbomer, xanthan gum, nicotinamide, arginine, rosa damascena flower oil, citrus medica L. extract, cucumis sativus fruit extract, bearberry leaf extract, rose extract, sodium hyaluronate, methyl glucose sesqui-stearate, PEG-20 methyl glucose sesqui-stearate, glyceryl stearate, phenoxyethanol and water. A natural cosmetic is prepared from whitening components of natural plants and directly acts on the facial skin, so that the effective ingredients permeate into the basal layer of the skin to reduce and decompose existing melanin, activate cells and diminish facial freckles; and the natural cosmetic is reasonable in compatibility, so that the skin is whitened and moistened and has delicate sheen.

A non-invasive tool for skin disease diagnosis would be a useful clinical adjunct. The purpose of this study was to determine whether visible / near-infrared spectroscopy can be used to non-invasively characterize skin diseases. In-vivo visible- and near-infrared spectra (400-2500 nm) of skin neoplasms (actinic keratoses, basal cell carcinomata, banal common acquired melanocytic nevi, dysplastic melanocytic nevi, actinic lentigines and seborrheic keratoses) were collected by placing a fiber optic probe on the skin. Paired t-tests, repeated measures analysis of variance and linear discriminant analysis were used to determine whether significant spectral differences existed and whether spectra could be classified according to lesion type. Paired t-tests showed significant differences (p<0.05) between normal skin and skin lesions in several areas of the visible / near-infrared spectrum. In addition, significant differences were found between the lesion groups by analysis of variance. Linear discriminant analysis classified spectra from benign lesions compared to pre-malignant or malignant lesions with high accuracy. Visible / near-infrared spectroscopy is a promising non-invasive technique for the screening of skin diseases.

The invention relates to a Chinese medicinal preparation for treating facial chloasma, which is the medicinal preparation prepared from 77 raw material medicaments such as peach seed, safflower, danshen root, red paeony root and hawthorn fruit. The medicinal preparation is powder, tablets, pills, capsules, electuary or oral liquid. A preparation method of the Chinese medicinal preparation comprises the following steps of: (1) sieving and crushing the raw material medicaments; (2) sieving, and taking screening; (3) disinfecting and sterilizing to obtain medicinal raw powder; and (4) preparing the medicinal raw powder into tablets, granules, pills or capsules. The preparation method also can comprise the following steps of: (1) preparing the raw material medicaments into medicinal water extracting solution; (2) preparing the medicinal water extracting solution into the oral liquid; (3) drying, crushing and sieving the medicinal water extracting solution, taking screening, disinfecting and sterilizing to obtain medicinal extracting powder; and (4) preparing the medicinal extracting powder into tablets, granules, electuary or capsules. The Chinese medicinal preparation has a formula based on Chinese medicinal theory, and makes five internal organs healthy, and Yin and Yang balanced. The Chinese medicinal preparation mainly treats facial chloasma, freckles and facial pigmentation, treats hair loss caused by vitality stagnation and blood stasis, and has good curative effect on irregular cycles and infertility. The Chinese medicinal preparation is prepared from pure Chinese medicaments and has the advantages of diversiform formulations, convenient use, safety, reliability, no toxic or side effects, and suitability for long term usage.

An extract from leaves of mulberry is disclosed. The extract has an IC50 value sufficient to inhibit α-glucosidase I. The extract may comprise 5-40% (w / w) total imino sugars and 20-70% (w / w) total amino acids. The extract may reduce the production of melanin for the treatment of such ailments or diseases caused by pigmentation as freckle, chloasma, striae gravidarum, sensile plaque and melanoma. The extract may also control blood glucose level.

The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL-11 or IGF) by genetic engineering technology. The fusion protein can be used independently or in a combination or combination with yeast fermentation products, or with varied emulsifiers, thickeners, moisturizer, preservatives, yeasts and ferments.

The invention discloses a Chinese medicinal herb softening, whitening, anti-aging, wrinkle-smoothing and freckle-removing cosmetic composition, which comprises a cosmetic emulsifying matrix and Chinese medicinal extracts, wherein the Chinese medicinal extracts are extracts of saffron, lucid ganoderma, bighead atractylodes rhizome, white peony root, white poria, Japanese ampelopsis root, liquorice, ash bark, bletilla striata, pine needles and mint. The composition comprises the following components in parts by weight: 20 to 30 parts of emulsifying matrix, 1 to 5 parts of saffron, 1 to 10 parts of lucid ganoderma, 2 to 10 parts of bighead atractylodes rhizome, 2 to 5 parts of white peony root, 1 to 4 parts of white poria, 1 to 8 parts of Japanese ampelopsis root, 5 to 10 parts of liquorice, 1 to 5 parts of ash bark, 3 to 10 parts of bletilla striata, 5 to 10 parts of pine needles, and 1 to 5 parts of mint. The composition can improve skin metabolism, promote skin blood circulation, increase skin nourishment, and smooth wrinkles and remove freckles on the skin to make skin fine, smooth, white and elastic. The cosmetic composition is a novel and unique cosmetic composition product.

The invention discloses a skin care agent capable of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing, and a preparation method of the skin care agent. The skin care agent is characterized by comprising the following raw materials in parts by weight: 0.1-10 parts of an aloe extract, 0.1-5 parts of vitamin A, 0.1-10 parts of vitamin D, 0.1-0.5 part of hyaluronic acid, 0.1-5 parts of a swertia mileensis extract, 0.1-2 parts of alpha-lipoic acid, 0.1-5 parts of a licorice extract, 0.1-3 parts of a green tea extract, 0.1-2 parts of a fructus viticis extract and 0.1-3 parts of a grape seed extract. The preparation method comprises the following steps of: respectively adding the substances into deionized water at 75-85 DEG C, and maintaining the constant temperature for 20min; cooling the water to 50 DEG C, and adding 1-2 parts of Twain-200 into the cooled product; and stirring and cooling the solution to obtain the skin care agent. The skin care agent has the beneficial effects of being reasonably prepared from the natural extracts, being capable of permeating into a corium layer so as to accelerate metabolism, repair damaged skin and recover and maintain the elasticity of the skin, and being capable of rapidly achieving the special effects of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing.

The invention relates to health food for enhancing human immunity and increasing bone mineral density and a preparation method thereof; the health food of the invention comprises the following components: hyaluronic acid, glucosamine, collagen, kudzu root extracts, chondroitin sulfate, vitamins, calcium, etc; because of the embedding processing of hyaluronic acid, the defect of property change of hyaluronic acid due to moisture absorption and influence of environmental factors is overcome; the health food prepared by the organic combination of the embedded hyaluronic acid with glucosamine, collagen, plant extracts, vitamins, mineral matter and the like has functions and effects which can supplement each other, has the effects of lubricating joints, increasing bone mineral density, and enhancing bone strength during long-term administration, and also has the functions of delaying aging, removing freckles and beautifying faces, and the like; the health food of the invention can be prepared into powder, granules, tablets, capsules, is convenient for carrying and taking, has stable and lasting efficacy, has no side effects, and is an ideal health food of patients with hypoimmunity and osteoporosis.

The invention discloses whitening and freckle-removing cream which comprises water, hydrogenated polydecene, butanediol, glycerol, ethylhexyl palmitate, isopropyl palmitate, ceteareth-25, ceteareth-6,C12-15 alcohol-benzene formic ester, cetostearyl alcohol, polydimethylsiloxane, magnesium ascorbyl phosphate, simmondsia chinensis seed oil, preservatives, tocopheryl acetate, arbutin, xanthan gum, bisabolol, allantoin, essence, EDTA (ethylene diamine tetraacetic acid) disodium, glycyrrhiza glabra root extracts, sodium hyaluronate and citric acid. Whitening active components such as the glycyrrhiza glabra root extracts, the magnesium ascorbyl phosphate and the arbutin are added in a formula, the whitening and freckle-removing cream can penetrate into skin bottoms, melanogenesis is continuously inhibited, melanin decomposition is accelerated, skins are thoroughly whitened from inside to outside, and rapid whitening and freckle-removing effects are achieved. The magnesium ascorbyl phosphateand vitamin E achieve synergistic effects, and the whitening and freckle-removing effects are better.

The invention discloses a traditional Chinese medicine facial mask for skin whitening, which is prepared form the following raw materials: rhizoma atractylodis macrocephalae, radix angelicae, rhizoma bletillae striatae, radix ampelopsis, radix paeoniae alba, white poria, silkworm larva and pearl powder. The facial mask provided by the invention is capable of adjusting sebum, improving skin microcirculation, and reaching the effects of skin whitening and removing freckles, and has the characteristics of being safe and reliable, free of any toxic and side effects, high in use ratio of effective components and taking effect quickly.

The invention relates to a micro plasma pen for removing freckles on skin, and comprises a plasma skin cleaning head, a handle shell, a micro transducer arranged in the shell, a power output controller and a power module. The pen is characterized in that: a high and variable frequency plasma power occurrence circuit made of an integrated circuit chip or a semiconductor microprocessor MCU is installed in the shell; and in a loop, a circuit connection is formed by a medium and high frequency output magnetic core transformer or a ceramic piezoelectric type medium and high frequency transformer. Since the mini plasma pen for removing the freckles on the skin has a small size, a long service life and extremely low cost, the pen has the advantages of no pain when put into use, a self-sterilizing function, capability of being used as a tool for personal beautifying like nail clippers and small blades, a large social demand of nearly for anyone, and capability of replacing a carbon dioxide laser epidermal freckle removing machine in a hospital on a plurality of occasions.

The present invention relates to novel, topically applied, cosmetic / dermatological compositions for the treatment of hyperpigmentation disorders and photodamaged human skin. The subject compositions combat hyperpigmented skin. In addition, the compounds described can be used in the treatment of many other pathologies. Due to a high degree of gentleness, along with potent antioxidant and moisturizing effects, the present invention can be used safely in the treatment of many conditions, such as the prevention and / or treatment of melasma, freckles, age spots (lentigo senilis) and photodamaged skin.

A sheet for whitening cosmetics comprises a sheet-like substrate and an adhesive layer which comprises a wet pressure-sensitive adhesive composition formed on the substrate. The whitening component includes vitamin C or its derivatives such as magnesium L-ascorbyl-2-phosphate, vitamin E nicotinate, kojic acid, hydroquinone, ellagic acid, albumin, galenical extracts, and rice bran extracts. Kojic acid and magnesium L-ascorbyl-2-phosphate are preferred. By contacting the adhesive layer with water and / or a hydrophilic medium such as alcohols, e.g., methanol, ethanol, etc., the wet pressure-sensitive adhesive composition exhibits excellent stickiness and excellent applicability to skin as well as excellent whitening effect with alleviating or eliminating stains, freckles, non-transparency, etc. on the skin.

The invention relates to the technical field of masks, and particularly relates to a Dendrobium officinale moisturizing and repair sleeping mask and a preparation method thereof. The mask comprises a phase A component and a phase B component, wherein the phase A component comprises moisturizer, emulsifier, sodium hyaluronate A and water; the phase B component comprises Dendrobium officinale extracting solution, Crocus sativus extract, ganoderma lucidum extract, agilawood extract, sodium hyaluronate B and cosolvent. The mask is prepared from Crocus sativus, ganoderma lucidum, agilawood and Dendrobium officinale, wherein the Crocus sativus achieves the main effect of activating blood circulation to dissipate blood stasis; the ganoderma lucidum and the agilawood respectively achieve the auxiliary effects of invigorating qi and calming the nerves, and promoting circulation of qi to relieve pain; the Dendrobium officinale achieves the adjuvant effect of nourishing yin and promoting salivation; and the whole composition achieves the effects of promoting flow of qi and blood circulation, dispersing blood stasis and nourishing the kidney-yin. Besides, since the Dendrobium officinale extracting solution contains abundant colloid, the loss of moisture and collagen in the skin can be supplemented, elastic fibers can be repaired, and cell tissues can be reformed, so that the original elasticity and gloss of the skin are recovered, the remarkable freckle removal effect is achieved; and under the condition of ensuring that the skin is sufficiently moisturized, the mask has a greatly improved skin repair function.

The invention discloses a multi-effect skin caring and smoothening traditional Chinese medicine lotion which is characterized by comprising, by weight, 35-45 parts of lightyellow sophora root, 35-45 parts of common cnidium fruit, 28-33 parts of Chinese gall, 35-45 parts of baical skullcap root, 18-22 parts of cattail pollen, 75-85 parts of ganoderma lucidum, 110-130 parts of cortex mori, 35-45 parts of milkvetch root, 35-45 parts of radix rehmanniae, 35-45 parts of oat, and glycerin which is 0.5-0.56 times of the aforementioned materials by weight, with the balance being clean water for extraction. The multi-effect skin caring and smoothening traditional Chinese medicine lotion made from natural and environment-friendly materials has stable and reliable effect and wide application range, especially has good effects in removing freckle, wrinkle and acne, whitening, moisturizing and healing skin injury, and can not only be used to delay aging of skin and repair injury to skin caused by some hormone drugs and cosmetics but also reduce and even remove face splash, acne and wrinkle to make skin smooth, bright and elastic.

The invention provides a polypeptide composition for skin whitening and spot relieving. The polypeptide composition comprises an MC1-R antagonist (namely an alpha-MSH competitive antagonist) and / or a composition of polypeptides inhibiting alpha-MSH expression and / or a tyrosinase inhibitor. The polypeptide composition can reduce the generation of melanin, and contributes to skin brightening, so as to achieve the purposes of relieving color spots (chloasma, butterfly rash, freckle and the like), improving sallow tone and whitening skin. The concentration of each polypeptide is 0.0001-5%. The polypeptide composition provided by the invention can be prepared into various beauty and skin-care products as well as medical products.

The invention provides an active collagen-beta-cyclodextrin facial mask and a preparation method thereof, belonging to the field of daily cosmetics. The preparation method comprises the steps of firstly, blending a beta-cyclodextrin solution of which the mass percent is 0.5-9% with natural active substances to prepare an embedded type beta-cyclodextrin solution containing the natural active substances; then, blending the embedded type beta-cyclodextrin solution with a collagen solution of which the mass percent is 1-30% to prepare a mixed solution of embedded type beta-cyclodextrin and collagen; defoaming the mixed solution, then injecting the mixed solution into a mold, freezing for 1-7 days at -20 DEG C; finally, performing freeze-drying to prepare a collagen-beta-cyclodextrin facial mask containing the natural active substances. The collagen-beta-cyclodextrin facial mask prepared by the preparation method is convenient to use, is safe and effective, and can embed a variety of natural active substances with different effects to achieve multiple effects of whitening skin, removing freckles, resisting wrinkles, repairing skin and the like. Besides, the mask is degradable, can not cause environmental pollution, and has a good market application prospect.

The invention relates to application of paeonol in preparation of cosmetic for eliminating macula and whitening skin or in preparation of medicament for whitening skin or curing pigment deposition ailment. The cosmetic and medicament are both external use. The mass concentration of said paeonol is 0.01-5 %, optimization scheme is 5-10%. The paeonol and ground substance carrier are mixed to form tincture, spirit, cataplasm, ointment, cream, emulsion, oil agent, face mask, gel, film coating agent, aerosol and solution agent to which other component such as light screening agent and / or antioxidant and / or component for eliminating macula and whitening skin except paeonol can be added. The mechanism of paeonol directly restraining tyrosine enzyme activity, melanin generation and transport is various. The application of paeonol in cosmetic or medicament has unambiguous effect on skin whitening and curing pigment deposition ailment.

The invention relates to a composition, which is prepared from the following raw materials in parts by weight: 1 to 20 parts of lemon slices and 1 to 2 parts of stevia. Any single component or combination from lilies, honeysuckle flowers, globe amaranth and peony flowers can be added into the composition. In addition, the invention also relates to the use of the composition for the preparation of a healthcare product or a medicament or a product for prevention and treatment of hypertension, digestion aiding, obesity reduction, prevention and treatment of diabetes, freckle removal, wrinkle removal or skincare and throat clearing and nourishing.

The invention discloses a skin whitening and freckle removing beautifying prescription. The skin whitening and freckle removing beautifying prescription comprises the following components in part by weight: 3-7 parts of white peony, 3-7 parts of Atractylodes, 3-7 parts of poria cocos, 2-3parts of licorice, 25-35 parts of donkey-hide gelatin, 8-12 parts of honey, 8-12 parts of Astragalus, 8-12 parts of Ligusticum chuanxiong, 8-12 parts of Codonopsis pilosula, 8-12 parts of black sesame seed, 8-12 parts of walnut, 3-5 parts of rose, 3-5 parts of aloe, 3-5 parts of jujube and 3-7 parts of wolfberry. The skin whitening and freckle removing beautifying prescription is applicable to symptoms of rough skin, sallow complexion, chloasma and pigmentation and the like caused by deficiency and cold of Qi and blood, and has efficacies of nourishing liver, increasing blood, beautifying skin and eliminating freckle; and after the skin whitening and freckle removing beautifying prescription is taken for 2-3 courses of treatment, the skin becomes white and shiny.

The invention specifically discloses a composite whitening and spot correcting lotion, and a manufacturing method thereof. The spot correcting lotion is manufactured from raw materials of, by weight: 2.5 to 25 parts of traditional Chinese medicine active site extracts, 0.5 to 5 parts of arbutin, 0.05 to 0.2 parts of sodium hyaluronate, 5 to 10 parts of soybean fermentation extract, 1 to 10 parts of 1,3-butylene glycol, 1 to 10 parts of propylene glycol, 0.2 to 0.8 parts of tween-80, 0.1 to 0.4 parts of methyl-p-hydroxybenzoate, 0.1 to 0.4 parts of propylparaben, 0.5 to 5 parts pf ethanol, and 33.2 to 89.05 of deionized water. The traditional Chinese medicine active site extracts comprise raw materials of, by weight: 5 to 15 parts of ginseng, 5 to 20 parts of mongolian milkvetch root, 5 to 25 parts of white peony root, 5 to 30 parts of licorice, and 5 to 35 parts of cottonrose hibiscus flower. According to the composite whitening and spot correcting lotion provided by the invention, a plurality of traditional Chinese medicine active components are added to whitening and spot correcting active substances, such that the activity of tyrosinase can be effectively inhibited, oxygen-derived free radicals can be removed with high efficiency, and melanin can be prevented from appearing. With the composite whitening and spot correcting lotion, various freckles and chloasma can be comprehensively and rapidly corrected. Also, the lotion brings no toxin or harm.

The invention discloses biotechnology skin-whitening cosmetics. The biotechnology skin-whitening cosmetics comprise the following raw materials: ascorbic acid, arbutin, licorice extracts, punica granatum fruit fermentation product extracts produced by fermentation of lactobacillus, lemon extracts, rice chaff extracts, rose extracts, acerola cherry fermentation products produced by fermentation of the lactobacillus, gallnut extracts, oriental cherry extracts, inulin, mycose, ellagic acid and semen coicis extracts. The biotechnology skin-whitening cosmetics depend on pharmacology characteristics of bioactive substances produced by the modern biotechnology, the skin state of a user is conditioned and improved fundamentally, a skin-whitening effect is obvious, fading of foxiness and freckle can be facilitated, uneven skin tone is improved, skin brightness of the user is improved, and the skin-whitening effect is high. The biotechnology skin-whitening cosmetics can effectively restrain activity of monophenyl oxidase, act on various stages of a melanin metabolic path, restrain generation of melanin on the aspect of molecular level and whiten the skin of the user; and a skin-whitening effect is achieved.

The invention discloses a Chinese medicinal compound extract for whitening and removing freckles and a preparation method thereof, relates to a medicament for whitening and removing the freckles, and solves the problems of slow curative effect, low cure rate and inconvenient administration of Chinese medicaments for a long term in the treatment for chloasma at present. The Chinese medicinal compound extract for whitening and removing the freckles is prepared from bupleurum, Chinese angelica, white paeony root, dogwood, large-head atractylodes rhizome, Indian buead, szechuan lovage rhizome, peach seed, white muscardine silkworm, roasted ginger, mint and radix glycyrrhizae preparata; and the product is prepared by adopting carbon dioxide supercritical extraction technology. The method has the advantages of simpleness and convenient operation, and can highly enrich active ingredients. Therefore, the bioavailability is improved; the pharmacological activity is obviously enhanced; and the obtained product has small volume and does not contain solid impurities which cannot be emulsified. The Chinese medicinal compound extract effectively suppresses the activity of tyrosinase and melanogensis, removes or improves the chloasma, and responds within about one month, and the cure rate reaches 99.98 percent. The Chinese medicinal compound extract can be used as an active ingredient for directly preparing an external medicinal preparation and cosmetics for whitening and removing the freckles, is easy to carry, and is convenient to use.

The invention discloses a compound active cosmetic collagen powder, particularly discloses a synergetic oral compound active cosmetic collagen powder integrating various functions of remarkably resisting oxidation, whitening skin, moisturizing, dispelling wrinkles and freckles, delaying senescence and the like and belongs to the technical field of nutrient health-care foods. The compound active cosmetic collagen powder is characterized in that active polysaccharides, natural fruit powder and vitamin E are added based on cosmetic collagen and has the advantages of being reasonable in proportioning, strong in pertinence, remarkable in synergy effect, good in taste, convenient to eat, good in safety, free of toxic and side effects, simple in production process, easy to produce, filling market blank and extremely having market development potential.

The invention relates to a method for preparing alpha-arbutin which comprises steps of preparing slope seeds, selecting culture mediums, optimizing reaction conditions and extracting products and so on. The invention employs Xanthomonas campestris to ferment to produce the alpha-arbutin without use of organic solvents during the production and generation of harmful substances during the fermentation process. The invention has advantages of low production cost, simple process, and safe operation. And the alpha-arbutin yield produced by the method is high, the alpha-arbutin content in fermentation liquor is 8-11g / L, and the conversion rate of the hydroquinone can be 91%. The alpha-arbutin can obviously inhibit activities of tyrosinase, reduce tyrosinase deposition in skins, and bleach skins, remove freckles.

Methods and formulations are provided to reduce pigmentation in skin, using an array of compounds selected from benzimidazoles, phenylthioureas, phenyltiols, phenylamines, bi- and multicyclic phenols, thiopheneamines, and benzothiamides. The compounds preferably inhibit pigment systhesis in melanocytes through the tyrosinase pathway. The methods can be used for lightening skin, and for treating uneven skin complexions which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically.

The invention discloses a new whitening and freckle eliminating agent for use in cosmetics, which contains the following components: 1.0 to 6 percent of glutathione, 10 to 25 percent of liquoric root extract, 10 to 25 percent of tonka bean extract, 1.0 to 10 percent of turmeric, 3.0 to 15 percent of vitamin C(VC)-ethylether, 0.5 to 5.0 percent of intensifier (alpha-lipoic acid and vitamin C ester) and 14 to 55 percent of solvent filling agent. The main freckle eliminating mechanism of the new skin freckle eliminating agent is to inhibit pycocatechol oxidase, prevent melanin from forming by preventing dopa from being oxidized into dopaquinone; the new skin freckle eliminating agent adopts a light wave conversion principle to improve dim complexion; and thus, the new skin freckle eliminating agent has freckle eliminating and whitening effect. Freckle eliminating and whitening products developed by using the whitening and freckle eliminating agent disclosed by the invention have good effects and low toxicity and meet the requirements of China's laws and regulations on cosmetics, overcome the drawbacks of the conventional products and can meet the urgent needs of yellow people with freckles and whitening needs.