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112 results about "Renal damage" patented technology

Kidney damage is any sort of injury or impairment that affects the overall function of these organs. Also referred to as renal damage, an arterial blockage is just one potential cause of the condition, but you may also suffer harm to the kidney due to infections, medications, toxins, surgical procedures or even an autoimmune...

Methods and compositions for diagnosis and prognosis of renal injury and renal failure

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of metalloproteinase inhibitor 2, soluble oxidized low-density lipoprotein receptor 1, interleukin-2, von Willebrand factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor receptor superfamily member 11B, neutrophil elastase, interleukin-1 beta, heart-type fatty acid-binding protein, beta-2-glycoprotein 1, soluble CD40 ligand, coagulation factor VII, C—C motif chemokine 2, IgM, CA 19-9, IL-10, TNF-α, and myoglobin as diagnostic and prognostic biomarkers in renal injuries.
Owner:ASTUTE MEDICAL

Methods and Devices for Detecting Kidney Damage

Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
Owner:MYRIAD RBM INC

Building method of acute hyperuricemia renal damage mouse model

The invention discloses a building method of an acute hyperuricemia renal damage mouse model. The method comprises the following steps of experiment mice are subjected to molding experiment for many days by using xanthine, ethambutol and oteracil potassium as molding agents; obtaining the acute hyperuricemia renal damage mouse model; observing the body weight, the serum uric acid level and the renal function change of the experiment mice and the kidney pathological change; the renal damage effect of the molding agent on the experiment mice is analyzed. The mice are used as model animals; the serum uric acid level of the mice is equivalent to the uric acid level of a hyperuricemia patient; the serum uric acid level is stable and can easily reappear; meanwhile, the combined effect of uric acid precursors of hypoxanthine is used; the uric acid excreted substances of ethambutol and uricase inhibitors of oteracil potassium are reduced; the acute hyperuricemia renal damage mouse model is built; the molding time is short; the model conforms to the clinical characteristics of human body hyperuricemia renal damage, and is applicable to screening hyperuricemia renal damage resisting medicine.
Owner:WUHAN POLYTECHNIC UNIVERSITY

Reduction of renal damage in companion animals

The present invention is directed to a pet food and its use in reducing renal damage in companion animals. More particularly, the pet food maintains muscle mass in animals with renal conditions or animals at risk for developing a renal condition.
Owner:MARS INC

Traditional Chinese medicine composite as well as product and application thereof

The invention relates to a traditional Chinese medicine composite as well as a product and an application of the traditional Chinese medicine composite. The composite comprises the following traditional Chinese medicine raw materials in parts by weight: 20-40 parts of Astragalus mongholicus and 10-20 parts of mulberry and also comprises one or several of the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of salviae miltiorrhizae, 5-15 parts of angelica sinensis, 10-20 parts of processed fleece-flower root, 5-15 parts of rhizoma chuanxiong and 1-5 parts of pseudo-ginseng. The traditional Chinese medicine composite has better actions on lowering sugar, lowering fat, improving a blood rheology index, reducing urine protein or improving the creatinine clearance rate and especially has the actions on protecting the vascular endothelial cell, alleviating the damage degree of the endarterium and the like, and therefore the traditional Chinese medicine composite can be prepared into oral administration or external application products used for treating or controlling renal damage, neuropathy around limbs, high blood fat, impotence, prostatic hyperplasia, diabetes mellitus and complications, such as diabetic foot, diabetic nephropathy and diabetic retinal inflammation, and has good protecting action on the liver, the kidney, the pancreas and the intestinal mucosa.
Owner:SICHUAN SUNNYHOPE PHARM CO LTD

New application of human urinary kallidinogenase and pharmaceutical composition with the human urinary kallidinogenase

The invention belongs to the field of medicine, in particular to a new application of human urinary kallidinogenase and a pharmaceutical composition with the human urinary kallidinogenase. According to the new application of the human urinary kallidinogenase, the human urinary kallidinogenase is used for preparing medicine for treating hypertensive nephropathy, and the test discovers that the human urinary kallidinogenase is capable of lowering the arterial pressure of a rat with hypertensive nephropathy and improving the glomerular filtration rate and renal plasma flow of the rat with hypertensive nephropathy through regulating the micro-circulation of glomerulus, and has a certain treatment effect for renal damage. The pharmaceutical composition for treating the hypertensive nephropathy comprises the human urinary kallidinogenase and betahistine hydrochloride and further comprises pentoxifylline, the pharmaceutical composition has an obvious blood pressure reducing efficiency and has an obvious treatment effect for the damaged kidney, and the pharmaceutical composition for treating the hypertensive nephropathy is definite in effect, low in side effect and better for the recovery of a patient with hypertensive nephropathy.
Owner:GUANGDONG TECHPOOL BIO-PHARMA CO LTD

Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto

ActiveUS20190292196A1Lower performance requirementsImproves contractile function and hemodynamic statusOrganic active ingredientsOrganic chemistryLeft ventricular sizeKidney
The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure; cardiac performance in heart failure; mortality, reinfarction, and / or hospitalization in connection with heart failure; acute heart failure; acute decompensated heart failure; congestive heart failure; severe congestive heart failure; organ damage associated with heart failure (e.g., kidney damage or failure, heart valve problems, heart rhythm problems, and / or liver damage); heart failure due to left ventricular dysfunction; heart failure with normal ejection fraction; cardiovascular mortality following myocardial infarction; cardiovascular mortality in patients with left ventricular failure or left ventricular dysfunction; left ventricular failure; left ventricular dysfunction; class II heart failure using the New York Heart Association (NYHA) classification system; class III heart failure using the New York Heart Association (NYHA) classification system; class IV heart failure using the New York Heart Association (NYHA) classification system; LVEF<40% by radionuclide ventriculography; LVEF≤35% by echocardiography or ventricular contrast angiography; and conditions related thereto.
Owner:ARENA PHARMA

Health care tea with hair generating and kidney benefiting efficacies

The invention belongs to the technical field of good processing, and particularly relates to a health care tea with hair generating and kidney benefiting efficacies. The health care tea is prepared from the following raw materials in parts by weight: 20 to 30 parts of radix polygoni multiflori, 8 to 10 parts of prepared rehmannia roots, 10 to 15 parts of arborvitae tops, 10 to 15 parts of rhizoma polygonati, 5 to 8 parts of Chinese wolfberry fruits, 5 to 10 parts of radix angelicae sinensis, 5 to 8 parts of red dates, 8 to 10 parts of spatholobus stems, 5 to 10 parts of glossy privet fruits and 10 to 15 parts of mulberry fruits. The health care tea has the advantages that the natural traditional Chinese medicine raw materials are used; the preparation is simple and convenient; the medicine sources are wide; the cost is low; the effects of warming the kidney to strengthen yang, promoting blood circulation to remove blood stasis and clearing away heat and toxic materials are achieved; the kidney blood flow is improved; the urine protein is reduced; the renal damage is delayed; the recurrence rate is low; the complete reliving rate is high; the medicine property is mild; the absorption of scalp external nutrition can be effectively promoted; the blood circulation is promoted; the hair nutrition state is improved; the hair development speed is high; the effects of nourishing the spleen and the kidneys, nourishing the blood for tranquilization, promoting hair growth, blackening the hair, promoting blood circulation and eliminating toxin are achieved; the materials are made into a beverage; the use is convenient.
Owner:兴义市东泰天然果蔬开发有限公司
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