2952results about How to "Promote differentiation" patented technology

The invention discloses a family of peptides termed NRP compounds or NRPs that can promote neuronal migration, neurite outgrowth, neuronal proliferation, neural differentiation and / or neuronal survival, and provides compositions and methods for the use of NRPs in the treatment of brain injury and neurodegenerative disease. NRP compounds can induce neurons and neuroblasts to proliferate and migrate into areas of damage caused by acute brain injury or chronic neurodegenerative disease, such as exposure to toxins, stroke, trauma, nervous system infections, demyelinating diseases, dementias, and metabolic disorders. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly, and directly into the nervous system of a patient. NRP compounds can be formulated into pharmaceutically acceptable dose forms for therapeutic use. Methods for detecting neural regeneration, neural proliferation, neural differentiation, neurite outgrowth and neural survival can be used to develop other neurally active agents.

The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of the peptides, and methods of use for the peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro.

Devices, systems and methods for treating medical conditions using cell therapy via body lumens. Localized delivery is achieved with the use of a stent-like expandable body seeded with cells. The expandable body is expanded to contact at least a portion of the inner walls of the body lumen and the cells, cellular products and / or other therapeutic agents are delivered to the surrounding tissue. The therapeutic benefit provided is dependent on the type of cells used and the features of the expandable body.

A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

A system and method is described for saving power in a wireless network, using a physical layer address filtering protocol based on a partial address subset of the complete destination MAC address. The system comprises a PHY layer filtering protocol for generating the partial address and writing the partial address into a PHY layer header portion (e.g., PLCP header) of a sending station, or reading the partial address from the PHY layer header portion upon transmission of each frame. A receiving station receives and decodes these PHY layer header portion bits, in accordance with the protocol, and compares whether the subset of bits match that of the stations' own partial address. If a station finds a match, the station then continues further decoding the frame at PHY layer and send the complete frame to the MAC layer for further processing. The stations that do not have a match will not activate their MAC layer components. Thus, the stations of the network will avoid wasting power decoding a significant portion of the complete frame of other stations of the wireless local area networks and unnecessary MAC layer processing. When group addressed, control / management frames or other such frames are detected at the sending station, the address filtering protocol may be “disabled” using a partial address containing a predetermined value (e.g., all zeros).

The present inventors studied the effects of inhibiting the IL-6 signaling pathway on muscle cell growth. As a result, they discovered that, administering an IL-6 inhibitor can promote the adhesion, proliferation, and differentiation of satellite cells and therefore muscle regeneration.

A system and method is described for saving power in a wireless network, using a physical layer address filtering protocol based on a partial address subset of the complete destination MAC address. The system comprises a PHY layer filtering protocol for generating the partial address and writing the partial address into a PHY layer header portion (e.g., PLCP header) of a sending station, or reading the partial address from the PHY layer header portion upon transmission of each frame. A receiving station receives and decodes these PHY layer header portion bits, in accordance with the protocol, and compares whether the subset of bits match that of the stations' own partial address. If a station finds a match, the station then continues further decoding the frame at PHY layer and send the complete frame to the MAC layer for further processing. The stations that do not have a match will not activate their MAC layer components. Thus, the stations of the network will avoid wasting power decoding a significant portion of the complete frame of other stations of the wireless local area networks and unnecessary MAC layer processing. When group addressed, control / management frames or other such frames are detected at the sending station, the address filtering protocol may be “disabled” using a partial address containing a predetermined value (e.g., all zeros).

A neuronal differentiation promoting agent for neural stem cells comprising, as an active ingredient, at least one member selected from the group consisting of ω-3 unsaturated fatty acids and ω-6 unsaturated fatty acids having 18 to 22 carbon atoms, and derivatives thereof. The agent can be used for induction of differentiation of neural stem cells and is useful for treating and / or preventing a variety of neurological diseases, and in the fields of nerve transplantation and / or regenerative medicine for nerves.

The present invention provides methods of identifying and / or characterizing agents that promote differentiation of stem cells to a particular differentiated cell type. The invention further provides methods of treating injuries and degenerative diseases by administering agents that promote the differentiation of stem cells to particular differentiated cell types.

The active hypolipemic components in 40 Chinese-medicinal materials and their relative medicines are disclosed. Said active components can suppress the activity of fatty acid synthetase and the differentiation from profat cells to fat cells and activate the activity of acyl-CoA synthetase. Said medicines feature high effect and low toxic by-effect.

The present invention proposes a method to filter electronic messages in a message processing system, this message processing system comprising a temporary memory for storing the received messages intended to users, a first database dedicated to a specific recipient, and a second database dedicated to a group of recipients, this method comprising the steps of: a) receiving an electronic message and storing it into the temporary memory, b) generating a plurality of proportional signatures of said message, each signature being generated from predefined length of the message content at random location, c) comparing with a first similarity threshold the generated signatures with the signatures present in the first database related to the message's recipient, and eliminating the generated signatures that are within the first similarity threshold of the first database's signatures, thus forming a set of suspicious signatures, d) comparing with a second predefined similarity threshold the suspicious signatures with activated signatures present in the second database, and flagging the message as spam if at least one of the suspicious signatures is within the second predefined similarity threshold of the second database's activated signatures, e) allowing a user to access the message, and moving said message from the temporary memory into a recipient's memory, f) if the message is accepted by the user, storing the generated signatures related to this message into the first database related to this recipient, g) if the message is declared spam by the user, using the suspicious signatures of said message in the second database for, either, if no similar signature exists, creating a non-activated signature into the second database with said signature or updating a previously stored signature that is within of a third similarity threshold of a suspicious signature by incrementing its first matching counter, and activating said previously stored signature if the matching counter is above a first counter threshold.

Method and system for the analysis and source localization of the dynamical patterns in medical and health data, and linking such dynamical patterns with the individual's genetic and / or molecular data. The invention makes use of optimally positioned sensors (sensor arrays) providing input data for signal processing, time-series analysis, pattern recognition and mathematical modeling to facilitate dynamical tracking of systemic arterial pressure without a pressure cuff, local vascular activity, electrocardiographic (ECG), respiratory, physical, muscular, gastrointestinal and neural activity, temperature and other physiological / health data. The invention also facilitates separation of local signals (such as local aneurisms or local vascular activity) from non-local, central or systemic patterns (e.g. systemic blood pressure). In addition, the invention improves identification of dynamical patterns associated with a specific genotype / disorder for screening, personalized risk assessment, diagnosis and treatment control. The system can be implemented in a specialized processor, such as an ambulatory blood pressure monitor, Electrocardiograph, Holter monitor located outside subject's body or implanted inside the body, mobile / cell phone or Smart Phone / Personal Digital Assistant, computer or computer network (the Internet), including wireless or mobile network. The system can be also linked to the electronic health / medical records and other databases.

Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.

An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells). Manufactured from a monolithic transparent material, the improved flow cell has an internal flow channel of polygonal transverse cross-section through which prepared samples can be metered and an external envelope suited to acquisition of optical parameters from formed bodies in such samples. Preferably, such flow cell is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired polygonal cross-sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.

One embodiment of the present invention provides a system that facilitates displaying calendar information on a display. The system operates by displaying a status bar in a location on the display, which does not preclude other content from being displayed simultaneously. In addition, the system displays a calendar timeline including calendar information in the status bar, wherein one end of the calendar timeline represents a beginning of a displayed time period and an opposite end of the calendar timeline represents an end of the displayed time period. Moreover, the status bar is continuously viewable to a user regardless of what other content is being displayed on the display.

The invention relates to a method for preparing a small intestinal submucosa (SIS) soft tissue repair patch, and the soft tissue repair patch prepared by the method. The invention also relates to application of the soft tissue repair path to tissue repair.

A multi-party communication enhancer includes an audio data input adapted to receive voice data associated with a plurality of communication participants. A participant identifier included in the multi-party communication enhancer is adapted to distinguish the voice of a number of communication participants as represented within the received voice data. A cue generator, also included in the multi-party communication enhancer, is operable to generate a cue for each distinguished voice, with the generated cue being outputted in association with the corresponding distinguished voice.

Stem cell reprogramming genes cloned into a single sustained expression-type Sendai viral vector are shown to reprogram differentiated somatic cells into induced pluripotent stem (iPS) cells without integration of vector sequences into the host cell's genome. The genes are transduced into normal differentiated somatic cells via infection with recombinant Sendai virus. After expression of the reprogramming genes and subsequent induction of pluripotency, the vector genome RNA including the reprogramming genes is removed from the cell to establish an iPS cell that is genetically identical to the parent somatic differentiated cell thus reducing the risk of tumorigenic transformation caused by random integration of vector sequences into the host genome. The method promises to provide safe, autologous iPS cells that can be used for human cell replacement and regeneration therapeutic applications.

The invention provides cell-adherent polymeric coatings for articles having a nanofibrillar structure. The coatings include a synthetic, non-biodegradable polymer having at least one pendent amine group, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long term culturing of cells using the polymer coated nanofibrillar structures. The polymer coated nanofibrillar structures of the invention have been found to be particularly useful for the growth and differentiation of cells, including neural precursors.

The invention provides cell-adherent polymeric coatings for articles, the coating including a synthetic, non-biodegradable polymer having a plurality of pendent amine groups, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long-term attachment of cells using the polymeric coatings.

Methods of stimulating or increasing differentiation to regulatory T cells, cultures of regulatory T cells and methods of reducing or decreasing an immune response, inflammation or an inflammatory response, among other things, are provided. Methods include, among other things, contacting blood cells or T cells with an amount of TGF-beta or a TGF-beta analogue and a retinoic acid receptor agonist, or an amount of a retinoid X receptor (RXR) or peroxisome proliferator activated receptor-gamma (PPARgamma) agonist, sufficient to stimulate or increase differentiation to regulatory T cells. Cultures of regulatory T cells include T cells that express a marker associated with regulatory T cells, such as cultures in which regulatory T cells represent, for example, 30% or more of the total number of cells in the culture.

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.

Stem cells, e.g. HSC and MSC-like stem cells, present in adipose tissue are used to treat diseases and disorders that would benefit from a hematopoietic stem cell transplant. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic renal benefit.

A weight-controlled, motorized vehicle can be accelerated in either direction, steered, or decelerated without hand controls and without repositioning of a rider situated atop the vehicle. Like a skateboard, the vehicle is normally ridden by a rider standing upon a platform on top of the vehicle with one foot in front of the other. The vehicle is propelled forward when the rider increases weight on the front portion of the platform and backward when weight is increased on the rear portion. The vehicle is steered like a skateboard, by tilting the platform from side-to-side. An improved drive system utilizes a single front drive wheel to power and steer the vehicle. The drive system eliminates need of a flexible power transmission coupling such as a U-joint or constant-velocity joint. It also eliminates need of the differential mechanism normally required for two laterally spaced drive wheels.

The present invention relates to a protected implantable sensor and methods of making the same. Sensors of the present invention are protected from deposition of extraneous materials or tissue by a non-biological or biological barrier. In embodiments where the sensor is protected by a non-biological barrier, the protected sensor includes a compliant member that forms part of one or more chambers that includes a substantially non-compressible medium disposed within the chamber(s). The medium is in contact with a surface of the sensor and with a second side of the compliant member. In embodiments where the sensor is protected by a biological barrier, the protected sensor is covered entirely or in part by a layer of endothelial cells. The endothelial cells may be attached to the sensor via interaction with an antibody, antigen binding fragment thereof, or small molecule that specifically binds to a ligand on the cell membrane or cell surface of endothelial cells and / or their progenitor cells or one or more extracellular matrix (ECM) molecules to which the desired cells naturally adhere. In specific embodiments, the implantable sensor to be protected a resonating sensor comprising at least one vibratable member.