128results about How to "Conducive to industrial scale-up production" patented technology

The invention discloses a preparation method of nitrogen-containing phosphaphenanthrene derivative flame retardant. The preparation method includes the following steps that 1, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide is added to a reaction kettle, and heating is performed to reach a molten state; 2, triallylisocyanurate and a catalyst are added, full stirring reaction is performed to obtain a coarse product; 3, the coarse product is subjected to washing, filtering and drying to obtain DOPO-TAIC, namely the nitrogen-containing phosphaphenanthrene derivative flame retardant is obtained. The preparation method adopts a melting method to prepare the nitrogen-containing phosphaphenanthrene derivative flame retardant, a reaction principle of the method is consistent to a solvent method, the adopted DOPO is a raw material and is also a solvent in the reaction process, the complicated solvent removing process in the solvent method is omitted, the yields of the same volume of reaction kettles within unit time are greatly increased, the production cost is effectively reduced, harmful organic solvents are not needed, an operation method and production processes are simple, and the method is beneficial to industrialized enlarged production.

The invention discloses a preparation method of a palladium-carbon catalyst for synthesizing meropenem. The preparation method comprises the following steps: (1) putting wood charcoal into a boiling alkali compound water solution, carrying out backflow treatment, washing by virtue of pure water, and drying to obtain an active carbon carrier; (2) preparing an active ingredient solution, and regulating the pH value of the active ingredient solution; (3) pulping the active carbon carrier, and stabilizing the active carbon carrier at a stirring condition, so as to obtain active carbon slurry; (4) adding the active ingredient solution into the active carbon slurry after the pH value of the active ingredient solution is regulated, and stirring to obtain a catalyst precursor; and (5) aging the catalyst precursor, and reducing the catalyst precursor by virtue of a reducing agent, so as to obtain a catalyst finished product. According the preparation method, a low-content alkali compound is utilized for processing the carrier so as to obtain a proper carrier with a reasonable surface chemical structure, so that the consumption of a reagent is reduced; chelated palladium ions of a certain size are prepared by regulating the pH value of the active component solution, so that purposes of controlling the activity and selectivity of the catalyst are realized; the preparation method has no special control point, is simple in process and is beneficial to the industrial large scale production.

The invention provides a preparation method of 3-(methyl alkoxy phosphoryl) propionic acid ester compound (I). Methyl ferro phosphoric acid dialkyl ester (III) and acrylic acid (II) are taken as raw materials to react under anhydrous and anaerobic conditions at 0 DEG C to 30 DEG C; and the reaction process is shown as the formula, wherein, R1 in the formula is equal to R2 and is methyl or ethyl. The product yield of the method can reach 96% and the operation is simple with no generation of three wastes, thus being beneficial to industrial amplifying production.

The invention belongs to the biochemical industry field and discloses a Bacillus subtilis and an application thereof in biocatalytic production of L-lactic acid. The method in biocatalytic production of L-lactic acid by using the Bacillus subtilis (the preservation number is CGMCC No.3242) comprises the steps as follows: taking immobilized cells or flocculated cells of the Bacillus subtilis (the preservation number is CGMCC No.3242) as a biocatalyst, catalyzing substrate lactonitrile to obtain L-lactic acid, dehydrating the reaction solution in a falling film evaporator, distilling and dehydrating by a molecular still to obtain the L-lactic acid with the product purity of over 95% and the product yield of over 90%. The invention has the advantages of simple technique operation, mild reaction condition, high utilization degree of the substrate, low energy consumption, high product purity, safety and environment protection, and wide application potential.

The invention discloses a high-temperature-resistant methanation catalyst. The high-temperature-resistant methanation catalyst comprises an active component, a carrier and / or an assistant. Nickel serves as the active component, the carrier is mesoporous nickel aluminate spinel, and the assistant is one or more of oxides of alkaline earth metals magnesium, calcium, strontium and barium. The invention further discloses a preparation method of the high-temperature-resistant methanation catalyst. Soluble nickel salt and soluble salt of the assistant are dissolved in water to form impregnation liquid; the mesoporous nickel aluminate spinel carrier is added to the impregnation liquid for impregnation, then drying and calcination are conducted, and then the high-temperature-resistant methanation catalyst is obtained. The high-temperature-resistant methanation catalyst is used at high temperature, the anti-sintering capacity of active center nickel is high, and activity is stable. The production method is simple, and industrial enlarged production is promoted.

The invention discloses a preparation method of Tirzepatide, and belongs to the technical field of peptide synthesis. According to the method, amino resin is adopted as starting resin, a solid-phase polypeptide synthesis method is adopted for preparation, Tirzepatide peptide resin is obtained by a polypeptide solid-phase synthesis method, then Tirzepatide resin is subjected to acidolysis to obtaina Tirzepatide crude product, and finally, the Tirzepatide crude product is purified to obtain a Tirzepatide pure product. According to the method disclosed by the invention, special protective aminoacids, namely Boc-Tyr (tBu)-Aib-OH and Fmoc-Lys (AEEA-AEEA-gamma Glu (alpha-OtBu)-Eicosanedioicacid (mon-tBu))-OH, Fmoc-Tyr-Ser (pro-me-me)-OH and Fmoc-(Dmb)Gly-OH, are adopted. According to the method, the purity of the crude peptide is improved, the material cost and the purification cost are greatly reduced, and industrial large-scale production is facilitated.

The invention provides a method for rapid preparation of sodium hyaluronate from a sodium hyaluronate fermentation broth, and the method comprises the following steps: 1) heating the sodium hyaluronate fermentation broth to 100-121 DEG C, maintaining for 10 to 30 minutes, and then quickly performing plate-frame pressure filtration; 2) diluting the filtrate with purified water of 2-4 times, adding 1%-5% of activated carbon for adsorption for 1-5 hours, performing the plate-frame pressure filtration; 3) adsorbing the filtrate with resin for 1 to 2 hours, proportionally adding 0.4mol / L sodium chloride into the adsorption solution; 4) precipitating the sodium hyaluronate with 2-3 times of ethanol, washing, curing and drying to obtain powdery sodium hyaluronate. The method for extraction and preparation of the sodium hyaluronate has the advantages that: redissolving of a crude product is omitted in the whole extraction process, the extraction time is greatly reduced, and the obtained sodium hyaluronate is high in purity, low in protein content, simple in process, less in preparation time, and conducive to large-scale industrial production.

The invention discloses a method for synthesizing naphthoquinone sulfonyl chloride and belongs to the technical field of organic synthesis.The method includes the step that naphthoquinone sulfonyl chloride is synthesized by naphthoquinone sulfonic acid and di(trichloromethyl) carbonic ester in an inert solvent under the condition that organic base serves as a catalyst.Naphthoquinone sulfonic acid serves as a raw material, safe and environment-friendly di(trichloromethyl) carbonic ester serves as an acylating chlorination reagent, the organic base is used, naphthoquinone sulfonyl chloride is prepared at moderate temperature under simple and convenient operating conditions, industrial production of the compound is promoted, and the whole reaction process meets the requirements on safety and environment friendliness.The yield of the prepared naphthoquinone sulfonyl chloride product is larger than 80%, and the purity of the prepared naphthoquinone sulfonyl chloride product is larger than 95%.

The invention relates to a spherical heteroatom Ni-SAPO-34 molecular sieve, and a preparation method and an application thereof. The preparation method comprises the following synthesis steps: (1) dissolving nickel nitrate hexahydrate in deionized water, and dropwise adding a chelating agent at room temperature while stirring to obtain a Ni chelate solution A; (2) mixing an aluminum source, a phosphorous source, a silicon source, a template and deionized water, and heating and stirring the obtained mixture to obtain an initial sol B; (3) adding the solution A to the initial sol B, and heating and stirring the solution A and the initial sol B to obtain a sol C; and (4) filling a reaction kettle with the sol C, carrying out a crystallization reaction, filtering and washing a product obtained after the reaction is completed until the product is neutral, and drying, calcining and cooling the neutral product to obtain the spherical heteroatom Ni-SAPO-34 molecular sieve. The spherical heteroatom Ni-SAPO-34 molecular sieve with a high crystallinity is synthesized by a sol-hydrothermal synthesis technology, the pressure drop of an accumulated catalyst bed is effectively reduced, the introduction of metallic nickel provides many active sites for the reaction, and the molecular sieve has an important application in an NH3-SCR reaction. The synthesis method has the advantages of simple steps, and easiness in operation.

The invention discloses a (S)-pantoprazole sodium dihydrate the chemically general name of which is (S)-5-difluoromethoxy-2[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium dihydrate. The invention also discloses a preparation method of the (S)-pantoprazole sodium dihydrate. The preparation method comprises the step of cooperatively salifying and crystallizing at a proper temperature by using dichloromethane as a solvent and an alkaline compound of metal sodium as a salifying reagent, thereby obtaining the (S)-pantoprazole sodium dihydrate. The preparation method is simple to operate and mild in reaction condition; the prepared (S)-pantoprazole sodium dihydrate is good in appearance and color, high in purity and stable in quality when stored at room temperature; and industrial production scale can recur.