45 results about "Nevus" patented technology

Hyperactive glandular conditions are treated using topically formulated botulinum toxin compositions. In the preferred embodiment of the invention, topical botulinum preparations are applied directly to the skin by a patient as needed to suppress his or her hyperhidrosis, bromhidrosis, chromhidrosis, nevus sudoriferous, acne, seborrhiec dermatitis or other glandular condition. In other embodiments, topical botulinum toxins are applied with the aid of mechanical, electrical, and / or chemical transdermal delivery enhancers.

The present invention provides methods for diagnosing melanoma in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from dysplastic nevi and / or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.

Hyperactive glandular conditions are treated using topically formulated botulinum toxin compositions. In the preferred embodiment of the invention, topical botulinum preparations are applied directly to the skin by a patient as needed to suppress his or her hyperhidrosis, bromhidrosis, chromhidrosis, nevus sudoriferous, acne, seborrhiec dermatitis or other glandular condition. In other embodiments, topical botulinum toxins are applied with the aid of mechanical, electrical, and / or chemical transdermal delivery enhancers.

The invention discloses a malignant melanoma and non-malignant melanin nevus classification method based on deep learning. The method comprises the following steps: firstly, acquiring data; performingdata preprocessing, then, enhancing the processed data; then, performing the malignant and non-malignant tumor classification at a small sliding block level, generating probabilistic thermodynamic diagrams, machine learning feature extraction, and finally, performing random forest classification based on pathological image levels. According to the invention, a very good experiment result of the small slide block level of the pathological image of the eye superpixel tissue is obtained; more importantly, a whole set of process of automatically classifying tissue pathological images as malignantor non-malignant is realized, a computer aided diagnosis (CAD) system which can be directly applied to clinical aided diagnosis is constructed, and the accuracy is very high.

The invention relates to the technical field of medicines and in particular relates to a novel chlorine photosensitizer-pyropheophorbide-a ether amino acid derivative, a preparation method thereof and an application to preparation of antitumor medicines. A chemical structure of the pyropheophorbide-a ether amino acid derivative is shown in a general formula (I) in the specification. The pyropheophorbide-a ether amino acid derivative has the advantages of high efficiency, low toxicity and the like, and can be used for preparing new medicines for photodynamic therapy of cancers, medicines for photodynamic therapy of benign vascular diseases, such as age-related macular degeneration and nevus flammeus and medicines for photodynamic therapy of condyloma acuminate.

The invention relates to a method for objectively measuring skin phototype by reflectance spectrophotometry. The improved method correlates well with clinician-based assessments and is non-invasive, rapid and accurate.

This invention is directed to a method for detecting melanoma in a tissue sample by measuring a level of methylation of one or more regulatory elements differentially methylated in melanoma and benign nevi. The invention provides methods for detecting melanoma, related kits, and methods of screening for compounds to prevent or treat melanoma.

Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus, benign skin mole, stretch marks, facial keratosis, thickened sunspots of the skin, or a vitiligo spot. The peptide-ionic metal complex is comprised of an ionic metal selected from copper(II), tin(II), tin(IV), and zinc(II), and salts thereof, and the peptide component can be a hydrolysis of casein, collagen, elastin, meat products, silk protein, or soybean protein, or a chemically synthesized dipeptide, tripeptide, tetrapeptide or the like which complexes with the ionic metal.

Methods and compositions for diagnosing and prognosing neoplasms, particularly malignant melanomas, and for identifying patients at high risk for melanocytic nevi and / or melanomas or other cancers are provided. Methods for distinguishing between nevi at high and low risk for malignant transformation and for characterizing or classifying lesions or nevi are also disclosed. Assays and kits for prognosis of melanoma in a human subject comprising assessment of BAP1 protein and / or BAP1 nucleic acid are provided.

The invention relates to a medicine capable of eliminating freckles and acnes, scars and birthmarks, and various stains and wrinkles, i.e., freckle-removing and mole-eliminating ling. The medicine comprises angelica sinensis, salvia miltiorrhiza, pawpaw, herba leonuri, saffron crocus, radix angelicae and liquorice. The medicine capable of eliminating freckles and acnes, scars and birthmarks, and various stains and wrinkles disclosed by the invention is prepared from pure traditional Chinese medicines, and has the advantages of being good in treatment effect, little in side effect, short in treatment course and the like; and the medicine has effects of promoting blood circulation and removing stasis, conditioning internal secretion, improving body microcirculation, promoting skin metabolism, avoiding the excessive accumulation of pigments in skin tissues, whitening skin, and eliminating various stains, wrinkles, moles and scars, and has functions of prolonging life and preventing ageing. The medicine has characteristics of a quick effectiveness and a high cure rate for treatment on acne vulgarises, freckles, acnes, scars, moles, and various stains and wrinkles.

The invention relates to the technical field of medicines and particularly relates to a novel chlorin photosensitizer, i.e., a chlorin p6 amino acid derivative, a preparation method therefor and use of the chlorin p6 amino acid derivative in preparation of antitumor drugs. The chlorin p6 amino acid derivative disclosed by the invention has a chemical structure represented by a general formula (I) shown in the description. The chlorin p6 amino acid derivative disclosed by the invention has the advantages of high efficiency, low toxicity and the like and can be used for preparing novel photodynamic cancer therapy drugs, drugs for photodynamic therapy on benign vascular diseases such as senile macular degeneration and nevus flammeus and drugs for photodynamic therapy on verruca acuminata.

The invention relates to a method for objectively measuring skin phototype by reflectance spectrophotometry. The improved method correlates well with clinician-based assessments and is non-invasive, rapid and accurate.

This invention is directed to a method for detecting melanoma in a tissue sample by measuring a level of methylation of one or more regulatory elements differentially methylated in melanoma and benign nevi. The invention provides methods for detecting melanoma, related kits, and methods of screening for compounds to prevent or treat melanoma.

A method and device to treat superficial lesions in the skin such as solar lentigines that involves a light based energy delivery system in conjunction with a pulsed cooling device to selectively heat surface targets without damage to deeper skin structures.

The invention provides a preparation method of a composition with a function of removing nevus. The preparation method comprises the following steps: firstly, adding a plant extract, a humectant, an emollient, calcium hydroxide, sodium carbonate and deionized water into a reactor according to weight parts and stirring for 0.5h; then adding an astringent, an adsorbent, modified pearl powder and anantioxidant and stirring for 0.5h to obtain a pre-mixed solution; secondly, adding the plant extract and the deionized water into the reactor according to weight parts, raising the temperature to 35 DEG C and stirring for 1h, adding the modified talcum powder and continuously stirring for 1h to obtain a mixture of the plant extract and the modified talcum powder; thirdly, putting the mixture of the plant extract and the modified talcum powder, and the pre-mixed solution into a high speed shearing machine, shearing and homogenizing at the rotating speed of 5000 to 6000r / min for 20 to 30 minutesto obtain homogenate; subpackaging after the product is qualified by detecting, thus obtaining the composition with the function of removing the nevus.

Methods of treating humans or animals having various conditions are disclosed which include administering a cyclosporine component. Among the conditions treated are dry mouth syndrome, verruciform xanthoma, achlorhydria, mucous cysts, oral submucous fibrosis, oral nevi, cancer of the oral mucosa, maloplakia of the genito-urinary tract, vulvovaginitis, helicobacter plylori infection, duodenal ulcers, peptic ulcers, conditions affecting the uterus and appendicitis.

The present invention includes compositions and methods for treating or preventing certain dermal disorders including dermal atrophy, pseudoscars, actinic keratosis, seborrheic or actinic keratoses, lentigines, focal areas of dermal thickening, and coarse wrinkles. In certain embodiments, the compositions useful within the invention comprise a therapeutically effective amount of a mTORC1 inhibitor and a dermatologically acceptable carrier.

The invention belongs to the field of medicine, specifically relates to an novel application of itraconazole, and provides a novel application of itraconazole in the preparation of drugs for treating hemangioma. Itraconazole can effectively inhibit the proliferation and migration performance of endothelial cells of hemangioma, has a good pharmaceutical value, can be used to treat hemangioma in clinic especially strawberry hemangioma, cavernous hemangioma, plexiform hemangioma, verrucous hemangioma, and mixed hemangioma, and can also treat hemangioma of each organ such as liver hemangioma, spleen hemangioma, brain hemangioma, and the like. A novel choice is provided for treating diseases of blood vessel excessive proliferation and blood vessel malignant proliferation, such as hemangioendothelioma, hemangiopericytoma, glomangioma, hemangiosarcoma, angiofibroma, angiolipoma, angiokeratoma, spider nevus, vascular malformation, telangiectasis, infantile hemangioma, adult hemangioma, senile hemangioma, Kaposi's sarcoma, and the like.

The invention relates to an external medicine for removing nevus, wart and hidroma and a preparation method thereof. The external medicine for removing the nevus, the wart and the hidroma is mainly prepared from the following traditional Chinese medicines: curcuma aromatica, curcuma zedoary, brucea javanica powder, old salt, kalimeris indica, kalimeris indica, rhizoma cyperi, smoked plums and horsetail. The external medicine can be used for effectively removing nevus, wart and hidroma without leaving scars, and is simple to use.

The invention discloses a method for preventing and controlling potato diseases by soaking seeds. The method comprises the following steps: selecting high-yield high-quality seed potatoes without pestor mechanical harm and suitable for local cultivation; airing the seed potatoes for 1-2 days and then performing seed-cutting treatment; preparing a 25g.L-1 fludioxonil suspended seed coating into aliquor diluted for 200 times by adopting a secondary diluting method and filling a bucket-shaped container; putting the cut seed potatoes into a plastic net bag, fully soaking in the prepared seed-soaking liquor, soaking for 20-25 minutes and then taking out the seed potatoes; and drying the liquor, airing in a shade place till the seed potatoes are free from water, and sowing in a conventional manner. Compared with the present method for preventing and controlling the diseases in the growth period, the method disclosed by the invention has the advantages that the seedling emergence of the potato is 3-5 days advanced, the emergence rate is increased by 8-10%, the preventing effect is increased by 15-20% and the commodity rate of the potato is obviously increased. The black nevus disease ofthe potato can be effectively prevented and controlled and the prevention effect for the traditional diseases, such as, the potato wilt, is obvious.

The invention relates to a container of an anorectal lubricant and an antibiotic medicine for treating constipation by injection, comprising a container body and a container body duct. A sealing filmis arranged on a container body duct mouth which is provided with an arc duct cap; a medicine outlet is arranged on the duct cap which is internally provided with a component capable of puncturing thesealing film at the container duct mouth; a sealing film capable of being torn is arranged outside the medicine outlet of the duct cap; the container body is provided with an auxiliary container cavity; a hard separating cavity layer is arranged between the container body and the auxiliary container cavity which is provided with a medicine-guiding duct; and the duct of the auxiliary container cavity is arranged in the duct cap. The container body and the cap adopt a double-sealing structure; the outer surface of the cap is an arc smooth surface, and the mouth does not need to be sheared. Thecontainer is safe, sanitary and convenient to use and is lubricant and smooth to administrate medicines, such as antibiotic medicines, hemostatic medicines or nevus sore cream, and the like in the auxiliary container cavity and can be used for further leading the antibiotic medicines and the hemostatic medicines into the anorectum of a patient.

To provide a novel agent for ameliorating a skin symptom such as pigmented macules or ephelides, a novel hair growth agent, and a novel slimming agent. The agent for ameliorating a skin symptom, the hair growth agent, or the slimming agent contains a dopamine agonist as an active ingredient, in which the skin symptom is selected from pigmented macules, periorbital dark circles, darkish skin, black darkish skin, moles, ephelides, birth marks, and seborrheic keratosis.

The invention discloses a nevus removal ointment and a utilization method thereof. The ointment is prepared from, by weight, 20-40 parts of glycerin, 40-60 parts of rhizoma pinelliae, 40-60 parts of aloe, 80-120 parts of quick lime, 20-40 parts of ginger, 20-40 parts of brown sugar, 700-800 parts of bentonite, 20-40 parts of retinoic acid, 15-25 parts of carbolic acid and 1400-1600 parts of water.The nevus removal ointment applied to nevus removal is safe, reliable and free of scars and side effects; no inconvenience is brought to a user in a treatment process; nevi, warts, speckles and others on the skin surface can be removed, and extensive application, great curative effects and short treatment period are realized; nevi, warts, speckles and others on the skin surface of users can be removed in short time, and a promising application prospect is achieved.

The invention provides a hydroxyapatite and collagen composition and application thereof in nevus removing, freckle removing, pigmentation reducing and whitening. Specifically, the composition or preparation or product is used for: (a) removing and / or fading a nevus; (b) removing and / or fading freckles; and / or (c) reducing pigmentation and / or carrying out whitening; wherein active ingredients comprise (Y1) a first active ingredient: hydroxyapatite. The composition provided by the invention is good in safety and high in effectiveness.

The invention discloses a pharmaceutical preparation for removing skin bromidrosis, peculiar smell, hemorrhoid and psoriasis, relates to a novel purpose of edible acetic acid preparation- vinegar in the pharmaceutical field, and aims to solve the technical problem that the edible acetic acid preparation-vinegar can be used to kill poisonous skin germs. The technical point for solving the problem is to perform diluting and heating treatment on the edible acetic acid preparation-vinegar. The main purpose of the pharmaceutical preparation is to treat chronic refractory germ fungal skin diseases such as psoriasis, hemorrhoid, sweaty feet, foot odor, bromhidrosis, and removes skin bromidrosis and peculiar smell.

The invention discloses a method and equipment for recognizing and removing speckles, pox and nevus, and a storage medium, and belongs to the technical field of facial beautification. The method comprises the following steps: inputting data comprising at least one face; identifying the data of at least one face to obtain n flaw features and n flaw areas and generate m flaw categories; generating m first masks according to the m defect categories; selecting the n flaw areas or the m first masks in an interaction mode to generate a second mask; processing according to the n flaw features or the m first masks and the m second masks to output a result graph; according to the method, masks for identifying different types of nevus scabs are obtained through an input graph and a network, and each mask layer represents one type of nevus scabs; a user can select different scabs and pox nevus for reservation; by means of the method, freckle and pox nevi can be removed in a customized mode, personal favorite characteristics of users are reserved, and the problem that different types of freckle and pox flaws cannot be distinguished and recognized in the prior art is solved.

The invention discloses a composition with effects of removing nevus, freckle and wart, which is prepared from the following components in parts by weight: a component A prepared by mixing 30-50 parts of mulberry branch and stem ash, 20-30 parts of veratrum nigrum branch and stem ash and 30-50 parts of weathered forged stone; a component B composed of10-30 parts of radix clematidis root juice; a component C composed of 40-50 parts of rhizoma pinelliae, 5-10 parts of centipede, 15-18 parts of radix arnebiae seu lithospermi, 20-25 parts of rhizoma pleionis, 30-50 parts of purple sand and 80-100 parts of fructus bruceae. The invention also provides a preparation method as well as a use method of the composition with the effects of removing nevus, freckle and wart. The invention provides the composition with the effects of removing nevus, freckle and wart as well as the preparation and use method and the application thereof. The method has the advantages that the operation of removing nevus, freckle and wart is simple, the nevus, freckle and wart is completely removed without leaving scars, the recovery is fast, the face can be normally washed with water during the removal period, and the pain is extremely small.

Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus, benign skin mole, stretch marks, facial keratosis, thickened sunspots of the skin, or a vitiligo spot. The peptide-ionic metal complex is comprised of an ionic metal selected from copper(II), tin(II), tin(IV), and zinc(II), and salts thereof, and the peptide component can be a hydrolysis of casein, collagen, elastin, meat products, silk protein, or soybean protein, or a chemically synthesized dipeptide, tripeptide, tetrapeptide or the like which complexes with the ionic metal.