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Tuckahoe extract and preparation method thereof

A Poria cocos extract and a Poria technique are applied in the field of the Poria cocos extract and its preparation, which can solve problems such as unreported research on the preparation process, and achieve the effects of improving learning and memory ability, reducing the number of errors and prolonging the latency period.

Active Publication Date: 2011-07-27
BEIJING UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] Poria cocos triterpenoids are another major component of Poria cocos. A large number of studies by Chinese and foreign scholars have shown that Poria cocos triterpenoids have good pharmacological activities, such as anti-inflammatory and immune regulation effects, but there is no report on its preparation technology. Especially the report of using macroporous resin to enrich triterpene active sites

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  • Tuckahoe extract and preparation method thereof

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Effect test

Embodiment 1

[0042] Embodiment 1: Capsules

[0043] Take Poria cocos 1kg, 90% ethanol 6L reflux extraction 2 times, extract 1 hour each time, recover the solvent to a certain volume under reduced pressure, make the solution concentration 0.3g / mL (based on the amount of crude drug), add 60% ethanol to dilute , so that the concentration of the solution is 0.1g / mL (based on the amount of crude drug). Through 3L HPD-826 macroporous adsorption resin, the adsorption flow rate is 1BV / h, the diameter-to-height ratio of the resin column is 1:9, the sample loading is 0.4g / mL (based on the amount of crude drug), washed with water for 5 times the volume of the resin, and the impurities are removed. Flow rate is 3BV / h, 90% ethanol elutes 5 times of resin volume, and elution flow rate is 3BV / h, collects 90% ethanol eluate, reclaims solvent, drys under reduced pressure, obtains the total triterpene extract of Poria cocos of the present invention, Add conventional auxiliary materials, and make capsules a...

Embodiment 2

[0048] Embodiment 2: tablet

[0049] Take Poria cocos 1kg, 70% ethanol 10L reflux extraction 3 times, extract 1.5 hours each time, recover the solvent to a certain volume under reduced pressure, make the solution concentration 0.3g / mL (based on the amount of crude drug), add 55% ethanol to dilute , so that the concentration of the solution is 0.1g / mL (based on the amount of crude drug). Through 4L HPD-826 macroporous adsorption resin, the adsorption flow rate is 1BV / h, the diameter-to-height ratio of the resin column is 1:12, the sample loading is 0.25g / mL (based on the amount of crude drug), washed with water 4 times the volume of the resin, and the impurities are removed. Flow rate is 3BV / h, 90% ethanol elutes 5 times of resin volume, and elution flow rate is 3BV / h, collects 90% ethanol eluate, reclaims solvent, drys under reduced pressure, obtains the total triterpene extract of Poria cocos of the present invention, Add conventional auxiliary materials, and make capsules a...

Embodiment 3

[0054] Embodiment 3: pill

[0055] Take Poria cocos 1kg, 80% ethanol 8L reflux extraction 2 times, extract 2 hours each time, recover the solvent to a certain volume under reduced pressure, make the solution concentration 0.2g / mL (based on the amount of crude drug), add 60% ethanol to dilute , so that the concentration of the solution is 0.1g / mL (based on the amount of crude drug). Through 5L HPD-826 macroporous adsorption resin, the adsorption flow rate is 1BV / h, the diameter-to-height ratio of the resin column is 1:15, the sample loading is 0.3g / mL (based on the amount of raw medicinal materials), washed with water twice the volume of the resin, and the impurities are removed. The flow rate is 3BV / h, 4 times of resin volume is eluted with 90% ethanol, the elution flow rate is 3BV / h, the 90% ethanol eluate is collected, the solvent is recovered, and dried under reduced pressure to obtain the total triterpene extract of Poria cocos of the present invention. Add conventional a...

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Abstract

The invention discloses a tuckahoe extract which is prepared through ethanol extraction and macroporous absorption resin purification. The tuckahoe extract enriches more effective parts. Moreover, a rat memory disorder model test proves that the tuckahoe extract can improve the learning and memory capacity of a model rat, so that the number of errors of the model rat is reduced and the latent period is prolonged.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a poria cocos extract and a preparation method thereof. Background technique [0002] Poria cocos (Schw.) Wolf is the dried sclerotium of the fungus Poria cocos of the family Polyporaceae. It is mainly produced in Yunnan, Anhui, Hubei and other provinces, and it is also cultivated in most other provinces. Poria cocos is the first batch promulgated by the Ministry of Health, and it is one of the 34 varieties that are both food and medicine according to tradition. As a food, Poria cocos contains polysaccharides, proteins and dozens of trace elements such as selenium, magnesium, potassium and sodium, and has health care functions such as beauty and anti-aging. As a medicine, Poria cocos is a species recorded in the Pharmacopoeia of the People's Republic of China. Its nature is flat, sweet and light. Guixin, lung, spleen, kidney channel. It has the effects of diuresis and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/076A61P25/28
Inventor 石任兵姜艳艳刘洋戴莹
Owner BEIJING UNIV OF CHINESE MEDICINE
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