147 results about "Cerebral function" patented technology

This invention encompasses methods for the treatment and prevention of disorders that include, but are not limited to, eating disorders; weight gain; obesity; irritable bowel syndrome; obsessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders; restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; cerebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. The invention further encompasses pharmaceutical compositions and dosage forms which comprise optically pure (+) sibutramine, optionally in combination with a phosphodiesterase inhibitor or a lipase inhibitor.

The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as pharmaceutical compositions and pharmaceutical unit dosage forms containing the same. In particular, the invention encompasses pharmaceutically acceptable salts of topiramate, including without limitation topiramate sodium, topiramate lithium, topiramate potassium, or polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, and amorphous forms thereof. The invention further encompasses novel co-crystals or complexes of topiramate, as well as pharmaceutical compositions comprising them. The invention also encompasses methods of treating or preventing a variety of diseases and conditions including, but not limited to, seizures, epileptic conditions, tremors, cerebral function disorders, obesity, neuropathic pain, affective disorders, tobacco cessation, migraines, and cluster headache.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

A cerebral function improving agent containing as the active ingredient a compound represented by the following formula:wherein R2 represents a hydrogen atom when R1 is a hydroxyl group;or R1 and R2 in combination represent an oxo group;R3 represents a hydrogen atom, an alkali metal, or a monohydric,dihydric or trihydric alcohol residue;which may be an oligomer composed of 2-10 molecules when R1 represents a hydroxyl group and R2 and R3 represent hydrogen atoms.The agent supresses cerebral edema, protects cerebral function, activates cerebral metabolisms and reduces the extent of cerebral infarction.

Methods of preparing, and compositions comprising, derivatives of venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

Methods of preparing, and compositions comprising, derivatives of venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

A simple always-portable stethoscope for enabling accurate diagnosis. A radiation / light-receiving fiber (11) serving as a probe part for noninvasively irradiating a diseased part with near-infrared light is applied to the diseased part so as to measure, e.g., a change of the cerebral circulation blood flow. The change is hard as sound pulse modulation to examine the change of the cerebral function. For example, a light beam of three wavelengths λ=760, 800, 830 nm from a semiconductor laser light source (22) is applied to the diseased part, the reflection data from the diseased part is processed by a control device (21), and the doctor can make a diagnosis with the doctor's ears by hearing with a receiver (32) the change as the change of the frequency of the sound the pitch and volume of which are constant.

The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as pharmaceutical compositions and pharmaceutical unit dosage forms containing the same. In particular, the invention encompasses pharmaceutically acceptable salts of topiramate, including without limitation topiramate sodium, topiramate lithium, topiramate potassium, or polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, and amorphous forms thereof. The invention further encompasses novel co-crystals or complexes of topiramate, as well as pharmaceutical compositions comprising them. The invention also encompasses methods of treating or preventing a variety of diseases and conditions including, but not limited to, seizures, epileptic conditions, tremors, cerebral function disorders, obesity, neuropathic pain, affective disorders, tobacco cessation, migraines, and cluster headache.

This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.

The invention discloses a wearable NIRS-EEG based schizophrenia early detection evaluation system. The system comprises an NIRS-EEG bimodal cerebral function monitor device, a mobile intelligent terminal and a network server, wherein the NIRS-EEG bimodal cerebral function monitor device is used for acquiring cerebral function information of schizophrenia patients or healthy persons in real time by adopting NIRS and EEG technologies, and transmitting the cerebral function information to the mobile intelligent terminal through bluetooth signals; the mobile intelligent terminal is used for uploading data to the network server for data processing via mobile internet; and the network server is used for saving the processed data, generating a corresponding diagnosis result, and feeding back to the mobile intelligent terminal for data waveform display. The system has the advantages of accurate detection evaluation result and extremely low power consumption, and can be used for quickly and conveniently performing early detection and disease early warning for schizophrenia patients and providing scientific and reasonable guidance for nursing schizophrenia patients, so that pains and psychological burden of schizophrenia patients and family members thereof can be reduced.

The invention provides a digital amplitude-integrated cerebral function monitor (CFM). The CFM comprises a signal acquisition system, a signal amplification system and a signal processing system, and signals are acquired by the signal acquisition system, amplified by the signal amplification system and further processed by the signal processing system, thereby obtaining an amplitude-integrated electroencephalogram (aEEG), wherein, the signal acquisition system is a single-lead or double-lead system; the signal amplification system comprises an isolation amplifier and a main amplifier; and the signal processing system comprises a CFM filter module, an amplitude-squeezing module and a peak detecting and smoothing module. The digital amplitude-integrated CFM provided by the invention has the advantages of low environmental requirements and high anti-interference and anti-drifting performance, and can achieve the continuous bedside detection on a real-time basis for a long time and reflect the changes in the cerebral function of patients on a timely basis.

The invention discloses a cerebrum cognitive status recognition method based on cerebral function imaging, comprising the following steps of: inputting experimental data series of cerebral nuclear magnetic resonance images; preprocessing the experiment data of the cerebral nuclear magnetic resonance images; establishing a multidimensional data set which includes a cerebrum coordinate dimension, acerebrum area dimension, an experiment time sequence dimension and a cognitive status dimension; extracting features; classifying and identifying the statuses. The invention extracts feature vectors from cerebral images of cerebra knowing the task statuses to train a support vector classifier, and classify the cognitive status for the feature vectors of an unknown cerebral image using the classifier. If the unknown cerebral image belongs to some category, then the cognitive state the category belongs to is identified as the cognitive status of the unknown cerebral image, thereby achieving theaim of cerebrum cognitive status recognition. The multidimensional data set of cerebral images of the invention are used for secondary analysis, treatment and integration of the cerebral images, thereby enabling the data calculation and analysis of the cerebral images to be more convenient, faster and more visual.

The invention provides a customizable multi-dimensional high-density flexible brain electrode and a manufacturing method thereof. The manufacturing method at least includes the steps that a contact biological electrode is prepared; a micro-needle biological electrode is prepared; the micro-needle biological electrode and the contact biological electrode are combined to form the multi-dimensional composite brain electrode. Non-degradable type flexible thin films in the contact biological electrode serve as an electrode supporting layer and an isolation layer to manufacture a customizable cerebral cortex contact biological electrode with high density and high attachment; degradable flexible thin films in the micro-needle biological electrode serve as a micro-needle and a substrate material, the micro-needle and the substrate material are integrated to be combined into a multi-dimensional composite biological electrode. According to the brain electrode, the sampling space resolution of brain electrical signals is high, the sampling result is precise, damage to living bodies is small, and a great breakthrough can be brought to brain function detection and research.

A near infrared cerebral function imaging helmet is composed of 9 orthopentagons with side length of 3cm and 23 orthohexagons with side length of 3cm. 20 laser probes, a laser light source probe and a laser receiving probe are arranged in the area covered by each orthopentagon. 19 laser probes, a laser light source probe and a laser receiving probe are arranged in the area covered by each orthohexagon.

The brain protein hydrolysate injection is prepared with health swine brain and contains 16 kinds of free amino acids and small amount of peptides. It is used in treating sequelae of craniocerebral trauma and cerebrovascular disease, improving cerebral function, etc. It is prepared through washing, homogenizing, thermal changing, enzyme hydrolysis, freezing, ultrafiltering, sterilizing and other steps.

The present invention discloses a preparation method of oxiracetam (4-hydroxypyrrolidone-2-acetylamine) which can be used as cerebral function improving agent. Said method uses diketene as initial raw material, and includes the following steps: firstly, making the diketene be reacted with chlorine gas to obtain chloroacetoacetyl chloride, then making the chloroacetoacetyl chloride undergo the processes of substitution, hydrogenation and cyclopolymerization, etc. so as to obtain the invented product.

This invention encompasses methods for the treatment and prevention of disorders that include, but are not limited to, eating disorders; weight gain; obesity; irritable bowel syndrome; obsessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders; restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; cerebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. The invention further encompasses pharmaceutical compositions and dosage forms which comprise optically pure (-) sibutramine, optionally in combination with a phosphodiesterase inhibitor or a lipase inhibitor.

The invention discloses a multi-mode imaging system for observing cerebral cortex functions of moving animals, comprising a light source device, an image transferring optical fiber, a light transferring optical fiber, a spectroscope, an intrinsic signal imaging part, a laser speckle contrast imaging part, a fluorescence Imaging part, an animal activity room, an image acquisition card, a computer, wherein the light source device generates three light sources needed by an imaging mode, the image transferring optical fiber is used for transferring the cerebral cortex images to a spectroscope when the animals moves around freely; the light transferring optical fiber transfers the light of the light source to the cerebral cortex of the aminals; the spectroscope divides imaging light beam transferred by the image transferring optical fiber into three beams and carries out intrinsic signal imaging, laser speckle contrast imaging and fluorescence Imaging; the intrinsic signal imaging part is used for the intrinsic signal imaging; the laser speckle contrast imaging part for laser speckle contrast imaging; the fluorescence Imaging part is used for fluorescence Imaging; the animal activity room is used for the experiment animals to move freely; the image acquisition card is used for image acquisition and the computer for system control and image receiving and processing.In the invention, optical fiber light and image transferring can be used to multi-mode imaging when the animals are conscious and active and the invention comprises intrinsic signal imaging, laser speckle contrast imaging and fluorescence Imaging.

This invention provides a composition comprising extracts from the husk of Wenguanguo and a process of producing the combined extract comprising the following steps: extracting Wenguanguo husks with an organic solvent to form an organic extract; removing the organic solvent from the extract to form aqueous extracts; and drying and sterilizing the aqueous extracts to form the combined extracts. The extracts can be used to make medicines or health foods for preventing cerebral aging, improving memory, improving cerebral functions and curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease and other diseases caused by cerebral dysfunction. The combined extracts contain saponin, saccharides, proteins and others.

The invention discloses a full parallel lock phase photon counting detection mode based NIRS (Near Infrared Spectrum) cerebral function imaging system. The full parallel lock phase photon counting detection mode based NIRS cerebral function imaging system includes a modulating LED light source unit, a source-detection optical fiber arrangement array unit, a detection unit, an FPGA and a computer control and data processing unit; the modulating LED light source unit includes an LED light source module, a multi-channel square signal generator module, and 20 source optical fibers; the LED light source module includes 60 LEDs having three wave lengths and an LED light source drive circuit; the multi-channel square signal generator module outputs 60 square signals with different frequencies; the source-detection optical fiber arrangement array unit includes a source-detection optical fiber arrangement paster for arranging 20 light source points and 12 detection points, a plurality of optical fibers and a plurality of detection optical fibers; the detection unit includes 12 detection optical fibers, 12 PMT photon counter and 12 channel X 60 variable gate lock phase photon counting detection modules. The imaging system is high in sensitivity, is large in dynamic range, and is high in time resolution.

The invention discloses a Chinese medicine combination for treating cardio-cerebral vascular diseases, which is composed of raw materials with the following parts by weight: 30-50 parts of radix astragali, 20-25 parts of angelica, 15-20 parts of hemlock parsley, 30-50 parts of salvia miltiorrhiza, 15-20 parts of pseudo-ginseng, 15-20 parts of hawkthorn and 20-30 parts of radix puerariae; the Chinese medicine combination of the invention has ingenious compatibility, simple prescription, broad source of raw materials, low price as well as the efficacies of tonifying both qi and blood, balancing yin and yang, activating blood circulation and dissolving stasis; the Chinese medicine combination can soften blood vessels through reducing blood fat and blood viscosity and eliminating blood scales and finally achieve the purposes of smoothing blood circulation and activating cardio-cerebral function; furthermore, the Chinese medicine combination has unique efficacy for resisting atherosclerosis as well as significant curative effect on cardio-cerebral vascular diseases like coronary heart disease, cerebral thrombosis, and the like; the total clinical effective rate can reach over 95% and the Chinese medicine combination can achieve good preventive and health care effect through long-term oral administration and has safe oral administration and no toxicity and side effect.

An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

The invention relates to multi-access near infrared light diffusion imaging system of brain functional research, which belongs to medical equipment technological field, comprising of near infrared light laser source, multi-access optical fiber switcher, reflected sensing head with multi-light source and multi-detector, electro optical signal collecting and magnifying circuit system, computer with data collection card and program or controlling signal collection and imaging. The sensing head is reflected sensing head with multi- light source and multi-detector, with a rectangular slice made of soft material as substrate; the light source and detector arrange according to the way of rectangular array, each detector light source is embedded in the central point of rectangular area formed by four light sources or switcher adjacent. Besides, the invention uses the way of contrast imaging, eliminating the effect caused by mismatching between the access, and it doesn't bring hurt, pocketable and stable, also, it can realize real time dynamic imaging which is easier to understand, suitable for clinical application.

An NMR time sequence method based on constrained optimization for testing the cerebral functions and diagnosing cerebral diseases includes acquiring functional NMR time sequence, reverse convolution operation to estimate the hamodynamic function of single pixel, estimating the hamadynamic function to different stimulations, optimizing the hamodynamic function, and statistical tentation examining to each pixel one by one.

The invention relates to a Chinese medicinal preparation for treating infantile epilepsia, which comprises the following raw material medicaments in part by weight: 1 to 10 parts of arisaema cum bile, 10 to 20 parts of stiff silkworm, 1 to 10 parts of pinellia tuber, 10 to 20 parts of gambir plant, 1 to 10 parts of earthworm, 10 to 20 parts of bupleurum, 10 to 20 parts of grassleaf sweelflag rhizome, 10 to 20 parts of tall gastrodia tuber, 10 to 20 parts of cicada slough, 1 to 10 parts of evodia fruit, 10 to 20 parts of fructus gardeniae seed, 10 to 20 parts of yanhusuo, 10 to 20 parts of polygalae, 10 to 20 parts of gypsum, 10 to 20 parts of dwarf lilyturf tuber, 10 to 20 parts of silktree albizzia bark, 10 to 20 parts of Chinese angelica, 10 to 20 parts of szechuan tangshen root, 10 to 20 parts of szechuan lovage rhizome and 1 to 10 parts of scorpion. The Chinese medicinal preparation controls the symptoms of the epilepsia and repairs and regenerates damaged cranial nerves fundamentally by combining the improvement of cerebral functions, namely brain invigoration and mentality promotion, conditioning by traditional Chinese medicines and epilepsia resistance, and has the effect of addressing root causes; and the side effect caused by western medicines is offset or resisted by the mutual effect of the medicaments, so that the Chinese medicinal preparation can be taken by infants safely. In addition, the Chinese medicinal preparation has good long-term curative effect, and the infantile epilepsia is difficult to relapse.

A Chinese medicine for improving cerebral function and preventing cerebra ischemic or anoxic injury, senile dementia and vascular dementia is prepared from astragalus root, rhodiola root and Chinaroot greenbrier rhizome or their extracts. Its preparing process is also disclosed.

A photoelectric electrode is capable of synchronously collecting EEG signals and blood oxygen signals. A disc electrode of an EEG collection system and a fiber probe of a near-infrared spectral cerebral function imaging system are integrated to form the photoelectric electrode. Therefore, the problem that cerebral neuronal firing activity and blood oxygen metabolic information cannot be collected synchronously is solved. The photoelectric electrode includes two separable parts, including an electrode part and a photo-electrode part. The electrode part is composed of a hollow disc electrode and a base and is used independently for collecting electroencephalograms; the photo-electrode part can be directly inserted into the base of the electrode part and is firmed through an L-shaped groove. On the basis of nationally standard 10-20 system electrode distribution, 64-channel EEG signals and 42-channel blood oxygen signals can be collected synchronously.

The invention relates to kudzuvine flower health tea as restoring tea of She nationality, which is prepared from kudzuvine flowers, kudzu roots, hovenia dulcis thunb, fiveleaf gynostemma herb, ginseng leaves and fresh tea leaves. The kudzuvine flower health tea is similar to a tea in the characters, a storage mode and a drinking method, can be drunk once being brewed with water, is convenient to drink when a person drinks wines and after the person drinks the wines, has the effects of preventing drunkenness and helping dispeling the effects of alcohol after drunkenness, also has various health effects of preventing and auxiliarily treating hypertension, hyperlipidemia, hyperglycemia, arteriosclerosis, thrombopoiesis, cardiovascular diseases, migraine, inflammation, gastrointestinal ulcer,tumors, cancers, the toxic or side effects of hormone medicines and the like, can calm nerves, nourish the nature, defer senility, improve mental activities, enhance the cerebral functions, activate human normal cells, inhibit fatness, strengthen the spleen and the stomach, relieve the fatigue, fulfill the functions of calming, hypnosis and stress resistance, strengthen the immune function of a human body, moisten the intestines to have remarkable effects on constipation, and also has certain actions of blacking hairs and beautifying. The kudzuvine flower health tea has the advantages of simple and complete compositions, moderate actions, no toxic or side effects and various health effects; the characters of the selected raw materials accord with the conventional acknowledgement of peopleto tea; and the kudzuvine flower health tea tastes fragrant after being brewed with water.

The present invention relates to a cerebral function state evaluation device, which comprises a brain oxyhemoglobin concentration variation acquiring component, acquiring brain oxyhemoglobin concentrations of a stroke patient, who is in a phase of completing finger-nose and heel-knee-tibia tests under instruction, by applying near-infrared spectroscopic brain imaging technology; a brain functional network constructing component; a typical feature acquiring component; and an evaluation model establishing component. The cerebral function state evaluation device evaluates a patient's motor ability based on brain hemoglobin information. By using the proposed evaluation device, an evaluation result can be given only if a patient completes several required actions. The device is inventive and simple to operate, and subjective factors in the process of the scale scoring can be avoided.