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Stable naloxone powder for injection

A technology for naloxone powder injection and naloxone, which is applied in the field of medicine, can solve the problems of inconvenient use, freezing of water injection, and high transport damage rate, and achieves the effects of convenient transportation, long storage period and good stability

Inactive Publication Date: 2005-07-20
GUANGDONG QIFANG MEDICINES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, my country has approved the marketing of naloxone hydrochloride injection, but with the continuous expansion of production, quality problems also appear from time to time, and the water injection freezes in winter in the north, which is inconvenient to use and has a high rate of damage during transportation. These are all settings for expanding use. Obstacles

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0011] The present invention is further illustrated below by specific examples, but is not limited to the following examples:

[0012] 1. Take the prescribed amount of naloxone hydrochloride and auxiliary materials, dissolve them with water for injection, adjust the pH to 3.0-7.0, and constant volume. The solution is sterile-filtered in a 100-level workshop, and divided into bottles containing 0.4 naloxone hydrochloride. mg or 1 mg or 2 mg or 4 mg of the solution, according to the freeze-drying method to obtain the finished freeze-dried powder.

[0013] 2. Use naloxone hydrochloride as the raw material in the workshop below 100 grades, add appropriate amount of water and auxiliary materials, adjust the pH to 3.0-7.0, the solution is sterile filtered, and the aseptic powder is obtained by freeze-drying method, crushed and packed into Each bottle contains 0.4 mg or 1 mg or 2 mg or 4 mg of naloxone hydrochloride, which is capped and packaged to obtain the finished product.

[00...

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PUM

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Abstract

The present invention relates to a stable naloxone powder injection. The naloxone powder injection described by said invention is formed from naloxone or its physiologically-aceptable salt and pharmacologically-allowable injection auxiliary material. It can be extensively used for curing various diseases of acute alcoholism, cerebrovascular accident, ischemic encephalopathy, coma, craniocerebral injury and imminent serious diseases, and can be used for removing respiratory inhibition and inducing awavening after combined anesthesia and operation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a stable medicine in a special dosage form for analgesia and antagonism of respiratory depression medicine. Background technique [0002] Naloxone was synthesized in 1960 as a derivative of oxy(di)hydromorphone. Naloxone is a pure opioid receptor antagonist clinically used in the treatment of overdose and poisoning of narcotic analgesics. In addition to being used to antagonize the respiratory depression caused by morphine drugs, clinical workers have also tried stress diseases such as overdose of non-narcotic drugs (ethanol, diazepam), shock, cerebral infarction, and neonatal asphyxia syndrome, and achieved relatively good results. The good therapeutic effect has aroused great interest of doctors at home and abroad. Naloxone has an antagonistic effect on the analgesia and respiratory depression induced by narcotic analgesics such as heroin, morphine, codeine, and pethidine. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/485A61P11/00A61P25/04
Inventor 孔庆文杨春玮刘军
Owner GUANGDONG QIFANG MEDICINES CO LTD
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