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Integral engineering rack of interface osteochondro tissue with bionic function

A technology of composite tissue and bionic function, applied in prosthesis, medical science, joint implants, etc., can solve the lack of functional interface of osteochondral composite tissue, poor mechanical strength of graft and host integration, quality defects of reconstructed tissue, etc. question

Inactive Publication Date: 2007-08-22
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Problems solved by technology

[0007] The present invention aims at the lack of ideal functional interface in the osteochondral composite tissue constructed in the prior art; there are defects in the quality of the reconstructed tissue, poor integration of the graft and the

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  • Integral engineering rack of interface osteochondro tissue with bionic function

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Embodiment Construction

[0016] As shown in Figure 1, 1-cartilage layer, 2-calcification layer, 3-subchondral bone layer, 4-pore,

[0017]The integrated engineering support of the present invention is composed of a cartilage layer 1, a calcification layer 2 and a subchondral bone layer 3 from top to bottom, and organically connects between the cartilage layer 1 and the calcification layer 2, and between the calcification layer 2 and the subchondral bone layer 3 , the cartilage layer 1 and the subchondral bone layer 3 are closely connected by means of the special composition and structure of the calcification layer 2, and are organically connected to each other. There is no boundary between each layer, but the structure and composition of each layer are different. The composition material of the cartilage layer 1 is medical type II collagen and chitosan; the weight ratio of type II collagen is 80% to 90%, and the weight ratio of chitosan is 10% to 20%, and the weight ratio of type II collagen / chitosan i...

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Abstract

The integral engineering rack of interface osteochondro tissue with bionic interface includes from the top to the bottom one cartilage layer, one calcified layer and one bone layer below cartilage connected organically. The cartilage layer consists of type II collagen and chitosan connected in covalent bond; the calcified layer consists of type II collagen and hydroxyapatite connected in covalent bond; the bone layer below cartilage consists of type I collagen and hydroxyapatite connected in covalent bond; and each of the cartilage layer and the bone layer below cartilage has at least one pore of 100-500 micron size. The integral engineering rack of the present invention has excellent biocompatibility, excellent degradability, sufficient mechanical first and bionic interface function.

Description

technical field [0001] The invention relates to a tissue engineering support for repairing human joint osteochondral defects, in particular to an integrated engineering support for osteochondral composite tissue with a bionic function interface. Background technique [0002] Osteochondral defects at the end of movable joints caused by trauma, infection, and degeneration are common orthopedic clinical diseases, often manifested as intractable pain, joint movement disorders, and severe cases may cause loss of motor function. According to statistics, the incidence of articular osteochondral defects in the United States is about 1.5‰ to 3‰, and it is 5 to 6 times that in my country. Because articular cartilage has no blood vessels, nerves, and lymphatic systems, osteochondral defects with a diameter of more than 2 mm to 4 mm can hardly be completely repaired. The existing treatment methods all have obvious defects, and it is difficult to make them truly achieve natural repair a...

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Application Information

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IPC IPC(8): A61L27/40A61F2/30
Inventor 王富友段小军杨柳戴刚
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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