40 results about "Pentoxyfylline" patented technology

Complex compounds or adducts of xanthine derivatives, for example propentofylline or pentoxyfylline, or phenazone derivatives, for example phenazone, propylphenazone and aminophenazone, and acesulfame-H, in which the components are present in a molar ratio of 1:1 or 1:2, have a pleasantly sweet taste and are suitable for numerous applications, for example in pharmaceuticals. The compounds can be prepared from the dissolved components by simple reaction.

The invention discloses a method for purifying a recovered pentoxifylline product, which can reduce the impurity content in the recovered pentoxifylline product, so that the maximum single impurity of the recovered product after being refined is reduced to less than 0.1%, and the total impurity is less than 0.5%, which satisfies The standard of finished pentoxifylline can improve the overall yield and reduce the reaction cost. The refining method comprises the following steps: (1) adding the pentoxifylline recovered product into water under heating conditions, dissolving, adding an alkaline liquid to adjust the pH value to 10-14, adding a reducing agent, keeping the temperature, and then cooling and filtering to obtain an alkaline solution; Wherein, in the pentoxifylline recovered product, mono-impurities < 5%, total impurities < 10%; (2) fully mixing the alkaline solution obtained in step (1) with organic solvent A, leaving it to stand for stratification, and steaming off the organic phase Then obtain a viscous liquid; (3) add organic solvent B to dissolve the above-mentioned viscous liquid, add activated carbon, filter the activated carbon after heat preservation, filter the material after the filtrate is reduced to below 20 DEG C, and dry to obtain pentoxifylline.

The invention belongs to the field of medicine, and in particular relates to an anti-scar silicone gel patch and a preparation method thereof. The anti-scar silicone gel patch includes a silicone gel patch and a plastic film; the silicone gel patch includes a silicone gel layer and a textile layer; by weight percentage, the silicone gel layer contains 10-14% Tamoxifen, 6‑10% pentoxifylline, and 75‑85% silicone polymer. Applying tamoxifen and pentoxifylline to silicone gel to make anti-scar silicone gel patch has obvious effect on reducing scar tissue formation. Compared with the lack of any one component, the combined use of the three can play a synergistic effect, can significantly inhibit the proliferation of skin scar cells, and effectively remove scar marks.

The invention provides a nano-carrier slow-release preparation for treating cardiovascular disease and a preparation method thereof, which is composed of pentoxifylline nano-carrier freeze-dried powder and pharmaceutical auxiliary materials. Described pentoxifylline nano-carrier lyophilized powder, the weight ratio of pentoxifylline and nano-carrier is 4~5:1; Described nano-carrier material is the composition of chitosan-deoxycholic acid-albumin, wherein The weight ratio of chitooligosaccharide, deoxycholic acid and albumin is 1:2-3:3.0-3.3; the weight ratio of the pentoxifylline and the pharmaceutical excipient is (4-7):1, the drug The excipients are composed of hydroxyethyl cellulose, micropowder silica gel and magnesium stearate, wherein the weight ratio of hydroxyethyl cellulose, micropowder silica gel and magnesium stearate is (5-6):(3-4):1. The dissolution rate of the sustained-release nanocarrier preparation for the treatment of cardiovascular provided by the present invention is stable, basically showing zero-order linear dissolution, avoiding sudden release, greatly ensuring the therapeutic effect of pentoxifylline, and significantly reducing adverse reactions; placed under accelerated conditions After 6 months, the content of degradation products is low and the quality is stable.

The invention relates to the technical field of pharmaceutical preparations, and specifically discloses a pentoxifylline injection and a preparation method thereof. The preparation method is as follows: adding the osmotic pressure regulator in the recipe amount to the water for injection with a total volume of 40-60%, stirring and dissolving, adjusting the pH to 6.5-7.5, then adding the pentoxifylline in the recipe amount, stirring and dissolving, Add water for injection to make up the total amount, adjust the pH to 6.5-7.5, filter through the multi-stage polyethersulfone filter element with decreasing pore size in turn, fill and sterilize to obtain pentoxifylline injection. Compared with the prior art, the present invention achieves the purpose of ensuring product quality stability without adding a stabilizer, and the prescription is simpler. It does not increase, the pH value is stable, the color of the solution is always a colorless and clear solution, and the production cost is also reduced, which is convenient for industrialized production and has high promotion value.

The invention relates to the field of analytical chemistry, in particular to a method for detecting related substances of 6-chloro-2-hexanone. The detection method is determined by gas chromatography, and the chromatographic conditions are as follows: the stationary liquid of the capillary chromatographic column: polyethylene glycol or modified polyethylene glycol; The temperature was raised to 220‑240 °C at a rate of 1 min and maintained for 5‑10 min. The detection method provided by the invention has good sensitivity, accuracy, precision, reproducibility, recovery rate and stability, and the detection result is accurate and reliable. The quality stability of the base and the safety of clinical medication are guaranteed.

The invention provides a muscular amino acids and nucleosides injection medicinal composition and discloses a preparation method of the medicinal composition. The medicinal composition is prepared from a muscular amino acids and nucleosides injection, pentoxifylline, fructose diphosphate sodium and polyethylene glycol. When the medicinal composition is applied in vitro, the liver homogenate breathing activity of a guinea pig can be increased, an activity stimulation index of breathing activity determined by using a Warburgs respirometer is about 4.2, which is far higher than the stimulation index of the liver homogenate breathing activity of the guinea pig during separate testing by using muscular amino acids and nucleosides, the pentoxifyllinum and the fructose diphosphate sodium, and thus, the treating effect on heart cerebrovascular disease is enhanced greatly.

The invention provides an in vitro fertilization liquid and a preparation method thereof, the in vitro fertilization liquid comprises basal fluid, human serum albumin, coenzyme Q10 and pentoxifylline, and the content of coenzyme Q10 in the in vitro fertilization liquid is 0.5- 2mg / L, the content of pentoxifylline in the in vitro fertilization fluid is 0.5-5g / L. The above in vitro fertilization fluid can provide a stable fertilization environment, reduce the damage of active oxygen to sperm and eggs, and can also improve sperm motility and fertilization rate.

The invention provides an artificial propagation technology for schizothorax grahami, and belongs to the technical field of freshwater fish propagation. The artificial propagation technology comprises the steps of parent fish domestication, parent fish selection, spawning induction, artificial insemination, roe incubation and fry breeding, and the spawning induction adopts pentoxifylline, caffeine and calcium dobesilate as spawning induction assistants; meanwhile a compound feed used in the artificial propagation technology is further provided, the compound feed contains resistant starch which is prepared in an acid environment and has a substitution degree of 0.18-0.21. The artificial propagation technology is stable and controllable in process, low in production cost, high in parent fish domestication success rate, small in production damage, high in fertilization rate and hatching rate, low in fry malformation rate and high in drug utilization rate; and the compound feed has the advantages of excellent swelling degree and slow release property, high digestion conversion rate and high biological effective utilization rate, and can improve the gonad maturation and reproductive capacity of parent fish, improve the quality of seminal fluid and egg granules and reduce the embryonic development malformation rate.

The invention discloses a vasoborpyrrole derivative bonded with a blood vessel blocking agent, which is formed by covalently bonding a near-infrared photosensitizer fenpyrrole and a blood vessel blocking agent 2,5-pentoxifylline. Simultaneously, the present invention also discloses a nano-diagnosis reagent obtained by self-assembly of the derivative and the electron-rich amphiphilic polymer methoxy-poly(ethylene glycol)-poly(2-diisopropylamino)methyl methacrylate And its application in type I photodynamic synergistic angioblocking therapy in tumor treatment. The structure of the target product of the present invention is clear, the synthesis process is simple, and the diagnostic and therapeutic reagent based on the target product has both type I photodynamic and pH-responsive vascular blocker release properties. Accurately reach the tumor site, block tumor blood vessels and kill tumor cells, effectively preventing tumor recurrence and metastasis.