211results about How to "Improve learning and memory ability" patented technology

The invention discloses a chewable tablet helpful for improving of memory. The chewable tablet is prepared from, by weight, 100-125 parts of pineapple pulp, 30-42 parts of apple pulp, 12-16 parts of peanut kernels, 8-12 parts of walnut kernels, 28-32 parts of milk tree juice, 100-110 parts of germinated brown rice milk, 15-20 parts of millet, 5-8 parts of herbs of Russian boschniakia, 6-8 parts of grassleaf sweelflag rhizomes, 12-14 parts of poria, 16-18 parts of shepherd's purse, 4-8 parts of Chinese wolfberry fruits, 2-5 parts of germanite, 12-14 parts of spirulina, 5-9 parts of kelp, 6-10 parts of mushrooms, 12-14 parts of black fungus, 0.15-0.25 part of isomalto-oligosacharide, 0.05-0.1 part of fructo-oligosaccharide, 0.2-0.3 part of peach gum powder, 1.5-1.8 parts of gulcomannan and 0.05-0.08 part of xanthan gum. The chewable tablet has an effect on improving of memory.

The invention discloses a traditional Chinese medicine composition with functions of treating insomnia, improving senile dementia, enhancing learning and memory abilities, resisting to depression and anxiety and soothing the nerves and benefitting intelligence.The traditional Chinese medicine composition comprises Rhizoma Gastrodiae, Radix Paeoniae Alba, Radix Acanthopanacis Senticosi and Semen Ziziphi Spinosae.The traditional Chinese medicine composition can be prepared into dosage forms acceptable clinically or pharmaceutically.Animal experiments show that the traditional Chinese medicine composition can improve the sleeping function and senile dementia and enhance learning and memory abilities, and has the anti-depression and anti-anxiety effects.

The invention provides application of a DNA (Deoxyribonucleic Acid) tetrahedron to preparation of a medicament for treating Alzheimer's disease. The DNA tetrahedron is assembled into a tetrahedron structure from four single-chain DNAs in a complementary base pairing manner; each edge of the tetrahedron is of a dual-chain DNA structure. The DNA tetrahedron provided by the invention can protect nerve cells in an amyloid-beta protein environment and restrain nerve cell apoptosis. The DNA tetrahedron has a very good application prospect in the preparation of the medicament for treating the Alzheimer's disease.

The invention discloses an application of Hericium erinaceus extract in the preparation of medicines, health products or foods for preventing and treating the Alzheimer's disease. In vitro cell experiment researches in the invention find that the Hericium erinaceus extract can significantly enhance the proliferation of PC12 cells and inhibit injuries of Abeta25-35 to the PC12 cells; in vivo animalexperiment researches find that the Hericium erinaceus extract can significantly improve the learning and memory abilities of Abeta25-35 and D-galactose induced senile dementia model rats; and acutetoxicity experiments of cells and animals confirm that the Hericium erinaceus extract has a broad safe dose range, and can be used in the fields of the medicines, health products or foods for preventing and treating the Alzheimer's disease.

The invention discloses a preparation method of hypericum perforatum extractive which is rich in hyperforin, which comprises the following steps of: taking the hypericum perforatum crude extractive which is sold in the market as the raw material; ultrasonically extracting in the ice water bath; preliminarily removing the impurity by means of two-phase extraction and the like to obtain 11-18% hyperforin-containing extractive; and separating and purifying by means of the silica column chromatography technology to obtain 37-57% hyperforin-containing extractive. The pharmacological test proves that the extractive has the functions of the depression resistant and the learning and memorizing promotion. The preparation method is simple and easy, is suitable for the small-scale preparation required by the pharmacological test and the like, and can save the extracting time and space.

The invention provides a nutritional composition for improving intestinal micro-ecology and learning and memory ability of infants fed by elderly lying-in women and application of the nutritional composition in preparation of infant formula milk powder or probiotic products. The utritional composition comprises, in weight percent, from 20% to 35% of sialylated oligosaccharides, from 50% to 60% of fucosylated neutral oligosaccharides, from 5% to 30% of non-fucosylated neutral oligosaccharides, and / or from 0.5% to 5% of osteopontin (OPN); the sialylated oligosaccharide comprises one or two of sialylated-lactose-N-tetrasaccharide c (LSTc) or sialylated-lactose-N-tetrasaccharide b (LSTb), the fucosylated neutral oligosaccharide comprises one or more of 2-fucosyllactose (2-FL), lactyl-N-fucopentasaccharide III (LNFP III), or lactyl-N-difucohexaose II (LNDFH II); and the non-fucosylated neutral oligosaccharide comprises a lactyl-N-neotetraose (LNnT).

The invention relates to a Lactobacillus with the efficacy of preventing and treating diabetic encephalopathy and a separation method and application thereof. The Lactobacillus is named as a Lactobacillus paracasei LC86 strain, and the preservation unit is China General Microbiological Culture Collection Center, the preservation time is December, 2013, the preservation number is CGMCC 1.12731, andthe address is No. 3, No. 1 Courtyard, Beichenxi Road, Chaoyang District, Beijing City. According to the Lactobacillus, the increase of the content of nitric oxide caused by diabetic encephalopathy can be obviously improved, the antioxidant enzyme activity of brain tissues can be improved, and the learning and memory ability can be improved. The Lactobacillus is applied to medicines for preventing and treating diabetic encephalopathy, has no toxic or side effect, and can be used for treating clinical patients together with other nutrients.

The invention relates to a preparation method and an application of a stemona effective part extract. According to the invention, stemona is subjected to reflux extraction by using 95% alcohol, such that an alcohol extract is obtained; the alcohol extract is dissolved by using water; the pH of the solution is regulated to 1-2 by using concentrated hydrochloric acid; the solution is filtered; the pH value of the filtrate is regulated to 9-11 by using concentrated ammonia water or a sodium hydroxide water solution; extraction is carried out by using a moderate polarity organic solvent; reduced-pressure concentration is carried out, such that a stemona total alkaloid extract is obtained; and the stemona total alkaloid extract is dissolved by using a small amount of ethanol; the solution is subjected to macroporous resin column chromatography; ethanol-water gradient elution is carried out; 50-80% ethanol-water elution part is collected; and the part is concentrated until dry, such that the stemona effective part extract is obtained. The application of the stemona effective part extract is the application in preparing an actylcholinesterase inhibitor.

The invention discloses application of emodin in antagonizing accumulation of amyloid beta protein, improving cognitive memory ability and reducing senile plaques. Alzheimer's disease (AD) is neurodegenerative disease characterized by neurofibrillary tangles, amyloid beta (A beta) protein plaque deposition and cognitive decline, wherein A beta protein extracellular toxicity accumulation is considered to be one of the main links in the pathogenesis of AD. The emodin is found to be capable of significantly inhibiting the accumulation of A beta protein 1-42 monomers so as to prevent the monomersfrom forming fibers, and is also found to be capable of inhibiting the formation of a beta secondary structure, improving the spatial memory learning ability of AD mice and obviously clearing amyloidplaques in brain tissues of APP / PS1 double-transgenic AD model mice; therefore, the emodin can be applied to the treatment of AD and the research and development of related drugs.

The invention discloses application of artemether to prevention and treatment of Alzheimer disease. The artemether is a safe and effective compound in anti-malaria treatment and activates an AMPK signal channel in the brain of an Alzheimer disease transgenic model mouse, the learning and memory ability of the Alzheimer disease transgenic model mouse is improved, apoptosis of nerve cells in the brain is reduced, the function of a choline acetyl transferase is improved, the activity of spongiocyte is inhibited, deposition of amyloid plaques, tangling of nerve fiber and the loss of nerve cells are reduced, and the experimental basis is provided for the clinical study for treating Alzheimer disease.