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301 results about "Dependent manner" patented technology

Glare Management of Reflective and Thermoreflective Surfaces

The reflectivity and transmissivity of building and vehicle surfaces is maintained while employing partial, variable, selective, or asymmetric diffusers between a surface and an external light source such that the reflected light is diffused to produce a reduction in glare, while minimally effecting the specular or collimated transmission (if any) of light through the surface. Glare is also reduced by utilizing diffuser devices that reflect light in a temperature dependent manner.
Owner:RAVENBRICK

Continuous directed evolution of proteins and nucleic acids

The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from cell to cell in a desired function-dependent manner. The linkage of the desired function and passage of the nucleic acid from cell to cell allows for continuous selection and mutation of the nucleic acid.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Modified nucleotide sequence encoding glucagon-like peptide-1 (glp-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (glp-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof

An isolated chimeric GLP-1 nucleic acid sequence encoding a human pro-insulin leader, a glucagon-like peptide-1 (GLP-1), and a furin cleavable site between the human pro-insulin leader sequence and the GLP-1 is provided. Also provided is an isolated modified chimeric GLP-1 nucleic acid sequence encoding a human pro-insulin leader, a glucagon-like peptide-1 (GLP-1), and a furin cleavable site between the human pro-insulin leader sequence and the GLP-1. Recombinant expression vectors comprising the chimeric GLP-1 nucleic acid sequences, which produce GLP-1 constitutively are provided, as are human cells transfected with such an expression vector in combination with an expression vector comprising a proinsulin nucleic acid sequence and an expression vector comprising a furin and a glucose-regulatable TGF-alpha promoter. Methods of producing human GLP-1 constitutively are provided as are method of producing GLP-1 and insulin or in a glucose-dependent manner using such transfected cells. Methods of treating a subject having Type II diabetes and methods of treating a subject prone to hyperglycemia or suffering from hyperglycemia are provided in which transfected cells produce human GLP-1 and insulin in a glucose-dependent manner. Also provided are methods of reducing weight in a subject by implanting into the subject transfected cells which produce human GLP-1 and insulin in a glucose-dependent manner.
Owner:BOEHRINGER INGELHEIM INT GMBH

System and method for providing multicharge ignition

A system and method of providing multicharge ignition are provided. The method and system preferably are adapted to trigger at least some of the multicharge events of the system and method in a current-dependent manner. Preferably, existing power train control units (PTCUs) can be used with the system and method, without the need for signals other than the timing signal (e.g., EST pulse) from the PTCU. The method comprises the steps of charging an inductive energy storage device by flowing electrical current through a primary side of the inductive energy storage device until a predetermined amount of energy is stored therein, discharging a portion of the predetermined amount of energy through a secondary side of the inductive energy storage device by opening a path of the electrical current through the primary side upon achieving the predetermined amount of energy in the inductive energy storage device, and repetitively closing and reopening the path to recharge and partially discharge, respectively, the inductive energy storage device, wherein reopening of the path is triggered based on the amount of energy stored in the inductive energy storage device. The multicharge ignition system comprises an inductive energy storage device and electronic ignition circuitry. The inductive energy storage device has primary and secondary sides inductively coupled to one another. The electronic ignition circuitry is connected to the primary side and is adapted to implement the aforementioned method.
Owner:DELPHI TECH IP LTD

Beam former using phase difference enhancement

Noise discrimination in signals from a plurality of sensors is conducted by enhancing the phase difference in the signals such that off-axis pick-up is suppressed while on-axis pick-up is enhanced. Alternatively, attenuation / expansion are applied to the signals in a phase difference dependent manner, consistent with suppression of off-axis pick-up and on-axis enhancement. Nulls between sensitivity lobes are widened, effectively narrowing the sensitivity lobes and improving directionality and noise discrimination.
Owner:DOLBY LAB LICENSING CORP

1-phenylalcoxy-2-beta-phenylethyl derivatives as p-glycoprotein (p-gp) inhibitors useful in drug resistance events

The invention relates to a new class of compounds, which are 1-phenylalcoxy-2-β-phenylethyl derivatives, as P-glycoprotein (P-GP) inhibitors. These compounds are useful in drug resistance events. They have been shown able to inhibit in a dose-dependent manner Glycoprotein-P (P-gp) activity in cell lines in which the expression of said glycoprotein is very high, like Caco-2 (human colon cancer) cells and MCF7 / Adr (adriamycin-resistant human breast carcinoma) cells. The invention also relates to methods of production and the utilization of such compounds as medicaments useful in the treatment of states linked to the difficulty for some drugs to cross the blood-brain barrier (BBB) and generally within the context of the problems of drug resistance induced by chemotherapy agents.
Owner:UNIV DEGLI STUDI DI BARI 60 +1

Method and a system for communicating bandwidth information of a digital broadcast network

In an embodiment of the invention the Network Operator (NO) manages the available bandwidth of the digital broadcast network in time-dependent manner. The NO announces the available bandwidth to the datacast operator (DCO) via an interface for a certain period of time. The interface is a data connection intermediator between the NO and the DCO. A network of computing systems couples the NO with the DCO. Advantageously, the network of computing systems comprises Internet. The DCO, which makes use of the NO's bandwidth for distributing electronic media to end-users, reserves some bandwidth for a certain period of time in accordance with the need, which the DCO obtains from a Content Provider (CP). The content is broadcast to the end-user in accordance with a schedule which is based on the bandwidth availability. Thus, the content is multicast via the digital broadcast network which is maintained by the network operator (NO).
Owner:NOKIA CORP

Method and apparatus for ophthalmic devices including gradient-indexed liquid crystal layers and shaped dielectric layers

ActiveUS20150077699A1Alters a focal characteristic of the lensSpectales/gogglesOptical articlesRefractive indexEngineering
This invention discloses methods and apparatus for providing a variable optic insert into an ophthalmic lens. A liquid crystal layer may be used to provide a variable optic function and in some embodiments, an alignment layer for the liquid crystal layer may be patterned in a radially dependent manner. The patterning may allow for the index of refraction of the optic device to vary in a gradient indexed or GRIN manner. At least a first layer of dielectric material that may vary in thickness at least across the optic zone of the device may aid in defining an electric field across the liquid crystal layer. An energy source is capable of powering the variable optic insert included within the ophthalmic lens. In some embodiments, an ophthalmic lens is cast-molded from a silicone hydrogel. The various ophthalmic lens entities may include electroactive liquid crystal layers to electrically control optical characteristics.
Owner:JOHNSON & JOHNSON VISION CARE INC
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