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Paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablet and preparation method thereof

A technology of phenamine and coffee sensitivity and prescription, which is applied in the field of medicine, can solve the problems of dust explosion safety hazards, increase the dust concentration in production workshops, and is not suitable for industrial scale-up production, and achieve the effect of simple operation and less dust

Inactive Publication Date: 2015-01-28
DIAO GRP CHENGDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the tablet pressing after the fine powder is sieved can solve the problem of sticking and punching during the tablet pressing process, the fine powder sieving increases the dust concentration in the production workshop. First, it is not conducive to the health of personnel, and second, it has potential safety hazards of dust explosion. It is suitable for industrial scale-up production. The third is that two processes are added, which also increases production costs and potential quality risks, which is not conducive to industrial scale-up production.

Method used

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  • Paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The prescription composition of embodiment 1 phenacamine tablets and its preparation method

[0021] Acetaminophen 150g

[0022] Aminopyrine 100g

[0023] Caffeine 30g

[0024] Chlorpheniramine Maleate 2g

[0025] Micronized silica gel 45g

[0026] 20g pregelatinized starch

[0027] Carboxypropyl cellulose 10g

[0028] Sodium Carboxymethyl Cellulose 40g

[0029] Sucrose 10g

[0030] Hypromellose 6.25g

[0031] Magnesium Stearate 2g

[0032] Preparation method: grind aminopyrine and anhydrous caffeine respectively and pass through an 80-mesh sieve; add 125 g of purified water to hypromellose and sucrose, and prepare a mixed aqueous solution of 5% hypromellose and 8% sucrose; Acetaminophen 150g, caffeine 18g, chlorpheniramine maleate 1.2g, micropowder silica gel 18g, pregelatinized starch 20g, add 5% hypromellose, 8% sucrose mixed aqueous solution to make 16 mesh wet granules , dry the granules at 80°C; add 5% hypromellose, 8%...

Embodiment 2

[0033] Embodiment 2 The prescription composition of phenacamine tablet and its preparation method

[0034] Acetaminophen 150g

[0035] Aminopyrine 100g

[0036] Caffeine 30g

[0037] Chlorpheniramine Maleate 2g

[0038] Micronized silica gel 30g

[0039] 25g pregelatinized starch

[0040] Croscarmellose Sodium 30g

[0041] Sucrose 17g

[0042] Magnesium Stearate 2g

[0043]Preparation method: Grind aminopyrine and anhydrous caffeine respectively and pass through 80-mesh sieve; add sucrose to purified water to prepare 8% sucrose mixed aqueous solution, then take 150g of paracetamol, 18g of caffeine, and chlorobenzene maleate Namin 1.2g, micropowder silica gel 12g, pregelatinized starch 15g, 8% sucrose mixed aqueous solution to make 24 mesh wet granules, temperature 80 ℃, dry granules; aminopyrine 100g, caffeine 12g, chlorobenzene maleate Namin 0.8g, micropowder silica gel 12g, pregelatinized starch 10g, and 8% sucrose mixed aqueous solution ar...

Embodiment 3

[0044] Embodiment 3 The prescription composition of phenacamine tablet and its preparation method

[0045] Acetaminophen 150g

[0046] Aminopyrine 100g

[0047] Caffeine 30g

[0048] Chlorpheniramine Maleate 2g

[0049] Micronized silica gel 50g

[0050] Carboxypropyl cellulose 40g

[0051] Crospovidone 40g

[0052] Hypromellose 15g

[0053] Magnesium Stearate 2g

[0054] Preparation method: Grind aminopyrine, acetaminophen, and anhydrous caffeine respectively and pass through an 80-mesh sieve; add hypromellose and purified water to prepare a 5% hypromellose aqueous solution; take paracetamol Phenol 150g, caffeine 18g, chlorpheniramine maleate 1.2g, micropowder silica gel 20g, carboxypropyl cellulose 24g, add 5% hypromellose aqueous solution to make 48 mesh wet granules, temperature 80℃, dry granules ; Aminopyrine 100g, caffeine 12g, chlorpheniramine maleate 0.8g, micropowder silica gel 20g, carboxypropyl cellulose 16g, add 5% hypromellose ...

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Abstract

The invention relates to a paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablet and a preparation method thereof. The tablet is prepared from the following effective active ingredients: paracetamol, aminophenazone, caffeine and chlorphenamine maleate and also comprises common auxiliaries such as filler, lubricant, a disintegrating agent and an adhesive. According to the preparation method, the defects of sticking pinch, greasy pinch and the like caused by adhesive objects in the tabletting process by screening auxiliaries in the formula, and the prepared tablet is smooth and clean in appearance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a phenammonate tablet and a preparation method thereof. Background technique [0002] Phenamine Kamin Tablets, also known as Pu Sen Min and Ke Sen Min, is a commonly used anti-cold compound preparation, which consists of acetaminophen, aminopyrine, caffeine, chlorpheniramine maleate and appropriate amount of auxiliary materials. Experiments have found that during the preparation of phenacamine tablets by wet granulation, when the materials are mixed and added to the binder, the interaction between the materials will lead to difficulty in granulation, resulting in flakes and sticking problems. The reason is that paracetamol is an organic acid, and aminopyrine is an organic base. The two react in the presence of water to form a compound that is very soluble in water. Grains are difficult, resulting in flower flakes and sticky punching problems. "Orthogonal Method Op...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K47/04A61K9/20A61P11/00A61K31/4402A61K31/167A61K31/4152
CPCA61K31/522A61K9/2009A61K9/2054A61K9/2059A61K31/167A61K31/4152A61K31/4402A61K2300/00
Inventor 胡海波罗晓鸣
Owner DIAO GRP CHENGDU PHARMA
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