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112 results about "Renal damage" patented technology
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Kidney damage is any sort of injury or impairment that affects the overall function of these organs. Also referred to as renal damage, an arterial blockage is just one potential cause of the condition, but you may also suffer harm to the kidney due to infections, medications, toxins, surgical procedures or even an autoimmune...
Markers of Renal Transplant Rejection and Renal Damage
InactiveUS20080153092A1Microbiological testing/measurementDisease diagnosisProtein markersRenal transplant rejection
The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.
Owner:ELECTROPHORETICS LTD
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
InactiveUS20120190044A1Eliminate needBioreactor/fermenter combinationsBiological substance pretreatmentsGlycoproteinMetalloproteinase inhibitor
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of metalloproteinase inhibitor 2, soluble oxidized low-density lipoprotein receptor 1, interleukin-2, von Willebrand factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor receptor superfamily member 11B, neutrophil elastase, interleukin-1 beta, heart-type fatty acid-binding protein, beta-2-glycoprotein 1, soluble CD40 ligand, coagulation factor VII, C—C motif chemokine 2, IgM, CA 19-9, IL-10, TNF-α, and myoglobin as diagnostic and prognostic biomarkers in renal injuries.
Owner:ASTUTE MEDICAL
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
InactiveUS20130210041A1Disease diagnosisColor/spectral properties measurementsRenal FailuresRenal injury
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays configured to detect a kidney injury marker as diagnostic and prognostic biomarkers in renal injuries.
Owner:ASTUTE MEDICAL
Compositions and methods for treating kidney disease
InactiveUS7585501B2Prevent progressive loss of renal functionAvoid premature deathHormone peptidesCell receptors/surface-antigens/surface-determinantsNephrosisNephropathy
Owner:STOWERS INST FOR MEDICAL RES
Methods and Devices for Detecting Kidney Damage
Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
Owner:MYRIAD RBM INC
Pharmaceutical composition, methods for treating and uses thereof
ActiveUS20160038524A1Few complianceFew convenienceBiocideMetabolism disorderPre diabetesKidney injury
Owner:BOEHRINGER INGELHEIM INT GMBH
Colloid selenium test paper for semi-quantitative determination of urinary trace albumin
The invention provides a test paper for semi-quantitatively detecting colloid selenium in microdose albumin in urine. The test paper can be applied in the fields of early diagnosis of diabetic nephropathy, hypertensive nephropathy and preeclampsia and injury of kidney caused by various poisonous substances. A plastic bottom plate of the test paper is orderly glued with a sampling liquid absorption part, a colloid selenium labeling part, a detection reaction part and a water absorption part, wherein the colloid selenium labeling part is a single-cloning antibody 1 which is coated by a glass fiber membrane, or acetic acid fiber membrane, or nylon membrane and labeled by the colloid selenium; the detection reaction part is a nitrocellulose membrane which is provided with two detection bands and quality control bands, T1 is a single-cloning antibody 2 which is precisely quantitative, and T2 is the single-cloning antibody 2 with a certain concentration; and the quality control bands are coated by antiplague IgG. The invention provides a method for semi-quantitatively detecting the microdose albumin in a urine sample conveniently, visually and quickly.
Owner:LANZHOU UNIVERSITY
Peritoneal dialysate
InactiveCN101861153AArbitrary adjustmentAvoid damagePeritoneal dialysisAnhydride/acid/halide active ingredientsPeritoneal dialysateTrehalose
It is intended to provide a safe and highly stable peritoneal dialysate which causes neither peritoneal membrane disorders nor peritoneal sclerosis in frequently repeated peritoneal dialysis treatment, can protect the residual renal functions in chronic renal failure and inhibit the progress of renal damage over a long period of time, and enables peritoneal dialysis treatment in a diabetic patient. A peritoneal dialysate which contains 0.05 to 3.5 w / v% of taurine and 0.1 to 6.5 w / v% of trehalose as osmotic agents and having a pH value regulated to 6.5 to 7.5.
Owner:CHEIRON JAPAN CO
Traditional Chinese medicine 'guiyuantangkang' for treating diabetes and its complication
InactiveCN101125173AReduce dosageMetabolism disorderBird material medical ingredientsDiet controlledHeart disease
The present invention discloses a traditional Chinese medicine formula Guiyuantangkang for the treatment of diabetes and the complications, the present invention takes membranous milkvetch root, common anemarrhena rhizome, swordlike atractylodes rhizome, raw common yam rhizome, kudzuvine root, Mongolian snakegourd root, stir-fried largehead atractylodes rhizome etc. as the raw materials. The present invention can not only effectively treat the hypertension, vascular diseases, renal damages, repeated infections, heart diseases and other various complications caused by diabetes, prevent the occurrence of the complications, but also can control the symptoms of the diabetes such as thirsty, starvation, emaciation and polyuria, stabilize the blood glucose fluctuations and tolerance caused by the western medicines for lowering blood glucose and effectively improve the quality of life of the patients with various diabetes without the diet control.
Owner:王慧林
Methods and systems for reducing substance-induced renal damage
InactiveUS20090182400A1Reduce severityReduce or avoid damageTherapeutic coolingTherapeutic heatingSubstance inducedContrast medium
Owner:ZOLL CIRCULATION
Building method of acute hyperuricemia renal damage mouse model
InactiveCN108785312AShort modeling timePromote reproductionHeterocyclic compound active ingredientsXanthineHypoxanthine synthesis
The invention discloses a building method of an acute hyperuricemia renal damage mouse model. The method comprises the following steps of experiment mice are subjected to molding experiment for many days by using xanthine, ethambutol and oteracil potassium as molding agents; obtaining the acute hyperuricemia renal damage mouse model; observing the body weight, the serum uric acid level and the renal function change of the experiment mice and the kidney pathological change; the renal damage effect of the molding agent on the experiment mice is analyzed. The mice are used as model animals; the serum uric acid level of the mice is equivalent to the uric acid level of a hyperuricemia patient; the serum uric acid level is stable and can easily reappear; meanwhile, the combined effect of uric acid precursors of hypoxanthine is used; the uric acid excreted substances of ethambutol and uricase inhibitors of oteracil potassium are reduced; the acute hyperuricemia renal damage mouse model is built; the molding time is short; the model conforms to the clinical characteristics of human body hyperuricemia renal damage, and is applicable to screening hyperuricemia renal damage resisting medicine.
Owner:WUHAN POLYTECHNIC UNIVERSITY
Compounds and methods for preventing or treating sensory hair cell death
ActiveUS9493482B2Avoid deathPrevent hearing lossSenses disorderOrganic chemistrySensory hairMedicine
Owner:FRED HUTCHINSON CANCER CENT +2
Pharmaceutical composition, methods for treating and uses thereof
InactiveUS20200268777A1Few complianceFew convenienceOrganic active ingredientsMetabolism disorderPharmaceutical drugPharmacology
Owner:BOEHRINGER INGELHEIM INT GMBH
Reduction of renal damage in companion animals
InactiveUS20050064017A1Lower protein levelMaintain qualityBiocideInorganic non-active ingredientsNephrosisCompanion animal
The present invention is directed to a pet food and its use in reducing renal damage in companion animals. More particularly, the pet food maintains muscle mass in animals with renal conditions or animals at risk for developing a renal condition.
Owner:MARS INC
Kidney repairing factor
InactiveUS20050048602A1High detection sensitivityEnabling detectionHydrolasesPeptide/protein ingredientsDiseaseDamages tissue
A protein [kidney regeneration factor (KRGF-1)] whose expression is increased at the time of regeneration of damaged tissues in patients with renal diseases is isolated, and a DNA encoding the protein and an antibody recognizing the protein are produced. These materials can be utilized in screening of therapeutic agents for regenerating damaged renal tissues and in diagnosis of renal damage.
Owner:KYOWA HAKKO KOGYO CO LTD
Constructing method for subacute hyperuricemia renal damage mouse model
InactiveCN108524553AGood effectReasonably constructedCompounds screening/testingHeterocyclic compound active ingredientsYeastOTERACIL POTASSIUM
The invention discloses a constructing method for a subacute hyperuricemia renal damage mouse model. The method comprises the following steps that yeast cream and oteracil potassium are taken as a molding agent, a molding experiment is constantly carried out on an experiment mouse for multiple days, a subacute hyperuricemia renal damage mouse model is acquired, wherein during the molding experiment process, the yeast cream is given to the experiment mouse every day, and after the yeast cream is given to the experiment mouse in the last day of the molding experiment, the oteracil potassium is given to the experiment mouse; the weight, serum uric acid level, renal function change and renal pathology change of the experiment mouse are observed, and damage of the molding agent to the experiment mouse is analyzed. According to the constructing method, the mouse is taken as a model animal, the yeast cream in which a uric acid precusor substance is added for a long term is adopted, the oteracil potassium as a uricase inhibitor is taken as the molding agent and is used, and the subacute hyperuricemia renal damage mouse model with stable effect is in accordance with clinical features and issuccessfully constructed.
Owner:WUHAN POLYTECHNIC UNIVERSITY
Compositions useful for reducing nephrotoxicity and methods of use thereof
ActiveUS20070270380A1Reduce nephrotoxicityPrevent nephrotoxicityOrganic active ingredientsBiocideNephrotoxicityOligosaccharide
The present invention provides compositions and methods to reduce renal damage caused by nephrotoxic drugs. The invention provides compositions comprising an anionically substituted oligosaccharide, a nephrotoxic drug and a pharmaceutically acceptable carrier, where the oligosaccharide is present in an amount effective for substantially inhibiting the nephrotoxic effect of the drug.
Owner:VERROW PHARMA
Method for the detection of renal damage
InactiveUS20120220480A1Damage causedFailure causedLibrary screeningDisease diagnosisAlpha-enolaseFetuin b
The invention relates to a method for determining the presence of renal damage in an individual and also to a method for detecting one or several proteins selected from the list comprising Reg3B, fetuin B, Ras-related GTP-binding protein A serine protease inhibitor A3L, subunit 1 of COP9, gamma subunit of ATP synthase, gelsolin, ribonuclease UK114, aminoacylase 1A, alpha-enolase, keratin 5, parvalbumin alpha, ribonuclease 4 or serine protease inhibitor A3K. The renal damage may be acute renal failure. Said renal pathologies may be caused by the administration of a nephrotoxic agent, wherein the nephrotoxic agent may be an aminoglycoside antibiotic such as gentamicin, or cisplatin. The invention also provides means to differentiate the renal damage or renal failure induced by gentamicin from that induced by cisplatin, through the biochemical analysis of the urinary level of Reg3B and / or gelsolin, or fragments thereof.
Owner:UNIV DE SALAMANCA
Gliquidone compound preparation capable of reducing renal damage
ActiveCN106361791AReduce the burden onExtend quality of lifeMetabolism disorderSulfonylurea active ingredientsFiltrationAmino acid
The invention discloses a gliquidone compound preparation capable of reducing renal damage. The gliquidone compound preparation capable of reducing renal damage is prepared from main drugs and auxiliary materials, and is characterized in that the main drugs are prepared from 20-30% (w / w) of gliquidone, 15-25% (w / w) of ligustrazine and the balance of radix notoginseng extract, wherein the dosage of the radix notoginseng extract is counted based on the mass of dry powder; the radix notoginseng extract is extracted from radix notoginseng, and comprises four types of substances, namely saponin, flavone, amino acid and polyose. The gliquidone compound preparation is supplemented with the radix notoginseng extract and the ligustrazine, so that the gliquidone dosage is reduced, and further the influence of the gliquidone on the renal function of a patient is reduced; the three types of drugs achieve a synergetic effect, so that the blood glucose is reduced, functions of glomeruli are protected, the glomerular filtration capability reduction is prevented, and the blood fat is regulated, so that the gliquidone compound preparation is more applicable to patients suffering from diabetic nephropathy.
Owner:BEIJING WANHUI DOUBLE CRANE PHARMA
Traditional Chinese medicine composite as well as product and application thereof
ActiveCN102631415AImprove general conditionImprove metabolic disordersNervous disorderMetabolism disorderHigh creatinineAngelica Sinensis Root
The invention relates to a traditional Chinese medicine composite as well as a product and an application of the traditional Chinese medicine composite. The composite comprises the following traditional Chinese medicine raw materials in parts by weight: 20-40 parts of Astragalus mongholicus and 10-20 parts of mulberry and also comprises one or several of the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of salviae miltiorrhizae, 5-15 parts of angelica sinensis, 10-20 parts of processed fleece-flower root, 5-15 parts of rhizoma chuanxiong and 1-5 parts of pseudo-ginseng. The traditional Chinese medicine composite has better actions on lowering sugar, lowering fat, improving a blood rheology index, reducing urine protein or improving the creatinine clearance rate and especially has the actions on protecting the vascular endothelial cell, alleviating the damage degree of the endarterium and the like, and therefore the traditional Chinese medicine composite can be prepared into oral administration or external application products used for treating or controlling renal damage, neuropathy around limbs, high blood fat, impotence, prostatic hyperplasia, diabetes mellitus and complications, such as diabetic foot, diabetic nephropathy and diabetic retinal inflammation, and has good protecting action on the liver, the kidney, the pancreas and the intestinal mucosa.
Owner:SICHUAN SUNNYHOPE PHARM CO LTD
Medicament for relieving alcoholism
The invention relates to a medicament for relieving alcoholism, prepared by the steps of: decocting kudzu root, loquat leaf, river snail, clam, fructus psoraleae, mung bean and liquorice in water to obtain decoction, concentrating the decoction, adding conventional auxiliary materials, adding purified water until the crude drug content is 1g / mL, filling and sterilizing to obtain the oral liquid preparation. The medicament provided by the invention has the efficacies of resolving heat, reducing pathogenic fire, expelling toxin, harmonizing the stomach, lowering the adverse flow of qi, removing dampness and detoxifying, has an obvious effect on relieving alcoholism, has no subsidiary reactions such as hepatic and renal damage and the like caused by western medicines, has no drug resistance of antibiotics and the like, and has an effective rate of 100% proven by clinical observation.
Owner:崔凤玉
Diagnostic method for detecting acute kidney injury using heat shock protein 72 as a sensitive biomarker
InactiveUS20130065239A1Microbiological testing/measurementDisease diagnosisReal-Time PCRsWestern blot
The invention relates to a reliable, easy-to-implement non-invasive diagnostic method for detecting early acute kidney injury by measuring the concentration of a biomarker in urine samples, said biomarker being selected from heat shock proteins of the 70 KDa family. More specifically, the invention relates to the identification of heat shock protein 72, whereby said biomarker is identified by means of ELISA and Western blot or by means of the level of RNAm using real-time RT-PCR. The invention helps to solve the current problem that exists in medicine whereby it is not possible to detect acute renal failure in the early stages or the severity of the renal damage in order to treat the patient in a timely manner with an effective therapy.
Owner:UNIV NAT AUTONOMA DE MEXICO
Use of 1,25-Dihydroxyvitamin D Values in Ratio with PTH as a Prognostic Biomarker
ActiveUS20170322230A1Worsening renal functionIncrease the areaDisease diagnosisBiological testingCvd riskBiomarker (petroleum)
The present invention relates to the use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker. More particularly, the present invention relates to a method for predicting or stratifying the risk of worsening renal function (WRF) in a patient at risk of renal injury or affected by renal injury. Levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) are measured in a biological sample and taken together with parathyroid hormone (PTH) levels to provide a ratio indicative of the risk of worsening renal function.
Owner:DIASORIN ITALIA SPA
New application of human urinary kallidinogenase and pharmaceutical composition with the human urinary kallidinogenase
InactiveCN104906564ARelieve painGood blood pressure effectPeptide/protein ingredientsPharmaceutical delivery mechanismSide effectEfficacy
The invention belongs to the field of medicine, in particular to a new application of human urinary kallidinogenase and a pharmaceutical composition with the human urinary kallidinogenase. According to the new application of the human urinary kallidinogenase, the human urinary kallidinogenase is used for preparing medicine for treating hypertensive nephropathy, and the test discovers that the human urinary kallidinogenase is capable of lowering the arterial pressure of a rat with hypertensive nephropathy and improving the glomerular filtration rate and renal plasma flow of the rat with hypertensive nephropathy through regulating the micro-circulation of glomerulus, and has a certain treatment effect for renal damage. The pharmaceutical composition for treating the hypertensive nephropathy comprises the human urinary kallidinogenase and betahistine hydrochloride and further comprises pentoxifylline, the pharmaceutical composition has an obvious blood pressure reducing efficiency and has an obvious treatment effect for the damaged kidney, and the pharmaceutical composition for treating the hypertensive nephropathy is definite in effect, low in side effect and better for the recovery of a patient with hypertensive nephropathy.
Owner:GUANGDONG TECHPOOL BIO-PHARMA CO LTD
Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
ActiveUS20190292196A1Lower performance requirementsImproves contractile function and hemodynamic statusOrganic active ingredientsOrganic chemistryLeft ventricular sizeKidney
Owner:ARENA PHARMA
Compositions useful for reducing nephrotoxicity and methods of use thereof
ActiveUS7658913B2Reduce nephrotoxicityPrevent nephrotoxicityOrganic active ingredientsBiocideNephrotoxicityCyclodextrin
Owner:VERROW PHARMA
Renal failure early-warning method and system based on urine specific gravity and urine volume monitoring
InactiveCN106845140AProbability of Predicting DamageTimely detection of lesionsMedical automated diagnosisSpecial data processing applicationsRenal FailuresUrine volume
The invention discloses a renal failure early-warning method and system based on urine specific gravity and urine volume monitoring. The method includes the steps: acquiring the urine specific gravity and stepping urine monitoring indexes of different patients, and building a database; performing training on a probabilistic neural network; calculating the urine specific gravity and the stepping urine monitoring indexes of the treated patients by the aid of the trained probabilistic neural network to obtain early-warning results. According to the method and the system, the detected urine specific gravity and the detected stepping urine monitoring indexes are analyzed, the probability of renal damage can be forecasted, renal lesions is timely discovered at the early stage of renal asymptomatic damage, and effective help is provided for clinic and early treatment.
Owner:CHONGQING TECH & BUSINESS UNIV
Traditional Chinese medicine composition for treating drug-induced renal damage of chicken
ActiveCN102178774AClearing heat and purging fireDiureticUrinary disorderPlant ingredientsDiuresisCurative effect
The invention provides a traditional Chinese medicine composition for treating drug-induced renal damage of chicken, comprising the following components in parts by weight: 15-20 parts of fringed pink, 15-20 parts of rhizoma alismatis, 10-15 parts of plantain, 10-15 parts of lysimachia, 5-10 parts of cape jasmine, 5-10 parts of tuckahoe, 5-10 parts of white atractylodes rhizome, 1-5 parts of liquorice and 1-5 parts of phellodendron bark. The traditional Chinese medicine composition has the efficacies of clearing heat and purging fire, inducing diuresis for treating stranguria, promoting the subsidence of swelling, alleviating pain, and replenishing qi to invigorate the spleen, and can be used for treating drug-induced renal damage of chicken with exact curative effect, and the cure rate reaches above 80%.
Owner:BAODING JIZHONG PHARMA
Medicinal composition for treating renal damage caused by diabetes
The invention discloses a medicinal composition for treating renal damage caused by diabetes, and aims to solve the problems of treatment of diabetic nephropathy. The medicinal composition is characterized in that the medicinal composition is prepared from the following raw medicaments in parts by weight: fructus cannabis, chingma abutilon seeds, magnolia amoena, poncirus barks, Chinese taxillus twigs, allium victorialis, gastrodia fruits, radix ranunculi ternati, Chinese starjasmine stems, erythrina indica lam, cassia twigs and rice-grain sprouts. Clinical experiments show that the medicinal composition for treating renal damage caused by diabetes has the characteristics of good curative effects and higher safety, and has high clinical application and popularization value.
Owner:刘渊
Health care tea with hair generating and kidney benefiting efficacies
InactiveCN106720717AEasy to prepareWide range of medicinesSenses disorderNervous disorderComplete remissionToxic material
The invention belongs to the technical field of good processing, and particularly relates to a health care tea with hair generating and kidney benefiting efficacies. The health care tea is prepared from the following raw materials in parts by weight: 20 to 30 parts of radix polygoni multiflori, 8 to 10 parts of prepared rehmannia roots, 10 to 15 parts of arborvitae tops, 10 to 15 parts of rhizoma polygonati, 5 to 8 parts of Chinese wolfberry fruits, 5 to 10 parts of radix angelicae sinensis, 5 to 8 parts of red dates, 8 to 10 parts of spatholobus stems, 5 to 10 parts of glossy privet fruits and 10 to 15 parts of mulberry fruits. The health care tea has the advantages that the natural traditional Chinese medicine raw materials are used; the preparation is simple and convenient; the medicine sources are wide; the cost is low; the effects of warming the kidney to strengthen yang, promoting blood circulation to remove blood stasis and clearing away heat and toxic materials are achieved; the kidney blood flow is improved; the urine protein is reduced; the renal damage is delayed; the recurrence rate is low; the complete reliving rate is high; the medicine property is mild; the absorption of scalp external nutrition can be effectively promoted; the blood circulation is promoted; the hair nutrition state is improved; the hair development speed is high; the effects of nourishing the spleen and the kidneys, nourishing the blood for tranquilization, promoting hair growth, blackening the hair, promoting blood circulation and eliminating toxin are achieved; the materials are made into a beverage; the use is convenient.
Owner:兴义市东泰天然果蔬开发有限公司
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