The invention discloses an aqueous polyurethane dispersion with scuffing resistance and high wet adhesion and the application thereof. The aqueous polyurethane dispersion is produced from reactive coupling agent, polymer polylol, polyisocyanate, hydrophilic chain extender, neutralizing agent and polyamine. The reactive coupling agent is added in a raw material system, and after being coated on metal, glass, fibre glass, cement substrate material, magnesia, ceramics or stone, the prepared aqueous polyurethane dispersion can remarkably improve the scuffing resistant capability and the adhesive force to the substrate material of the coating, especially the adhesive force to the substrate material under the damp environment, thereby effectively makes up the deficiencies of the prior coating technology.