Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
42 results about "Bilobalide" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
Process for extracting ginkgo biloba flavone, ginkgo biloba lactone and ginkgo biloba phenolic acid from ginkgo biloba leaves
ActiveCN102727538AQuick contactAccelerated leaching extractionNervous disorderGinkgophyta medical ingredientsAfter treatmentBULK ACTIVE INGREDIENT
The present invention discloses a process for extracting ginkgo biloba flavone, ginkgo biloba lactone and ginkgo biloba phenolic acid from ginkgo biloba leaves. The process comprises the following steps: (1) carrying out a pretreatment on ginkgo biloba leaves; (2) carrying out extraction by an ultrasonic device; (3) carrying out reduced pressure concentration; (4) loading the resulting solution on a macroporous resin to carry out a treatment; (5) collecting the resulting eluate; (6) carrying out reduced pressure concentration; (7) detecting the resulting extract; and (8) carrying out drying and storing on the extract. With the process of the present invention, the ginkgo biloba flavone content and the ginkgo biloba lactone content in the extract prepared by the process of the present invention are high, the loss of active ingredients are avoided, the production process is simplified, the production cycle is shortened, and the ginkgo biloba phenolic acid content after treatment is substantially reduced.
Owner:JIANGSU EHAI PHARMA CORP
Bilobalide B hydrolyzed derivatives and application thereof
InactiveCN102190664AEffective prosecutionEnsure safetyOrganic chemistryComponent separationFreeze-dryingBilobalides
The invention discloses two bilobalide B hydrolyzed derivatives of which the structural formulae are disclosed in the specification, and also discloses application thereof as impurity reference substances in inspection of related substances of methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B raw materials and preparations. The methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B preparations are methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B water injection, methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B freeze-dried powder injection, methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B high-capacity injection and methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B solid oral liquid. The invention effectively controls the related substances of the methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B raw materials and preparations, thereby ensuring the safety and effectiveness of the methylsulfonyl 10-O-(dimethylaminoethyl)bilobalide B preparations in clinical use.
Owner:秦引林
A kind of preparation method of ginkgo golden ear fruit wine
ActiveCN102286324AHigh medicinal valuePreserve metabolite advantageAlcoholic beverage preparationMicroorganism based processesBiotechnologySporeling
The invention relates to a method for preparing gingko golden fungus fruit wine, which comprises the following steps that: golden fungus type spore and monoxenous stereum hirsutum parent strains are used for carrying out liquid bottle shaking seed culture of the golden fungus type spores, the seed tank culture of the golden fungus type spores, the bottle shaking seed culture of the autoecious stereum hirsutum, the bottle shaking expansion culture of the autoecious stereum hirsutum and the seed tank culture of the autoecious stereum hirsutum, the seed tank seed of the golden fungus type sporesand the seed tank seed of the autoecious stereum hirsutum are subjected to the mixed fermentation culture, ginkgo starch substrates and wine brewing yeasts are added into the mixed fermentation liquid of golden fungus type spores and the autoecious stereum hirsutum for carrying out post fermentation, the gingko golden fungus fruit wine with golden fungus extracellular polysaccharide, stereum hirsutum terpene, ginkgo flavone and bilobalide b can be obtained, the alcohol volume is higher than 3 percent, the ginkgo phenolic acid is smaller than 1ppm, and the hydrocyanic acid is lower than 0.1microgramme per liter. The gingko golden fungus fruit wine obtained by the method has an anti-radiation health care function.
Owner:江苏同源堂生物工程有限公司
Bilobalide k and complex thereof, preparation method and use for the same
ActiveCN1919848AImprove pharmacological activityNuclear pyknosis reliefOrganic active ingredientsOrganic chemistrySolubilityDrug carrier
The invention discloses a preparing method and application of bilobalide K with general formula as (I), which is characterized by the following: G is alkaline material; possessing stability and water-solubility.
Owner:JIANGSU KANION PHARMA CO LTD
Soft bilobalide capsule and its prepn.
InactiveCN1389205AImprove stabilityEasy to takeOrganic active ingredientsUnknown materialsWaxVegetable oil
The present invention discloses a bilobalide soft capsule formed from two portions of liquid medicine and capsule shell, in which the liquid medicine is formed from bilobalide, vegetable oil and bee wax, and the capsule shell is made up by using gelatin, water, glycerin and antiseptic nipagin. Said invention also discloses its preparation method, said product possesses good stability, and can obtain good therapeutic effect for curing apoplexy and coronary heart disease.
Owner:张平
Medicinal composition containing bilobalide B and its preparation process and usage
The invention discloses a medicinal composition containing bilobalide B, which comprises Ligustrazine phosphate and bilobalide B by the weight ratio of 10-500 : 1. the invention also discloses the process for preparing the pharmaceutical composition.
Owner:弘和制药有限公司
Synthesis for weak hydrophobic framework amide resin and application of the same in purifying gingko total lactone
InactiveCN101100495AGood use strengthGood synergyGinkgophyta medical ingredientsLactone synthesisFlavones
Synthesis of amide adsorptive resin with weak hydrophobic skeleton is carried out by co-polymerizing methyl acrylate with vinyl benzene to obtain ester-based resin, aminolyzing for ester base, acidylating to obtain amide adsorptive resin with weak hydrophobic skeleton, adsorbing flavone compound from Ginkgo extract onto resin by the resin and hydrogen bond synergistic function, flowing ginkgo-lactone, re-crystallizing and eluting to obtain final product. The purity is above 90%, it's simple and non-toxic, it has friendly environment and can be used to supply experimental samples for development of ginkgo lactone.
Owner:NANKAI UNIV
Medicinal composition with synergetic function
ActiveCN1714832APrevent relapseHigh incidenceNervous disorderMetabolism disorderVascular diseaseMedicine
The present invention relates to a kind of medicine composition, and its preparation process and application. The said medicine composition contains mainly bilobalide and paeoniflorin. The medicine composition of the present invention may be used in treating and preventing diabetes, senile dementia and cardiac and cerebral vascular diseases and in preventing recurrence of cardiac and cerebral vascular diseases.
Owner:YUNNAN BIOVALLEY PHARMA CO LTD
Bilobalide K derivative and preparation method and application thereof
ActiveCN104892628AGood water solubilityHigh activityOrganic active ingredientsNervous disorderSolubilityDisease
The invention discloses a bilobalide K derivative and a preparation method and application thereof according to the formula I. Since structural modification is performed on bilobalide K, the bilobalide K derivative with higher water solubility and higher activity can be obtained and applied to prevention and treatment of cardiovascular and cerebrovascular diseases. Meanwhile, the bilobalide K derivative preparation process is facilitated and is adaptive to industrial production. (img file = 'DDA0000748217710000011.TIF' wi = '595' he = '515' / ).
Owner:CHENGDU BAIYU PHARMA CO LTD
Preparation and applications of biologically camouflaged targeting nano drug delivering system for treating ischemic cerebral stroke
ActiveCN108815134AGood water solubilityInhibit aggregationOrganic active ingredientsAntipyreticBilobalidesTarget peptide
The invention relates to preparation and applications of a biologically camouflaged targeting nano drug delivering system for treating ischemic cerebral stroke. The nano drug delivering system is compose of a drug, an inner core drug carrier, a biologically camouflaging shell, and a target finding material, wherein the drug is bilobalide B, the inner core drug carrier is recombinant high density lipoprotein, a drug is physically embedded into the drug carrier to form a drug loaded inner core; the biologically camouflaging shell is a blood platelet membrane, the drug loaded inner core is embedded in the blood platelet membrane in a co-extrusion mode to form a biomimetic drug loaded nano particle; the target finding material is a cerebral ischemia targeting peptide (CITP), and the CITP is used to modify the surface of the biomimetic drug loaded nano particle to form the biologically camouflaged targeting nano drug delivering system. Recombinant high density lipoprotein is used to wrap bilobalide B to form the drug loaded inner core, a blood platelet membrane and a blood platelet with a CITP modified surface are taken as the biomimetic shells to construct a nano particle for treatingischemic cerebral stroke, the circulation time of the nano particle in human body is prolonged, and the nano particle has a good targeting performance.
Owner:CHINA PHARM UNIV
Application of tremella fuciformis thalli in preparation of ginkgolide B
The invention discloses application of tremella fuciformis thalli in preparation of ginkgolide B. According to the application, a method for preparing ginkgolide B comprises the following steps: carrying out amplification culture on tremella fuciformis strains, taking thalli which are obtained through a test tube slant, a liquid shake flask, seed culture and thallus separation as a catalyst, converting ginkgolide into ginkgolide B, and enabling a conversion solution to be subjected to centrifugation, ethyl acetate extraction and anhydrous alcohol crystallization, so as to separate ginkgolide B from fermentation liquor. By using the method, the purity of obtained ginkgolide B is not lower than 99%, and the ginkgolide conversion ratio is higher than 90%.
Owner:BEIJING LYUKE TIANCHENG BIO TECH
Method for extracting shikimic acid and quinic acid from ginkgo leaves
ActiveCN111233658AIncrease production capacityAchieve regenerationBulk chemical productionCarboxylic compound separation/purificationBiotechnologyQuinamic acid
The invention belongs to the field of organic acid extraction and separation, and relates to a method for extracting shikimic acid and quinic acid from ginkgo leaves. The problems of long consumed time, large wastewater treatment capacity, environmental pollution, complicated operation and the like in the existing method are solved; the chemical properties of each component in the ginkgo leaves are compared; a carbon dioxide supercritical extraction-extraction-membrane filtration-electrodialysis-crystallization method is combined for use; on the premise of commercial value, various active ingredients, including chlorophyll, ginkgetin, bilobalide, gingko polysaccharide and the like, in the ginkgo leaves are developed to the maximum extent, and finally, shikimic acid and quinic acid productsare obtained through separation, and the content of the shikimic acid and the content of the quinic acid are respectively greater than 98%.
Owner:SHAANXI JIAHE PHYTOCHEM
Traditional Chinese medicine composition treating diabetic nephropathy and preparing method thereof
InactiveCN104983759AGood curative effectImprove efficiencyOrganic active ingredientsMetabolism disorderGinsenoside RdGlucoside
The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition treating diabetic nephropathy and a preparing method thereof. The traditional Chinese medicine composition comprises total flavones of moringa oleifera leaf, stibene glucoside, ginsenoside Rb 1, ginsenoside Rg1, ginsenoside Rd, ginsenoside Re, bilobalide, kaempferol and quercetin. The medicine components are reasonable, the synergism effect is high, the traditional Chinese medicine composition serves as the medicine compatibility for treating the diabetic nephropathy, and the clinic verifies that very obvious effects are achieved.
Owner:QINGDAO LANSHENGYANG PHARMA & BIOTECH CO LTD
New application of human urine kininogenase and medicine composition comprising same
ActiveCN104940914ADelay disease progressionRestore memoryNervous disorderPeptide/protein ingredientsDiseasePentoxyfylline
The invention belongs to the field of medicine, and particularly relates to a new application of human urine kininogenase and a medicine composition comprising the human urine kininogenase. The human urine kininogenase is applied to prepare medicine for treating the Alzheimer's disease. The invention further provides the medicine composition for treating the Alzheimer's disease. The medicine composition comprises the human urine kininogenase and bilobalide, and further comprises pentoxifyline. The medicine composition can remarkably recover the memory capacity of a patient suffering with the Alzheimer's disease, improve the cognition capacity of the patient suffering with the Alzheimer's disease, delay the disease progress of the Alzheimer's disease, greatly improve the life quality of the patient suffering with the Alzheimer's disease, improve the treatment compliance of the Alzheimer's disease, improve the treatment effect, provide the effective treatment medicine for the patient suffering with the Alzheimer's disease, and greatly relieve pain of the patient of the Alzheimer's disease.
Owner:GUANGDONG TECHPOOL BIO-PHARMA CO LTD
Application of plant NIA1 gene in increasing content of flavone and content of lactone of ginkgoes
The invention discloses application of a plant NIA1 gene in increasing the content of flavone and the content of lactone of ginkgoes. The NIA1 gene of arabidopsis is transferred into gingko cells and stably expressed through an agrobacterium tumefaciens mediated transformation method, after culturing is carried out for 35 days, the total flavone content and total lactone content in NIA1-modified gingko cells are increased by 103.5% and 78.4% respectively compared with those in non-genetically-modified gingko cells, and thus significant application meaning is achieved on simultaneously increasing the content of flavone and the content of lactone in gingkoes.
Owner:HANGZHOU NORMAL UNIVERSITY
Pharmaceutical composition and preparation thereof for treating stroke and sequelae thereof
ActiveCN104415044AIncrease contentImprove quality controlOrganic active ingredientsNervous disorderDiseaseHead injury sequelae
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation process for a pharmaceutical composition and the injection thereof for treating stroke and sequelae thereof. The pharmaceutical composition contains 10-100 parts of bilobalide B and 100-1000 parts of gastrodin. The invention overcomes shortages in the prior art, and provides a preparation method for a traditional Chinese medicine injection formed by combining bilobalide B with gastrodin, and a treatment medicine for cerebrovascular diseases of stroke, stroke sequelae, vascular dementia, dizziness, migraine and the like.
Owner:陈震
Production process of gingko oral solution
The invention relates to a production process of a ginkgo flavone and lactone oral solution and belongs to the processing of health-care products. The invention aims to develop a production process of a ginkgo leaf beverage containing ginkgo lactone and polysaccharide, which is safe and efficient, is scientific and concise and can produce in a large scale. The original taste and flavor of ginkgos can be effectively kept after harmful substances of a ginkgolic acid in ginkgo leaves are removed and the original taste and flavor of the ginkgos are kept; and the healthy beverage is enriched with beneficial components including natural ginkgo lactone, flavone and the like. The production process disclosed by the invention takes the natural and high-quality ginkgo leaves as main raw materials to prepare the ginkgo oral solution through steps of: preparing a ginkgo leaf raw solution, disacidifying the ginkgo leaf raw solution, adjusting flavor and filing, and adding Vc, potassium sorbate and the like. After being taken, the ginkgo flavone and lactone oral solution is beneficial for improving the health of blood capillary circulation of a human body and improving the immunity.
Owner:镇江市丹徒区南山溪园茶叶专业合作社
Method for preparing dimethylamino ethyl bilobalide B by using micro reaction device
The invention discloses a method for preparing dimethylamino ethyl bilobalide B by using a micro reaction device. The method comprises the following steps: simultaneously and respectively pumping an organic solvent solution of dimethylamino ethyl chloride hydrochloride and a solution of metallic iodide into a micro mixer, sufficiently mixing, simultaneously and respectively a discharged material and an organic solvent solution of bilobalide B into a fixed bed microwave micro mixer, and enabling the components to react sufficiently, thereby obtaining a product. Compared with the prior art, the method is simple and efficient in process, and moreover continuous production can be achieved. Meanwhile, a product prepared by using the method is stable in quality and relatively high in conversion rate.
Owner:NANJING UNIV OF TECH
Application of bilobalide composition in preparation of medicine for preventing/treating glaucoma
InactiveCN104352538AEasy to prepareSuitable for industrial productionSenses disorderGinkgophyta medical ingredientsDiseaseIntraocular pressure
The invention discloses an application of a bilobalide composition to preparation of a medicine for preventing / treating glaucoma. The bilobalide composition consists of total lactone of ginkgo and medicinal auxiliary materials, wherein the total lactone of ginkgo is used as an active component of the bilobalide composition. The total lactone of ginkgo mainly comprises bilobalide A, bilobalide B, bilobalide C and bilobalide, and HPLC-ELSD detection shows that the content of the total lactone is 80.0% to 99.9%. The bilobalide composition disclosed by the invention is subjected to curative effect detection and safety detection and the results show that the bilobalide composition has the effects of reducing intraocular pressure, expanding blood vessels, increasing blood flow volume, improving blood supply of optic nerves and the like, can be used for preparing the medicine for preventing / treating glaucoma diseases, provides a new traditional Chinese medicine for treating the glaucoma diseases in clinical application and has relatively large clinical application value and relatively good social benefits.
Owner:SHANGHAI SINE PROMOD PHARMA
Gingko drink
The invention discloses a gingko drink which is characterized by being prepared by using a ginkgo biloba leaf extract (GBE) as a raw material and matching with a cosolvent, honey, a sweetener, agal-agal, sodium alga acid, potassium sorbate, spice and the like. The invention has the advantages that the drink prepared from the ginkgo biloba leaf extract contains abundant ginkgo flavonglycosides, a ginkgolide compound, multiple amino acids necessary for a human body, beneficial trace elements and the like, and has a higher officinal value and a health care function. The drink has the efficacy of clearing heat and detoxicating, tonifying qi and kidney, nourishing lung and relieving asthma, improving blood circulation, softening blood vessels, eliminating in vivo radicals, moisturizing skin, resisting ageing and prolonging life after being taken for a long time by people.
Owner:褚丹秋
Drug for preventing and treating cerebral apoplexy and preparation method of drug
InactiveCN109464450AAnticoagulantAnti-oxidative stressOrganic active ingredientsBlood disorderTreatment effectAntioxidative stress
The invention relates to a drug for preventing and treating cerebral apoplexy and a preparation method of the drug. The drug for preventing and treating cerebral apoplexy contains osmanthus phenylethanoid glycosides and a pharmaceutically acceptable carrier. The pharmacological study indicates that osmanthus phenylethanoid glycosides have anticoagulant and oxidative stress resistant effects, neurological function damage of cerebral arterial thrombosis can be effectively prevented and treated, and the drug can be applied to prevention and treatment of cerebral apoplexy, especially cerebral arterial thrombosis. When osmanthus phenylethanoid glycosides are combined with other active ingredients such as rutin, troxerutin, heparin and bilobalide, especially troxerutin, the treatment effect is better.
Owner:佳木斯大学附属第一医院
Bilobalide bi-layer osmotic pump control tablet and preparation method thereof
InactiveCN103599099ASmall toxicityAvoid peaks and valleys in blood concentrationOrganic active ingredientsNervous disorderBULK ACTIVE INGREDIENTDrug administration
The invention belongs to the field of medical technologies, and provides a bilobalide bi-layer osmotic pump controlled tablet and a preparation method thereof. An osmotic pump is composed of a drug-containing layer, a boosting layer and a coating film, wherein the drug-containing layer is composed of the following components in percentage by weight: 10-50% of bilobalide, 30-80% of a suspension agent, 0-20% of osmotic-pressure active substances, and the balance of other accessories; the boosting layer is composed of the following components in percentage by weight: 50-82% of a swelling agent, 13-45% of osmotic-pressure active substances, and 0.5-5% of a lubricant; and the semipermeable coating film comprises 10-20 g of semipermeable polymer materials and 2-5 g of a water-soluble pore-foaming agent in every 100 tablets. The active ingredient bilobalide mainly comprises bilobalide A and bilobalide B, and the total amount of the bilobalide A and the bilobalide B is not less than 90%; and the bilobalide bi-layer osmotic pump control tablet can realize the synchronous constant-speed release of the compositions in preparations, so that the stability of plasma concentration can be maintained, the toxic and side effects of drugs can be lowered, the number of times of drug administration can be reduced, and the compliance of patients can be improved.
Owner:SHENYANG PHARMA UNIVERSITY
Production process of gingko leaf capsule
The invention relates to a production process of a gingko leaf capsule and belongs to the processing of health-care products. The invention aims to develop a production process of a ginkgo leaf capsule enriched with ginkgo lactone and polysaccharide, which is safe and efficient, is scientific and concise and can produce in a large scale. Ginkgolic acid harmful to a human body is removed and the original taste and flavor of ginkgos can be effectively kept; the capsule which is enriched with beneficial components including natural ginkgo lactone, flavone and the like can be produced; and after being taken, the gingko leaf capsule is beneficial for improving the health of blood capillary circulation of a human body and improving the immunity.
Owner:镇江市丹徒区南山溪园茶叶专业合作社
Pharmaceutical composition for treating dementia and preparation method thereof
ActiveCN104042607BEquivalentAcute toxicity equivalentOrganic active ingredientsNervous disorderDevergie's diseaseMemory impairment
The invention provides a pharmaceutical composition for treating dementia and a preparation method thereof. The pharmaceutical composition comprises a combination of bilobalide and any one or both of ginkgolides A and C. The pharmaceutical composition containing bilobalide provided by the present invention has multiple neuroprotective effects, including promoting nerve growth, improving old memory function, preventing the occurrence of senile dementia, and the like. Experiments have shown that in the treatment of dementia, this product has a certain effect on improving memory impairment in mice.
Owner:HEILONGJIANG ZBD PHARMA
Method of extracting ginkgolide from gingko leaves
InactiveCN109020993ASimple processThe process takes a short timeOrganic chemistryAcetic acidEthyl ester
The invention relates to a method of extracting ginkgolide from gingko leaves, which includes steps of: drying and crushing the gingko leaves, extracting the gingko leaves with ethanol, recycling theethanol through pressure reduced concentration, extracting the gingko leaves with ethyl acetate and recycling the ethyl acetate, water-washing the extract, extracting the gingko leaves with petroleumether and recycling the petroleum ether to obtain a ginkgolide crude product. The method is simple in process, is short in time and low in cost, is high in yield and purity of the ginkgolide. The yield of the ginkgolide crude product is 0.25-1%, and purity of the same is 26-37%.
Owner:HUBEI ENG UNIV
Blood pressure-lowering health soybean milk and preparing method thereof
InactiveCN104814158AEasy to prepareEasy to operateCardiovascular disorderMilk substitutesPEARBlood pressure kit
The invention discloses blood pressure-lowering health soybean milk and a preparing method thereof. The health soybean milk comprises the following raw materials in parts by weight: 60-70 parts of red beans, 45-50 parts of sticky rice, 30-40 parts of natto, 35-40 parts of lotus root starch, 15-20 parts of cauliflowers, 15-20 parts of tomatoes, 5-6 parts of honey dew melons, 9-10 parts of hericium erinaceus, 2-4 parts of jade butterfly seeds, 4-6 parts of gynostemma pentaphylla, 1-2 parts of ligustrum dela-vayanum hariot, 2-4 parts of felwort, 0.5-1.0 part of evening primrose, 8-10 parts of mashed jujube flesh, 2-4 parts of prickly pear, 3-4 parts of bilobalide, 1-2 parts of trans-fatty acids, 12-16 parts of dark plum juice, 30-35 parts of honey and a proper amount of water. The health soybean milk disclosed by the invention is simple in preparing method, convenient to operate, clear, transparent, fragrant and tasty and has the effects of refreshing and quenching thirst, and the added heath Chinese herbal medicines can be used for achieving the effects of cooling blood, lowering blood pressure, clearing heat, removing heat from liver and the like and are suitable for patients suffering from vascular hypertension to be used for lowering the blood pressure.
Owner:合肥寿保农副产品有限公司
Application of Tremella Fungus in Preparation of Ginkgolide b
The invention discloses application of tremella fuciformis thalli in preparation of ginkgolide B. According to the application, a method for preparing ginkgolide B comprises the following steps: carrying out amplification culture on tremella fuciformis strains, taking thalli which are obtained through a test tube slant, a liquid shake flask, seed culture and thallus separation as a catalyst, converting ginkgolide into ginkgolide B, and enabling a conversion solution to be subjected to centrifugation, ethyl acetate extraction and anhydrous alcohol crystallization, so as to separate ginkgolide B from fermentation liquor. By using the method, the purity of obtained ginkgolide B is not lower than 99%, and the ginkgolide conversion ratio is higher than 90%.
Owner:BEIJING LYUKE TIANCHENG BIO TECH
Traditional Chinese medicinal composition for treating chronic obstructive pulmonary diseases
ActiveCN108096242AImprove breathing rateHas the effect of treating chronic obstructive pulmonary diseaseOrganic active ingredientsRespiratory disorderMedicineObstructive Pulmonary Diseases
The invention provides applications of a bilobalide composition in preparing medicines for preventing / treating chronic obstructive pulmonary diseases. The experiment proves that the bilobalide composition has the efficacies of improving the respiratory rate and pulmonary function of a model rat, reducing the expression of IFN-gamma and IL-6 of a model group rat, increasing the expression of IL-10of the model rat, increasing the number of pulmonary alveoli, reducing the content of collagen, and alleviating the airway remodeling in a dose-dependent manner, so that the effect of treating the chronic obstructive pulmonary diseases is achieved. Therefore, the bilobalide composition has the effect and application value of being prepared into medicines for preventing / treating the chronic obstructive pulmonary diseases.
Owner:JIANGSU KANION PHARMA CO LTD
Medicinal composition containing bilobalide B and vitamin K antagonist as well as preparation method and application of medicinal composition
ActiveCN105456256APromote anti-platelet aggregation functionPromote aggregationBlood disorderHeterocyclic compound active ingredientsMechanism of actionCurative effect
The invention provides a medicinal composition containing bilobalide B. The medicinal composition contains bilobalide B and a vitamin K antagonist. The invention further provides a preparation method and an application of the medicinal composition. The experiment proves that bilobalide B can obviously promote the anti-platelet aggregation function of warfarin, also can eliminate / reduce the natural drug resistance of a patient generated due to only use of warfarin, and enhance the affinity between the liver receptor of a patient and warfarin, and bilobalide B and warfarin have the synergistic interaction. The medicinal composition is novel in formula, simple in components, definite in action mechanism and obvious in curative effect, tolerance is difficultly generated, and industrial production can be realized.
Owner:CHENGDU BAIYU PHARMA CO LTD
Extraction and separation method of ginkgo active components and application of extracted active substances in drugs for treating cardiovascular and cerebrovascular diseases
ActiveCN102416027BAchieve separationGinkgophyta medical ingredientsCardiovascular disorderAdditive ingredientActive matter
Owner:XUZHOU MEDICAL COLLEGE
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com