124 results about "Skin pigment" patented technology

The present invention relates generally to an illumination device used in dermoscopy. More particularly, the invention comprises an improved apparatus for enhanced imaging and illumination of the skin for medical examination and treatment. An array of LEDs encircle a magnifying lens assembly. One set of surrounding LEDs provides cross-polarized white light to aid in canceling the reflected light from the skin and creating less glare. Another set of surrounding LEDs provides non-polarized white light for traditional immersion fluid dermoscopy or for non-polarized viewing of the skin. A third set of surrounding LEDs provides polarized colored light, wherein the wavelength color is selected at a color wavelength that maximizes the viewing of skin pigment regions which is important for early detection of skin cancers and other skin diseases. In an embodiment of the invention the colored LEDs comprise orange light at a wavelength of 588 nm. The present invention also discloses that the range of colored LEDs in the orange portion of the visible spectrum, namely at 581 nm to 600 nm wavelengths.

The present invention is a cosmetic or dermatological preparation comprising at least one UV filtering substance and 8-hexadecene-1,16-dicarboxylic acid. The present invention also includes a method of using the preparation to treat or prevent undesired skin aging, skin pigmentation, or skin pigment disorders, and a method of using the preparation to lighten or prevent undesired pigmentation of the hair.

This invention relates to an external use medicine for treating skin pigment reduction and its preparing method. This external use medicine is prepared by using alcohol, radices polygoni multiflori, fructus psoraleae, flos sophorae immaturus, dioxyacetonem through refining. The medicine has the strongpoint of fast effectiveness, high curative effect, innocuity, no side-effect, convenience in use and low price, especially suitable for treatment of vitiligo.

An ultrasonic skin pigment application device where the device moves the needle applying the pigment at an ultrasonic rate. The device can be a self contained, self-powered, or externally powered. The invention may also include replaceable needles, and or a pigment reservoir. The device may also have adjustments for stroke length, stroke force, and stroke rate. The needle moving mechanism may be either an ultrasonic linear piezo drive or solenoid type drive mechanism or actuator.

The invention discloses a composition for improving skin color and a whitening cosmetic. The composition comprises tranexamic acid, acetyl chitosamine and beta-nicotinamide mononucleotide. The tranexamic acid, the acetyl chitosamine and the beta-nicotinamide mononucleotide are compounded, the beta-nicotinamide mononucleotide is combined with the tranexamic acid and the acetyl chitosamine, pigmentation caused by ultraviolet rays or other skin irritation can be inhibited, and skin pigmented spots related to pigmentation are effectively prevented or improved. The acetyl chitosamine can improve transdermal absorption of effective components such as the tranexamic acid and the beta-nicotinamide mononucleotide, has a whitening effect, and can achieve a synergistic whitening effect when being used together with the tranexamic acid and the beta-nicotinamide mononucleotide, so that the tranexamic acid, the acetyl chitosamine and the beta-nicotinamide mononucleotide can achieve whitening and brightening effects at a low concentration, and are stable, safe and non-irritant.

The invention relates to a preparation method for glabrous greenbrier rhizome extract. The method comprises the following steps of adding coarse powder into an organic solvent-aqueous solution, performing refluxing extraction, and performing standing, filtering and concentration to obtain glabrous greenbrier rhizome crude extract; dispersing the extract by using water, performing separation and purification by using a macroporous adsorption resin column, performing elution sequentially by using water, a 40 to 80 percent organic solvent-aqueous solution and an 85 to 95 percent organic solvent-aqueous solution, and concentrating and drying eluent of each part to obtain extract of each part, wherein the glabrous greenbrier rhizome extract is obtained by performing concentration and drying on the part eluted by water or the 40 to 80 percent organic solvent-aqueous solution, and is used for inhibiting the activity of tyrosinase and the synthesis of melanin, and a composition comprises 0.01 to 15 mass percent of glabrous greenbrier rhizome extract. The preparation method has the advantages that various whitening effect tests show that the glabrous greenbrier rhizome extract can be used for effectively inhibiting the activity of the tyrosinase and the synthesis of the melanin, can be used for an external skin product as an active whitening raw material, and is high in safety, and the effects of improving skin pigmentation and whitening skin can be achieved.

The invention relates to the field of commodities, specifically to a moisture-retaining whitening face cream. The moisture-retaining whitening face cream comprises the following substances by weight: 5 to 8 parts of glycerin, 3 to 5 parts of aloe essence, 5 to 8 parts of green tea seed oil, 8 to 15 parts of pearl powder, 3 to 5 parts of vitamin E acetate, 2 to 5 parts of lecithin wax, 5 to 8 parts of candelilla wax, 8 to 15 parts of refined shea butter, 8 to 20 parts of refined coconut oil, 3 to 8 parts of vitamin B, 1 to 5 parts of stearoxyl trimethyl silane, 3 to 15 parts of hyaluronic acid, 5 to 15 parts of micro walnut powder, 5 to 8 parts of alga extract, 8 to 15 parts of molecular distillation monostearin, 10 to 15 parts of olive oil, 3 to 8 parts of arbutin and 3 to 8 parts of squalane. The moisture-retaining whitening face cream provided by the invention is rich in abundant vitamins, protein and collagen, can effectively retain moisture, supplement water and soften cutin, and is capable of promoting metabolism, activating skin cells, improving blood circulation and accelerating melanin decomposition and excretion, thereby reducing deposition skin pigment and whitening the skin.

The skin care product with added fine oil consists of refined citric oil, refined lavender oil, refined geranium oil, refined cablin patchouli oil, vitamin E, antioxidant, etc. The skin care product has the features of natural attractive smell, no irritation, no toxic side effect, no allergic reaction, and capacity of lightening skin pigment, beautifying skin, eliminating acne, etc.

The invention relates to a mask, and especially relates to a mask having moisturizing and anti-oxidation functions, and its making method. The mask is obtained through using the following raw materials, by weight, 10-20 parts of ginkgo leaf, 15-25 parts of aloe, 5-15 parts of pawpaw, 10-20 parts of chrysanthemum, 5-15 parts of licorice, and 5-15 parts of Lophatherum gracile. The mask having the advantages of scientific and reasonable formula, easily available raw materials, low price, supplementation of abundant natural vitamins for skins, skin pigment removal, prevention of oxidizing damages comprising ultraviolet ray damage, anti-ageing, increase of the skin elasticity, helpfulness for the increase of the immunization and protection effects of skins, restoration of black spots caused by sun exposure and sleep insufficiency, and no anaphylactic reaction, and is an ideal moisturizing and anti-oxidation skin moistening mask.

The invention relates to yoghourt added with grape pigment and chenopodium quinoa. The yoghourt added with the grape pigment and chenopodium quinoa comprises the following components in parts by weight: 100-500 parts of dried skim milk, 100-300 parts of a sweetening agent, 500-1000 parts of chenopodium quinoa pulp, 1000-2000 parts of grape skin pigment liquid and trace amount of a leavening agent. The yoghourt added with the grape pigment and chenopodium quinoa has the advantages of being fine and smooth in taste and having strong grape flavour; the content of protein and other nutritional ingredients in the yoghourt is increased, and the oxidation resistance of the yoghourt is improved; meanwhile, grape skins are utilized, and eating ways of chenopodium quinoa are expanded.

An illumination device used in dermoscopy for enhanced imaging and illumination of the skin for medical examination and treatment. An array of LEDs encircle a magnifying lens assembly. One set of surrounding LEDs provides cross-polarized white light to aid in canceling the reflected light from the skin and creating less glare. Another set of surrounding LEDs provides non-polarized white light for traditional immersion fluid dermoscopy or for non-polarized viewing of the skin. A third set of surrounding LEDs provides polarized colored light, wherein the wavelength color is selected at a color wavelength that maximizes the viewing of skin pigment regions which is important for early detection of skin cancers and other skin diseases. In one embodiment, the colored LEDs comprise orange light at a wavelength in the range of 581 nm to 600 nm wavelengths.

The invention discloses a polarized skin lens, which can be applied for observing the deep-layer fine structure of a skin pigment damaging part directly, and does not need an infiltrated liquid. The polarized skin lens provided by the invention comprises a lens base, a lens group and a ring-shaped light source, wherein the lens group is arranged in the lens base; the ring-shaped light source is arranged at the periphery of the lens base; the lens group comprises at least two lenses; the polarized skin lens also comprises a first polarized sheet arranged in the lens base, and a ring-shaped second polarized sheet arranged at the periphery of the lens base; the first polarized sheet is arranged between the lenses of the lens group; the second polarized sheet is arranged between the ring-shaped light source and a skin sample to be tested; and the second polarized sheet and the first polarized sheet are vertical on the polarization direction. The polarized skin lens does not need the infiltrated liquid, and has the characteristics of being small, convenient and simple and being easy in operation.

The invention discloses a novel human epidermal culture method. The method includes the following steps of (1), skin sample treatment and cell separation; (2), culture of epidermal cells; (3), passage of the epidermal cells and stripping of tissue engineered skin; (4), quality inspection of the tissue engineered skin. A preparation method of a KMSFM culture medium includes: taking DSFM of Gibco as a basis; using low calcium ion concentration; adding bovine pituitary extract (BPE), bovine insulin, bovine transferrin, bFGF, cortisol, heparin and endothelin at the same time. By the novel human epidermal culture method, bovine serum is removed, mixing of non-human-derived ingredients can be reduced greatly, and cost and unsafe factors are reduced; a culture system coated by I-type collagen is used, cell growth slowness caused by removing of nourishing layer cells is avoided, and the novel human epidermal culture method can be used for treating skin pigment diseases such as leukoderma and giant pigmented nevus.

The invention discloses traditional Chinese medicine mineral face applying mud comprising the following components: pearls, white poria, radix sileris, medical stones, honey, angelica sinensis, peppermint, folium ginkgo, flos rosae rugosae, vitamin E and dextrin. A preparation method of the traditional Chinese medicine mineral face applying mud comprises the following steps of: firstly respectively selecting, decontaminating and cleaning the botanical drugs; then soaking the botanical drugs in clear water for 20-60 minutes; decocting for 40-80 minutes; filtering and removing slag; then crushing the medical stones together with the pearls to 800-1000 meshes in an ultramicro way; sufficiently mixing the decoction of the decocted botanical drugs with medical stone powder, pearl powder, the honey, the vitamin E and the dextrin into paste face mud; and sterilely and quantificationally packaging so as to obtain the traditional Chinese medicine mineral face applying mud. The traditional Chinese medicine mineral face applying mud is simple and easy to prepare, materials are easy to obtain, and the traditional Chinese medicine mineral face applying mud can effectively promote the metabolism function of skin cells, enhance the refreshment, the tenderness and the elasticity of facial skin and inhibit the skin pigments and has no toxic and side effect when being used for a long time.

The invention discloses traditional Chinese medicine mineral face applying mud comprising the following components: seaweeds, pearls, white poria, radix sileris, medical stones, honey, angelica sinensis, radix angelicae, tea polyphenol, vitamin E and talcum powder. A preparation method of the traditional Chinese medicine mineral face applying mud comprises the following steps of: firstly drying the seaweeds, the white poria, the radix sileris, the angelica sinensis and the radix angelicae in the sun; crushing to 100-200 meshes; then crushing the medical stones and the pearls to 400-600 meshes in an ultramicro way; and finally sufficiently mixing botanic power and mineral power with the honey, the vitamin E, the tea polyphenol and the talcum powder into paste so as to obtain the traditional Chinese medicine mineral face applying mud. The traditional Chinese medicine mineral face applying mud is simple and easy to prepare, materials are easy to obtain, and the traditional Chinese medicine mineral face applying mud can effectively promote the metabolism function of skin cells, enhance the refreshment, the tenderness and the elasticity of facial skin and inhibit the skin pigments by sufficiently utilizing rich seaweed resources and superior moisturizing property thereof and matching with other natural botanical components and has no toxic side effect when being used for a long time.

The invention discloses a whitening composition. The composition comprises active ingredients comprising yeast extract and an undaria pinnatifida extracting solution. In order to improve the whitening effect, the composition can further comprise an active ingredient palmitoyl tripeptide-5. The invention further discloses an application of the whitening composition in preparation of whitening cosmetics. The whitening composition disclosed by the invention achieves the effects of inhibiting tyrosinase activity in multiple aspects, reducing production and shift of skin pigments, promoting collagen synthesis, prolonging skin aging and rapidly, safely and effectively achieving the effect of whitening skin. Particularly, the whitening composition with usage of three whitening components such as the undaria pinnatifida extracting solution, the yeast extract and the palmitoyl tripeptide-5 has a stronger synergistic whitening effect.

The invention discloses a dirt removal and skin brightening mask for men. The mask comprises 30-50 parts of water, 10-20 parts of alcohol, 10-15 parts of butanediol, 15-18 parts of glycosyl trehalose, 5-10 parts of arginine, 10-15 parts of glycerol, 5-10 parts of hydrogenated starch hydrolysates, 5-8 parts of glycine betaine, 8-15 parts of EDTA disodium, 5-8 parts of dipotassium glycyrrhizinate, 3-8 parts of arginine, 5-10 parts of malic acid, 5-10 parts of xanthan gum, 13-28 parts of a dirt removal agent, 15-20 parts of a sea mud agent, 15-20 parts of a water supplementing agent, 15-18 parts of an oil removal agent, 10-18 parts of brightening agent and 15-25 parts of polyphenol antioxidant. The dirt removal and skin brightening mask has the effects of dirt removing, cleaning, skin brightening, rich nutrition, moistening, skin whitening and the like, cells are effectively prevented from accumulating toxin, the skin is brightened, the skin color is uniform, the skin pigment is diluted, and the skin becomes soft, white, smooth and elastic.

The invention discloses an extraction process for grape-skin pigment. The extraction process for grape-skin pigment comprises the following steps of: (1) mixing dried grape-skin powder with 95 wt% ethanol, adjusting the pH value to 2-4 by citric acid aqueous solution, performing high-speed pre-treatment and homogeneous extraction at a room temperature, and filtering; (2) mixing the filter residue obtained after filtering with 95 wt% ethanol, adjusting the pH value to 2-4 by citric acid aqueous solution, performing homogeneous extraction again, and filtering; and (3) centrifuging the filtrate, collecting the supernatant, freeze-drying the supernatant into a powder, namely, the grape-skin pigment, wherein the high-speed pre-treatment is performed for more than 5 minutes at a speed of 5000-10000 r / min; and the homogeneous extraction is performed for more than 10 minutes at a speed of 1000-4000 r / min. The invention further discloses the grape-skin pigment prepared by the process. The extraction process disclosed by the invention is simple, low in requirements on production equipment, high in extraction efficiency, greatly shortened in extraction time, and obviously superior to the traditional solvent extraction method. The obtained grape-skin pigment is good in water solubility, good in appearance colour, stable in character, and suitable for use as a food additive or a healthcare food raw material.

The present invention discloses an application of methanol extract of breviscapine in the skin whitening and spot removing, which takes the breviscapine extract as the active ingredient to prepare the skin whitening or / and spot removing cosmetics, the medical supplies and foods for the inhibition of tyrosinase activity or / and melanin biosynthesis. The trials prove that the methanol extract of breviscapine can effectively inhibit the tyrosinase activity and the melanin formation without the side effects on the skin and whiten the tanned skin after the ultraviolet radiation, as well as prevent, improve and treat the age spots, freckles, red spots and other skin pigment deposition symptoms caused by the sun. The present invention explores a new usage of the methanol extract of breviscapine and has excellent application prospect.

The invention relates to a skin care emulsion with whitening and anti-wrinkling effect, comprising the following materials in parts by weight per 1000g: 1-4 parts of anthocyanin, 5-20 parts of collagen, 2.5-10 parts of arbutin, 1.5-6 parts of sodium hyaluronate, 8-12 parts of lauryl sodium sulfate, 1-6 parts of N- acetyl ethanolamine, 80-100 parts of octadecanol, 1-6 parts of methylnaphthalene sodium sulfonate, 45-55 parts of glycerol, 0.5-2 parts of p-hydroxybenzoate, 10-40 parts of ring polydimethylsiloxane, and the balance of distilled water. The skin care emulsion of the invention is used on face, and has the following effects of: (1) improving cellular micro ecological environment rapidly; (2) decreasing the accumulation of skin pigment, and dispelling trauma spots, sunburns, chloasmas, freckles and the like; (3) eliminating wrinkles, and improving the excessive cornification of skin to ensure that the skin is ruddy and glossy gradually; (4) stabilizing the nature during use without generating a phenomenon of allergy.

Human skin tissue sample methods and models for validating hypotheses for mechanisms driving skin pigmentation as well as methods for driving skin pigment levels in ex-vivo skin tissue. The method includes providing a first cultured human skin tissue sample and testing the effectiveness of the test agent for driving skin pigmentation, and comparing the transcriptional profile generated from the treated human skin tissue sample to the transcriptional profile of a control to validate the hypothesis that the test agent drives skin pigmentation.

The invention discloses a grape skin pigment extraction technology. The technology comprises the following steps: 1, mixing dried grape skin powder with 95wt% ethanol, adjusting the pH value of the above obtained solution to 2-4 by using an aqueous citric acid solution, carrying out high speed pretreatment at room temperature, homogeneously extracting, and filtering; 2, mixing filter residues obtained after the filtration with 95wt% ethanol, adjusting the obtained solution to 2-4 by using the aqueous citric acid solution, homogeneously extracting, and filtering; and 3, centrifuging the obtained filtrate, collecting the obtained supernatant, and freeze-drying to obtain powder in order to obtain a grape skin pigment. The high speed pretreatment is carried out under 5000-1000rpm for above 5min, and the homogeneous extraction is carried out under 1000-4000rpm for above 10min. The invention also discloses the grape skin pigment obtained through the technology. The extraction technology has the advantages of simplicity, low requirements on a production device, high extraction efficiency, and great shortening of the extraction time, is obviously better than traditional solvent extraction methods. The obtained grape skin pigment has the advantages of good water solubility, good appearance color and stable properties, and is suitable for being used as a food additive and a health food raw material.

The invention relates to a human pluripotent stem cell exosome loaded with photosensitive drugs and preparation and a use thereof. The photosensitive drug is 8-methoxypsoralen, 5-methoxypsoralen, trimethoprim or a traditional Chinese medicine photosensitizer. Compared with the prior art, the exosome derived from embryonic stem cells and induced human pluripotent stem cells is used as a photosensitive drug carrier including 8-methoxypsoralen, constructs a powerful nano-drug delivery system for promoting skin pigment secretion and improving skin functions, and can be used for treating leucoderma, parapsoriasis guttata, psoriasis and other refractory skin diseases.

The invention discloses a method for preparing a natural red jujube skin pigment and application of the natural red jujube skin pigment. The method comprises the following steps of: removing jujube flesh from red jujubes to obtain red jujube skin; drying the red jujube skin, crushing, leaching in a weak base solution, and filtering to obtain a red jujube skin pigment stock solution; and concentrating, drying and crushing the red jujube skin pigment stock solution to obtain powdered natural red jujube skin pigment. According to the method, a process is simple and low in cost and is suitable for large-scale production; and the powdered red jujube skin pigment ensures the stability and wide application of the pigment. The prepared natural red jujube skin pigment has the antibacterial activity on gram-positive bacteria of staphylococcus aureus, listeria monocytogenes, lactobacillus, alicyclobacillus and the like and on gram negative bacteria of escherichia coli, proteus, shigella dysenteriae, pneumobacillus, acinetobacter and the like.

The invention relates to a method for manufacturing banana skin pigment powder by adopting the technology with the combination of ultrasonic extraction and ceramic filtration membrane separation and purification and using the banana skin pigment powder as protein textile material antibacterial dye. The method comprises the following steps of fresh banana skin obtaining, vacuum drying, smashing, ultrasonic extraction, rough filtration, ceramic filtration membrane filtering, condensation through the adoption rotary evaporation, spray drying, powder pigment obtaining, direct dying, cleaning and brown protein textile obtaining. According to the method, the extraction rate of flavonoid and tannin polyphenol pigment in banana skin is increased, polysaccharide, pectin, protein and other macromolecule impurities in the banana skin are removed, and the purity and the antibacterial activity of the pigment are improved. The obtained banana skin pigment is safe and high in antibacterial activity, and the Escherichia coli decreasing rate of the obtained brown protein textile reaches more than 90%.

The invention relates to the technical field of beverage processing and particularly relates to a preparation method of natural red date juice which has the advantages of easiness and convenience in operation of a making process, multiple nutrients and low cost. The preparation method comprises the following steps of: selecting high-quality red dates; removing impurities; cleaning by using clear water; disinfecting; scratching lines; soaking in clear water for 3-5 minutes; soaking in a soak solution; fishing out the red dates, and naturally airing; carrying out high-pressure steam treatment; pulping; filtering to separate slurry from residues; removing date skin and date pits; separating the date skin from the date pits in the residues; keeping the date skin for later use; adding water to the date slurry and extracting; filtering; adding pectinase and cellulase to filter liquor for carrying out enzymolysis; adding granulated sugar, glucose and a food additive to the filter liquor; sterilizing; and encapsulating. The natural red date juice is made of high-quality red dates, ensures certain mouthfeel, nutrition, and the like of red date juice and retains the self faint scent taste of the red dates without destroying the health-care effect of the red dates by adding no preservative agent and essence harmful to human bodies. The preparation method disclosed by the invention can be used for effectively extracting the date skin pigments by independently digesting the date skin.

The invention discloses a preparation method of skin cream. The method comprises the following steps: (1) preparing the following components in parts by weight: 4-5 parts of stearic acid, 2-3 parts of octadecanol, 2-3 parts of hexadecanol, 2-4 parts of white oil, 0.3-0.7 part of Twenn-60, 1-1.5 parts of wool fat, 0.3-0.7 part of olive oil, 1-3 parts of glycyrrhizic acid solution, 1-3 parts of bitter gourd solution, 1-3 parts of water hyacinth solution, 6-7 parts of glycerinum, 0.2-0.4 part of triethanolamine, 0.5-1 part of Chinese angelica extract, 60-80 parts of distilled water, 0.3-0.7 part of essence and 0.1-0.3 part of a preservative; (2) preparing an oil-phase mixture, namely stirring the stearic acid, octadecanol, hexadecanol, white oil, Twenn-60, wool fat and olive oil in an electric heating constant temperature water bath kettle, and forming the oil-phase mixture; (3) preparing an aqueous phase mixture, namely stirring the glycyrrhizic acid solution, glycerinum, triethanolamine, water hyacinth solution, bitter gourd solution, Chinese angelica extract and distilled water in the electric heating constant temperature water bath kettle, preserving the temperature for 10-30 minutes, sterilizing and filtering to obtain the aqueous phase mixture; and (4) mixing, stirring, standing, cooling to obtain the emulsifiable paste shaped skin cream. The invention also discloses skin cream prepared by the method. The skin cream can eliminate skin pigments, and the skin is natural, white and bright in color.

The invention provides a composition for whitening skin and removing spots and a whitening and spot-removing skin-care product containing the composition. The composition is prepared from rhEGF, hamamelis virginiana extract, wax gourd peel aqueous extract and licorice root ethanol extract. In the skin-care product, the weight content of the composition is 1-2 percent. According to the composition, the hamamelis virginiana extract, wax gourd peel aqueous extract and licorice root ethanol extract are compounded with the rhEGF to effectively avoid inactivation of the rhEGF, greatly improve the rhEGF efficiency, promote absorption of the rhEGF, and reduce loss of the rhEGF in the infiltrating process. The skin-care product added with the composition can be used for promoting regenerated skin cells to replace and update senescent cells, so that the content of melanin and colored cells in skin cells can be reduced, chromatosis of skin pigments can be relieved, and the aim of whitening skin and removing spots can be achieved.

The present invention relates to a method and composition for generating a non-naturally occurring intron and its components capable of being processed into small hairpin RNA (shRNA) and / or microRNA (miRNA) molecules by skin cells and thus inducing specific gene silencing effects on skin pigment-related genes and / or aging-causing genes in the cells. The gene silencing effects so obtained are not only useful for lightening and whitening skin colors but also useful for suppressing unwanted aging gene activities in skins.

The invention discloses an extraction process of a grape skin pigment. The extraction process comprises the steps of: drying; crushing; extraction; concentration and drying; and purification. The extraction process provided by the invention is characterized by simple extraction technology, low requirements for production equipment, high extraction efficiency and short extraction time, and is superior to traditional technologies. The extracted red pigment is natural and pure green, has stable character and pure color, can be widely used in food processing and other industries, and is of far-reaching significance for improving the food safety of people.