162 results about "Hair cell" patented technology

The invention comprises a totally implantable hearing prosthesis for hearing impaired persons. An inertial vibrational element is hermetically sealed and implanted in bone between the lateral and superior semicircular canals without breaching the integrity of the canals. The vibrational element is adapted to vibrate the walls of the canals and the fluids contained therein, thereby vibrating contiguous fluids within the cochlea thus stimulating hair cells and creating a hearing percept. The invention can also be adapted to be a tinnitus masking system, and / or used in combination with a coehlear implant hearing system.

The invention relates to one or more inhibitors, in particular siRNAs, which down-regulate the expression of human pro-apoptotic genes. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating or preventing the incidence or severity of hearing impairment (or balance impairment), particularly hearing impairment associated with cell death of the inner ear hair cells or outer ear hair cells, comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient.

The invention provides a light emitting device having an array of light emitting diodes (LED). The array of the device is arranged to illuminate a surface area of a scalp and the LEDs exhibit a plurality of wavelengths within the near infrared region of the electromagnetic spectrum between about 600-1000 nm, wherein the plurality of wavelengths synergistically combine to decrease follicular apoptosis. The array of light emitting diodes can include LEDs that are pulsed and can contain an array of light emitting diodes corresponding to about 30-200, preferably about 50-150, and more preferably about 80-120 LEDs. The light emitting device of the invention also can include a headband or a stationary mount or other mount for positioning over a target area. Also provided is a method of reducing follicular cell apoptosis. The method includes illuminating a surface area of a scalp containing a follicular hair cell for an effective period of time with an array of light emitting diodes (LED). The array of LEDs exhibit a plurality of wavelengths within the near infrared region of the electromagnetic spectrum between about 600-100 nm, wherein the plurality of wavelengths synergistically combine to decrease follicular cell apoptosis. The method can include inducing an increase in nitric oxide production compared to an untreated follicular hair cell as well as inducing mitochondrial chromophore activation. An effective period of time can include about 5-30 minutes, about 10-20 minutes or about 12-18 minutes and can promote vaso perfusion of the scalp or reduction in hair loss.

A new speech processing strategy, termed Frequency Modulated Stimulation (FMS), is provided for use with a cochlear prosthetic. The FMS strategy advantageously mimics the neural firing patterns of the healthy cochlea by controlling when and where stimulation pulses are presented in the cochlea. The benefits of this approach are its simplicity and its ability to provide temporal information at relatively low power consumption. The stimulation that results has high temporal precision and a low pulse presentation rate. The power efficiency of the FMS strategy is three to six times greater than that of a CIS strategy with comparable thresholds. The FMS strategy depends on the probability that at any point along the basilar membrane the ganglion cells are most likely to respond during the upward motion of the basilar membrane, when the hair cells are pushed toward the tectorial membrane. At low frequencies, this probability accounts for phase locking of the neurons to each peak of the motion. At high frequency locations, phase locking occurs at integer multiples of the vibration cycles because the vibration of the membrane is faster than the refractory period of the neurons. The FMS strategy provided by the invention takes advantage of the natural behavior of the ganglion cells by outputting a biphasic pulse at the preset integer multiples of the vibration cycles. Integer multiples are determined by counting the positive-to-negative zero crossings, or equivalent frequency counting, at the output of the band pass filters that decompose the incoming audio signal(s).

A non-planar transistor having floating body structures and methods for fabricating the same are disclosed. In certain embodiments, the transistor includes a fin having upper and lower doped regions. The upper doped regions may form a source and drain separated by a shallow trench formed in the fin. During formation of the fin, a hollow region may be formed underneath the shallow trench, isolating the source and drain. An oxide may be formed in the hollow region to form a floating body structure, wherein the source and drain are isolated from each other and the substrate formed below the fin. In some embodiments, independently bias gates may be formed adjacent to walls of the fin. In other embodiments, electrically coupled gates may be formed adjacent to the walls of the fin.

The invention relates to one or more inhibitors, in particular siRNAs, which down-regulate the expression of human pro-apoptotic genes. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating or preventing the incidence or severity of hearing impairment (or balance impairment), particularly hearing impairment associated with cell death of the inner ear hair cells or outer ear hair cells, comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient.

Systems and methods are disclosed for manufacturing grounded gate cross-hair cells and standard cross-hair cells of fin field-effect transistors (finFETs). In one embodiment, a process may include forming gate trenches and gates on and parallel to row trenches in a substrate, wherein the gate trenches and gates are pitch-doubled such that four gate trenches are formed for every two row trenches. In another embodiment, a process may include forming gate trenches, gates, and grounded gates in a substrate, wherein the gate trenches and gates are formed such that three gate trenches are formed for every two row trenches.

The invention relates to Chinese medicinal multifunctional hair-growth and health-care medicinal liquor and a preparation method thereof. The Chinese medicinal multifunctional hair-growth and health-care medicinal liquor is prepared from the following Chinese medicinal raw material medicaments by weight: 290 to 310 grams of tall gastrodia tuber, 480 to 520 grams of prepared tuber fleeceflower root, 190 to 210 grams of Chinese angelica, 190 to 210 grams of radix rehmanniae praeparata, 190 to 210 grams of szechuan lovage rhizome, 190 to 210 grams of papaya, 170 to 190 grams of Chinese wolfberry, 450 to 620 grams of cochinchnese asparagus root, 170 to 200 grams of dahurian angelica root and 9,000 to 15,000 grams of distilled spirit. The Chinese medicinal multifunctional hair-growth and health-care medicinal liquor has the advantages of wide source of raw materials and low preparation cost, capability of invigorating blood circulation, nourishing blood and tonifying kidney, dispelling wind and growing hair, blackening hair, activating the metabolism of hair cells, promoting blood circulation all over the body and improving hair quality effectively and no side effect; and the preparation method has the advantages of simple using equipment and short process flow.

The present invention relates to compositions and methods for the protection and restoration of hearing. In particular, the present invention relates to treatments to facilitate the protection and re-growth of the auditory nerve. The present invention further provides methods of preventing hair cell loss and the accompanying loss in hearing. The present invention thus provides novel interventions for a variety of hearing impairments.

The invention provides a method for inducing mesenchymal stem cell in the bone marrow to obtain the nerve prosoma cell, which comprises the following steps: doing generation culture for the separated and purified mesenchymal stem cell in the bone marrow, switching stable generation mesenchymal stem cell into induction culture medium, inducing and culturing for 7-20 d, obtaining nerve prosoma cell. The induction culture medium is basic culture medium which is charged with growth factor, wherein the growth factor mainly comprises an epiderm growth factor (EGF), a base fibroblast growth factor (bFGF), an insulin growth factor-1 (IGF-1) and a nerve nourishment factor 3 (NT-3). The invention provides a method for inducing mesenchymal stem cell in the bone marrow to obtain the nerve prosoma cell which can be differentiated into nerve cell and the nerve prosoma cell can be switched into inner ear hair cell and inner ear supporting cells, which provides experiment evidence for cochlear cell transplantation therapeutic sound perception nerve deafness and solves the problem of the transplantation cell resource.

Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and / or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and / or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and / or supporting cells to treat a subject at risk of or affected with, hearing loss or a subject at risk of or affected with vestibular dysfunction.

The invention discloses an anti-dropping and hair reviving shampoo. The anti-dropping and hair reviving shampoo comprises the following components in part by weight: 65 to 85 parts of shampoo substrate and 15 to 35 parts of plant extract. The invention also discloses a preparation method for the anti-dropping and hair reviving shampoo. The shampoo can suppress the secretion of sebaceous glands, sterilizes and restrains pathogen, activates hair cells, promotes hair cell division, and can fundamentally solve the problems of baldness, hair growth and the like effectively.

A vestibular prosthesis includes micro-electric-mechanical (MEMS) sensors, gyroscopes in each sensitivity axis (X, Y, Z), accelerometers in each sensitivity axis (X, Y, Z) to detect an angular and linear movement providing displacement measurements, gyroscopes in each one of the spatial axes (X, Y, Z), a microprocessor connected to the MEMS sensors and producing an electric pulse pattern or a continuous galvanic current pattern, a conditioning unit that amplifies and conditions the microprocessor output to apply current to the stimulation electrodes, the microcontroller being configured to determine the displacement of the cupula and the otolithic mass, determine a membrane potential as a result of a displacement detected by the MEMS sensors by means of determining a transduction current, and determine an action potential discharge pattern for the primary afferent neuron, which synapses with the hair cell by means of a mathematical model of the informative process of the vestibular mechanoreceptor.

Method and compositions for inducing the self-renewal of stem / progenitor supporting cells comprised by a cochlear cell population, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

The invention provides a method for inducing mesenchymal stem cell in the bone marrow to obtain the inner ear hair cell prosoma, which comprises the following steps: doing generation culture for the separated and purified mesenchymal stem cell in the bone marrow, switching stable generation mesenchymal stem cell into induction culture medium, inducing and culturing for 7-20 d, obtaining the inner ear hair cell prosoma. The induction culture medium is basic culture medium which is charged with growth factor, wherein the growth factor mainly comprises an epiderm growth factor (EGF) and an insulin growth factor-1 (IGF-1), the charging quantity is EGF 10-30ng / ml basic culture medium and IGF-1 40-60ng / ml basic culture medium. The beneficial effect of the invention is that the invention provides a method for inducing mesenchymal stem cell in the bone marrow to obtain the inner ear hair cell prosoma and supplies a firm base for cochlear cell transplantation therapeutic sound perception nerve deafness, which is provided with significant clinical meaning.

The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

The invention provides an adeno-associated virus (AAV) containing variant capsid protein and application of the AAV. The variant AAV-ie is constructed by inserting an amino acid sequence DGTLAVPFK between N589 and R590 of wild type AAV-DJ capsid protein VPI. The variant AAV-ie can efficiently infect hair cells and supporting cells, is greatly improved as compared with AAV-ie parents and provides better technical support for scientific research.

A method for hair cell stimulation includes determining a frequency band corresponding to damaged hair cell region in accordance with a preset algorithm, determining the frequency band corresponding to the damaged hair cell region as a target frequency band, and outputting an acoustic signal with given intensity to the target frequency band so as to stimulate the damaged hair cell region. The method treats hearing loss by acoustic signal.

The invention provides a medical scar treatment plaster. The medical scar treatment plaster comprises a back lining layer, a gel coagulation layer and an antisticking layer, wherein the gel coagulation layer sequentially comprises a medical silicone gel layer and a hyaluronic acid gel coagulation layer; the medical silicone gel layer is a mixture consisting of active substances, peppermint oil, aradix salviae miltiorrhizae extract, a cortex phellodendri extract, rhododendron root powder, and purified water; and the hyaluronic acid gel coagulation layer is a mixture consisting of sodium hyaluronate and crust growth factors. The invention further provides a preparation method of the medical scar treatment plaster. The medical scar treatment plaster has the beneficial effects of being soft in texture, high in auto-adhesion and convenient to use, has favorable moisture permeability and air permeability, can promote scars to be softened and flat, can lighten pigment, and is high in safetyand suitable for children. The medical scar treatment plaster can restrain hair cell hyperplasia, reduce collagen deposition, control scar hyperplasia, and promote skin tissue repair and healing. Thepreparation method of the medical scar treatment plaster is simple to operate, the raw materials are wide in source, the preparation cost is low, and the medical scar treatment plaster is safe and reliable to use.

The invention discloses an evoked potential recorder based on time characteristic indicators, which can carry out the computation and the function indicator measurement based on the following functional relation: L-Lmin=ae-bx or lg(L-Lmin)=-Bx+A, wherein L is response delay of a nervous system to a certain frequency simulating signal, x is logarithm of instantaneous strength of the simulating signal or constant coefficient of an increasing function; P(t) is the instantaneous strength; and Lmin, a and b, A(A=lga) and B(B=b / ln10), and K and T are constants relevant to the time response characteristics of the nervous system. Lmin is the shortest delay, T is a time conversion coefficient, K is a time (sound-electricity) conversion index, and the Lmin, the T and the K can respectively reflect various physiological functions and changes thereof of transfer characteristics of nerve fibers and synapses of hair cells, mechanical transfer characteristics of sound, sensibility of auditory center system nerve cells, sound-electricity conversion characteristics and the like.

The invention provides a preparation method of compound plant anti-loss hair-growth liquid, which relates to the field of a cosmetic. The compound plant anti-loss hair-growth liquid adopts pure natural botanical ingredients, is mild and non-irritating, has the function of regulating the secretion of scalp oil, and activates the hair cell, which can effectively prevent the hair loss and grow hairs.The compound plant anti-loss hair-growth liquid is prepared by mixing the five plant materials of a ginseng extract, a platycladus orientalis extract, a sophora flavescens extract, a pseudo-ginseng extract, and a Chinese angelica extract in a mass ratio of 3:3:2:1:1, and the materials are subjected to 0.22 [mu]m filtration and sterilizing extraction in a 10,000-scale preparation workshop.

Provided are compositions and methods for using Wnt agonist, GSK3-alpha inhibitor, or GSK3-beta inhibitors in combination with TGF-beta inhibitors to induce the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining in the daughter cells the capacity to differentiate into hair cells.

Provided are compositions and methods for inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells, and including compositions and methods of using GSK3-alpha inhibitors, and salts thereof, optionally in combination with a Differentiation Inhibitor such as a Notch agonist or an HDAC inhibitor (e.g., valproic acid).

The invention discloses a method for differentiating a sustentacular cell into an inner ear hair cell. The method is characterized by comprising the steps of cultivating a cochlear epithelial cell into a single cell, adding the single cell to an expansion culture medium containing an epidermal cell growth factor, a fiber forming mother cell factor, an insulin factor-1, a glycogen kinase inhibitor-3, valproic acid, 2-phosphoric acid-L-ascorbic acid and an ALK5 inhibitor, expanding the sustentacular cell to obtain an Lgr5+ cell, adding an induction culture medium containing an LY411575 factor and the glycogen kinase inhibitor-3, performing induced differentiation cultivation for 10 days to obtain the inner ear hair cell, and detecting a gene level and a protein level of the inner ear hair cell subjected to induced differentiation to confirm the inner ear hair cell. According to the method, division and multiplication of the sustentacular cell are promoted by the culture medium containing the factors, and then the sustentacular cell is induced to be differentiated into the inner ear hair cell by the induction culture medium, so that the high-purity and high-ratio inner ear hair cell can be obtained.

The invention discloses a method for inducing differentiation of mouse embryonic stem cell to obtain inner ear hair cells, which comprises the following steps: using a conditioned medium and an induction nutrient solution for inducing embryonic stem cell for differentiation of precursor cells of hair cell; and then using a combination method of the induction nutrient solution and trophoblastic cells for inducing precursor cell for differentiation of mature inner ear hair cells. The method can effectively induce the differentiation of embryonic stem cell to obtain the precursor cells of inner ear hair cell and mature inner ear hair cell, the differentiation ratio is high, hair cell specific gene and protein can be expressed by cells obtained through differentiation, and the cells have certain electrophysiological function of hair cells.

The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

The invention discloses a composition for promoting cell regeneration and a preparation method and use thereof. The composition for promoting cell regeneration provided by the invention is prepared by the following method: first, conducting in vitro culture of human bone marrow mesenchymal stem cells: adding a human stem cell growth factor, a granulocyte colony-stimulating factor and a clam extract, so that the human bone marrow mesenchymal stem cells can secrete a variety of human growth factors to form a human growth factor composition; and finally embedding the composition by a Water-in-Oil-in-Water (W / O / W) liposome embedding technology. The composition obtained by embedding can smear on epidermis to promote e wound healing of epidermal tissue, reduce scar formation, and activate hair follicle melanocytes and stimulate hair cell regeneration. In addition, the composition can be taken orally to promote regeneration and repair of damaged brain substantia nigra cells and hippocampal gyrus neurogenesis, and stimulate the proliferation of bone marrow hematopoietic stem cells.

Disclosed are methods and devices depicting fabrication of non-planar access devices having fins and narrow trenches, among which is a method that includes wet etching a conductor to form a recessed region and subsequently etching the conductor to form gates on the fins. The wet etching may include formation of recesses which are may be backfilled with a fill material to form spacers on the conductor. In some embodiments, portions of a plug may be removed during the wet etch to form overhanging spacers to provide further protection of the conductor during the dry etch.