210 results about "Melanin synthesis" patented technology

This invention discloses skin darkening (sunless tanning) compositions based on enhancement of melanin synthesis by tyrosinase enzyme by providing essential substrates for tyrosinase as well as the essential elements to activate the active-site of tyrosinase enzyme. These compositions thus also act as promoters of tyrosinase enzyme.

The invention relates to a preparation method for glabrous greenbrier rhizome extract. The method comprises the following steps of adding coarse powder into an organic solvent-aqueous solution, performing refluxing extraction, and performing standing, filtering and concentration to obtain glabrous greenbrier rhizome crude extract; dispersing the extract by using water, performing separation and purification by using a macroporous adsorption resin column, performing elution sequentially by using water, a 40 to 80 percent organic solvent-aqueous solution and an 85 to 95 percent organic solvent-aqueous solution, and concentrating and drying eluent of each part to obtain extract of each part, wherein the glabrous greenbrier rhizome extract is obtained by performing concentration and drying on the part eluted by water or the 40 to 80 percent organic solvent-aqueous solution, and is used for inhibiting the activity of tyrosinase and the synthesis of melanin, and a composition comprises 0.01 to 15 mass percent of glabrous greenbrier rhizome extract. The preparation method has the advantages that various whitening effect tests show that the glabrous greenbrier rhizome extract can be used for effectively inhibiting the activity of the tyrosinase and the synthesis of the melanin, can be used for an external skin product as an active whitening raw material, and is high in safety, and the effects of improving skin pigmentation and whitening skin can be achieved.

There is provided a topical lightening composition having a melanin synthesis-regulating agent and a vehicle. There is also provided a topical lightening composition having an extract of perilla leaf and a vehicle. There is also provided a topical lightening composition having a lightening agent selected from the group consisting of coconut water, palm water, palm nut milk, pecan nut milk, almond nut milk, cashew nut milk, walnut nut milk, concentrates of the foregoing, and any combinations thereof, along with a vehicle. The compositions and methods of the invention are effective to lighten skin, hair, lips, and / or nails.

The invention discloses a tuber fleeceflower root hair blackening formula, which comprises the following Chinese medicinal compositions in part by weight: 1 to 40 parts of tuber fleeceflower root, 1 to 40 parts of black sesame, 1 to 40 parts of rhizoma drynariae, 1 to 40 parts of yerbadetajo herba ecliptae, 1 to 30 parts of glossy privet fruit, 1 to 30 parts of south dodder seed, 1 to 30 parts of prunella spike, 1 to 30 parts of hiraute shiny bugleweed herb, 1 to 30 parts of mint, 1 to 30 parts of szechuan lovage rhizome and 1 to 30 parts of dried ginger. Two external formulations such as a lotion and a liniment / tincture can be prepared by adding a certain amount of water into the tuber fleeceflower root hair blackening formula or extracting with ethanol. Through the pathogenic wind dispersing, tonifying and blood circulation invigorating effects of the tuber fleeceflower root hair blackening formula, the activity of tyrosinase in hair follicles is enhanced, the synthesis of melanin is promoted for blackening hair and poliosis is improved. A plurality of raw materials are used together, so that blood circulation of scalp is promoted, the scalp, hair and hair follicle obtain sufficient nutrition, the regeneration of hair melanin cells is promoted, and white hairs becomes black from roots. Moreover, the tuber fleeceflower root hair blackening formula has the effects of removing scurf, stopping itching in head, washing hair and protecting hair.

The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and / or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and / or interrupt an inflammatory cycle.

The invention discloses a hair blackening solution with a hair blackening effect and a preparation method thereof. The hair blackening solution is prepared from the following traditional Chinese medicinal components: 1-20 parts of polygonum multiflorum, 1-20 parts of black sesame, 1-10 parts of Chinese angelica, 1-10 parts of Chinese arborvitae twig, 1-10 parts of raw rehmannia, 1-10 parts of glossy privet fruit, 1-10 parts of eclipta, 1-10 parts of mulberry leaf, and 1-10 parts of radix stemonae. The hair blackening solution adopts a traditional Chinese medicinal formula, contains synergetic traditional Chinese medicines, can be used for activating the tyrosinase activity in hair follicles and promoting synthesis of melanin, and plays the effect of blackening hair.

Disclosed herein is a skin-whitening cosmetic composition comprising an extract of Magnolia sieboldii as an active ingredient. The Magnolia sieboldii extract has an excellent effect of inhibiting tyrosinase activity and melanin production, and the cosmetic composition comprising the Magnolia sieboldii extract as an active ingredient has an excellent skin-whitening effect.

Compositions for topical use and having a melanin synthesis-inhibiting activity that include an amount of a botanical extract of at least one of Aspalathus Linearis, Matricaria, Saxifraga, Astragalus, Taraxacum officinale / mongolicum, Ferula varia / foetida, Carthamus tinctorius, Sophora flavescentis, or Chrysanthemum morifolium effective to reduce melanin synthesis are described. Methods for inhibiting melanin synthesis and for skin whitening are also described.

The invention discloses a whitening and freckle-removing composite preparation which comprises the following components: deionized water, sucrose stearate, glycerol, butanediol, N-methyl pyrrolidone, carbomer, phenoxyethanol, glyceryl stearate, polydimethylsiloxane, squalane, butyrospermum parkii, phytosterol hydroxystearate, a pepper extract, seed oil of prinsepia utilis, a camellia reticulata tea extract, a folium artemisiae argyi extract, a horse chestnut extract, tetrahydrocurcumin, glutathione, azelaic acid and xanthan gum. The whitening and freckle-removing composite preparation disclosed by the invention is mainly designed from four whitening and freckle-removing mechanisms of melanin synthesis inhibition, skin barrier remediation, blood vessel factor improvement and inflammation prevention and has the functions of whitening the skin, removing freckles and beautifying the face. The invention further discloses a preparation method of the whitening and freckle-removing composite preparation. The problem of dissolving azelaic acid is solved by using a special process, and thus the stability of the product is improved.

The invention relates to a tyrosinase inhibition compound and an application thereof. The tyrosinase inhibition compound contains beta-arbutin, gallogen, carnosine and sodium ascorbyl phosphate. The tyrosinase inhibition compound is used for directly inhibiting the key targeting tyrosinase for melanin synthesis, indirectly competing, reducing the midbody in the melanin forming process and inhibiting the melanogenesis by eliminating four target spots of the oxygen radicals of the catalytic reaction of the tyrosinase.

Present Invention relates to a skin whitening cosmetic composition comprising arctiin, arctigenin or a mixture thereof as an active ingredient. The disclosed composition can control or inhibit the synthesis of melanin by acting on a melanin synthesis route of alpha-MSH secreted by UV, and thus show an excellent whitening effect compared to a conventional skin whitening cosmetic. Also, the composition has high formulation stability and low skin irritation.

Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY, YRSRK, and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.

The invention discloses an anti-aging cosmetic composition capable of whitening and brightening skin, which relates to the technical field of cosmetics. The anti-aging cosmetic composition capable ofwhitening and brightening the skin is prepared from retinol palmitate, wrapped retinol, a citrus peel extract, a yeast extract, a hylocereus undatus extract, carnosine, 3-o-ethyl ascorbic acid, saccharomycetes / rice fermentation product filtrate and wrapped ferulic acid. According to the invention, under the combined action of the matching of the components; the composition can absorb ultraviolet rays, resist oxidation, inhibit alpha-MSH from stimulating melanin synthesis of B16 melanoma cells, reduce melanin, inhibit tyrosinase activity, inhibit transport of melanin by driver protein, promoteactivation and renewal of epidermal cells, avoid abnormal cutin accumulation, increase skin gloss and remove dull yellow. The composition can also avoid various defects when being used independently,and the whitening efficiency is improved. The whitening and skin brightening effects are achieved through cooperation of the action principles of different components.