57 results about "Ischaemic encephalopathy" patented technology

The present invention relates to a method and kit for in vitro diagnosing a complex disease such as cancer, in particular, acute myeloid leukemia (AML), colon cancer, kidney cancer, prostate cancer; transient ischemic attack (TIA), ischemia, in particular stroke, hypoxia, hypoxic-ischemic encephalopathy, perinatal brain damage, hypoxic-ischemic encephalopathy of neotatals asphyxia; demyelinating disease, in particular, white-matter disease, periventricular leukoencephalopathy, multiple sclerosis, Alzheimer and Parkinson's disease; in a biological sample. For the diagnosis, use is made of measuring at least two different species of biomolecules and classifying the results by means of suitable classifier algorithms and other statistical procedures. With the present invention, a significant improvement of the reliability of e.g. expression profiles alone, are achieved. In other words, in a defined collective, an up to 100% accurate positive diagnosis could be achieved, which renders the method of the present invention superior over the prior art.

The invention is for the combination of EDTA, cystine, selenium, Vitamin C, Vitamin E, and zinc for anti-thrombotic effect and for the effect of restoring platelet aggregation, an integral component of thrombus formation, to normal and for the monitoring of the response to therapy with the combination. Methods for use of the components and method for performing the monitoring are included. The combination and method are particularly efficacious for vascular deficiency ailments including atherosclerotic vascular disease, reduction of ischemic cerebal event, complications from surgical procedures including restenosis, neurogenerative disease, and erectile disfunction, and vascular deficiency resulting from etiology of sepsis and chronic infection.

An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

It is intended to provide a novel polypeptide having an activity of growing vascular endothelial cells, an activity of promoting transcription form c-fos promoter, an activity of promoting transciption from VEGF promoter and / or an angiogenic activity; a polynucleotide encoding this polypeptide; the above polypeptide and / or a pharmaceutical composition containing the polypeptide for treating a disease selected from the group consisting of obstructive arteriosclerosis, Buerger's disease, peripheral vascular disorder, angina, myocardial infraction, brain infarction, ischemic heart disease and ischemic brain disease; a method of treating these diseases; and an antibacterial composition. The above problems can be solved by isolating a novel peptide having the above-described activities and a nucleotide encoding this peptide.

The invention provides aporphine and oxoaporphine compounds that have endothelial nitric oxide synthase (eNOS) maintaining or enhancing activities and may be used to manufacture a medicaments for preventing or treating ischemic diseases in human and mammal, and the ischemic diseases may include ischemic cerebral apoplexy, ischemic cerebral thrombosis, ischemic cerebral embolism, hypoxic ischemic encephlopathy, ischemic cardiac disease or ischemic enteropathy etc.

The invention relates to the prophylactic and therapeutic applications of certain estrogenic components, such as estetrol, in neurological disorders, such as neonatal hypoxic-ischemic encephalopathy (HIE).

An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and / or conditions, including but not limited to diseases and / or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

The invention belongs to the medical technical field and discloses a drug combination used for the cardio-cerebrovascular disease. The drug combination contains the pharmacodynamic components of the raw materials of the drugs of snakegourd or snakegourd extract and hawthorn leaves or hawthorn leaf extract. The invention also discloses preparations, which contain the drug combination and the preparation method of the preparations. The drug combination can be made into the preparation type, which is acceptable in the clinic or the pharmacy, and the injection preparation and the oral preparation are preferential. The drug combination is mainly used for remedying the cardio-cerebrovascular diseases of the coronary heart disease, the angina, the miocardial infarction, the blood stasis type corpulmonale, the ischemic encephalopathy, the cerebral thrombosis, the hypertension, the hyperlipemia etc. The drug combination of the invention has the synergistic interaction. Compared with simply using the snakegourd or the snakegourd extract and the hawthorn leaves or the hawthorn leaf extract, the effect is improved greatly, and the invention is provided with low toxicity, high safety and good stability.

The invention relates to a tanshinone derivative as well as preparation and an application thereof. The derivative has good storage stability, and can be applied to preparation of medicaments for treating or preventing coronary heart disease, angina pectoris, myocardial infarction, arrhythmia, ischemic encephalopathy, and peripheral circulation disturbance diseases, such as microcirculation disturbance, hypertension, hyperlipidaemia and other diseases caused by various arteriosclerosis, angiitis and diabetes mellitus.

[Object] To provide an excellent pharmaceutical composition for preventing and / or treating vascular diseases.[Means for Solution] Useful to provide a pharmaceutical composition for preventing and / or treating vascular diseases, which comprises 1) a COX-1 selective inhibitor and 2) clopidogrel or a pharmaceutically acceptable salt thereof. The present invention is useful as an excellent pharmaceutical composition for preventing and / or treating vascular diseases is provided and is particularly useful as a pharmaceutical composition for preventing and / or treating arterial thrombosis, ischemic heart disease, ischemic brain disease, pulmonary embolism, peripheral circulation disorder, restenosis and reocclusion, essential thrombocytosis and so on is provided.

The invention provides a new application of Chinese caterpillar fungus. The Chinese caterpillar fungus has a new application in preparation of anti-inflammatory drugs, and further can be used for preparing drugs with neuroprotective effect to ischemic encephalopathy. The new application of Chinese caterpillar fungus is realized through lowering the levels of interleukin, tumour necrosis factor and intercellular adhesion molecules, and reducing the expression of nitric oxide synthase and cyclooxygenase by inhibiting the activity of transcription factor protein family NF-kB. The invention also provides a medicament composition which takes Chinese caterpillar fungus as the main component or one of the main components and is provided with therapeutic effect to ischemic encephalopathy.

A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and / or conditions, including but not limited to diseases and / or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

To find a compound having a tissue fibrinosis-inhibitory activity and a fibrinolytic activity, and to provide a novel compound that is useful for preventing and / or treating tissue fibrinosis diseases (pulmonary fibrosis, renal fibrosis etc.), diseases caused by pathological blood clots such as ischemic heart diseases (myocardial infarction, angina), intraatrial thrombus, pulmonary embolism, deep venous thrombosis, disseminated intravascular coagulation, ischemic cerebral diseases (cerebral infarction, cerebral bleeding) and arteriosclerosis and the like. To provide a pharmaceutical drug comprising a 5-phenyl-3-pyridazinone derivative represented by the following general formula (I):and an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, useful for preventing and / or treating disease conditions or symptoms mediated by plasminogen activator inhibitor-1.

It is intended to provide a novel polypeptide having an activity of growing vascular endothelial cells, an activity of promoting transcription form c-fos promoter, an activity of promoting transciption from VEGF promoter and / or an angiogenic activity; a polynucleotide encoding this polypeptide; the above polypeptide and / or a pharmaceutical composition containing the polypeptide for treating a disease selected from the group consisting of obstructive arteriosclerosis, Buerger's disease, peripheral vascular disorder, angina, myocardial infraction, brain infarction, ischemic heart disease and ischemic brain disease; a method of treating these diseases; and an antibacterial composition. The above problems can be solved by isolating a novel peptide having the above-described activities and a nucleotide encoding this peptide.

Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and / or conditions, including but not limited to diseases and / or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

The invention discloses bear gall powder capable of inhibiting thrombosis and platelet aggregation and preventing cerebral ischemia and application. The bear gall powder can be used for adjusting blood fat, reducing total cholesterol, preventing cardiovascular and cerebrovascular diseases and preventing atherosclerosis; the invention discloses a preparation method of the bear gall powder and the bear gall powder obtained through the method. In a bear gall powder preparation process, materials are subjected to ice crystallization, then freeze drying is conducted, and the obtained freeze dried bear gall powder can be called ice crystal state bear gall powder or can be called ice crystal bear gall powder; especially, the bear gall powder which can be called Senbao bear gall powder does not contain any auxiliaries or chemical additives; especially, the ice crystal state bear gall powder not only can more effectively adjust the blood fat and reduce the total cholesterol, but also can be more effectively used for preventing the cardiovascular and cerebrovascular diseases, preventing atherosclerosis and preventing and treating solid tumors and hematological system tumors, and more especially, the ice crystal state bear gall powder can be effectively used for inhibiting thrombosis, inhibiting platelet aggregation and preventing cerebral ischemia and ischemic encephalopathy.

The present invention discloses pharmaceutical use of Echinacoside (ECH) for treatment of hypoxic-ischemic encephalopathy. The experimental results of the present invention indicate that the Etoposideat a dose of 160 mg / kg can significantly improve cerebral infarction volume and neuronal damage and apoptosis in a hypoxic-ischemic model of neonatal rats when used in a safe dose range, and prove that the Etoposide can promote the recovery of neuronal ischemia and hypoxia injury and prevent disability and death after hypoxic ischemic encephalopathy.

The present invention relates to a stable naloxone powder injection. The naloxone powder injection described by said invention is formed from naloxone or its physiologically-aceptable salt and pharmacologically-allowable injection auxiliary material. It can be extensively used for curing various diseases of acute alcoholism, cerebrovascular accident, ischemic encephalopathy, coma, craniocerebral injury and imminent serious diseases, and can be used for removing respiratory inhibition and inducing awavening after combined anesthesia and operation.

The refreshing musk preparation for treating ischemic cerebral diseases is prepared with the medicine powder of leech, ground beetle, artificial bezoar, nux vomica seed, pearl, ginseng, natural musk and borneol in certain proportion, and through mixing through stirring in some container and capsulizing or tabletting to make capsule or tablet. By means of the synergistic effects of the medicine components, the refreshing musk preparation can improve body's micro circulation, improve cardiac and cerebral ischemia, anoxia and hemerheological state, increase nourishing blood flow rate, reduce blood fat, lipofuscin, serum urea nitrogen and creatinie effect, eliminate arteriosclerosis block, resist thrombosis and platelet aggregation, and eliminate pathological change damage.

The invention provides aporphine and oxoaporphine compounds that have endothelial nitric oxide synthase (eNOS) maintaining or enhancing activities and may be used to manufacture a medicaments for preventing or treating ischemic diseases in human and mammal, and the ischemic diseases may include ischemic cerebral apoplexy, ischemic cerebral thrombosis, ischemic cerebral embolism, hypoxic ischemic encephlopathy, ischemic cardiac disease or ischemic enteropathy etc.

The invention discloses a traditional Chinese medicine composition, fermented medicine liquor prepared from the traditional Chinese medicine composition, a preparation method and application. The traditional Chinese medicine composition is prepared from, by weight, 160-480 parts of kudzuvine roots, 80-320 parts of radix salvia miltiorrhiza, 120-400 parts of radix paeoniae alba, 120-400 parts of milkvetch roots, 40-240 parts of rhizoma curcumae longae, 60-280 parts of rhizoma atractylodis macrocephalae, 40-240 parts of semen brassicae, 60-280 parts of fructus crataegi, 60-280 parts of radix bupleuri, 60-280 parts of flos chrysanthemi, 40-240 parts of rhizoma gastrodiae, 60-280 parts of rhizome panacis japonica, 60-280 parts of rhizoma cyperi and 40-240 parts of herba salviae chinensis. Every 1,000 parts by weight of the fermented medicine liquor is prepared by adding and fermenting, by weight, 10-50 parts of saccharomyces cerevisiae, 10-50 parts of bacillus aceticus, 10-50 parts of lactobacillus and the balance traditional Chinese medicine decoction. Experiments show that the fermented medicine liquor has the obvious effect on oxidative stress injuries of cerebral microvascular endothelial cells and can significantly inhibit cerebral microvascular endothelial cell apoptosis and aging which are induced by hydrogen peroxide. Clinical experiments show that the fermented medicine liquor prepared from the traditional Chinese medicine composition can effectively treat ischemic encephalopathy, is safe and effective in treatment, has no adverse influence on the liver and kidney functions of a patient, can be taken for a long term and is worthy of clinical application and popularization.

The invention discloses an application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy. According to the invention, when in a safe dosage range, verbascoside with a dose of 240 mg / kg can obviously improve early nerve function disorder of a hypoxic and ischemic model of a newborn rat, reduce cerebral infarction volume of an ischemic region and neuron necrosis,experiments show that the verbascoside has the function of promoting recovery of the nerve function and preventing newborn bodies from death or disability caused by hypoxic and ischemic encephalopathy.

The invention relates to a medicinal composition for treating cerebral ischemia, coronary disease and angina pectoris, which comprises cape jasmine 160-1600 weight parts, root of red rooted saliva 160-2500 weight parts, notoginseng 160-1600 weight parts (or notoginsen triterpenes 8-50 weight parts), cape jasmine 160-1600 weight parts and notoginseng 160-1600 weight parts (or notoginsen triterpenes 8-50 weight parts), breviscapine 3-20 weight parts, cape jasmine 160-1600 weight parts, red sage root 160-2500 weight parts and breviscapine 3-20 weight parts.

The invention discloses a medicine for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis and application. The medicine comprises indole-3-methanol and a derivative thereof, or diindolylmethane and a derivative thereof. The medicine further comprises a carrier acceptable on pharmacy, wherein the carrier comprises a beverage or a food. The medicine can be used for treating and preventing coronary atherosclerotic heart disease, ischemic heart disease caused by luminal stenosis or luminal occlusion due to inflammation thrombosis, embolism or damage, thrombosis, cerebral infarction, ischemic cerebral apoplexy, cerebral thrombosis, cerebral embolism, lacunar ischemic cerebral apoplexy, frequent ischemic cerebral apoplexy and transient ischemic attack.

The invention relates to the prophylactic and therapeutic applications of certain estrogenic components, such as estetrol, in neurological disorders, such as neonatal hypoxic-ischemic encephalopathy (HIE).

The present invention relates to medical technique field, to provide a medicinal composition for treating cardiovascular and cerebrovascular diseases, its preparation method and preparation containing the medicinal composition, constitution of the raw materials used for preparing the medicinal composition containing the effective components are red sage root or red sage root extraction and cattail pollen or cattail pollen extraction. The medicinal composition can be prepared into clinic or pharmaceutical acceptable preparations, optimizing oral preparation or injection. Mainly used for preparing medicine for treating cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, myocardial infarction, blood stasis type pulmonary heart disease, ischemic encephalopathy, cerebral thrombus, hypertension, hyperlipemia and etc. The medicinal composition of the present invention has synergistic interaction, effect is increased greatly than using single red sage root or red sage root extraction and single cattail pollen or cattail pollen extraction, low toxicity, high safety, and good stability.