94 results about "Aminophenazone" patented technology

Complex compounds or adducts of xanthine derivatives, for example propentofylline or pentoxyfylline, or phenazone derivatives, for example phenazone, propylphenazone and aminophenazone, and acesulfame-H, in which the components are present in a molar ratio of 1:1 or 1:2, have a pleasantly sweet taste and are suitable for numerous applications, for example in pharmaceuticals. The compounds can be prepared from the dissolved components by simple reaction.

The invention discloses a glassy carbon electrode (GCE) modified by aniline-co-aminophenol copolymer carbon nanotube composite, a preparation method thereof and a method for removing perchlorat from water. The preparation method of the glassy carbon electrode comprises the following steps: dispersing carbon nanotubes in DMF; taking a proper amount of mixed liquor to drip onto the clean surface of the glassy carbon electrode, and air drying; carrying out electrolytic polymerization on a three-electrode system consisting of a glassy carbon working electrode modifying the carbon nanotube, a platinum counter electrode and a calomel reference electrode in the mixed liquor of hydrochloric acid, aniline and o-aminophenol through a constant bit method; thus, generating aniline-co-aminophenol copolymer carbon nanotube composite on the surface of the carbon nanotube modified glassy carbon electrode after a certain time. The modified electrode is washed by diluted hydrochloric acid and secondary water successively, forms the three-electrode system with the platinum counter electrode and the calomel reference electrode, and is doped in the water body containing perchlorat. The perchlorat is doped on the glassy carbon electrode modified by the aniline-co-aminophenol copolymer carbon nanotube composite, which can be seen clearly in an X-ray photoelectron spectroscopy.

This invention describes the coding gene and applications of a nitrobenzene nitro-reducing enzyme, comprising a protein from the following amino acid residue sequences: 1) SEQ ID No. 1 in the sequence table; 2) the amino acid residue sequence in SEQ ID No. 1 is a protein substituted, deleted or added with 1-10 amino acid residues and having the nitrobenzene nitro-reducing enzyme function. The nitrobenzene nitro-reducing enzyme and its coding gene in this invention play an important role in the production of ortho-aminophenols and their derivatives.

Novel addition products of isocyanates with oxyalkylene-substituted aminophenol compounds as intermediates for the production of urethane-substituted xanthene colorants, particularly triphenylmethane derivatives such as rhodamines, are provided. The xanthene colorants exhibit improved wax and / or oil solubility and high purity. The urethane-substituted xanthene colorant features very good wax and / or oil solubility, and is believed to be relatively nontoxic. A method for producing this novel colorant is also provided.

The invention relates to a grinding aid as well as a production process and application thereof, and belongs to the technical field of cement additives. The grinding aid is prepared from the followingraw materials, by weight: 3-7 parts of triethanolamine, 1-9 parts of acetic acid, 1-5 parts of butyltriphenylphosphonium bromide, 85-105 parts of water, 2-8 parts of sodium dodecyl benzene sulfonate,3-7 parts of p-aminophenol, 3-9 parts of acid sophorolipid, 7-13 parts of sodium alginate, 1-7 parts of aminophenol, 6-14 parts of biosurfactant and 10-14 parts of hyperdispersant. The mixing amountof the grinding aid in the cement clinker grinding process is 0.03%-0.05%, and the grinding aid has the effect of improving the cement clinker grinding efficiency so as to reduce the energy consumption in the cement clinker grinding process.

The invention, which relates to the technical fields of nano material, catalysis and chemical sensing, provides a novel copper-doped-carbon-nano-dot-based method for enzyme-ratio-free fluorescence detection of the organophosphorus pesticide. With anhydrous copper chloride, tris(hydroxymethyl) aminomethane and L-dopa as raw materials, fluorescent copper-doped carbon nano-dots with high stability and peroxidase activity are synthesized by a one-step hydrothermal method. O-phenylenediamine oxidized by hydrogen peroxide is catalyzed based on peroxidase-like activity of the copper-doped carbon nano-dots and fluorescent oxidized molecule 2,3-diaminophenazine is genreated, so that two fluorescent emission peaks of the copper-doped carbon nano-dot and 2,3-diaminophenazine are generated at the lengthes of 375 nm and 555 nm; and the ratio of the fluorescence intensities at the two wavelengths is linearly related to the concentration of the organophosphorus pesticide, thereby realizing enzyme-ratio-free fluorescence detection of the organophosphorus pesticide. The sensor is constructed simply and easily; no biological enzyme is needed; the influences of the probe concentration and environmental factor are low; and the linear range is wide and the sensitivity is high.

The present invention relates to one p-nitrobenzene chloride ring opening enzyme gene and its expression product. The gene is from Comamonas testosteroni CNB1 CGMCC No. 1028 strain, has size of 1770 bp, and contains two ORF opening read frames in the same direction of 942 bp and 813 bp separately, separated by 15 bp, coding two different protein products beta-subunit and alpha-subunit. Two beta-subunits and two alpha-subunits constitute one active enzyme molecule. The enzyme can catalyze the ring opening cracking in the 1 and the 6 place of 2-amino phenol and the direct ring opening cracking of p-nitrobenzene chloride. Therefore, the gene may be used in constituting gene engineering bacterian and produce active enzyme for treating sewage containing p-nitrobenzene chloride and similar compound and in biological conversion engineering.

The invention relates to a chlortetracycline (CTC) molecularly imprinted (MIP) affinity membrane sensor and a preparation method thereof. The specific affinity membrane is formed based on an electropolymerization method, and CTC as a template molecule and o-aminophenol (OAP) as a functional monomer form a molecularly imprinted polymer membrane on the surface of a glassy carbon electrode by an electrochemistry method. CTC contains a phenolic hydroxyl group, an enol group and a dimethylamino group and the hydroxyl group in the OAP structure can be used as a latent coordination site so that OAP amino group, and phenolic hydroxyl group and enol group of CTC undergo intermolecular hydrogen bond interaction. OAP hydroxyl group and CTC dimethylamino group undergo a reaction so that multiple binding sites between OAP and CTC exist and the prepared molecularly imprinted polymer has very high CTC selectivity and bonding capability. The sensor can be used for on-site fast detection, does not need specimen pre-treatment, and has a low cost, simple processes and high sensitivity. The sensor has a detection linear range of 20-610nM and sensitivity of 15nM.

The invention discloses capillary electrophoresis electrochemical enzyme linked immunoassay for detecting amnesic shellfish toxicity, which belongs to the technical field of assay and detection. Solution of standard substances and shellfish samples with the amnesic shellfish toxicity are assayed by combining the capillary electrophoresis technology and electrochemical enzyme linked immunoassay technology. The capillary electrophoresis electrochemical enzyme linked immunoassay comprises the following steps of: reacting sample solution and an amnesic shellfish toxicity antibody marked by a horse radish peroxidase (HRP) in a noncompetitive mode; separating an amnesic shellfish toxicity-enzyme labeled antibody compound and the rest amnesic shellfish toxicity antibody marked by the HRP in the mixed solution by capillary electrophoresis; generating a 3-aminophenazine with electrochemical activities by using aminophenol which is the oxidogenic substrate of peroxide in the presence of a catalyst; and performing electrochemical detection. The method simplifies a sample treatment process and has high selectivity and high accuracy. The linear detection range of the solution of amnesic shellfish toxicity standard substances of the method is 0.5 to 50ng / mL and a detection limit of the method is 0.2ng / mL. The method is an ideal method for detecting the amnesic shellfish toxicity of shellfish samples.

The invention relates to the technical field of chemical isomer analysis and measurement, in particular to a functionalized mesoporous material modified electrode and a method for measuring three aminophenol isomers at the same time thereby. The method comprises the preparation of the functionalized mesoporous material modified electrode and the operation for measuring three aminophenol isomers at the same time by using the electrode. The functionalized mesoporous material modified electrode material is simple and convenient to synthesize and low in price, and the electrode is simple and convenient to prepare and easy to update and has the advantages of good repeatability, no toxicity and no pollution to the environment; and meanwhile, the measuring method effectively reduces the interference of concomitant substances and has the advantages of good selectivity and high sensitivity.

The invention discloses a preparation method and application of a perovskite quantum dot-molecular imprinted electrochemiluminescence sensor for detecting prometryn. The method is characterized by comprising the following steps: putting a pretreated glassy carbon electrode into a CsPbBr3 QDs solution with the concentration of 10.0 mg / mL, circularly scanning for 20 circles under the conditions that the scanning speed is 50mV / s and the potential range is 0-1.6 V, and carrying out electrodeposition to obtain CsPbBr3-QDs / GCE; putting the perovskite quantum dot into an ethyl acetate solution containing o-aminophenol and prometryn, carrying out cyclic scanning polymerization for 25 circles to obtain an MIP / CsPbBr3-QDs / GCE polymer membrane electrode, and soaking the electrode in a solution formed by mixing methanol and acetic acid according to a volume ratio of 7: 3 so as to obtain the perovskite quantum dot-molecular imprinted electrochemiluminescence sensor for detecting prometryn. The method has the advantages of strong specificity, high sensitivity and high accuracy.

The invention discloses a rosa roxburghii tratt beverage and a preparation method thereof, wherein the rosa roxburghii tratt beverage comprises a rosa roxburghii tratt juice, sulfur dioxide, citric acid, white granulated sugar, and water. The preparation method comprises: selecting fresh rosa roxburghii tratt fruit with a maturity of 80-90%, washing, placing into a breaker, breaking, pressurizing, and collecting a fruit juice; sealing the fruit juice into a pool, and standing for 7 days; adding gelatin and treating; filtering to obtain a rosa roxburghii tratt juice; and mixing the rosa roxburghii tratt juice, sulfur dioxide, citric acid, white granulated sugar and water according to a certain ratio, uniformly stirring, disinfecting, and packaging to obtain the rosa roxburghii tratt beverage. According to the present invention, the product has characteristics of clear and transparent color, sweet and sour taste and rich nutrition, and contains a large amount of carbohydrates, vitamins and trace elements necessary for the human body; the method has advantages of simple process and convenient large-scale production; and the experiment results show that the rosa roxburghii tratt provides protection effects for aminophenazone and nitrite-induced liver poisoning and liver cancers, provides prevention and treatment effects for lead poisoning, can be adopted as the auxiliary agent for prevention and treatment of lead poisoning, and has characteristics of good lead expelling better and no toxic-side effect.

The invention relates to a preparation method of fluorine-containing autocatalytic phthalonitrile resin. The method comprises the following steps: (1) adding fluorine-containing aminophenol, a basic catalyst, an organic solvent and 4-nitrophthalonitrile into a reactor, and reacting to obtain a fluorine-containing autocatalytic phthalonitrile monomer; and (2) putting the fluorine-containing self-catalyzed cyanophenyl monomer into an aluminum foil mold, and carrying out gradient temperature rise and curing to obtain the fluorine-containing phthalonitrile resin material. The synthesis period is short, the yield is high, the processing technology is simple, and the obtained resin can be widely applied to the fields of composite materials, aerospace, electronic packaging and the like.

The invention discloses a method for detecting acetaminophen and other chemicals in a herbal beverage. The method comprises the following steps: 1) preparing a herbal beverage sample solution; 2) preparing a series of control sample solutions; 3) making a standard curve; and 4) determining the herbal beverage sample solution. The detection method has the advantages of simplicity in operation, fastdetection speed, good precision and high sensitivity, meets high-throughput screening requirements, and fills in the gap in the detection of acetaminophen and other chemicals in the herbal beverage at present.

The invention discloses a method for detecting compound aminophenazone and barbital injection by means of high performance liquid chromatography. By virtue of the method, all effective components in the compound aminophenazone and barbital injection can be completely separated from impurity peaks, the content of each component in the injection can be determined correctly, the operation is simple and convenient without special flowing phase or chromatographic column, the equipment loss is small, the cost is low and a guarantee is provided for the injection drug safety.

The invention relates to the preparation and application of a nano-nickel / silver / copper (Ni / Ag / Cu) composite catalyst and belongs to the field of nano-catalyst preparation and catalytic research. The preparation comprises the following steps: preparing a hollow Ni / Ag / Cu composite nano-catalyst by using copper nitrate, silver nitrate and nickel nitrate as raw materials; performing reaction through the catalyst by using p-nitrophenol and absolute ethyl alcohol as the raw materials to raise the reaction temperature to 80-160 DEG C, maintaining the temperature, and reacting for 2-8h to obtain high-purity p-aminophenol. The hollow Ni / Ag / Cu composite nano-catalyst is in a spherical particle shape, is small in dosage and is high in catalytic activity and stability. A method for preparing the p-aminophenol through the nano-Ni / Ag / Cu composite catalyst is simple in process requirement and meets an industrialization requirement.

The invention belongs to the technical field of binders, and particularly relates to an environment-friendly anti-oxidation carton adhesive and a preparation method thereof. The adhesive comprises the following components: dry starch, p-aminophenol epoxy resin, hydrogen peroxide, borax, sodium dicyandiamide, dimethyl carbonate, phthalic anhydride polyester polyol, polyethylene terephthalate, triethanolamine and antioxidant. The anti-oxidant is a compound of hindered phenol, phosphite ester, and a metal ion chelating agent. The adhesive not only has high bonding strength, but also has the effects of non-discoloring, mildewing and the like when used for a long time.

The invention discloses an orange fluorescent carbon dot and application thereof in detection of peroxynitrite ions. The carbon dot (CDs) is prepared from rhodamine B and p-aminophenol as raw materials through a one-step hydrothermal synthesis method; the carbon dot is a zero-dimensional carbon nanomaterial and can emit bright orange fluorescence. The preparation method is simple and convenient, and the prepared carbon dots are good in water solubility and stable in fluorescence property. The peroxynitrite ions can be rapidly and sensitively detected by taking the carbon dots as a fluorescentprobe. When peroxynitrite ions exist, fluorescence of the carbon dots is effectively quenched by peroxynitrite. Meanwhile, the color of the CDs solution is changed into blue black from pink. Comparedwith a pure fluorescence analysis method, the analysis method for detecting the ONOO<-> has the advantages that a dual-mode output method has more advantages in practical application, and it is indicated that the analysis method has potential application prospects in discussion of the effect of the ONOO <-> in cytobiology.

This invention provides methods for the solution-phase synthesis of arylbenzoxazoles. The methods involve condensation of aminophenols with benzaldehydes to form a Schiff base. The Schiff base is then induced to undergo oxidative cyclization in the presence of DDQ. The resulting arylbenzoxazoles can be separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion exchange resin.

The invention provides a method for generating a 2-aminophenoloxazine-3-ketone compound by catalyzing oxidation of molecular oxygen in a water phase. According to the method, gallic acid is used as acatalyst, metal salts are used as a co-catalyst, and an o-aminophenol compound carries out reactions in a water phase in an oxygen or air environment in the presence of an alkali to generate the 2-aminophenoloxazine-3-ketone compound. The reaction is carried out in a water phase, and other organic solvents do not need to be added. The catalyst is simple, high in catalytic activity and high in reaction efficiency; and the method is simple in synthesis process, less in waste and environment-friendly, and has a wide industrial application prospect.

The invention relates to the technical field of the analysis and determination of a geometric isomer, in particular to a method for preparing a hexadecyl functionalized mesoporous silicone modified glass carbon electrode by utilizing a constant-current deposition method and also for simultaneously determining three geometric isomers of aminophenol. The electrode is simple to produce, the price of raw materials is low, the stability is good, no toxicity exits, and the environment is not polluted; moreover, by adopting the determination method, the interference of coexisting substances can be effectively reduced, the selectivity is good, and the sensitivity is high.

The invention discloses a method for preparing p-aminophenol from nitrobenzene, which mainly comprises the following steps: carrying out hydrogen reduction reaction in a CO2 / H2O system in a high-pressure reaction kettle at 100-150 DEG C for 4-7 hours by using Pt as a main active component and Mg, Cr and Ni as assistants under the conditions that the H2 pressure is 0.5-2 MPa and the CO2 pressure is 4-6 MPa; after the reaction is finished, filtering the catalyst out and drying the same for continuous use, wherein the selectivity of the p-aminophenol can reach 85% or above. According to the reaction, a CO2 / H2O system is used for replacing a traditional sulfuric acid system, the problems of sulfuric acid pollution to the environment and aftertreatment are solved, meanwhile, the problem of corrosion of sulfuric acid to equipment is avoided, the catalyst with the HZSM-5 molecular sieve as the carrier can adjust the acidity of the carrier, meanwhile, the defect that the acidity of the CO2 / H2O system is insufficient is overcome, and the stability of the catalyst is good.

The invention relates to an asymmetric squarylium cyanine colorimetric probe for identifying copper ions and application of the asymmetric squarylium cyanine colorimetric probe, and a preparation method of the asymmetric squarylium cyanine colorimetric probe comprises the following steps: synthesizing 3-ethyl-1, 1, 2-trimethyl-1H-benzo [e] indole from 1, 1, 2-trimethyl-1H-benzo [e] indole and iodoethane, synthesizing diethoxy squaric acid from squaric acid and ethanol, and synthesizing diethoxy squaric acid from 3-ethyl-1, 1, 2-trimethyl-1H-benzo [e] indole and 3-ethyl-1, 1, 2-trimethyl-1H-benzo [e] indole. The preparation method comprises the following steps: synthesizing 3-ethyl-1, 1, 2-trimethyl-1H-benzo [e] indole squaric acid hemicyanine from 3-ethyl-1, 1, 2-trimethyl-1H-benzo [e] indole, and synthesizing asymmetric double-square acid cyanine from the 3-ethyl-1, 1, 2-trimethyl-1H-benzo [e] indole squaric acid hemicyanine and 3-diethylaminophenol for selective recognition and detection of copper ions. The asymmetric squarylium cyanine chemical sensor has the beneficial effects that the asymmetric squarylium cyanine chemical sensor has the characteristics of good optical performance and high sensitivity. When the copper ions are detected and identified, the color of the solution is obviously changed, so that colorimetric detection is facilitated.

The invention discloses a detection method for relative substances in a compound aminophenazone and barbital injection. The method utilizes a high performance liquid chromatography to determine. The detection method disclosed by the invention can be used for completely separating the peaks of effective components and impurities of the compound aminophenazone and barbital injection at the same time. The invention provides an effective relative substance detection method. Meanwhile, the method can be used for effectively detecting impurities generated in products which are stored for long time or are degraded, has a wide applicable range and provides guarantees to medicine safety of the injection.

The invention discloses an indole ring substituted aminophenoxy zinc complex, a preparation method thereof and application of the indole ring substituted aminophenoxy zinc complex in catalyzing lactone ring-opening polymerization. The preparation method comprises the steps of directly reacting a neutral ligand with a metal raw material compound in an organic medium, filtering, concentrating, and recrystallizing to obtain the target compound. The indole ring substituted aminophenoxy zinc complex disclosed by the invention is an efficient lactone ring opening polymerization catalyst and can be used for catalyzing polymerization reaction of lactide and other lactones; and the method has a good effect on ring-opening polymerization of racemic lactide. The indole ring substituted aminophenoxy zinc complex has very obvious advantages that the raw materials are easy to obtain, the synthesis route is simple, the product yield is high, the catalytic activity and the three-dimensional adjustability are better, a high-impurity-specification and high-molecular-weight polyester material can be obtained under general conditions, and isotactic selectivity can be achieved by adding small organic molecules with an auxiliary coordination effect. The structural formula is shown in the description.

The invention relates to a paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablet and a preparation method thereof. The tablet is prepared from the following effective active ingredients: paracetamol, aminophenazone, caffeine and chlorphenamine maleate and also comprises common auxiliaries such as filler, lubricant, a disintegrating agent and an adhesive. According to the preparation method, the defects of sticking pinch, greasy pinch and the like caused by adhesive objects in the tabletting process by screening auxiliaries in the formula, and the prepared tablet is smooth and clean in appearance.

The invention relates to a preparation formula of a paracetamol oral solution which can be prepared into a frozen state for a patient to take. The preparation formula comprises 0.5-8.0% (g / L) of a main medicine paracetamol, 2.0-40.0% (g / L) of a high-hydrophilicity cyclodextrin derivative, 50.0-96.0% (g / L) of water, and 0-20.0% (g / L) of other auxiliary components. The oral solution prepared with the formula has a good taste. The oral solution can be taken as an oral solution, and can be frozen into a solid in a freezing environment of a domestic refrigerator, wherein the temperature can be set as 0 to -20 DEG C. Then the solid can be taken. Therefore, medication adaptability of patients, especially children, can be improved.

The invention discloses a tissue adhesive as well as a preparation method and application thereof. According to the tissue adhesive, when the tissue adhesive adheres to the surface of pigskin for lessthan 8h, the adhesion strength is smaller than or equal to 55kPa, and when the surface adhesion time is more than or equal to 8h, the adhesion strength I greater than 55kPa. Due to the fact that thetissue adhesive contains amino, phenolic hydroxyl and a natural cross-linking agent, the tissue adhesive can form non-covalent and covalent bonds with groups such as the amino and the sulfydryl on thesurface of tissue, and the tissue adhesive has high adhesion strength through the synergistic effect of multiple action bonds. The preparation method of the tissue adhesive is simple in process and low in raw material cost, and the tissue adhesive is a natural source material. The tissue adhesive has good biocompatibility, is high in adhesive strength under physiological conditions, is simple, convenient and safe to use, and has a good application prospect in tissue adhesion repair.

The invention discloses a benzothiazole ring substituted aminophenoxy zinc complex, a preparation method thereof, and an application of the benzothiazole ring substituted aminophenoxy zinc complex inhigh-activity and high-selectivity catalysis of lactone ring opening polymerization. The preparation method comprises the following steps: directly reacting a neutral ligand with a metal raw materialcompound in an organic medium, filtering, concentrating, and recrystallizing to obtain the target compound. The benzothiazole ring substituted aminophenoxy zinc complex disclosed by the invention is an efficient lactone ring opening polymerization catalyst and can be used for catalyzing a polymerization reaction of lactide and other lactones; and especially for racemic lactide, polylactide with high isotacticity can be obtained. The benzothiazole ring substituted aminophenoxy zinc complex has the very obvious following advantages: the raw materials are easy to obtain, the synthesis route is simple, the product yield is high, the catalytic activity and stereoselectivity are very high, a high-regularity and high-molecular-weight polyester material can be obtained, and the requirements of industrial departments can be met. The structural formula is shown in the specification.