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New application of human urinary kallidinogenase and pharmaceutical composition with the human urinary kallidinogenase

A technology of urokininogenase and its composition, which is applied in the field of medicine, can solve the problems such as the insignificant therapeutic effect of the kidneys, and achieve a significant effect of lowering blood pressure, improving the therapeutic effect, and definite curative effect

Inactive Publication Date: 2015-09-16
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For the treatment of hypertensive nephropathy, although the effective lowering of blood pressure has a certain therapeutic effect on kidney damage, the therapeutic effect of simple antihypertensive drugs on the kidney is not obvious

Method used

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  • New application of human urinary kallidinogenase and pharmaceutical composition with the human urinary kallidinogenase
  • New application of human urinary kallidinogenase and pharmaceutical composition with the human urinary kallidinogenase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, Human urinary kininogenase injection

[0027] Take 2 mg of human urinary kininogenase that was sterilized by filtration, add an appropriate amount of water for injection to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add sodium chloride to adjust isotonicity, filter aseptically, and pack into 1000 ampoules In, that is.

Embodiment 2

[0028] Embodiment 2, Injection of human urinary kallikrein and betahistine hydrochloride pharmaceutical composition

[0029] Take 2 mg of human urinary kininogenase that was sterilized by filtration, add an appropriate amount of water for injection to dissolve, then add 0.2 mg of betahistine hydrochloride to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add mannitol to adjust isotonicity , sterile filtered, and packed in 1000 ampoules, that is.

Embodiment 3

[0030] Embodiment 3, Injection of human urinary kallikrein and betahistine hydrochloride pharmaceutical composition

[0031] Take 3 mg of human urinary kininogenase that was sterilized by filtration, add an appropriate amount of water for injection to dissolve, then add 1.8 mg of betahistine hydrochloride to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add glucose to adjust isotonicity, Sterile filtration, subpackage into 1000 ampoules, that is to say.

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Abstract

The invention belongs to the field of medicine, in particular to a new application of human urinary kallidinogenase and a pharmaceutical composition with the human urinary kallidinogenase. According to the new application of the human urinary kallidinogenase, the human urinary kallidinogenase is used for preparing medicine for treating hypertensive nephropathy, and the test discovers that the human urinary kallidinogenase is capable of lowering the arterial pressure of a rat with hypertensive nephropathy and improving the glomerular filtration rate and renal plasma flow of the rat with hypertensive nephropathy through regulating the micro-circulation of glomerulus, and has a certain treatment effect for renal damage. The pharmaceutical composition for treating the hypertensive nephropathy comprises the human urinary kallidinogenase and betahistine hydrochloride and further comprises pentoxifylline, the pharmaceutical composition has an obvious blood pressure reducing efficiency and has an obvious treatment effect for the damaged kidney, and the pharmaceutical composition for treating the hypertensive nephropathy is definite in effect, low in side effect and better for the recovery of a patient with hypertensive nephropathy.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of human urinary kallikrein and a pharmaceutical composition containing human urinary kallikrein. Background technique [0002] Human Urinary Kallidinogenase is a serine protease composed of 238 amino acids extracted from human urine. Its main function in the body is to hydrolyze kininogen into kinin, thereby exercising a series of Physiological function, it has the effects of dilating capillaries, relaxing vascular smooth muscle, improving microcirculation, increasing blood flow, anticoagulation, thrombolysis, reducing blood viscosity and lowering blood pressure, etc. It is a protease with high medicinal value. [0003] In recent years, with the in-depth research on human urokininogenase, more and more new uses of human urokininogenase have been found. For example, Chinese patent 101134106B discloses a pharmaceutical composition containing human urokininoge...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/08A61P13/12A61P9/12A61K31/4402A61K31/522A61K31/4525
Inventor 王旭郑少亮许文勤肖益热
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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