The invention relates to an aircraft hardware-in-the-loop simulation device, belonging to the technical field of simulation. The aircraft hardware-in-the-loop simulation device comprises a flight training device, a control surface control mechanism, a flight scene system, an atmospheric data testing device, a three-degree-of-freedom electric turntable and an inertial navigation system, which are all integrated as a whole through network; the flight training device is provided with a server, a central console, a sidebar and a display mechanism; the control surface control mechanism is provided with an aircraft physical mode, an aileron, a rudder, an elevating rudder and a rudder loop control system; the flight scene system displays flight attitude, data or trajectory; the atmospheric data testing device comprises a computer, a direct current power supply module, a power supply control module, an adaptor module and a signal conditioning box module; the three-degree-of-freedom electric turntable comprises an inner frame, a middle frame, an outer frame as well as a turntable pedestal and a control system thereof; and the inertial navigation system is provided with a sensor assembly mounted on the three-degree-of-freedom electric turntable and a computer. The aircraft hardware-in-the-loop simulation device has the advantages of novel structure, compact assembly, good dynamic performance, high simulation degree and being visual and convenient, etc.