91 results about "Pigmented spots" patented technology

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

The present invention relates to a composition suitable for topical application to the skin, containing a dispersion of colloidal particles, which do not have thickening properties, of at least one inorganic filler—in particular silica—in a physiologically acceptable medium containing at least one volatile oil and at least one nonvolatile oil, the composition being free of cyclopentasiloxane. Advantageously, the weight ratio of volatile oils to nonvolatile oils is between 1:1 and 3:1. It also relates to a method of cosmetic treatment, in particular of an aged skin or a greasy skin, comprising the application to the skin of the abovementioned composition, and the cosmetic uses of this composition, in particular for smoothing wrinkles and fine lines and / or retightening the skin of the face and / or of the neck, for softening or concealing skin imperfections such as fine lines, pores, irregularities of the skin microrelief and pigmented spots, and for mattifying the skin.

Uses of topical compositions comprising a 2-hydroxycarboxylic acid or related compound to alleviate or improve signs of skin, nail and hair changes associated with intrinsic or extrinsic aging are disclosed. 2-Hydroxycarboxylic acids and their related compounds include, for example, 2-hydroxyethanoic acid, hydroxypropanoic acid, 2-methyl 2-hydroxypropanoic acid, 2-phenyl 2-hydroxyethanoic acid, 2-phenyl 2-methyl 2-hydroxyethanoic acid, 2-phenyl 3-hydroxypropanoic acid, 2,2-diphenyl 2-hydroxyethanoic acid, 2-hydroxybutane-1,4-dioic acid, 2,3-hihydroxybutane-1,4-dioic acid, 2-carboxy 2-hydroxypentane-1,5-dioic acid, 2-ketopropanoic acid, methyl 2-ketopropanoate, ethyl 2-ketopropanoate, and gluconolactone. Topical application of compositions comprising 2-hydroxycarboxylic acid and / or related compounds has been found to alleviate or improve skin lines; blotches; blemishes; nodules; wrinkles; pigmented spots; atrophy; precancerous lesions; elastotic changes characterized by leathery, coarse, rough, dry and yellowish skin; and other skin changes associated with intrinsic aging or skin damages caused by extrinsic factors such as sunlight, radiations, air pollution, wind, cold, dampness, heat, chemicals, smoke and cigarette smoking. Topical applications of such compositions have also been found to improve the overall qualities of nail and hair affected by intrinsic aging or damaged by extrinsic factors.

The invention discloses a composition for improving skin color and a whitening cosmetic. The composition comprises tranexamic acid, acetyl chitosamine and beta-nicotinamide mononucleotide. The tranexamic acid, the acetyl chitosamine and the beta-nicotinamide mononucleotide are compounded, the beta-nicotinamide mononucleotide is combined with the tranexamic acid and the acetyl chitosamine, pigmentation caused by ultraviolet rays or other skin irritation can be inhibited, and skin pigmented spots related to pigmentation are effectively prevented or improved. The acetyl chitosamine can improve transdermal absorption of effective components such as the tranexamic acid and the beta-nicotinamide mononucleotide, has a whitening effect, and can achieve a synergistic whitening effect when being used together with the tranexamic acid and the beta-nicotinamide mononucleotide, so that the tranexamic acid, the acetyl chitosamine and the beta-nicotinamide mononucleotide can achieve whitening and brightening effects at a low concentration, and are stable, safe and non-irritant.

A Chinese-medicinal face mask for removing pigmented spots without damage to face skin is prepared from 13 Chinese-medicinal materials including liquorice root, gingko leaf, safflower, Chuan-xiong rhizome, etc.

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

The invention discloses a feed capable of preventing the fading of spots of channel catfish. The feed capable of preventing the fading of the spots of the channel catfish comprises the following components in percentage by mass: 15.5% of expanded soybean meal, 4.2% of fermented soybean meal, 15.0% of Peruvian fishmeal, 16.0% of rapeseed meal, 15.65% of cottonseed protein, 14.6% of rice bran, 13.0% of wheat middling, 1.8% of monocalcium phosphate, 1.0% of soya-bean oil, 1.5% of phospholipid oil, 1.0% of a premix, 0.02% of vitamin E, 0.03% of vitamin C, 0.05% of complex enzyme, 0.15% of composite bile acid with mass concentration of 20% and 0.5% of traditional Chinese herbal medicine additives, wherein the sum of the mass percentages is 100%. According to the feed capable of preventing the fading of the spots of the channel catfish, the components of the feed are optimized; the composite bile acid and the traditional Chinese herbal medicine components are added according to a certain ratio so as to the effects of improving the capability of the channel catfish body in decomposing and using fat, improving the activity of fatty acid, promoting the emulsification of the fatty acid and the steatolysis effect of pancreas, reducing the content of the cholesterol in the blood, reducing the pressure of the fish body liver for decomposing the fat, activating the activity of tyrosinase, promoting the deposition of melanin and spots and promoting the deposition of the pigment spots and the rapid growth of the channel catfish under the conditions of normal water quality and high-density feeding.

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;

The invention discloses a ground beeltle biological activity small peptide effective part composition used for removing spots and whitening skin, and belongs to the field of traditional Chinese medicine. The composition is prepared from ground beeltle small peptide extracted from ground beeltles, prepared rehmannia root total polysaccharides extracted from rehmannia roots, angelica sinensis total phenolic acid extracted from angelica sinensis and licorice root total flavonoids extracted from licorice roots according to a certain matching ratio. Conventional auxiliary materials in pharmacy are added, and the composition is prepared in various dosage forms and can be clinically used for treating pigmented spots, whitening skin and reducing pigmentogenesis.

The invention relates to a preparation method of a skin caring product, and belongs to the field of Chinese medicinal skin caring health products. The skin caring cosmetic comprises the following materials (by weight part): Poria cocos 10-15, Lycium barbarum fruit 15-20, Carthamus tinctorius flower 15-20, Angelica dahurica 15-20, Astragalus membranaceus 15-20, Panax ginseng 10-15, Semen Persicae 10-15, Ligusticum chuanxiong 8-12, Coix lacryma-jobi seed 10-15, Cuscuta chinensis seed 10-15, green tea 15-20, Astragalus complanatus seed 10-15, and Polygonum multiflorum 8-12. The product is developed in accordance with Chinese medicine theory and by integrating with 8 years' clinic experiences of the inventor. The product has effects of invigorating qi, promoting blood circulation, nourishing yin, dredging meridians, tonifying liver and kidney, clearing away heat and toxic materials, moistening skin, lightening pigmented spots, caring skin, delaying skin aging, enhancing immunity and so on, and has distinct therapeutic effect on facial freckle, chloasma, acne, and dark and lusterless complexion.

The invention relates to the use of the tetrapeptide PKEK for brightening human skin, for bleaching pigmented spots and / or for leveling out irregularities in skin coloration.

The invention discloses milk powder for resisting wrinkles and moistening skin of women, which is prepared by mixing the following raw materials: 1-15g of fish collagen protein powder, 0.1-1g of soy isoflavones, 1-20mg of vitamin A, 1-20mg of vitamin B1, 1-20mg of vitamin B2, 1-20mg of vitamin B6, 1-20mg of vitamin C, 0.1-1g of vitamin E powder, 1-10g of fructooligosaccharide, and 72.9-97.795g of milk powder. The milk powder can prevent sebum diffusion, balance oil and fat, make skin glossy and elastic, inhibit melanogenesis and chronic melanin deposition, prevent and treat chloasma, freckles, senile plaques and pigmented spots, and eliminate acnes and the like, and is particularly suitable for being taken by people with dry skin.

Provided is a cosmetic agent superior in a whitening effect (including prophylaxis and removal of pigmented spot) and having high safety. In addition, a superior melanin production suppressive agent is provided.A cosmetic agent or melanin production suppressive agent comprising (A) a cysteine derivative represented by the formula (I) or a salt thereof:whereinX and Y are each independently OR1 or NHR2 wherein R1 and R2 are each independently a hydrogen atom or a C1-22 alkyl group;Z is a hydrogen atom or a C1-22 alkyl group; andW is a C1-22 alkyl group, a C1-22 alkoxy group or a C1-22 alkylamino group, and(B) a whitening agent.

The invention discloses a medicine composition with skin whitening and tendering functions and a preparing method thereof. The medicine composition is mainly prepared from, by mass, 0.5-5.0 parts of rhizoma bletillae polysaccharide, 4.0-12.0 parts of sea buckthron oil, 0.2-4.0 parts of alpha-arbutin, 0.5-4.0 parts of centella asiatica total glycosides, 0.2-2.0 parts of radix angelica oil, 0.2-1.0 part of jasmine oil and 0.05-0.15 part of vitamin E. Active portions or components of natural medicine are adopted as the skin whitening and tendering medicine composition, hydrogel type emulsion is adopted as a medicine delivery carrier, and the medicine composition is externally used for treating pigmented spots, has the targeted medicine delivery function that the medicine active components reach a nidus directly and has the functions of whitening skin, fading spots, resisting wrinkle, improving elasticity, resisting ageing and preventing rhagades on skin.

A powder substrate liquid for eliminating the pigmented spots from face skin and preventing regeneration of melanin is prepared from active pearl nanoparticles, talc powder, titanium white powder, sun shielding agent, triglyceride octoate decanoate, potassium azelate biglycinate, humectant, thickening agent, neutralizing agent, essence, antiseptic, deionized water, etc.

A Chinese medicine 'Tiaojing Yangyan pill' for treating menoxenia, menalgia, dark face and pigmented spots is an improvement to existing relative medicine in the form of capsule. Its preparing process is also disclosed. Its advantages are high curative effect, high release speed and high biologic utilization rate.

The invention discloses sugar-free multi-fruity tabletting candies with pigment spots. The tabletting candies comprise the following raw materials in weight percentage: 81-90% of sorbitol, 0-7% of malic acid, 1-5% of maltitol, 0-3% of maltodextrin, 0-0.5% of hydrogenated plant oil, 0-0.1% of phosphatide, 0-1% of Arabic gum, 0-4% of food flavors, 0-1% of citric acid, 0-0.3% of aspartame, 0-0.2% of acesulfame potassium, 0-0.03% of pigment, and 0.1-2% of magnesium stearate. A preparation process of the invention is simple, and single-fruity or multi-fruity tabletting candies can be obtained. The tabletting candies are suitable for a wide range of population, beautiful in appearance, and unique in taste. Functional tabletting candies can be prepared with addition of vitamin C.

The invention relates to the use of the tetrapeptide PKEK for brightening human skin, for bleaching pigmented spots and / or for leveling out irregularities in skin coloration.

The present invention relates to a cosmetic peeling method using a composition containing: (a) from 10 to 70% by weight of at least one compound chosen from: nicotinic acid, nicotinic acid esters and nicotinamide, and (b) from 10 to 70% by weight of at least one compound chosen from: ascorbic acid and its precursors, each relative to the total weight of the composition. It also relates to the use of the abovementioned composition for performing a superficial chemical peeling by topical application to the skin, in order to attenuate wrinkles and fine lines and / or pigmented spots and / or scars such as acne or varicella marks.

The invention discloses a medicament for treating chloasma, which is prepared from Chinese angelica, white paeony roots, the root of Chinese thorowax, tuckahoe, white atractylodes rhizome, peppermint, cassia twigs, dried ginger, red paeony roots, red-rooted salvia roots and licorice roots as raw materials. The medicament can be prepared into various dosage forms used in clinic, and the oral liquid is a preferable dosage form. The medicament has the efficacy of soothing the liver, dispelling melancholy, nourishing the blood, strengthening the spleen, invigorating the circulation of blood and eliminating stasis. The medicament also has the advantages of good curative effect on various pigmented spots such as chloasma and the like, high effective rate, clinic safety and reliability and no obvious toxic or side effect.

The present invention relates to a composition for softening skin comprising an effective amount of a salicylic acid embedded in starch microcapsules and an antifungal compound. The present invention further relates to a method of treating the skin to reduce wrinkling, modifying its color, reducing surface pigmented spots or eliminating squamae. The present invention further relates to a method of manufacturing a skin softening cream.

The invention discloses pure natural lipstick containing traditional Chinese medicine ingredients and a preparation method thereof. The pure natural lipstick is prepared from the following ingredients: 50 to 81 weight parts of cherokee rose seed oil extraction liquid, 1 to 6 weight parts of shea nut oil, 10 to 20 weight parts of bee wax, 1 to 4 weight parts of carnauba wax, 4 to 7 weight parts of traditional Chinese medicine pigments, 0.2 weight part of honey, 0.2 weight part of VE and 0.6 weight part of folium artemisiae argyi oil or clove oil, wherein the cherokee rose seed oil extraction liquid is extraction liquid of at least two kinds of materials from radix arnebiae seu lithospermi, radix angelicae sinensis, rhizoma curcumae longae, fruit of Chinese wolfberry, cherokee rose seeds, cortex cinnamomi and indigo naturalis in the cherokee rose seed oil. The pure natural lipstick has the effects of preserving moisture, fading cheilogramma, resisting crease, preventing crack, diminishing inflammation, resisting bacteria, resisting oxidation, resisting pigmented spots and the like; the natural lipstick prepared from traditional Chinese medicine pigment and some natural grease wax type ingredients better protects the lip and also achieves the beautifying effect; meanwhile, the harm cannot be caused on the human body after the natural lipstick is used for a long time.

The invention discloses coix seed powder facial mask cream and a composition preparation method thereof. The cream is prepared from the following raw materials in percentage by weight: 35-50 percent of coix seed powder, 5-15 percent of seaweed meal, 20-30 percent of honey, 2-5 percent of vitamin E, 2-5 percent of pearl powder, 35-50 percent of goat milk and 2-5 percent of chitosan. The coix seed powder facial mask cream has functions of whitening, nourishing, relieving wrinkles, eliminating pigment spots, improving skin metabolism and moistening, can be used for effectively preventing skin dryness, enhancing facial nutrition absorption and recovering natural elasticity and luster, and more importantly, can be used for protecting face since the facial mask cream is prepared from pure natural products and does not have side effect.

The invention relates to cosmetics and especially relates to a freckle removal liquid. The freckle removal liquid is a toning for removing freckles and a part of punctate pigmented spots. The freckle removal liquid is characterized in that phenol as a remover and traditional Chinese medicine active ingredients are mixed and prepared into an ethanol solution, wherein a mass ratio of ethanol, phenol, Chinese angelica, Taiwan angelica root, safflower, red sage root to borneol is 30: (80-100): (15-20): (10-15): (8-10): (8-10): (5-6). The freckle removal liquid utilizes phenol as a permeating agent, and realizes removal of freckle from epidermis by using weak acidity of phenol so that active ingredients of the traditional Chinese medicine can be permeated into the skin to produce effects thereby beautifying the skin. Traditional Chinese medicines of Chinese angelica, Taiwan angelica root, safflower and red sage root have effects of invigorating the circulation of blood, removing freckle and repairing the skin. Borneol has permeation effects. Through synergism of the traditional Chinese medicines, the freckle removal liquid can produce satisfactory effects.

The present invention relates to a molecular signature of pigment spots on the skin, comprising the MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2 genes, and various applications of this signature. The invention relates in particular to a method for characterizing an apparent or suspected pigment spot in a human being, which comprises comparison of the levels of expression, in samples of skin taken from said spot and of non-lesioned adjacent skin, of at least one dermal gene related to matrix remodelling or to the extracellular proteoglycan and glycoprotein components thereof, chosen from the list consisting of the MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2 genes. The invention also relates to methods for evaluating the efficacy of a treatment for pigment spots, to cosmetic and therapeutic methods for treating pigment spots, and also to various modulators of said genes and the use thereof.

An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is grafted onto a non-human animal, is provided.

The invention relates to an external traditional Chinese medicine capable of treating facial acne, chloasma and drug pigment spots to improve dull skin and particularly relates to spot-removing beauty powder and a preparation method thereof. The spot-removing beauty powder mainly comprises the following raw materials in parts by weight: 14-25 parts of rose, 15-28 parts of honeysuckle flower, 25-36 parts of peony flower, 8-20 parts of white poria, 10-20 parts of moutan bark and 10-20 parts of radix angelicae. The preparation method of the spot-removing powder comprises the following steps: 1, separately crushing the raw materials and screening the raw materials by a 120-mesh screen to obtain powder; 2, drying in air and sterilizing the powder, then mixing the powder at a ratio to obtain the spot-removing powder, and packing the spot-removing powder. Through the adoption of the technical scheme, the spot-removing powder has the positive effects of skin whitening, skin spot removing, skin compacting and skin moisturizing.

The object of the present invention is to provide a method for evaluating or selecting an agent having preventive or alleviative effects on spots, which method realizes reliable and effective screening of candidate substances of the agent; a method for predicting spot formation; and a method for analyzing the condition of skin spots. The method of the present invention for evaluating or selecting an agent having preventive or alleviative effects on spots, includes evaluating a substance which suppresses a p53 activity, or an expression level of a p53 gene, a p53 target gene or an expression product thereof in an epidermal cell.