295results about How to "Prevent agglutination" patented technology

The invention provides methods for preparing pharmaceutical formulations for injection such that upon injection the formulation does not cause erythrocyte agglutination, hemolysis, and / or cell shrinkage. To prevent agglutination, a pharmaceutical formulation ready for injection needs to have a sufficient ionic strength. To prevent hemolysis or cell shrinkage, a pharmaceutical formulation ready for injection needs to be about isotonic with respect to plasma. The invention provides methods that prepare pharmaceutical formulations for injection that have both the sufficient ionic strength to prevent agglutination and the requisite tonicity to prevent significant hemolysis or cell dehydration or shrinkage. The present methods involve the use of sodium chloride solutions that are about 25 mM to about 150 mM for reconstituting lyophilized cakes (or other non-liquid pharmaceutical formulations) into solution or for diluting pharmaceutical formulation solutions.

The invention relates to a traditional Chinese medicine for treating cardiac, cerebral and vascular diseases; the drug is composed of forty kinds of crude drugs by weight parts: milk veteh, salvia miltiorrhiza, root of common peony, ligusticum wallichii, lumbricus, sanguisuga, rhizoma acori graminei, polygala root, red ocher, oyster, angelica, the root of kudzu vine, arisaema cum bile and the like; the preparation method is that: (1) the crude drugs are prepared into water extract liquid; (2) the water extract liquid is prepared into oral liquid; (3)the water extract liquid obtained by the step (1) is dried, crushed, sieved, undersize material is extracted powder; (4) the extracted powder prepared by the step (3) is prepared into various dosage forms. The preparation method of crude powder is that: lime earth of the crude drugs is sieved, and then the crude drugs are crushed and sieved, the undersize material is taken out and is sterilized to be crude powder, and the crude powder is prepared into various dosage forms. The traditional Chinese medicine has the major functions of treating miocardial infarction and angina caused by coronary heart disease, high blood pressure and cerebral thrombosis, hemiplegia, cerebral infarction, cerebrovascular accident, sequel of apoplexy and other symptoms, and the medicine has obvious effect on headache, dizziness and heart cerebrovascular diseases caused by high blood pressure and cerebral circulation insufficiency.

Disclosed is a method for producing a metal particle dispersion wherein a metal compound is reduced by using carbodihydrazide represented by the formula (1) below or a polybasic acid polyhydrazide represented by the formula (2) below (wherein R represents an n-valent polybasic acid residue) in a liquid medium. By reducing the metal compound in the presence of a compound having a function preventing discoloration of the metal, there can be obtained a metal particle dispersion having excellent discoloration preventing properties. Metal particles produced by such methods have a uniform particle diameter and are excellent in dispersion stability. By using a conductive resin composition or conductive ink containing a metal particle dispersion obtained by such production methods, there can be formed a conductive coating film, such as a conductive circuit or an electromagnetic shielding layer, having good characteristics.

The invention discloses coarse cereal food subjected to treatment of germination and a preparation method of the coarse cereal food. The coarse cereal food subjected to treatment of germination consists of the following coarse cereal materials in parts by weight: 100g of millet, 100g of glutinous broom corn, 100g of sorghum, 100g of black soybean, 50g of grain amaranth, 100g of buckwheat, 100g of oat, 100g of black rice, 150g of coix seed, 20g of mung bean, 10g of pea, 20g of red bean, 5g of cowpea and 5g of small lentil. The coarse cereal materials subjected to treatment of germination are purely natural materials and free of toxic and side effects; and the nutritions contained in the materials are activated and easy to be absorbed by the human body and can be used for promoting gastrointestinal peristalsis, helping digestion, increasing appetite and preventing gastrointestinal diseases.

The invention discloses fermented coarse cereal food and a preparation method of the fermented coarse cereal food. The fermented food is composed of the following coarse cereal materials in parts by weight: 100g of sorghum, 100g of millet, 100g of buckwheat, 100g of oat, 100g of barley, 100g of black rice, 100g of proso millet, 150g of coix seed, 20g of green bean, 20g of phaseolus angularis, 10g of broad bean, 10g of pea, 5g of cowpea, 100g of black bean and 13g of zymophyte. The coarse cereals adopted by the preparation method provided by the invention are completely pure natural materials, thereby being free from tonic or by effect, lactic acid bacteria is used for guaranteeing delicious and soft taste for the fermented food, and the fermented food can promote gastrointestinal peristalsis, improve digestive ability, add appetite and prevent diseases.

The invention provides a preserving fluid and a preparation method therefor. The preserving fluid is used for preserving umbilical cords and / or placentas. The preserving fluid comprises 50-60g / L of dextran, 6-7g / L of sodium chloride, 200-250mg / L of calcium chloride, 200-400mg / L of potassium chloride, 1-1.2g / L of glucose and 10-30g / L of human serum albumin. The invention further discloses a preparation method for the preserving fluid. Compared with a conventional preserving fluid, the preserving fluid disclosed by the invention reduces the metabolism amount of umbilical cord tissue cells in a process of preserving the umbilical cords, and also can provide certain basic nutrient substances and energy substances to keep a low metabolism level, so that the cell activity is in a stable state, and the conditions such as shape variation or differentiation due to growth and cultivation are avoided; and moreover, the dextran in the components has an anticoagulation effect and can prevent the blood agglutination, so that the interference on the follow-up separation operation is avoided.

The invention relates to coarse grain noodles which comprise the following raw materials in parts by weight: 80-100 parts of flour, 2-5 parts of corn powder, 1-3 parts of peanut powder, 1-3 parts of millet powder, 5-8 parts of mashed pumpkin, 0.5-2 parts of yeast powder and 0.3-0.8 part of guar gum. The invention also relates to a preparation method of coarse grain noodles. In the invention, the raw materials of the coarse grain noodles are fermented, and the overall nutritional value of the coarse grain noodles is increased; as functional noodles, the coarse grain noodles provided by the invention are rich in dietary fibers easy to digest and absorb as well as other nutrient substances.

The invention relates to a noodle capable of reducing blood sugar and a preparation method thereof. The noodle is composed of the following components in parts by weight: 2 to 6 parts of pumpkin powder, 3 to 5 parts of sorghum, 4 to 7 parts of buckwheat, 3 to 6 parts of wheat bran, and 72 to 85 parts of wheat flour. The noodle is prepared from pumpkin powder, sorghum, buckwheat, wheat bran, and wheat flour according to a fixed ratio; the pumpkin powder, sorghum, buckwheat, and wheat bran are natural foods, no additive is added, and the effective components and functions of pumpkin powder, sorghum, buckwheat, and wheat bran are fully utilized and combined with wheat flour to prepare the healthcare noodle, which has the advantages of reasonable and balanced nutrients, low sugar content, low cost, simple production technology, and smooth, fine, and delicious taste, and also has the functions of improving digestion, retarding the absorption of sugar in intestines, regulating the blood pressure of diabetes patients, promoting the insulin secretion of diabetes patients, and adjusting the blood sugar of diabetes patients. Moreover, the noodle will not break and the soup will not turn turbid even if the noodle has been cooked for a long time.

Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processes for preparation of clopidogrel hydrogensulfate Form I, Form II, Form III, Form IV, Form V, Form VI and amorphous form.

The invention discloses a Chinese medicine combination for treating cardio-cerebral vascular diseases, which is composed of raw materials with the following parts by weight: 30-50 parts of radix astragali, 20-25 parts of angelica, 15-20 parts of hemlock parsley, 30-50 parts of salvia miltiorrhiza, 15-20 parts of pseudo-ginseng, 15-20 parts of hawkthorn and 20-30 parts of radix puerariae; the Chinese medicine combination of the invention has ingenious compatibility, simple prescription, broad source of raw materials, low price as well as the efficacies of tonifying both qi and blood, balancing yin and yang, activating blood circulation and dissolving stasis; the Chinese medicine combination can soften blood vessels through reducing blood fat and blood viscosity and eliminating blood scales and finally achieve the purposes of smoothing blood circulation and activating cardio-cerebral function; furthermore, the Chinese medicine combination has unique efficacy for resisting atherosclerosis as well as significant curative effect on cardio-cerebral vascular diseases like coronary heart disease, cerebral thrombosis, and the like; the total clinical effective rate can reach over 95% and the Chinese medicine combination can achieve good preventive and health care effect through long-term oral administration and has safe oral administration and no toxicity and side effect.

This invention is directed to an analysis chip comprising a substrate having a surface on which a selective binding substance is immobilized; a cover member adhered to the substrate; and particles movably contained or injected in a void between the substrate and the cover member; wherein the surfaces of the particles are coated with a surfactant. By this invention, generation of bubbles which inhibit the selective reaction between the test substance and the immobilized selective binding substance is suppressed, thereby reducing the deviation of data, suppressing the lowering of sensitivity, and promoting the reproducibility of the measurement.

The present invention discloses a fruit and coarse cereal mixed nutrition granule and a preparation method thereof. The fruit and coarse cereal mixed nutrition granule comprises the following raw materials in parts by weight: 22-26 parts of buckwheat, 20-22 parts of red beans, 17-19 parts white kidney beans, 6-8 parts of Diospyros oldhami, 11-13 parts of Rosa roxbunghii, 10-12 parts of Physalis peruviana, 9-11 parts of Holboellia latifolia, 6-8 parts of Rubus buergeri, 8-10 parts of Ribes reclinatum, 6-8 parts of Tremella aurantialba, 10-12 parts of royal jelly, 1-3 parts of camellia pollen, 2-4 parts of lotus pollen, 5-7 parts of seed coat-retained lotus seeds, 5-7 parts of poria, 1-3 parts of radix angelicae, 5-7 parts of grape seeds, 2-4 parts of cucumber seeds and 20-22 parts of crystal sugar,. The fruit and coarse cereal mixed nutrition granule is rich in nutrition and has effects in stabilizing blood pressure, lowering blood lipid and improving human immunity.

Disclosed are: conductive particles which can be prevented from being aggregated, can damage oxide coating films on the surfaces of electrodes in circuit members upon the connection the circuit members to each other, and can achieve high connection reliability; and an anisotropic conductive film, an assembly, and a connection method each utilizing the conductive particles. Each of the conductive particles comprises a core particle and a conductive layer formed on the surface of the core particle, wherein the core particle is a nickel particle, the conducive layer is a nickel-coated layer having a phosphorus concentration of 10 mass% or less in the surface part thereof, and the conductive layer has an average thickness of 1 to 10 nm.

The invention relates to a process for the preparation of finely divided rubbers (rubber powders) by precipitation from aqueous mixtures, which comprise filler in the form of suspensions, water-soluble salts of a metal of groups IIa, IIb, IIIa and VIII of the periodic table of the elements arid a rubber latex (polymer latex), aqueous emulsions of a rubber or rubber solution, in which one or more organosilicon compound(s) containing at least one alkoxy group is or are dissolved or emulsified, optionally in the presence of a surface-active substance, in water, or the compounds mentioned are mixed directly, optionally with a surface-active substance, with an aqueous suspension of an oxidic or silicatic finely divided filler or a mixture of these fillers at a temperature of 10 to 60° C., preferably at room temperature, while stirring, the amount of this mixture envisaged for incoporation in the rubber, based on the filler content, in general being divided into two batches.

The present invention provides a complex in which metal nanoparticles are included in a porous coordination polymer (PCP), wherein the PCP is configured from a metal ion and an organic ligand.

A food in which a plant sterol and / or plant stanol whose dissolution in water is difficult is stably dispersed homogeneously while suppressing any deposition or coagulation (ring formation) thereof; and a process for producing the same. An emulsifier of 6 to 16 HLB and a plant sterol are added to a food raw material in a weight ratio of 3:8 to 10:1 and heated at 110 DEG to 200 DEG C, thereby obtaining an intended food.

A composite medicine for treating cardiovascular and cerebrovascular diseases is proportionally prepared from gingko leaf, or its extract, or its general flavone, or the ginkalide and kakonein.

The invention discloses a chewable tablet helpful for improving of memory. The chewable tablet is prepared from, by weight, 100-125 parts of pineapple pulp, 30-42 parts of apple pulp, 12-16 parts of peanut kernels, 8-12 parts of walnut kernels, 28-32 parts of milk tree juice, 100-110 parts of germinated brown rice milk, 15-20 parts of millet, 5-8 parts of herbs of Russian boschniakia, 6-8 parts of grassleaf sweelflag rhizomes, 12-14 parts of poria, 16-18 parts of shepherd's purse, 4-8 parts of Chinese wolfberry fruits, 2-5 parts of germanite, 12-14 parts of spirulina, 5-9 parts of kelp, 6-10 parts of mushrooms, 12-14 parts of black fungus, 0.15-0.25 part of isomalto-oligosacharide, 0.05-0.1 part of fructo-oligosaccharide, 0.2-0.3 part of peach gum powder, 1.5-1.8 parts of gulcomannan and 0.05-0.08 part of xanthan gum. The chewable tablet has an effect on improving of memory.

The invention belongs to the field of the detection on flow cytometry, and provides a preparation method of a flow cytometry sample for chrysanthemum. The method comprises the following steps: carrying out a splitting decomposition step, namely, carrying out the splitting decomposition on a chrysanthemum sample, filtering and centrifuging to obtain a cell nucleus to be dyed; and carrying out a dyeing step, namely, dyeing the cell nucleus to be to be dyed to obtain the dyed cell nucleus. According to the flow cytometry analysis, an appropriate cell lysis buffer solution is adopted, so that cytoplasmic fragments remained in the complete cell nucleus of the chrysanthemum can be effectively eliminated, the stability of the cell nucleus in suspension liquid can be maintained, and the agglutination of the cell nucleus in the suspension liquid can be prevented; DNA can be protected from degradation; an appropriate environment is provided for the exclusive nucleus DNA chemical staining, and the adverse impact of the cytoplasm component on the dyeing can be effectively reduced; by optimizing the sample preparation flow, the disturbance peak in the computer testing can be effectively reduced, and the precision, accuracy and stability of a detection result can be improved.

The present invention discloses one kind of composite soft lutein capsule and its preparation process. The content in each capsule includes lutein1-10 mg, alpha-linolenic acid 100-300 mg, vitamin A 0-5 mg and vitamin E 0-7.5 mg; and the capsule covering consists of gelatin, glycerin, water, and opacifier or edible color. The lutein is prepared through supercritical CO2 extraction process, and has no pollutant and organic solvent residue. The composite soft lutein capsule product has stable quality and high bioavailability, and has certain preventing and treating effect on senile macular degeneration, cataract and cardiac and cerebral vascular diseases.

The invention provides a water-based beverage containing phytosterol and a preparation method thereof. The water-based beverage contains the phytosterol, vegetable oil and at least one emulsifying agent. In the water-based beverage containing phytosterol and the preparation method thereof, the phytosterol is successfully dispersed into the water-based beverage, the consumption of the emulsifying agent is reduced, the temperature required by a melting raw material in the preparation process is reduced, the formed oil phase droplets containing the phytosterol are less than 1 micron, the water-insoluble phytosterol does not need to be prepared into the phytosterol which has high price and does not belong to a normal food component, the phytosterol is directly added into the water-based beverage by using oil-in-water emulsifying technology to obtain the water-based beverage containing the phytosterol with excellent stability, agglutination of the phytosterol due to crystallization can be effectively inhibited, and sediments are not produced even in long-time storage.

The invention discloses black bean health-preserving and health-care noodles, which are prepared from the following raw materials in part by weight: 100 to 110 parts of flour, 10 to 12 parts of oat kernel flour, 5 to 8 parts of konjac flour, 2 to 4 parts of black bean peel extract, 2 to 3 parts of rape pollen, 1 to 3 parts of salt, 0.1 to 0.2 part of grape seed oil, 2 to 4 parts of gynostemma pentaphyllum, 3 to 5 parts of dictyophora, 3 to 5 parts of great burdock achene, 5 to 6 parts of red date, 2.5 to 3.5 parts of acanthopanax, 3 to 4 parts of dwarf lilyturf root, 5 to 7 parts of manyflower solomonseal rhizome, 5 to 8 parts of longan, 5 to 8 parts of dried roselle calyx and 1 to 2 parts of Lecai. The black bean health-preserving and health-care noodles are good in mouthfeel, delicious and rich in nutrition and simultaneously have a dietetic and health-care effect.

The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of traditional Chinese medicines. The invention aims at providing the medicine for treating the cardiovascular and cerebrovascular diseases, which has small side effect and obvious therapeutic effect. The invention discloses the medicine for treating the cardiovascular and cerebrovascular diseases, which is characterized in that: the medicine is prepared from the following pharmaceutical raw materials in parts by weight: 800 parts of ginkgo leaves, 500 parts of radix paeoniae alba, 500 parts of liquorice, 500 parts of witloof, 200 parts of radix notoginseng, 100 parts of lychee seeds and 100 parts of lumbricus. The medicine has the following beneficial effects: a pharmaceutical composition in the invention has small side effect and obvious therapeutic effect; when the medicine is adopted, the experimental carotid artery thrombosis time of a rat can be obviously prolonged, and the platelet aggregation of the rat can be obviously inhibited; and the medicine has the obvious therapeutic effects of resisting thrombosis, and treating thrombotic diseases, ischemic cardiovascular and cerebrovascular diseases, blood circulation obstacles and the like.