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Composition of medication prepared from ginkgo leaves and puerarin

A kind of composition, technology of ginkgo biloba, applied in the field of medicine

Inactive Publication Date: 2007-10-10
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there is no report on the use of ginkgo biloba and puerarin interaction compatibility formula for the preparation of drugs for the treatment of cardiovascular and cerebrovascular diseases, etc.

Method used

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  • Composition of medication prepared from ginkgo leaves and puerarin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] The preparation of embodiment 1 Ginkgo biloba extract

[0152] Preparation of Ginkgo biloba extract

[0153] Take Ginkgo biloba leaves, crush them, heat and reflux with 40% ethanol to extract three times, each time for 2 hours, combine the extracts, recover the ethanol and concentrate it to a relative density of 1.10-1.13, add it to the treated D101 macroporous adsorption resin column, Sequentially eluted with water and 70% ethanol, collected the ethanol eluate, concentrated the recovered ethanol to a relative density of 1.21-1.25, and spray-dried to obtain the final product.

[0154] Identification of Ginkgo Biloba Extract

[0155] Take 0.2g of ginkgo biloba extract, add 15ml of n-butanol, soak in a water bath for 15 minutes and shake it from time to time, let it cool, filter, evaporate the filtrate to dryness, add 2ml of ethanol to the residue to dissolve, and use it as the test solution. Another 0.2 g of ginkgo biloba control extract was taken, and the control extr...

Embodiment 2

[0171] Example 2 Preparation of Ginkgo Leaf Total Flavonoids

[0172] Preparation of total flavonoids from Ginkgo biloba leaves

[0173] Take Ginkgo biloba leaves, chop them, add 70% ethanol and soak at 80°C for two times, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add appropriate amount of water to obtain a suspension equivalent to 1g of the original medicinal material per 1ml, Refrigerate for 12 hours, centrifuge, take the supernatant, add to the treated polyamide column (100g, 30-60 mesh, ethanol wet packing, first wash the column with 2 times the column volume of ethanol, and then wash it with water until nearly No alcohol smell, spare), first wash with 3 times column volume of water, then wash with 2 times column volume of 10% ethanol, discard the eluent, and use 4 times column volume of 80% ethanol for elution , collect the eluent, recover ethanol, concentrate under reduced pressure to a relative density of 1.08-1...

Embodiment 3

[0185] The preparation of embodiment 3 ginkgolides

[0186] Preparation of Ginkgolide

[0187] Take Ginkgo biloba leaves, chop them, add 70% ethanol and soak at 80°C for two times, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add appropriate amount of water to obtain a suspension equivalent to 1g of the original medicinal material per 1ml. Add 1 / 2 amount of petroleum ether to shake and extract 4 times, discard the petroleum ether extract; then use 1 / 2 amount of ethyl acetate to shake and extract 4 times, combine the ethyl acetate solution, recover the solvent under reduced pressure, and evaporate to dryness , add 30% ethanol to the residue and heat to dissolve, leave to crystallize, crystallize and recrystallize once with 30% ethanol to obtain the product.

[0188] Identification of Ginkgolides

[0189] Take 0.1g of ginkgolide, add 10ml of water, heat in a water bath to dissolve, add 2 drops of 2% hydrochloric acid solut...

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Abstract

A composite medicine for treating cardiovascular and cerebrovascular diseases is proportionally prepared from gingko leaf, or its extract, or its general flavone, or the ginkalide and kakonein.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of ginkgo biloba and puerarin, a preparation containing the pharmaceutical composition, a preparation method and application thereof, and belongs to the technical field of medicine. 2. Background technology [0002] In medicine, cardiovascular and cerebrovascular diseases refer to diseases of heart ischemia or hemorrhage caused by hardening of the heart and arteries, including coronary heart disease, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction, etc. Cardiovascular and cerebrovascular diseases have always been known as the number one killer threatening human health. Hypertension, hyperlipidemia, coronary heart disease, and diabetes have become "the plague of the times." According to relevant survey reports, more than 3 million people die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total n...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P9/10A61P9/12A61P9/06A61K31/7048
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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