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Application of paeonol in preparation of whitening and freckle-removing cosmetic or pigmentation disease-treating medicine

A skin whitening and pigmentation technology, applied in skin diseases, cosmetics, cosmetic preparations, etc., can solve the problems of whitening and treatment of abnormal pigmentation diseases that have not been reported.

Active Publication Date: 2006-12-27
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Paeonol is currently used to treat allergic skin diseases, but it has not been reported in skin whitening and treatment of abnormal pigmentation diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1, the application of paeonol in the preparation of skin whitening and freckle-removing cosmetics or medicines for treating pigmentation diseases, the prepared cosmetics or medicines contain paeonol; for whitening and treatment of pigmentation diseases (such as tan spot), the effective mass concentration is 5%. The dosage form is tincture; base carrier tincture base. At the same time, it contains 0.5% of antioxidant vitamin E nicotinate and 15% of sunscreen agent cinnamate. The medicine or cosmetic is externally used for skin whitening, freckle removal and treatment of pigmented skin diseases.

Embodiment 2

[0066] Embodiment 2 is substantially the same as embodiment 1, but the mass concentration of paeonol is 10%. The dosage form is spirit; the matrix carrier is spirit matrix. It also contains antioxidant vitamin E 2% and sunscreen agent titanium dioxide 5%.

Embodiment 3

[0067] Embodiment 3 is substantially the same as embodiment 1, but the mass concentration of paeonol is 5%. The dosage form is spirit; the matrix carrier is spirit matrix. The antioxidant is vitamin E nicotinate 0.5%; the sunscreen is 8% aminobenzoate.

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PUM

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Abstract

The invention relates to application of paeonol in preparation of cosmetic for eliminating macula and whitening skin or in preparation of medicament for whitening skin or curing pigment deposition ailment. The cosmetic and medicament are both external use. The mass concentration of said paeonol is 0.01-5 %, optimization scheme is 5-10%. The paeonol and ground substance carrier are mixed to form tincture, spirit, cataplasm, ointment, cream, emulsion, oil agent, face mask, gel, film coating agent, aerosol and solution agent to which other component such as light screening agent and / or antioxidant and / or component for eliminating macula and whitening skin except paeonol can be added. The mechanism of paeonol directly restraining tyrosine enzyme activity, melanin generation and transport is various. The application of paeonol in cosmetic or medicament has unambiguous effect on skin whitening and curing pigment deposition ailment.

Description

technical field [0001] The invention relates to a new application of a substance, in particular to the application of paeonol in the preparation of skin whitening and freckle removing cosmetics, or in the preparation of medicines for skin whitening and treatment of pigmentation diseases. Background technique [0002] The color of human skin is mainly determined by the color development of melanin. Dyspigmentation disease is a common cosmetic skin disease. Most of the drugs currently used to treat such diseases, such as hydroquinone and arbutin, are aimed at the synthesis of melanin, and have a certain effect in practical applications, but the overall effect is not satisfactory. The reason may be that The models for screening these drugs are flawed. The current in vitro screening models in this area mainly include the determination of extracellular mushroom tyrosinase activity, cell tyrosinase activity and melanin synthesis, and whole animal models. These models can only de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K31/343A61Q19/10A61Q19/00A61P17/00
Inventor 马鹏程陈志强解士海
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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