The invention provides a novel amino acid peritoneal dialysate and relates to the technical field of peritoneal dialysis. The novel amino acid peritoneal dialysate comprises N-acetyl-L-cysteine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-phenylalanine and other amino acids. The novel amino acid peritoneal dialysate comprises buffer base, an electrolyte and the like; the buffer base is any one of lactate, citrate, isocitrate, pyruvate, succinate, fumarate, malate and oxaloacetate; the electrolyte comprises sodium ions, calcium ions, magnesium ions and chloride ions. The novel amino acidperitoneal dialysate provided by the invention has the benefits of better ultra-filtration drug effect, capability of preventing cardiovascular complications, stronger antioxidant stress capability and the like.