2424 results about "Formamides" patented technology

Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein.

The present invention provides one kind of 1, 2, 3-thiobiazole-5-formamide compounds and their synthesis process and pesticide bioactivity screening. The screening system includes the determination of tobacco mosaic disease resisting activity, tobacco mosaic disease virus resistance inducing activity, and pesticidal and fungus-inhibiting activity. The related compounds are 1, 2, 3-thiobiazole-5-formamide derivatives with the general expression as shown, and include 7 hetero cycle containing 1, 2, 3-thiobiazole-5-formamide derivatives, 2 benzene ring containing 1, 2, 3-thiobiazole-5-formamide derivatives, and 2 aliphatic radical containing 1, 2, 3-thiobiazole-5-formamide derivatives.

The present invention relates to crystalline solvate forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods for their preparation. The present invention further relates to pharmaceutical compositions comprising the crystalline solvate forms, as well as methods of treatment therewith.

A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxo-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.

The present invention relates to compounds of the formula I:wherein R1 to R8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and / or prophylaxis of diseases which are associated with the modulation of CB1 receptors, such as obesity.

The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.

The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.

The invention relates to high-efficiency heat-insulation environmentally-friendly flame-retardant modified polyolefin indoor heat-insulation foam and a preparation method thereof. The preparation method comprises the following steps of: kneading low-density polyethylene resin, a composite flame retardant, an anti-smoke agent, an antioxidant and a lubricant at normal temperature, then discharging to an internal mixer for internal mixing, then discharging to a single-screw extrusion granulator, and carrying out melting, plastication and granulation to obtain a master batch A; adding low-density polyethylene resin to a high-speed mixer, then adding azobisformamide, talc powder, a lubricant and zinc stearate, kneading at normal temperature, and then discharging to a single-screw extruder for granulating to obtain a master batch D; adding low-density polyethylene resin, ethylene-vinyl acetate copolymer, ethylene propylene terpolymer, the master batch A, a master batch B, hollow ceramic microbeads, a rheologic agent and a lubricant to a high-speed mixer, kneading at normal temperature for 3 minutes, then discharging to a single-screw extruder, and extruding into sheets; carrying out radiation cross-linking on the extruded sheets through an electronic accelerator; placing the cross-linked sheets in a foaming furnace for foaming; and coating expansible fireproof paint on the surface of the foam.

The present invention relates to a process of preparing a compound of the following formula III:wherein R1-R4 are as defined herein. The present invention also relates to the preparation of intermediates used to prepare the compound of formula III.

An electrophotographic photosensitive member including a support, and a charge generating layer and a charge transporting layer on the support, wherein the charge generating layer includes a gallium phthalocyanine crystal in which an organic compound is contained, wherein the organic compound is at least one compound selected from the group consisting of dimethylsulfoxide, N,N-dimethylformamide, N-methylformamide, N-propylformamide, N-vinylformamide and N-methylpyrrolidone, the content of the organic compound is 0.1% by mass or more and 1.5% or less based on a gallium phthalocyanine in the gallium phthalocyanine crystal, and the charge transporting layer includes a polyester resin having a structural unit represented by formula (1).A-B  (1).