40 results about "Senile plaques" patented technology

The invention relates to a pyrro-quinoline quinine (PQQ) sodium salt derivative and a preparation method thereof, belonging to the field of pharmacy. In the preparation method, PQQ is used as a raw material, and an acid-base neutralization reaction with PQQ is carried out in a basic solvent of sodium hydroxide to prepare the PQQ sodium salt derivative represented in the structural formula (I), wherein R1, R2 and R3 can be identical or different and respectively represents H, ammonium ion (NH3), potassium ion, sodium ion, magnesium ion, calcium ion or zinc ion, and at least one of R1, R2 and R3 is sodium ion. The invention has mild reaction conditions, easy product refining and purification, simple preparation steps and high yield more than 80%. The PQQ sodium salt derivative has the functions of inhibiting GSK-3 activity, reducing senile pigment formation in a transgenic mouse brain, reducing tau protein phosphorylation and the like. Thus, the PQQ sodium salt derivative can be medically used for treating senile dementia and other diseases.

Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.

Personalized skin-specific topical formulations containing conditioned medium obtained from cultures of fibroblasts has been developed. Unlike other topical formulations, these formulations are specific for the recipient-skin type specific, and conditioned medium is obtained from a subject with desired skin characteristics. For example, since African American skin is known to wrinkle less and later than Caucasian skin, conditioned medium may be obtained from African American skin for application to pale skin. In another embodiment, the fibroblasts are obtained from young skin for administration to older skin. In still another embodiment, the fibroblasts are obtained from skin that does not suffer from acne or discoloration, for application to skin that is prone to acne or discoloration. Examples of skin donor selection criteria include delayed wrinkling, small pores, resistance to sunburn, resistance to acne, uniform coloration or lack of blotching or age spots and good moisture retention.

Methods and formulations are provided to reduce pigmentation in skin, using an array of compounds selected from benzimidazoles, phenylthioureas, phenyltiols, phenylamines, bi- and multicyclic phenols, thiopheneamines, and benzothiamides. The compounds preferably inhibit pigment systhesis in melanocytes through the tyrosinase pathway. The methods can be used for lightening skin, and for treating uneven skin complexions which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically.

This invention relates to a novel method of reducing the appearance of rhytides (“facial wrinkles”) and / or infra-orbital shadows (“dark circles”) under the eyes, and striae (“stretch marks”), or lentigo senilis (“age spots”), and hyper / hypo pigmentation on other anatomical areas. Particularly, this invention relates to a topical patch worn on the skin that in a preferred embodiment incorporates two distinct layers, each providing useful features and together providing a novel article and method of improving skin cosmesis. Ease of use, patient comfort and cost effectiveness are provided. The patch is applied to the affected area and preferably worn at least several hours and more preferably worn overnight. The product increases the hydration level of the skin over which it is applied. There is a slight increase to the volume of the local superficial tissue, which serves to tighten the overlying skin and reduce the size and quantity of fine wrinkles at least temporarily. Various active ingredients, such as peptides, vitamin compounds, antioxidants, growth factors, glycolic or alphahydroxy acids, etc., may be incorporated into the present invention thereby providing an enhanced effect or other perceived advantage in the market.

The invention discloses the application of biphenyl cyclooctene containing substance in the process for preparing Alzheimer disease treating medicine, wherein the substance has the formula disclosed in the specification. The biphenyl cyclooctene containing substance can effectively reduce the output of Abetta, suppress the formation of aged speckle, improve the learning and memory capability for the modeled mouse, thus achieving the goal of treating and delaying AD disease.

The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

A composition, a method, and a kit are provided for chemical skin peeling, based on nano-structured thixotropic inorganic gels, which have a higher potency and are less irritant of the conventional peeling formulations. The gels of the invention can easily be applied on the skin, where they form a stable, uniform layer, that doesn't strain. The kit comprises by a defatting gel, different types of peeling gels and a neutralizing gel. The defatting gel is characterized by a markedly enhanced defatting capacity in comparison to the conventional products, because the sebum solubilized by the solvent is strongly adsorbed on the huge surface of the nano-structured material of the gel. The peeling gels are based on conventional peeling compounds, such as glycolic acid, trichloroacetic acid, pyruvic acid, salicylic acid, Jessner solution, but the presence of nano-structured material strongly increases the peeling effect, allowing the use of lower concentrations of peeling compound, with only minimal skin irritation for the user. The neutralizing gel is characterized by a colour change that allows the operator to verify in real time the neutralization of the peeling agent on the treated skin surface. All the gels of the invention can be easily removed from the skin after the treatment. The thixotropic gels of the invention can be used in chemical skin peeling for the treatment of various cosmetic conditions and dermatological disorders, including dry skin, acne, dandruff, keratoses, age spots, wrinkles and disturbed keratinisation.

Compositions and methods for treatment of skin conditions, such as age spots, liver spots, photodamaged skin, skin folds, diminished hair growth, non-infectious cellulite and “orange skin”, or for repairing damaged DNA in a skin cell, utilize a formulation including about 0.01-1 part by weight tretinoin, and about 1-45 parts by weight dimethylfsulfoxide. Compositions may include about 5-40 parts by weight urea, and about 45-90 parts by weight carrier.

The invention discloses a composition with skin whitening, freckle removing and acne removing functions. Active components of the composition include small-molecular anion water, agilawood, glycerinum, propylene glycol, olive oil, vitamin E, vitamin C and allantoin. The composition can penetrate into and nourish skin, promote cell nutrient absorption, adjust blood circulation, enhance immunity, promote blood follicle cell metabolism, and have an effective restraining and decomposing effect on freckles, chloasma, senile plaque, melanin deposition and the like caused by solarization, hormonal secretion imbalance and age increase; the composition can promote blood follicle cell metabolism, dredge follicles, clean follicles, discharge dermatotoxins, eliminate troubles of patients suffering from whelks and acne rosacea, improve skin elasticity and smoothness, and relieve skin ageing.

The present invention relates to a mixture comprising acetylglucosamine and 4-(1-phenylethyl)-1,3-benzenediol for use as a cosmetic and / or medicament, and particularly for the inhibition of melanin biosynthesis, and to a cosmetic and / or pharmaceutical formulation comprising such a mixture for the treatment of hyperpigmented lesions of the skin such as, for example but without limitation, lentigo solaris, age spots, melasma and chloasma, for rendering uniform the color of the skin, for counteracting the formation of free radicals, and for counteracting or preventing signs of skin aging such as wrinkles and lack of skin tone, and generally for improving the aesthetic conditions of the skin.

The invention discloses a traditional Chinese medicine spot removal skin whitening repair composition. The composition is prepared from, by weight, ginseng, bletilla striata, Moutan bark, Angelica sinensis, cinnamon, lucid ganoderma, pollen, cordyceps sinensis, silkworm larva, saffron crocus, golden cypress, licorice roots, lily, mulberry bark, bearberry and scutellaria baicalensis. The composition has the remarkable advantages that the curative effect is rapid, no toxic or side effect is caused, both symptoms and root causes are treated, skin diseases such as sores, furunculosis, acnes, tineacorporis, rosacea, fat granules, skin allergy pruritus, coupe rose skin, rhinitis sore-toxin and burning and scalding scars can be treated rapidly, and no damage is caused to skin; acne marks, scars,chloasma, butterfly rash, cyasma, senile plaque, sunburn, transmissibility plasue and sebum secretion unbalance are regulated, oily skin, blackheads and coarse pores are improved, cutting is digested, and the obvious curative effect is achieved for problem skin for achieving sun screen and skin tendering and whitening.

The invention relates to the field of biotechnology and in particular discloses polypeptide, which has the amino acid sequence of His-Asp-Pro-Ala-Pro-Rrg-Thr. The invention also provides application of the polypeptide as a beta secretase inhibitor and an A beta aggregation inhibitor and in preparing medicaments for treating Alzheimer disease. Experiments show that: the polypeptide can specifically combine restriction enzyme cutting site of beta secretase on APP to inhibit the enzyme digestion of the beta secretase, the generation of A beta40 and A beta42 and the aggregation and cytotoxicity of the A beta42. After the polypeptide is injected into an AD transgenic mouse for animal memory experiments, results show that the polypeptide can obviously improve the spacial memory capacity of the mouse and decrease the number of cerebral amyloid plaques. The polypeptide has small molecular weight, is easy to pass through a blood brain barrier, has poor antigenicity and small side effect than an antibody, and has wide clinical application prospect.

The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars and salts thereof (formula I). The compounds of the present invention possess wide-spectrum antibacterial and antifungal biological activity suitable for topical or oral application for the treatment of infections and topical ailments in mammals, including acne, rosacea, topical wounds, infections, dandruff, skin disfigurements caused by infection, skin discoloration, age spots, wrinkles, excess facial oil, and veterinary problems including canine infections;

The invention relates to a nanometer material belonging to the field of biomedical science, in particular to a preparation method of prussian blue nanometer particles for targeting A beta age spots. The prussian blue nanometer particles are functionally modified, so that the prussian blue nanometer particles can load transferrin having the function of penetrating through a blood-brain barrier andcongo red molecules targeting A beta age spots. The prepared nanometer particles have favorable r1 longitudinal relaxation rate and r2 lateral relaxation rate, so that simultaneous imaging of MRI(T1 / T2) of the A beta age spots can be realized.

The invention discloses application of epicatechin to antagonistic beta amyloid protein aggregation, cognition and memory ability improvement and age pigment reduction. AD (Alzheimer's disease) belongs to a neurodegenerative disease using nerve cell fiber entanglement, beta amyloid protein (A beta) plaque deposition and cognitive function reduction as pathological features, wherein the A beta protein extracellular toxicity accumulation is regarded as one of the major link of the occurrence of the AD. The effect that the epicatechin can obviously inhibit the fiber formation through the beta amyloid protein aggregation, inhibit the formation of a beta secondary structure, improve the space memory study capability of AD mice, and obviously clear the amyloid plaque in the APP / PS1 dual transgenic AD model mouse brain tissue is discovered. The result shows that the epicatechin can be applied to the treatment of AD and relevant medicine research and development.

The invention relates to a PP2A agonist for preventing and treating mental disorders caused by normal aging or reduction of PP2A activity or expression. The inventor of the invention finds that MPH has a treatment effect on mental disorders of old zebrafish, old mice and ppp2r2cm / m mutant zebrafish, can eliminate DNA damaged and senile nerve cells of the old zebrafish, the old mice and the ppp2r2cm / m mutant zebrafish and improve PP2A activity, and further finds that the PP2A agonist can improve the mental disorders of the ppp2r2cm / m zebrafish, the old zebrafish and the old mice and eliminate DNA damaged and senile nerve cells of the old zebrafish, the old zebrafish and the old mice. On the basis, the invention provides an application of MPH and PP2A agonists to preparation of medicines for preventing and treating mental disorder caused by normal age increase or PP2A activity reduction.

The present invention provides a skin-whitening product which contains human angiogenin with effective concentration to inhibit the production of melanose of skin, said effective concentration is 0.000001% to 0.1% of total weight. Said product can be used for removing freckle, black spot, aged-mark, melanotic nevus and dermal abnormal change due to melanosis, and / or can be used for eliminating wrinkles, raising skin elasticity and preventing dermal senility.

The invention discloses freckle removing cream. The freckle removing cream is mainly prepared from an ecdysone extract, an aloe extract, a radix paeoniae alba extract, a safflower extract, a bletilla extract, a radish root extract, a stiff silkworm extract, pearl powder, vitamin E and Vaseline according to an appropriate proportion, and then the speckle removing purpose is achieved. The freckle removing cream has the obvious treatment effect on chloasma, cyasma, senile plaques and freckles, has no side effect after being used, can improve the nutrition state of the skin, moisten the skin, promote skin cell metabolism and improve functions, is safe and effective and can treat both symptoms and root causes.

The invention belongs to the field of cosmetics and specifically relates to a beverage-removing mask fluid and a preparation method thereof. The invention provides a beverage-removing mask fluid comprising the following components in percentage by weight: 0.5-1% of 20-hydroxyecdysone, 0.5-1% of arbutin, 0.5-1% of 3-O-ethyl ascorbic acid, 1-2% of tanshinol, 0.5-1% of leonurine, 0.5-1.5% of polyglutamic acid, 1-3% of hyaluronic acid, 0.1-0.3% of polyvinylpyrrolidone, 1-5% of propylene glycol, 1-3% of butanediol, 2-8% of glycerinum, 0.1-0.5% of methylparaben, and 72.7-91.3% of water. The beverage-removing mask fluid is capable of fading pigmentation, such as chloasma, malar rash, senile plaques, and the like, whitening skin, and improving dull yellow skin color, and has good permeability and moisturizing effect.

The invention relates to a purpose of glycine, in particular to an application of glycine to the preparation of medicine for treating AD (alzheimer diseases), which solves the problem of lack of effective medicine for treating AD and provides medicine for effectively preventing and treating AD. AD mice with high-fructose diet or intraperitoneal galactose injection and AlCl3 induction are adopted for experiments, the damaged memory function of the mice can be effectively improved through the oral administration of the glycine, and the Abeta1-40 level in the brain, the number of age pigment and the abnormal phosphorylation expression of Tau protein are reduced. The results show that the glycine has the obvious prevention and treatment effect on AD and can be widely applied to the medicine for treating AD.

The invention belongs to articles for make-up and beautification and particularly relates to a skincare cream composition rich in isoflavones. The skincare cream composition rich in the isoflavones comprises the following ingredients in percentage by weight: 5.0-10.0% of soy bean or kudzuvine root extract rich in isoflavone substances, 2.0-5.0% of spermaceti oil, 12.0-20.0% of beeswax, 40.0-60.0% of liquid paraffin, 2.0% of cetanol, 1.0% of sodium borate, 0.2% of hydroxybenzoic acid, 0.5% of essence and the balance being distilled water. The skincare cream composition is rich in isoflavone compounds and can inhibit the activity of casein enzyme and suppress the deposition of skin melanin, and thus, the skincare cream composition has a whitening effect on skins, is applicable to the prevention and the treatment of brown spots and senile plaques, and is the skincare cream which is particularly suitable for aged people.

The invention discloses active traditional Chinese medicine skin care cream. The skin care cream consists of animal fat and a traditional Chinese medicine mixture tincture, wherein the traditional Chinese medicine mixture tincture consists of licorice roots, cortex pseudolaricis, red peony roots, rhubarb, honeycombs and part of propolis. The skin care cream has functions of nourishing skin, inhibiting and killing bacteria, activating blood circulation to dissipate stasis and relieving itching and pain, has the effects of delaying skin aging, fading senile plaques and chloasma, removing wrinkles and maintaining beauty after use, and is proved to have good therapeutic effects on acne, eczema, tinea cruris, tinea pedis, senile plaques, scalds and frostbite after being used by part of patients. As the skin care cream is a pure traditional Chinese medicine component, the skin care cream has no side effects such as cracking, skin peeling, aging and cornification after use and has functions of prevention, treatment and beauty maintenance.

The present invention provides a skin-whitening product which contains human angiogenin with effective concentration to inhibit the production of melanose of skin, said effective concentration is 0.000001% to 0.1% of total weight. Said product can be used for removing freckle, black spot, aged-mark, melanotic nevus and dermal abnormal change due to melanosis, and / or can be used for eliminating wrinkles, raising skin elasticity and preventing dermal senility.

The invention discloses a skin effect tender and smooth emulsion containing an edible tulip component and a preparation method of the skin effect tender and smooth emulsion. The skin effect tender andsmooth emulsion is prepared from an edible tulip extract, a caulis et folium stauntoniae extract, mushroom polysaccharide, a semen plantaginis extract, a cape jasmine fower extract, natural glycerides and pectin. The skin effect tender and smooth emulsion can go deep into skin to promote skin metabolism, gently clean skin residual dirt, prevent cell aging, promote cell regeneration, enhance capillary permeability, replenish active nutrients for the skin, reduce thin lines and wrinkles, remove free radicals which damage the skin, reduce accumulation of aged cutin and effectively protect the skin from sunning and freezing, the formation of melanin and senile plaques is effectively prevented, the skin is not greasy after the skin effect tender and smooth emulsion is used, the skin effect tender and smooth emulsion is verified after 16 years of trial, 3-6 ml of the skin effect tender and smooth emulsion is applied to faces and hands once every morning and evening, if you had used the skineffect tender and smooth emulsion every day 15 years ago, then 15 years later, your skin is still as exquisite and delicate as it was 15 years ago, and it is an unexpected effect.

The invention discloses a cell beauty preparation, and the technical problem to be solved is to treat gynecological diseases and qi and blood caused by chloasma, senile plaque, pigmentation, acne, alopecia, psoriasis, vitiligo, hyperthyroidism, hypothyroidism, frailty, cold and dampness Deficiency, low immune function, cerebral anemia, cerebral hypoxia, fatigue and menopausal syndrome. This product is made of the following raw materials in mass ratio: ants 1-6000, pearl powder 1-3500, motherwort 1-2000, angelica 1-1500, bee pollen 1-2500, medlar 1-3000. Compared with the prior art, the present invention provides necessary and sufficient life substances to human tissue cells by nourishing the kidneys and essence, replenishing qi and nourishing blood, clearing the meridians, ensuring the integrity of the cell structure and the normal progress of metabolism, and making the tissue cells full of youth. Vitality, delaying the aging process of cells, and solving wrinkles, pigmentation, memory loss, and lack of energy caused by the inability of cells to carry out normal life activities.