43 results about "Vascular spasm" patented technology

Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and / or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and / or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.

Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.

An intracellular calcium concentration increase inhibitor containing as the active ingredient (1) a boron compound represented by the formula (I).The compound represented by the formula (I) inhibits the increase of the intracellular calcium concentration, and therefore it is deemed to be useful as an agent for the prophylaxis and / or treatment of platelet aggregation, ischemic diseases in hearts and brains, immune deficiency diseases, allorgosis, bronchial asthma, hypertension, cerebrovascular spasm, various renal diseases, pancreatitis, Alzheimer's disease, etc.

A therapeutic device and method for use thereof for treatment of blood flow disorders is disclosed. In one embodiment, a first line emergency response system for treatment of acute thrombotic and / or vasospastic vascular obstructions via the noninvasive application of low frequency vibration with at least one, and preferably a plurality of randomly administered vibratory waveform characteristics (herein after “Randomic Vibration”) is detailed. The disclosed apparatus and methods are based on the intuition that transcutaneously imparted low frequency randomic vibration can provide enhanced clot disruption and mixing of clot disruptive agents to acutely thrombosed vessels, due to the addition of mechanical chaos via non-regular, multi-vectored convection currents. In a preferred embodiment, the disclosed apparatus and methods preferably utilize randomic vibration as an adjunct to systemically administered drug therapy, most preferably intravenously administered thrombolytic drug therapy.

Methods and compositions are disclosed for inhibiting proliferation of human colon adenocarcinoma cells, reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present invention describes the use of phenolic compositions, purified from oats or synthetically produced, to decrease the effective amount of pro-inflammatory molecules and / or cell adhesion molecules. Alternatively, an alcoholic extract or concentrate from oats can be used. The methods of the present invention can be used as a treatment or prophylaxis of a wide variety of disorders associated with inflammatory states and / or with a lack of or need for nitric oxide (NO), such as inflammatory conditions, pain, free radical associated disorders, cardiovascular diseases, autoimmune disorders, pathological platelet aggregation, pathological vasoconstriction, vascular effects of diabetes, stroke, atherosclerosis, hypertension, abnormal vasospasm, and restenosis after angioplasty.

The present invention is medicine composition for treating cerebral ischemia and its medicinal application. The medicine composition has ginsenoside and salvianolic acid as main components. It can reduce the cerebral infarction area obviously, reduce behavior disorder caused by cerebral tissue necrosis obviously, and reach the aim of treating cerebral blood supply insufficiency, cerebral thrombosis, cerebral embolism, cerebral vascular spasm, senile dementia, etc.

Methods and compositions are disclosed for reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present invention describes the use of phenolic compositions, purified from oats or synthetically produced, to decrease the effective amount of pro-inflammatory molecules and / or cell adhesion molecules. Alternatively, an alcoholic extract or concentrate from oats can be used. The methods of the present invention can be used as a treatment or prophylaxis of a wide variety of disorders associated with inflammatory states and / or with a lack of or need for nitric oxide (NO), such as inflammatory conditions, pain, free radical associated disorders, cardiovascular diseases, autoimmune disorders, pathological platelet aggregation, pathological vasoconstriction, vascular effects of diabetes, stroke, atherosclerosis, hypertension, abnormal vasospasm, and restenosis after angioplasty.

The invention discloses a gingko drop pill for prevention and cure of cardio-cerebrovascular diseases, which mainly solves the problem of slow effect caused by the slow absorption rate of the ginkgo tablet during the disease treatment process. The drop pill comprises the following constituents with parts by weight, ginkgo leaf extract 1-60 parts, red sage root extract 0-60 parts, ground substance 20-80 parts. The content of active bilobanone ingredient in the medicament is 1-60%, the content of bilobalide is 0.5-6%.

Methods and compositions are disclosed for reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present invention describes the use of phenolic compositions, purified from oats or synthetically produced, to decrease the effective amount of pro-inflammatory molecules and / or cell adhesion molecules. Alternatively, an alcoholic extract or concentrate from oats can be used. The methods of the present invention can be used as a treatment or prophylaxis of a wide variety of disorders associated with inflammatory states and / or with a lack of or need for nitric oxide (NO), such as inflammatory conditions, pain, free radical associated disorders, cardiovascular diseases, autoimmune disorders, pathological platelet aggregation, pathological vasoconstriction, vascular effects of diabetes, stroke, atherosclerosis, hypertension, abnormal vasospasm, and restenosis after angioplasty.

A method of treating cerebral vasospasm includes delivering at least a first blood vessel including an expandable segment to a position within a blocked or constricted portion of a vessel and transitioning the expandable segment from a collapsed configuration to an expanded configuration to dilate the vessel and to restore adequate blood flow through the vessel. The expandable segment has a pre-set outer diameter substantially equal to or less than an inner diameter of the vessel. Additionally, the expandable segment is configured to expand with a minimal amount of radial force necessary to contact and expand the inner walls of the vessel. After dilation of the vessel, the device is removed from the patient's body. If necessary, additional blood vessel dilation devices each including an expandable segment having a pre-set outer diameter greater than the previous device's expandable segment can be used in order of increasing pre-set outer diameter of the expanded segment to further dilate the blocked or constricted portion of the vessel and restore blood flow through the vessel. Once adequate blood flow through the vessel has been restored, the blood vessel dilation device is withdrawn.

The invention relates to an external ventricular drainage and hematoma clearance device. The external ventricular drainage and hematoma clearance device includes a drainage tube, and a first drainageneedle and a second drainage needle which are connected to a head end and a tail end of the drainage tube respectively; a surface of an inner wall of the drainage tube is coated with an anticoagulantcoating; and a filtering device, a pressure application device and a three-way tube are successively arranged on a tube line of the drainage tube. The external ventricular drainage and hematoma clearance device can adopt different drainage manners according to the ventricular hematoma degree: for ventricular cast severe cerebral hemorrhage, the two drainage needles adopt transorbital puncture, puncture a lateral ventricle posterior horn, and adopt angle puncture and enter a ventricle, and a hematoma-lateral ventricle frontal horn drainage-purging in vitro-lateral ventricle posterior horn backflow circulation loop is established; and for mild ventricular hemorrhage, the first drainage needle and the second drainage needle are combined into a puncture needle, and a local circulation is established. The external ventricular drainage and hematoma clearance device can clear up ventricular blood clots, in particular ventricular cast, can effectively relieve secondary lesion such as hydrocephalus, encephaledema, and vasospasm due to ventricular hemorrhage and ventricular cast.

The present invention relates to a stable naloxone powder injection. The naloxone powder injection described by said invention is formed from naloxone or its physiologically-aceptable salt and pharmacologically-allowable injection auxiliary material. It can be extensively used for curing various diseases of acute alcoholism, cerebrovascular accident, ischemic encephalopathy, coma, craniocerebral injury and imminent serious diseases, and can be used for removing respiratory inhibition and inducing awavening after combined anesthesia and operation.

Methods and compositions are disclosed utilizing the optically pure (-) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (-) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (-) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.

The invention relates to salvinorin compositions and uses thereof. Specifically, the invention relates to administering salvinorin compositions to treat diseases and disorders associated with vasoconstriction, vaso-occlusion, or disruption of blood flow and autoregulation. For example, salvinorin compositions may be administered to subjects with cardiac arrest, subarachnoid hemorrhage, stroke, cerebral vascular spasm, cerebral hypoxia / ischemia, cerebral artery occlusion, or any condition involved in autoregulation impairment.

Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses (206) of energy to respective focal points (213) at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm (216) in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.

The invention discloses application of the compound (I) as shown in formula (I) in preparing a pharmaceutical composition for treating cerebrovascular spasm. Animal experiments confirm that: SB-3CT has certain curative effect to CVS after SAH (subarachnoid hemorrhage), and can mitigate the thickening degree of spastic vessel walls and the lumen stenosis, thus providing a new treatment approach for CVS after SAH.

The invention discloses application of SKF96365 in preparation of a medical composition for treating cerebral angiospasm. According to the invention, a cisterna magna primary blood injection method rat SAH model is adopted to disclose TRPC (Transient Receptor Potential Canonical)1 and TRPC4 expression up-regulation of vascular wall after SAH. The activating level is closely associated with the pathologic change degree of spasm vascular wall in expression time phase, so as to indicate that TRPC1 and TRPC4 participate in occurrence and development of CVS (Cerebral Vascular Spasm). A TRPC channel paralyser SKF96365 is used to prevent and treat cerebral vascular spasm, and the TRPC channel is paralyzed to limit calcium influx of smooth muscle cell, so that the degree of lumen stenosis and lumen thickening can be partially relieved, and a certain treating effect is shown.

The invention relates to a novel crystal form of anisodine hydrobromide and a preparation method of the novel crystal form. The novel crystal form of anisodine hydrobromide is named as a crystal form D. The crystal form has the beneficial effects that the stability is good, the solubility and the hygroscopicity meet pharmaceutical requirements, a preparation process is simple in operation and low in cost, and the crystal form has important value to the optimization and development of drugs in future. The crystal form can be used for preparing preparations of drugs for treating hemicranias, vascular headache, retinal vascular spasm, ischemic optic neuropathy, nervous system inflammation and acute paralysis, paralysis agitans, depression and the like caused by blood vessels of brain.

The present invention is one kind of class-II medicine for stopping pain, diminishing inflammation and resisting cancer. It may be used to improve the survival quality of cancer patient and prolong the survival period of cancer patient. It may be used to replace morphine and will produce no dependence. It is one oral medicine without toxicity and anaesthesia; may be used to treat pain caused by Raynauds disease, angiospasm and zoster. It has obvious curative effect on diabetes as well as rheumatism, rheumatoid disease, scapulohumeral periarthritis and phlebitis.

The invention relates to a method for using genbo acid to prepare the drug in the brain angiospasm treatment. The animal test has proved the effect of genbo acid on the treatment of brain angiospasm, while it can reduce the penetration of spaced connection, or close some connecting channels to restrain the transmission of ion flow, second message molecule and the current between cells, to reduce the number of smooth muscle cells in the contraction to restrain the contraction of smooth muscle cell.

The invention relates to a renal artery sympathetic cold saline radiofrequency ablation catheter with a sealing valve, which comprises: a spiral ablation tube, and a through hole for guide wire penetration and saline injection is arranged in the ablation tube along the spiral direction; connected to the through hole Remote sealing valve. The injection of cold saline in the ablation tube of the present invention and the penetration of the guide wire share a through hole, and a sealing valve is provided at the far end of the through hole. It can inject cold saline through the through hole during ablation to prevent coking of the inner wall of the blood vessel and vascular spasm, which greatly simplifies the internal structure of the inner tube, reduces the outer diameter of the catheter, and reduces the difficulty and cost of manufacturing. When it is spiral, it provides a reliable curvature, so that it is close to the inner wall of the renal artery and improves the ablation effect. The present invention can be applied to renal artery denervation.

The present invention relates to medicine technology, and is especially the application of estrone derivative EA204 in preparing medicine for treating vascular smooth muscle spasm disease. In in vitro animal experiment, estrone derivative EA204 can relax rabbit's in vitro descending aorta contracted with adrenalin, noradrenalin, barium chloride or potassium chloride. Estrone derivative EA204 may be used in preparing medicine for treating hypertension, coronary atherosclerosis, cerebral vascular spasm disease, etc.

The invention discloses a multifunctional surgical operation flushing solution and a preparation method and application thereof. The multifunctional surgical operation flushing solution comprises an anti-spasm functional component and NaCl (sodium chloride). The multifunctional surgical operation flushing solution has the advantages that the vision field of operation is cleaned, the higher concentration of magnesium ions and glutin or albumin is maintained at the local part of a wound, and the operation is convenient, timely and efficient; the tissue organs can be protected, the pain of the operation wound can be relieved, the spasm of muscles around the wound is relieved, and the spasm of tissue blood vessels around the wound is relieved; the magnesium ions and the glutin or albumin in the surgical operation flushing solution disclosed by the invention can generate the synergistic function, so as to realize the preventing and treatment function on the pain of incision, spasm of muscles, spasm of blood vessels, and injury of tissues.

The invention discloses a foot bath traditional Chinese medicine for treating diabetes, which comprises the following raw materials in parts by weight: 3-15 parts of camphor wood, 10-26 parts of astragalus, 15-30 parts of safflower, 10-28 parts of asarum, and 9-19 parts of red peony 10‑30 parts of mugwort leaves, 6‑20 parts of cassia twig, 8‑20 parts of Achyranthes achyranthes, 10‑25 parts of terrazzo, 10‑25 parts of frankincense, 7‑16 parts of honeysuckle, 4‑15 parts of Panax notoginseng. The invention also provides a preparation method of the foot bath traditional Chinese medicine. The foot bath traditional Chinese medicine provided by the invention can remove blood stasis, remove blood stasis, dredge collaterals, act directly on the skin of the foot to reach interstitial spaces, reconcile qi and blood, dredge meridians, expand capillaries, reduce blood viscosity, accelerate blood circulation, and relieve blood vessel pain. Spasm, can dredge meridian qi.

A vasospasm monitoring device based on a triboelectrification technology includes a vascular stent. A plurality of hole-shaped structures are distributed on the vascular stent. A triboelectric film sleeve is inserted into each hole-shaped structures in a matched mode, and the triboelectric film sleeve includes an inner electrode, an inner triboelectric material layer, an outer triboelectric material layer, and an outer electrode. The inner triboelectric material layer and the outer triboelectric material layer can generate electricity by friction, and the inner electrode and the outer electrode are electrically connected to a bioelectric signal processing patch.

The present invention relates to a long acting composition of the fibrin glue vasodilating agent with sustained release property, which comprises a vasodilating agent and a spasmolysant of effective amount, fibrin glue that can delay the releasing of the vasodilating agent. The present invention is characterized in that the composition is a mixture of the fibrin glue and the vasodilating agent; the mixing concentration changes in the range from 0.1mg per ml to 10mg per ml according to various kinds of vasodilating agents. In the present invention, the long acting composition of the fibrin glue vasodilating agent with sustained release property has the following properties of good tissue compatibility, slow releasing of the drugs, long maintenance in the application area and reduction of the side effects to the human body. The present invention is applied in the control during surgery as well as the prevention and treatment after the surgery, which can cause the vasospasm attack. The present invention is particularly applied in the prevention and reduction of the convulsive seizure, which occurs in the coronary artery bypass grafting operation or after the operation. Therefore the pain of the patient is dramatically decreased and the cure rate is improved, and the recurrence is reduced.

A method of treating a patient inflicted with Reynaud's Disease including the step of injecting into the back of the patient's hand an effective amount of a hyaluronic product, thereby creating a glove-like insulation to decrease the blood vessel vasospasm.

The present invention relates to a long acting composition of the fibrin glue vasodilating agent with sustained release property, which comprises a vasodilating agent and a spasmolysant of effective amount, fibrin glue that can delay the releasing of the vasodilating agent. The present invention is characterized in that the composition is a mixture of the fibrin glue and the vasodilating agent; the mixing concentration changes in the range from 0.1mg per ml to 10mg per ml according to various kinds of vasodilating agents. In the present invention, the long acting composition of the fibrin glue vasodilating agent with sustained release property has the following properties of good tissue compatibility, slow releasing of the drugs, long maintenance in the application area and reduction of the side effects to the human body. The present invention is applied in the control during surgery as well as the prevention and treatment after the surgery, which can cause the vasospasm attack. The present invention is particularly applied in the prevention and reduction of the convulsive seizure, which occurs in the coronary artery bypass grafting operation or after the operation. Therefore the pain of the patient is dramatically decreased and the cure rate is improved, and the recurrence is reduced.

The invention discloses a heart-lung-soothing honey-fried pill and a preparation method thereof, the heart-lung-soothing honey-fried pill has two prescriptions of deficiency, excess, cold and heat, and is suitable for excess heat. The heart-lung-soothing honey-fried pill is prepared from the following raw materials: radix bupleuri, astragalus membranaceus, rhizoma atractylodis macrocephalae, dandelion, oriental wormwood, poria cocos in Yunnan, rhizoma alismatis, charred triplet, agastache rugosus, rhizoma cyperi, musk, salviae miltiorrhizae, safflower carthamus, elecampane, pericarpium citri reticulatae, radix rehmanniae, radix rehmanniae preparata, radix polygoni multiflori preparata, ephedra, coptis chinensis, golden cypress, radix ophiopogonis, semen plantaginis, angelica sinensis, leonurus, polygala tenuifolia, liquorice, rhizoma polygonati, ligusticum wallichii and mirabilite. The heart-lung-soothing honey-fried pill provided by the invention has the functions of treating liver, spleen, kidney and intestinal tract, so that endocrine disorder of a human body returns to normal, and the heart-lung-soothing honey-fried pill relieves vasospasm, eliminates vascular stenosis, reduces blood vessel pressure, reduces blood viscosity to achieve heart and lung soothing effect by diffusing the lung, soothing the liver, regulating qi, clearing damp, reducing phlegm, promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, tonifying qi, nourishing blood, moistening and relaxing bowels, nourishing yin and yang of the kidney and eliminating food retention.