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Extractive of ginkgo tree leaves, prepn. method and application thereof

A technology of ginkgo biloba leaves and extracts, which is applied in the field of preparation of ginkgo biloba extract injections and freeze-dried powder injections, can solve the problems of low total amount of active ingredients, lack of industrialization conditions, and unreasonable process routes.

Active Publication Date: 2007-02-14
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems in the existing technology: the total amount of active ingredients extracted is not high, the process route is not reasonable enough or the industrialization conditions are not available, and the active ingredients cannot be directly used in injection forms, etc.

Method used

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  • Extractive of ginkgo tree leaves, prepn. method and application thereof
  • Extractive of ginkgo tree leaves, prepn. method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1: the preparation of Ginkgo biloba extract

[0076] The dried ginkgo leaves of the test amount were crushed through a 40-mesh sieve to obtain coarse powder of the medicinal material, and 8 times the amount of 60% ethanol was added, heated and refluxed for 1.5 hr, the extract was filtered out, and the same volume of 60% ethanol was added for the second extraction. Combine the 2 extracts and filter, recover under reduced pressure and evaporate the solvent, until the volume of the concentrated solution is 1 / 10 of the total volume (that is, the concentrated solution with a solid content of 20-30%), add the same volume of deionized water, and cool the environment Put it in the water for 12 hours, fully analyze the insoluble matter, filter or centrifuge to remove the precipitate; add concentrated ammonia water to the filtrate or supernatant under the condition of sufficient stirring, adjust the pH to 9, place it in a cool environment for 1 hour, filter or centrifug...

Embodiment 2

[0077] Embodiment 2: Preparation of Ginkgo biloba extract injection

[0078] Weigh 200g of sorbitol plus 4500ml of 5% ethanol, stir to dissolve completely, add 10g of ginkgo biloba extract, stir to dissolve completely, adjust pH to about 5.5 with 20% NaOH, and finally add 5% ethanol solution to Specified volume, stir to mix evenly.

[0079] Filtration: Pressure filtration through 0.45μm and 0.2μm microporous membranes respectively.

[0080] Filling: Aseptically fill 5.1-5.2ml of the filtered drug solution into the treated ampoule.

Embodiment 3

[0081] Embodiment 3: Preparation of Ginkgo biloba extract powder injection

[0082] Weigh 150g of mannitol and add an appropriate amount of 5% ethanol, stir to dissolve completely, add 10g of ginkgo leaf extract, stir to dissolve completely, then add 26g of disodium hydrogen phosphate dodecahydrate, and adjust the pH to about 6.0, finally add 5% ethanol solution to the specified volume, stir to mix evenly.

[0083] Filtration: Pressure filtration through 0.45μm and 0.2μm microporous membranes respectively.

[0084] Filling: fill the filtered medicinal solution in 3.1ml vials that have been treated.

[0085] Freeze-drying: The eutectic temperature of the above solution of this product is -23°C. Prefreezing at -30°C below the eutectic point for 5 hours can fully freeze this product completely. In the vacuum freeze dryer, the vacuum degree of the freeze dryer is controlled to be about 0.1-0.3 mbar, and the temperature of the condenser is -40°C. The separator temperature was m...

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Abstract

A gingko leaf extract used for preparing liquid injection or freeze-dried powder injection is prepared from gingko leaves through breaking, thermal reflux extracting with the aqueous solution of alcohol, vacuum volatilizing of solvent, depositing in ammonia water to remove polyphenol, extracting with n-hexane to remove ginkgolic acid, adsorbing by macroreticular resin, separating, refining, ultrafiltration and spray drying.

Description

technical field [0001] The invention relates to a production process of ginkgo leaf extract and a preparation method of medicinal preparations, in particular to a preparation method of ginkgo leaf extract injection and freeze-dried powder injection. Background technique [0002] Blood circulation disorders such as cardiovascular and cerebrovascular diseases and peripheral blood vessels are one of the most common clinical diseases and a major class of diseases that affect people's health and longevity. The role of Ginkgo biloba extract and its preparations in cardiovascular and cerebrovascular diseases and peripheral vascular diseases has attracted more and more attention from all over the world. Ginkgo biloba (Ginkgo biloba L.) is an ancient relic plant, also known as ginkgo tree. Ginkgo biloba is a rare species in my country and a precious medicinal plant resource in the world. Especially in the past 40 years, domestic and foreign studies on the chemical components and ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/19A61P9/00A61P25/00A61P43/00A61K127/00
Inventor 张树祥刘文辉崔娜娜
Owner BEIJING SUNHO PHARMA
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