The invention discloses a preparation process of
cyclohexanone-
oxime. The process comprises the following steps: carrying out ammoximation under the condition of the existence of catalyst and
tertiary butanol solvent, and filtering, distilling and leaching when the conversion ratio of
cyclohexanone is 99.5% in the ammoximation; then adding
hydroxylamine for performing oximation reaction; and finally neutralizing and filtering to obtain the
cyclohexanone-
oxime solution when the conversion ratio of the cyclohexanone is 100%. The process combines two different kinds of the oximation reactions to ensure that the conversion ratio of the cyclohexanone reaches to 100%, solves the defect that the cyclohexanone can not be fully converted in the existing ammoximation process, reduces the consumption of
hydrogen peroxide and eliminates safety hidden troubles brought by excessive
hydrogen peroxide. Compared with the traditional process, the process of the invention abrogates working procedures such as regenerating extractant by rectification, removing
ketone, dealcoholization
tower, regenerating cyclohexanone-
oxime by rectification and the like, saves equipment investment and reduces
energy consumption; and as for a device by which the annual cyclohexanone-oxime yield is 100,000 tons, the saved equipment investment is close to ** million yuan, and the saved energy sources such as water,
electricity, steam and the like are close to ** yuan.