2962 results about "Crude drug" patented technology

This invention concerns the method of extracting salvianolic acid A from Chinese crude drug: danshen root, and the quality control methods and drug combinations, and the application of this drug. It can be used in the preparation of the prevention drugs for cardiovascular disease, liver damage, liver fibrosis, pulmonary fibrosis and other.

The invention provides a production method for extracting sweet tea glucoside from sweet tea leaves. The method comprises the following process flows of: smashing a sweet tea crude drug; extracting a solvent; concentrating; precipitating with alcohol; purifying with macroporous resin; concentrating; carrying out chromatography with polyamide resin; concentrating; crystallizing and recrystallizing; drying; and obtaining a finished product. By using the method, a high-quality sweet tea glucoside product can be produced, and the method also has the advantages of reducing the material loss, shortening the production period, improving the product yield and reducing the production cost and is suitable for the industrial production; the purity of the sweet tea glucoside produced by utilizing the method is higher than 98 percent, so that the product purity is high, and the component is single; the color of the sweet tea glucoside is white and good; and meanwhile, the technical difficulty of industrially producing a high-content and high-quality sweet tea glucoside extractive is overcome, so that large-scale production is smoothly produced.

An oral composition includes an oil extract of mastic and an antiphlogistic. An oral hygiene method includes brushing teeth with a dentifrice to which the oral composition has been added, and gargling with a mouth wash which includes at least one extract of crude drug selected from the group consisting of glycyrrhizae radix (glycyrrhiza), arecae semen (betel nut), myristicae semen (nutmeg) and leonuri herba (leonurus sibiricus).

The invention discloses a plaster and a preparation method of the plaster. The crude drugs of the plaster include: 55-65g of Strychnos, 85-95g of radi of x clematidis, 40-50g of frankincense, 40-50g of myrrh, 25-35g of dragon's blood, 40 -50g of angelica, 25-35g of pseudo-ginseng, 45-55g of Ligusticum wallichii, 45-55g of Rhizoma Wenyujin Concisum, 40-50g of safflower, 45-55g of Processed Radix Aconiti, 45-55g of Processed Radix Aconiti Kusnezoffii, 55-65g of ephedra, 85-95g of cassia twig, 35-45g of notopterygium root, 35-45g of radix angelicae pubescentis, 55-65g of garden balsam stem, 45-55g of lycopodium clavatum, 35-45g of Rhizoma Drynariae, 45-55g of radix dipsaci, 45-55g of Eupolyphaga, 25-35g of scorpio, 40-50g of lumbricus, 40-50g of pangolin, 40-50g of Asarum and 15-25g of borneol. The formula is unique, the production method is simple and the curative effect is notable.

The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-alpha-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

The invention discloses a traditional Chinese medicine pesticide and belongs to the technical field of pesticides. The traditional Chinese medicine pesticide is prepared from the following crude drugs in parts by weight: 9-11 parts of anemarrhena asphodeloides, 9-11 parts of gardenia jasminoides, 9-11 parts of forsythia suspensa, 9-11 parts of radix stemonae, 4-6 parts of lonicera japonica, 2-4 parts of sophora flavescens, 2-4 parts of giant typhonium rhizome, 2-4 parts of illicium verum, 2-4 parts of common carpesium fruit, 2-4 parts of ulmus macrocarpa hance, 4-6 parts of rhizoma cimicifugae, 2-4 parts of folium artemisiae argyi, 4-6 parts of radix adenophorae, 2-4 parts of radix lithospermi, 4-6 parts of bunge corydalis herb, 2-4 parts of acorus calamus, 4-6 parts of garden balsam stem and 4-6 parts of radix isatidis. The invention also discloses a preparation method of the traditional Chinese medicine pesticide and an application of the traditional Chinese medicine pesticide to prevention of crop aphids, mites, viral diseases and cabbage worms. The crude drugs of the traditional Chinese medicine pesticide have different pharmacological characteristics; good insect killing, insect expelling and sterilization effects are achieved after the compatibility of the crude drugs; diseases can be prevented and cured; the application range is quite wide.

The purpose of the invention is to provide applications of a traditional Chinese medicine composition in the preparation of health food or medicaments for preventing and relieving physical fatigue; the traditional Chinese medicine composition comprises 5-90 parts by weight of American ginseng, 5-160 parts by weight of lucid ganoderma, 1-90 parts by weight of fermented cordyceps sinensis powder and / or 1-120 parts by weight of cordyceps sinensis; the sources of the raw materials are traditional Chinese medicines or traditional Chinese medicine extracts equivalent to the crude drug amounts of the above traditional Chinese medicines; and 5-90 parts by weight of roses can be added into the composition; the invention also relates to an application of the composition in the preparation of health food or medicaments for preventing high blood lipid and reducing blood lipid; the invention also relates to an application of the composition in the preparation of health food or medicaments for preventing and resisting oxidation; the invention also relates to an application of the composition in the preparation of health food or medicaments for improving hypoxia tolerance; the pharmaceutical composition of the invention can be added with any one of pharmaceutically-acceptable auxiliary materials so as to be prepared into any routine dosage form.

The invention relates to a traditional Chinese medicine for treating cardiac, cerebral and vascular diseases; the drug is composed of forty kinds of crude drugs by weight parts: milk veteh, salvia miltiorrhiza, root of common peony, ligusticum wallichii, lumbricus, sanguisuga, rhizoma acori graminei, polygala root, red ocher, oyster, angelica, the root of kudzu vine, arisaema cum bile and the like; the preparation method is that: (1) the crude drugs are prepared into water extract liquid; (2) the water extract liquid is prepared into oral liquid; (3)the water extract liquid obtained by the step (1) is dried, crushed, sieved, undersize material is extracted powder; (4) the extracted powder prepared by the step (3) is prepared into various dosage forms. The preparation method of crude powder is that: lime earth of the crude drugs is sieved, and then the crude drugs are crushed and sieved, the undersize material is taken out and is sterilized to be crude powder, and the crude powder is prepared into various dosage forms. The traditional Chinese medicine has the major functions of treating miocardial infarction and angina caused by coronary heart disease, high blood pressure and cerebral thrombosis, hemiplegia, cerebral infarction, cerebrovascular accident, sequel of apoplexy and other symptoms, and the medicine has obvious effect on headache, dizziness and heart cerebrovascular diseases caused by high blood pressure and cerebral circulation insufficiency.

A method for extracting effective components from natural products by adopting triple liquid phases belongs to the technical field of bioengineering. The method is characterized by directly adding inorganic salt solutions, hydrophilic low-molecular organics and hydrophobic organics into ground natural products in proportion, or adding solid inorganic salts and hydrophobic organics into the extractof the hydrophilic low-molecular organics of the natural products in proportion, evenly stirring the mixture, carrying out standing or centrifuging on the mixture to form triple liquid phases; the effective components are enriched on the top phase, middle phase and bottom phase respectively based on different polarity and distributing partial protein, and polysaccharides and crude drug residue among phase interfaces to achieve the purpose of simultaneously extracting the effective components with different polarity from the natural products. The invention has the effects and benefits of developing an easily industrialized method for extracting and separating the effective components from the natural products, increasing the extraction efficiency, effectively combining the technologies ofextraction, separation and purification and being beneficial to reducing the production cost of the effective components from the natural products.

The invention relates to an active carbon material, and particularly relates to a method for preparing food hygiene-level active carbon by use of biological waste resource bagasse. The method comprises the steps of collecting and cleaning the residual bagasse after sugar production; sufficiently fermenting at 10-50 DEG C, drying, grinding and sieving; then performing the operation treatment such as soaking in an active agent solution, charring, activation and the like on the pretreated bagasse; washing, drying and grinding to obtain a high-performance active carbon product which can be applied to decoloration, refining and impurity removal of the sugar industry and the fields of foods and medicines such as medicinal crude drugs and the like. According to the method provided by the invention, by adopting the waste bagasse as a raw material, the comprehensive utilization of resources and environmental protection are facilitated; moreover, the price is low, the product quality is high, and the economic and social benefits are good.

The invention discloses a vacuum freeze-drying process for retaining the medicative active components of a traditional Chinese medicine of radix tetrastigme, which comprises the following steps of: selecting a raw material of the radix tetrastigme, washing, slicing, predrying, loading with a tray, prefreezing, sublimating, drying and discharging after resolving and drying. The process adopts the reasonable configuration of the parameters of the time, the temperature, the pressure and the like of vacuum freeze-drying, thereby retaining the medicative active components furthest. The radix tetrastigme prepared by the process can furthest preserve the medicative components of an original medicine and reduces the properties of a crude medicine, the main anti-tumor component of general flavone is 3.6 times that of a traditional processing method, and saponin is 2.5 times that of the traditional processing method. By carrying out pulverization, physical wall breaking, discharge, dehumidification, packaging and sterilization on the radix tetrastigme after being resolved and dried by adopting the invention, an oral preparation which is an eating mode of the radix tetrastigme with best medicinal value can be prepared.

A preparation method for a traditional Chinese medicine composition for improving immunity of livestock and poultry relates to a traditional Chinese medicine composition. The preparation method comprises the following steps: taking acanthopanax root, crushing and sifting; adding ethanol to dynamically soaking and performing reflux extraction; depressurizing the supernatant and recycling ethanol from the supernatant until no alcohol smell is detected; adding ethanol of low concentration to be prepared into crude drug; centrifuging and putting supernatant on macro-porous absorption resin column; using water to elute reaction negativity and successively eluting by ethanol, then collecting ethanol and eluted part of ethanol and combining to obtain acanthopanax total glucoside; taking astragalus root and extracting with ethanol, then mixing with acanthopanax root dregs; filtering and recycling ethanol from filter liquid to obtain total polysaccharide; combining acanthopanax total glucoside with total polysaccharide and filling into bottles, then sterilizing to obtain injection liquid. The invention uses the technical solution in combination with ethanol extraction method and water extraction method to extract acanthopanax total glucoside, total polysaccharide and astragalus root polysaccharide. The acanthopanax total glucoside, total polysaccharide and astragalus root polysaccharide are added with excipient and processed by common procedures or added with pharmaceutically acceptable excipient to be made into clinically acceptable dosage forms.

The invention pertains to the field of extracting active ingredients of natural products and particularly relates to an extracting method and a purifying method of crude phellinus igniarius polysaccharides. The technical problems needed to be solved are to disclose a method for extracting the extract of crude phellinus igniarius polysaccharides and an efficient method for preparing phellinus igniarius polysaccharides through countercurrent chromatography. An ultrasonic extraction is adopted by the invention to extract crude phellinus igniarius polysaccharides from phellinus igniarius fruit bodies; the high-speed countercurrent chromatography is adopted to further purify the crude phellinus igniarius polysaccharides. The extracting method and the purifying method of the invention have high yield of crude phellinus igniarius polysaccharides, and can take up 6 percent of crude drugs; the purity of the further purified phellinus igniarius polysaccharides is greatly improved to be about 75 percent.

The invention relates to a method for extracting salidroside, polysaccharose and tannin-type substances from rhodiola root crude drugs. The method comprises the following steps of: firstly, drying and crashing rootstalks of the rhodiola root crude drugs; then, adopting the supercritical carbon dioxide technology to extract oil type substances from the rhodiola root crude drugs, and carrying out microwave extraction, deposition in alcohol and filtration so as to obtain sediment and supernatant fluid; and then, drying the sediment to obtain a rough polysaccharose powder product of the rhodiola, and carrying out absorption by macroporous resin, elution and drying to the supernatant fluid so as to obtain a salidroside powder product; and finally, using acetone for extracting microwave extraction residue, and obtaining the rhodiola root tannin extract after centrifugation and drying. The method can simultaneously extract three active ingredients, namely, salidroside, polysaccharose and tannin in the rhodiola root, thus improving the utilization rate of the rhodiola root and increasing the utilization value of the rhodiola root.

The invention relates to the technical field of crude drug, more specifically to a linaloe leaf extract. The invention also discloses its preparation and use in pharmaceuticals and health products.

The invention discloses a milk health preserving and hygienic wine and preparing method, which comprises the following steps: sterilizing; defatting; getting whey liquid; yeasting with fruit and traditional crude drugs; distilling; aging; filtering; curing; sterilizing; loading; getting the product. This invention can modify the taste and control alcohol degree of the product wine, which can reach health preserving and hygienic function.

A natural shampoo is provided. The natural shampoo is made using a herbal medicine mature decoction which is obtained by putting herbs including lotus roots, lotus leaves, red ginseng, Hippophae rhamnoides leaves and trunk, persimmon leaves, thuja orientalis, ginger, rosemary, black beans, black sesame, aloe, mulberry leaves, Orostachys japonicus, Angelica gigas, green tea, pine needles, mint, pleuropterus multflorus, blueberry, Acorus gramineus, and garlic in a maturing device, maturing the herbs in temperatures of 65 to 95° C. depending on the herb for 3 to 21 days, then pouring distilled water or soft water, and decocting the matured herbs mixed with the water.

The present invention discloses a traditional Chinese medicine composition to treat Rheumatoid Arthritis and its preparation method. The composition is mainly comprised of the following crude drugs: ant, Radix Salviae Miltiorrhizae, Radix Aconiti Preparata, Radix Ginseng, Caulis Spatholobi, and Ramulus Cinnamomi, etc. According to pharmaceutical methods, various clinical acceptable dosage forms can be prepared of the composition of the present invention, including but not limited to one of the following dosage forms: tablets, capsules, pills, granules, suspension, dripping pills, oral liquid preparation, etc. The drug of the present invention has the functions of invigorating the kidney and spleen, promoting blood flow and clearing out the vein, expelling wind-evil and removing wetness, eliminating cold to stop pain. It can be effectively used in the treatment of lingering arthralgia with weak, arthralgia, intumesce and morning stiffness, numbness and stickiness, difficult to flex and extend, rigor and deforming, the rheumatism and rheumatoid arthritis with the above symptoms.

The invention relates to a cefamandole nafate hydrate. The molecular formula of the cefamandole nafate hydrate is C19H17N6NaO6S25H2O. The preparation method of the cefamandole nafate hydrate comprises the following steps of: dissolving cefamandole nafate crude drug in water and placing the dissolved cefamandole nafate crude drug in a crystallizer; adding 5-15 parts of elution agents, cooling the mixture to 2-8 DEG C, separating out solids and then filtering; and rinsing the solids in the elution agents, drying for 3-5 hours at the drying temperature of 10-50 DEG C under a ventilated or vacuumcondition to obtain the cefamandole nafate hydrate. The invention also provides a cefamandole nafate for injection, which is prepared by using the cefamandole nafate hydrate as the crude drug. The cefamandole nafate hydrate obtained in the method has the advantages of smooth surface, good stability and high dissolving sped in water. After the cefamandole nafate hydrate is dissolved in the water, the action mechanism and the clinical effect of the cefamandole nafate hydrate are the same as those of cefamandole nafate prepared in the traditional process.

The invention provides a method for detecting pesticide residue in a white paeony root crude drug, comprising the following steps of: extracting powder of the white paeony root crude drug with acetonitril in oscillation, then, performing dispersed purification by using N-propyl ethylene diamine as a dispersion purifying agent and using anhydrous magnesium sulfate as a drying agent; evaporating solvent of the extract to dry at 40 DEG C in a rotary evaporators; and taking liquid chromatogram as a separation means and taking mass spectrum as a detection means after dissolving the residual again. The method provided by the invention can simultaneously detect 23 kinds of pesticide residues of organic chloride, organic phosphor and organic nitrogen types. By using the method provided by the invention to analyze the pesticide residue in the white paeony root crude drug, the sample is simply and conveniently processed, rate of recovery is high, and universality is high, so that the method has better application prospect.

The present invention relates to extraction process of fragrant solomonseal polysaccharide and its medicine preparation and use. Fragrant solomonseal polysaccharide extracting process includes cutting fragrant solomonseal rhizome into small dices, twice boiling in water, filtering, centrifuging to obtain supernatant, decompression concentration to relative density of 1.08-1.25, ethanol precipitation, dissolving the precipitate in hot distilled water, ethanol precipitation to obtain precipitate, thrice alcohol washing of the precipitate, freeze drying, vacuum drying and crushing to obtain white powdered fragrant solomonseal polysaccharide. The fragrant solomonseal polysaccharide may be further prepared into various fragrant solomonseal polysaccharide preparations, including tablet, capsule, granule, oral liquid, etc. via adding proper amount of supplementary material and the preparations has the functions of lower blood sugar and blood fat.

The invention provides a Chinese herb extract composition, containing the following components by weight percent: 41-45% of dendrobium candidum extract, 20-25% of American ginseng extract and 31-35% of barbary wolfberry fruit extract. Dendrobium candidum, American ginseng and barbary wolfberry fruit are taken as materials respectively, and the crude drugs are sorted, cleaned, dried and smashed into coarse particles, is subjected to backflow extraction with purified water or edible alcohol, is refined by adopting a macroporous resin method and an ultrafiltration method, and then is subjected to vacuum concentration and drying and smashing to obtain the compound dendrobium extract composition. The Chinese herb extract composition has the function of delaying senility, and the compatibility of all extract components in the composition achieves the effect of synergy.

The invention relates to a refining method for a lansoprazole crude drug, which is characterized in that the lansoprazole sample is dissolved in anhydrous alcohol and stirred to complete dissolution, and activated carbon is added to be stirred, pumped and filtered; then the solution which is placed in a freezing chamber to freeze and crystallize is pumped and filtered to be dry, the filter cake is washed to be dry by the anhydrous alcohol, and white solid can be obtained; finally, the obtained white solid is dried in an oven, and the solid is turned over discontinuously during the drying until reaching constant weight. The preparation method for the lansoprazole crude drug is simple and convenient, high in refining yield, low in the total impurities of the refined lansoprazole and good in clarity after being prepared into injections.

The invention provides a macadamia nut green peel extract, namely macadamia nut green peel polyphenol or macadamia nut green peel aqueous extract which is prepared with the following method: taking macadamia nut green peel powder, adding warm water for water extraction three times, then adding 5% sulfuric acid, keeping quenching for 24h, and filtrating; washing a filter cake with deionized water to remove residual sulfuric acid until the washing liquid is neutral, and obtaining the macadamia nut green peel polyphenol; or washing macadamia nut green peel original crude drug coarse powder with water, putting into boiling water, boiling for 30min, stopping heating, keeping the water temperature at 60 DEGC-70 DEG C, performing ultrasonic extraction for 1h, centrifuging an aqueous extraction liquid at 2000r / min for 4min to obtain a supernatant liquid, then concentrating the supernatant liquid to thick paste, and obtaining the macadamia nut green peel aqueous extract. The macadamia nut green peel extract is used for preparing toning lotion and toning cream. The invention also provides application of the macadamia nut green peel polyphenol or macadamia nut green peel aqueous extract to preparation of cosmetics, as well as application to preparation of a tyrosinase inhibitor and preparation of an antioxidant.

The invention relates to a drink containing the components of cistanche deserticola and coffee, in particular to the cistanche deserticola coffee consisting of cistanche genus plants, coffee and other additives which can be in a solid state or in a liquid state. In one specific proposal of the invention, the cistanche genus plants can be any one or combination of a plurality of the extract, crude drugs, decoction pieces, whole powder, ultrafine powder or solution of cistanche tubulosa, cistanche and cistanche salsa; the extract of the cistanche tubulosa of the cistanche genus plants is preferred. In another specific proposal, the coffee is any one or the combination of a plurality of coffee beans, whole coffee powder, ultrafine coffee powder or soluble coffee in a solid or liquid state; the soluble coffee is much more preferred. The drink organically combines the features of the cistanche genus plants and coffee, and is easy to drink. If drunk for a long time, the drink has the effect of anti-fatigue, nourishing and strengthening muscles, enhancing immunity, reducing blood lipid, gaining sunny color and anti-aging, etc. If the cistanche genus plants are the cistanche tubulosa from Hetian, the effect of the drink is much better.

The invention discloses a method for measuring genotoxic impurities (or doubtful genotoxicity), namely phenylhydrazine compound residues, in crude drugs through the HPLC (high performance liquid chromatography). The detection is directly implemented by taking phenyl bonded silica gel as a chromatographic column of a solid phase and organic phase and buffer solution mixed solvent gradient elution as a mobile phase. The detection method is high in detection sensitivity, strong in specificity, high in precision, high in accuracy, convenient to operate and strong in adaptability and can be used for detecting phenylhydrazine compounds in various crude drugs, and the quality of the crude drugs can be effectively controlled.

The invention discloses a medicine for preventing and treating porcine reproductive and respiratory syndrome (PRRS). The medicament is prepared by smashing and uniformly mixing the following main crude drugs in parts by weight: 9-11 parts of pine needles, 1.5-2.5 parts of dried tangerine or orange peel, 0.8-1.2 parts of white ginseng, 0.8-1.2 parts of scutellaria baicalensis, 0.8-1.2 parts of golden cypress, 1.5-2.5 parts of gardenia jasminoides ellis, 1.5-2.5 parts of isatis root, 0.2-0.4 part of liquorice, 1.5-2.5 parts of honeysuckle flower, 1.5-2.5 parts of oriental wormwood, 3.5-4.5 parts of milkvetch root, 1.5-2.5 parts of cyrtomium rhizome, 0.8-1.2 parts of fructus forsythiae, 1.5-2.5 parts of platycodon grandiflorum, 0.8-1.2 parts of giant knotweed rhizome and 0.3-0.5 part of milkvetch root polysaccharide. The medicament has a better preventing function on pigs which are not infected by the PRRS, has a good therapeutical effect on pigs which suffer from moderate PRRS and also has an obvious control effect on swine influenza, swine streptococcosis and swine erysipelas.

The invention discloses a stomach-nourishing biscuit and a preparation method thereof, wherein the method comprises the following steps: respectively weighing medicinal materials such as maltum, hawthorn fruits, endothelium corneum gigeriae galli, dried orange peels and radish seeds in a certain weight proportion, then adding water of which the weight is 5-8 times of the total weight of the medicinal materials above; heating and extracting, namely controlling the temperature at 85-95 DEG C and carrying out heat preservation for 2-4 hours, filtering the obtained product so as to obtain an extracting solution; after repeatedly carrying out extraction 1-3 times, merging the obtained extracting solutions; carrying out vacuum concentration under reduced pressure until the crude drug content of the merged extracting solution is 0.5-0.8 g / ml, then obtaining a concentrated liquid medicine; mixing the concentrated liquid medicine with other raw materials, and uniformly stirring so as to form a dough for standby; rolling the dough into a noodle strap in a roll machine, then rolling and cutting the noodle strap into biscuit blanks; and baking the biscuit blanks so as to obtain stomach-nourishing biscuit products. The stomach-nourishing biscuit disclosed by the invention not only has a nutritive value and a health care function of stomach nourishing, but also is easy to carry.

The invention specifically relates to novel polypeptide and Periplaneta americana total polypeptide extract capable of promoting tissue repair, and application thereof, belonging to the fields of traditional Chinese medicines and crude drugs. The novel polypeptide capable of promoting tissue repair is named as Periplapeptide A and has a structure as shown in a formula I H-Ala-Ala-Pro-Tyr-Ala-His-Val-Ala-Ala-Pro-Tyr-Ala-His-Phe-OH. The Periplaneta americana total polypeptide extract capable of promoting tissue repair is prepared by subjecting the bodies of Periplaneta americana to alcohol extraction, degreasing and enrichment via a reversed-phase material, wherein the mass percentage content of total polypeptide is greater than 50%, and the extract contains Periplapeptide A. The novel polypeptide and the Periplaneta americana total polypeptide extract containing novel polypeptide in the invention can promote propagation of mouse embryo fibroblasts and migration of immortalized human epidermal cells at low concentrations, have low toxic and side effect and good medicinal prospects, and are applicable to preparation of medicines used for treating wounds, burns and ulcers or cosmetics and daily chemical articles used for beautifying the skin.

Pharmaceutical composition and food comprising edible carboxylic acid and / or its acidic salt and optionally caffeine, crude drug and pharmaceutical acceptable carrier are disclosed. The invention also discloses the use and method of composition or food. The composition or food of the present invention can prevent, treat or relief allergy, ache, cold, viral infection, thrombus or clotting, inflammation, cancer, intoxication, memory decay, caffeine dependence. The invention also relates to feedstuff for animals.