210 results about "Melanin synthesis" patented technology

The invention discloses rhodiola rosea fermentation protoplasm cosmetic and a preparation method thereof. Efficient ingredients of the rhodiola rosea fermentation protoplasm cosmetic are supernate obtained by mixing powder of rhodiola rosea root, water and zymophyte to obtain an initial system, fermenting the initial system to obtain zymotic fluid and sterilizing and centrifuging the zymotic fluid. The zymophyte is saccharomycete. The rhodiola rosea root is subjected to whole plant fermentation by adopting the saccharomycete, all functional ingredients and activity of the plant are kept, and loss of active ingredients caused by an extracting method is avoided. Any organic reagents are not added during extraction, fermentation temperature and fermentation pH are mild, structure of plant active ingredients is not damaged, natural activity of the plant is kept, and chemical components of essence and the like are not added in the fermentation protoplasm so as to ensure the safety of products on the human body. The rhodiola rosea fermentation protoplasm cosmetic is rich in salidroside, arbutin and the like having activities of restraining tyrosinase activity and restraining melanin synthesis so as to have a relatively strong whitening function on skin and has a synergistic effect with the components in the fermentation filtrate simultaneously.

This invention discloses skin darkening (sunless tanning) compositions based on enhancement of melanin synthesis by tyrosinase enzyme by providing essential substrates for tyrosinase as well as the essential elements to activate the active-site of tyrosinase enzyme. These compositions thus also act as promoters of tyrosinase enzyme.

Present Invention relates to a skin whitening cosmetic composition comprising arctiin, arctigenin or a mixture thereof as an active ingredient. The disclosed composition can control or inhibit the synthesis of melanin by acting on a melanin synthesis route of α-MSH secreted by UV, and thus show an excellent whitening effect compared to a conventional skin whitening cosmetic. Also, the composition has high formulation stability and low skin irritation.

The present invention provides a whitening cosmetic composition comprising a stem cell, a culture medium thereof or a protein isolated from the culture medium and a method of whitening a skin which comprises administering to the skin an therapeutically effective amount of a stem cell, a culture medium thereof or a protein isolated from the culture medium.

The invention relates to a whitening composition (uniGlow) and an application thereof. The whitening composite comprises phenylbenzimidazole sulfonic acid, hydroxyphenylpropylamide benzoic acid, dipotassium glycyrrhizinate, undecylenoyl phenylalanine, hydrolyzed shellfish protein, beta-arbutin, ellagic acid, sodium ascorbate phosphate, carnosine, nicotinamide, inositol, papain and hesperidin extract. The whitening composition performs targeted inhibition from the melanin forming inducements of UV, inflammatory factors, melanoma and endothelin; in the melanin synthesis process, tyrosinase inhibits the reduction with a melanin intermediate, blocks the melanin transfer pathway, accelerates stratum corneum spalling and accelerates the metabolism; by conditioning, the skin is fine, tight, natural, white and bright.

The invention discloses an active polypeptide and tyrosinase inhibitor composition for whitening and freckle removal. The composition comprises polypeptides with a melanogenesis inhibition function and / or polypeptides with a glycosylation resistance function, and other components with a tyrosinase activity inhibition function. The composition is capable of inhibiting melanogenesis, resisting glycosylation, eliminating saccharified dark yellow proteins and eliminating in-vivo free radicals, so as to achieve the aims of improving the skin types, whitening and removing freckles.

The invention relates to a preparation method for glabrous greenbrier rhizome extract. The method comprises the following steps of adding coarse powder into an organic solvent-aqueous solution, performing refluxing extraction, and performing standing, filtering and concentration to obtain glabrous greenbrier rhizome crude extract; dispersing the extract by using water, performing separation and purification by using a macroporous adsorption resin column, performing elution sequentially by using water, a 40 to 80 percent organic solvent-aqueous solution and an 85 to 95 percent organic solvent-aqueous solution, and concentrating and drying eluent of each part to obtain extract of each part, wherein the glabrous greenbrier rhizome extract is obtained by performing concentration and drying on the part eluted by water or the 40 to 80 percent organic solvent-aqueous solution, and is used for inhibiting the activity of tyrosinase and the synthesis of melanin, and a composition comprises 0.01 to 15 mass percent of glabrous greenbrier rhizome extract. The preparation method has the advantages that various whitening effect tests show that the glabrous greenbrier rhizome extract can be used for effectively inhibiting the activity of the tyrosinase and the synthesis of the melanin, can be used for an external skin product as an active whitening raw material, and is high in safety, and the effects of improving skin pigmentation and whitening skin can be achieved.

There is provided a topical lightening composition having a melanin synthesis-regulating agent and a vehicle. There is also provided a topical lightening composition having an extract of perilla leaf and a vehicle. There is also provided a topical lightening composition having a lightening agent selected from the group consisting of coconut water, palm water, palm nut milk, pecan nut milk, almond nut milk, cashew nut milk, walnut nut milk, concentrates of the foregoing, and any combinations thereof, along with a vehicle. The compositions and methods of the invention are effective to lighten skin, hair, lips, and / or nails.

The invention discloses a whitening black-removing compound which contains the following components by weight percent: 1-10% of nicotinamide, 1-5% of licochalcone A, 1-10% of arbutin, 0.5-1.5% of bletilla root extract, 0.5-1.5% of atractylodes root extract, 0.05-0.3% of pearl extract, 0.05-0.3% of ginseng extract, 0.01-0.5% of nymphaea alba flower, 0.01-0.5% of ligusticum root, 20-40% of glyceroland the balance of water. The whitening black-removing compound is capable of whitening and removing black at three aspects of melanin synthesis, transferring and removing, so that the whitening effect can be greatly promoted.

The invention discloses a tuber fleeceflower root hair blackening formula, which comprises the following Chinese medicinal compositions in part by weight: 1 to 40 parts of tuber fleeceflower root, 1 to 40 parts of black sesame, 1 to 40 parts of rhizoma drynariae, 1 to 40 parts of yerbadetajo herba ecliptae, 1 to 30 parts of glossy privet fruit, 1 to 30 parts of south dodder seed, 1 to 30 parts of prunella spike, 1 to 30 parts of hiraute shiny bugleweed herb, 1 to 30 parts of mint, 1 to 30 parts of szechuan lovage rhizome and 1 to 30 parts of dried ginger. Two external formulations such as a lotion and a liniment / tincture can be prepared by adding a certain amount of water into the tuber fleeceflower root hair blackening formula or extracting with ethanol. Through the pathogenic wind dispersing, tonifying and blood circulation invigorating effects of the tuber fleeceflower root hair blackening formula, the activity of tyrosinase in hair follicles is enhanced, the synthesis of melanin is promoted for blackening hair and poliosis is improved. A plurality of raw materials are used together, so that blood circulation of scalp is promoted, the scalp, hair and hair follicle obtain sufficient nutrition, the regeneration of hair melanin cells is promoted, and white hairs becomes black from roots. Moreover, the tuber fleeceflower root hair blackening formula has the effects of removing scurf, stopping itching in head, washing hair and protecting hair.

The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and / or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and / or interrupt an inflammatory cycle.

The invention relates to a preparation method for paper mulberry fruit extracts and application of the paper mulberry fruit extracts in skin whitening. The preparation method comprises the following steps: taking paper mulberry fruit, adding an organic solvent (ethanol) 5 to 30 times the weight of the paper mulberry fruit, carrying out reflux extraction at a temperature of 50 to 100 DEG C for 1 to 10 h and standing, filtering and concentrating an obtained liquid extract so as to obtain a crude paper mulberry fruit concrete; and dispersing the concrete with water, carrying out separation and purification with a macroporous adsorption resin column and subjecting obtained eluates to condensation and drying so as to obtain the paper mulberry fruit extracts from different parts. The extracts are used for inhibiting activity of tyrosinase and synthesis of melanin and preparation of externally applied compositions for skin whitening, and the usage amount of the extracts is 0.01 to 15% by mass. The invention has the following advantages: according to results of a variety of skin whitening efficacy tests, the paper mulberry fruit extracts have a powerful effect on inhibiting activity of tyrosinase and synthesis of melanin, can be used for preparation of in-vitro skin whitening cosmetics and externally applied pharmaceuticals and have high security and good whitening effects.

The invention discloses a Chinese medicine extract composition with a whitening skin care function and application of the Chinese medicine extract composition. The medicine extract composition is prepared by compounding a grape seed extract, a shatian pomelo seed extract, a glycyrrhiza glabra extract, a white muscardine silkworm extract, a Szechuan lovage rhizome extract, a litchi pericarp extract, a spina date seed extract and a chickpea extract. The Chinese medicine extract composition can be used for whitening skin care cosmetics, can effectively inhibit tyrosinase activity and melanin synthesis, has effects of eliminating free radicals and resisting ultraviolet rays, and is a safe and high-efficiency whitening skin care agent.

The invention discloses a hair blackening solution with a hair blackening effect and a preparation method thereof. The hair blackening solution is prepared from the following traditional Chinese medicinal components: 1-20 parts of polygonum multiflorum, 1-20 parts of black sesame, 1-10 parts of Chinese angelica, 1-10 parts of Chinese arborvitae twig, 1-10 parts of raw rehmannia, 1-10 parts of glossy privet fruit, 1-10 parts of eclipta, 1-10 parts of mulberry leaf, and 1-10 parts of radix stemonae. The hair blackening solution adopts a traditional Chinese medicinal formula, contains synergetic traditional Chinese medicines, can be used for activating the tyrosinase activity in hair follicles and promoting synthesis of melanin, and plays the effect of blackening hair.

Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

Compositions for topical use and having a melanin synthesis-inhibiting activity that include an amount of a botanical extract of at least one of Aspalathus Linearis, Matricaria, Saxifraga, Astragalus, Taraxacum officinale / mongolicum, Ferula varia / foetida, Carthamus tinctorius, Sophora flavescentis, or Chrysanthemum morifolium effective to reduce melanin synthesis are described. Methods for inhibiting melanin synthesis and for skin whitening are also described.

The invention discloses a whitening and freckle-removing composite preparation which comprises the following components: deionized water, sucrose stearate, glycerol, butanediol, N-methyl pyrrolidone, carbomer, phenoxyethanol, glyceryl stearate, polydimethylsiloxane, squalane, butyrospermum parkii, phytosterol hydroxystearate, a pepper extract, seed oil of prinsepia utilis, a camellia reticulata tea extract, a folium artemisiae argyi extract, a horse chestnut extract, tetrahydrocurcumin, glutathione, azelaic acid and xanthan gum. The whitening and freckle-removing composite preparation disclosed by the invention is mainly designed from four whitening and freckle-removing mechanisms of melanin synthesis inhibition, skin barrier remediation, blood vessel factor improvement and inflammation prevention and has the functions of whitening the skin, removing freckles and beautifying the face. The invention further discloses a preparation method of the whitening and freckle-removing composite preparation. The problem of dissolving azelaic acid is solved by using a special process, and thus the stability of the product is improved.

The invention relates to a tyrosinase inhibition compound and an application thereof. The tyrosinase inhibition compound contains beta-arbutin, gallogen, carnosine and sodium ascorbyl phosphate. The tyrosinase inhibition compound is used for directly inhibiting the key targeting tyrosinase for melanin synthesis, indirectly competing, reducing the midbody in the melanin forming process and inhibiting the melanogenesis by eliminating four target spots of the oxygen radicals of the catalytic reaction of the tyrosinase.

The invention relates to application of a combination of polypeptide conjugates and epidermal stem cell exosomes in medicine and cosmetics. According to the present invention, exosomes are extracted and obtained from epidermal stem cells, the exosomes and polypeptide conjugates are prepared into a composition that inhibits melanin synthesis, and at the same time, skin experiments prove that the composition has the effects of removing freckles and preventing acne.

The invention provides applications of a biological active peptide with melanin synthesis inhibition activity in skin whitening, and belongs to the technical field of biological medicine and comestic.The amino acid sequence of the biological active peptide is represented by formula I: X1-(Gly-L-Gys)n-X2-X3 (I), wherein X1 is used for representing nothing or L-Phe, X2 is used for representing nothing or Gly, X3 is used for representing nothing or L-Phe, X1 and X3 are not used for representing nothing at the same time, and n is equal to or smaller than 8. The biological active peptide is capable of penetrating epidermis, entering corium layer, penetrating cell membrane, and entering cells, and is hydrolyzed into corresponding glycine and cysteine under the effect of hydrolase in cells, so that tyrosinase is inhibited, synthesis of melanin is inhibited, and effective skin whitening is achieved. The biological active peptide can be used for preparing a plurality of preparations used for preventing and treating human body chromatosis diseases and melanoma caused by excess melanin, and other preparations used for inhibiting the activity of tyrosinase.

The invention discloses an elsholtzia ciliata hyland extract, a preparation and an application thereof. The elsholtzia ciliata hyland extract is prepared by virtue of water extraction, has the effects of remarkably resisting free radicals, oxidation and radiation, resisting and inhibiting bacteria, promoting skin cell proliferation, protecting skin from ultraviolet injury and preventing skin from oxidation injury. By virtue of the characteristics, the elsholtzia ciliata hyland extract has the functions of preventing oxidation injury of skin, reducing melanin synthesis and delaying skin senescence, and has remarkable effects of allergy and senescence resistance when being applied to cosmetics.

Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY, YRSRK, and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.

The invention discloses application of conic gymnadenia rhizome in inhibiting the synthesis of skin melanin. The conic gymnadenia rhizome has an effective inhibiting function for tyrosinase, inhibitsthe generation of the melanin and achieves the effects of whitening faces and removing spots.

The invention provides a conjugate for inhibiting melanin synthesis, and shows a good inhibition activity for tyrosinase. Meanwhile, after the conjugate is prepared into the cosmetics, the cosmetics do not irritate skins and have a good whitening function.

The invention discloses an anti-aging cosmetic composition capable of whitening and brightening skin, which relates to the technical field of cosmetics. The anti-aging cosmetic composition capable ofwhitening and brightening the skin is prepared from retinol palmitate, wrapped retinol, a citrus peel extract, a yeast extract, a hylocereus undatus extract, carnosine, 3-o-ethyl ascorbic acid, saccharomycetes / rice fermentation product filtrate and wrapped ferulic acid. According to the invention, under the combined action of the matching of the components; the composition can absorb ultraviolet rays, resist oxidation, inhibit alpha-MSH from stimulating melanin synthesis of B16 melanoma cells, reduce melanin, inhibit tyrosinase activity, inhibit transport of melanin by driver protein, promoteactivation and renewal of epidermal cells, avoid abnormal cutin accumulation, increase skin gloss and remove dull yellow. The composition can also avoid various defects when being used independently,and the whitening efficiency is improved. The whitening and skin brightening effects are achieved through cooperation of the action principles of different components.

The invention provides a composition for inhibiting melanin synthesis. The composition comprises an active ingredient (trans-dibydromorin) and solvents.

The invention discloses a CHMM1 culture medium suitable for in-vitro culture of Chinese epidermal melanocytes. The CHMM1 culture medium takes a base culture medium suitable for in-vitro culture of the epidermal melanocytes as a matrix, wherein the matrix is added with the following components: (1) serum with the volume concentration of 5%-20%, (2) 1-100 ng / mL of bFGF and 1-100 ng / mL of GM-CSF, and (3) 1-100 [mu]g / mL of 3-isobutyl-1-methylxanthine (IBMX) and 3-3000 ng / mL of alpha-MSH. The invention provides the culture medium suitable for in-vitro culture of the Chinese epidermal melanocytes, and the culture medium can be used for culture of the epidermal melanocytes having strengthened proliferation and melanin synthesis abilities, so that the epidermal melanocytes are better applied in transplantation treatment of skin disease patients with hypopigmentation or no pigments.