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Hydroxyapatite and collagen composition and application thereof in nevus removing, freckle removing, pigmentation reducing and whitening

A technology of hydroxyapatite and collagen, which is applied in the fields of medical devices, cosmetics, and medicine, can solve problems such as disfigurement, pigmentation, and depigmentation.

Pending Publication Date: 2021-10-26
上海睿星医疗器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment methods for pigmented spots and melanoma mainly include laser, microwave, electrocautery, freezing, chemical peeling, grinding, etc. Their common feature is to remove the pigmented spots by physical or chemical methods, However, these methods are costly, have a high recurrence rate, and are safe
For example, chemical drugs are often corrosive, and improper use may cause long-term pigmentation or depigmentation, and even cause scars and disfigurement.

Method used

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  • Hydroxyapatite and collagen composition and application thereof in nevus removing, freckle removing, pigmentation reducing and whitening
  • Hydroxyapatite and collagen composition and application thereof in nevus removing, freckle removing, pigmentation reducing and whitening
  • Hydroxyapatite and collagen composition and application thereof in nevus removing, freckle removing, pigmentation reducing and whitening

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] To explore the effect of different proportions of HAP and collagen combined on the synthesis of melanin in B16 melanoma cells.

[0104] Determination of melanin content: B16 cells in the logarithmic growth phase were digested with 0.25% trypsin, and the cell concentration was adjusted to 5×10 5 / ml, inoculate in 6-well culture plate, add 2ml of cell suspension to each well, place at 37°C, 5% CO 2 cultured in an incubator. After the cells adhered to the wall for 24 h, the culture medium was discarded. In the experimental group, 2 ml of the whole culture solution containing HAP and collagen was added according to the concentrations shown in Table 1, and there were 81 groups in total.

[0105] Table 1

[0106]

[0107] An equal amount of complete medium was added to the blank group. Each group of treatments replicated 6 wells. Add 1 mol / L NaOH containing 10% DMSO, sonicate for 30 min, place in a 90° C. water bath for 2 h, and measure the absorbance (A) at 450 nm. ...

Embodiment 2

[0119] Mole Lightening / Mole Removal

[0120] 1. Evaluation method:

[0121] Select a healthy adult, where there are melanomas growing, select a 2cm*2cm test area, and count the number of melanomas in the test area.

[0122] Distribute the test product, use it twice a day, once in the morning and once in the evening, and use it after cleansing. Stop using other mole lightening and mole removal products during the experiment.

[0123] Evaluation after continuous use. Using self-contrast before and after, doctors and patients will jointly evaluate according to the following grading standards.

[0124] 0: melanoma remains, protruding from the skin surface, and the color has not changed;

[0125] 1: The nevus shrinks and protrudes from the skin surface (or the nevus does not become smaller and the protrusion decreases), and the color does not change;

[0126] 2: The color of melanoma becomes lighter or changes from black to yellowish brown;

[0127] 3: The melanoma shrinks,...

Embodiment 3

[0135] Lighten spots / freckles, reduce pigmentation

[0136] 1. Evaluation method:

[0137] Choose a healthy adult with spots or pigmentation, take a 2cm*2cm area as the test site, distribute the test product, use it twice a day, once in the morning and once in the evening, and use it after cleansing. During the experiment, stop using other spot-lightening and pigmentation-reducing products. Evaluate according to the degree of skin tone loss.

[0138] Evaluation after continuous use. Using self-contrast before and after, doctors and patients will jointly evaluate according to the following grading standards.

[0139] 0: There is no change in the area of ​​spots and pigmentation, and there is no change in color;

[0140] 1: The area of ​​spots and pigmentation shrinks, and the color does not change;

[0141] 2: There is no obvious change in the area of ​​spots and pigmentation, and the color becomes lighter or changes from black to yellowish brown;

[0142] 3: The area of ...

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Abstract

The invention provides a hydroxyapatite and collagen composition and application thereof in nevus removing, freckle removing, pigmentation reducing and whitening. Specifically, the composition or preparation or product is used for: (a) removing and / or fading a nevus; (b) removing and / or fading freckles; and / or (c) reducing pigmentation and / or carrying out whitening; wherein active ingredients comprise (Y1) a first active ingredient: hydroxyapatite. The composition provided by the invention is good in safety and high in effectiveness.

Description

technical field [0001] The invention relates to the fields of medicine, medical equipment and cosmetics. It specifically relates to the use of hydroxyapatite composite collagen for removing moles / lightening moles, removing spots / lightening spots, reducing pigmentation, and whitening, and compositions and preparations based thereon. Background technique [0002] With the continuous improvement of living standards and medical standards, the restoration of skin shape is not only to restore its function alone, but more importantly, to meet the aesthetic requirements and improve the quality of life. The treatment and prevention of facial pigmentation and melanoma has always been a difficult problem in the medical field, especially the photoaging skin pigmentation spots, age spots, solar keratosis, post-acne hyperpigmentation spots, freckles, lentigo, Various types of nevus and pigmented nevus have a very high incidence rate, and they will occur, increase, and expand with age or ...

Claims

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Application Information

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IPC IPC(8): A61K8/65A61K8/24A61Q19/02A61K38/39A61P17/00A61K33/42
CPCA61K8/65A61K8/24A61Q19/02A61K38/39A61K33/42A61P17/00A61K2800/592A61K2300/00
Inventor 马驰廖兴王芳黄新凡罗平
Owner 上海睿星医疗器材有限公司
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