The invention discloses a novel Chinese medicinal composition for treating kidney failure diseases and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: medlar, American ginseng, campanumaea pilosula, raw astragalus, pantotrichum, common yam rhizome, sea horse, medicinal indianmulberry root, cordyceps sinensis, lucid ganoderma, south dodder seed, gordon euryale seed, eucommia bark, radix rehmanniae preparata, Chinese angelica, white paeony root, cochinchnese asparagus root, glossy privet fruit, amur corktree bark, Indian buead, gardenia, plantain seed, longhairy antenoron herb, talc and oriental waterplantain rhizome. The Chinese medicinal composition can be prepared into any common oral preparation by the conventional Chinese medicinal preparation method. The Chinese medicinal composition can obviously improve symptoms such as edemaofface, edema of limbs, inability to get food down, bradypsychia, uroschesis, creatinine, albuminuria, dreaminess, insomnia and the like, and can improve various complications which seriously influence health and life and even cause depth such as infection, diseases of cardiovascular systems, nervous systems and digestive systems, electrolyte disturbance, metabolic acidosis and the like caused by renal function hydrolysis. The Chinese medicinal composition has the advantages of exact clinical effects, obvious curative effect, quick response, low cost, basically no toxic or side effects and the like because the Chinese medicinal composition basically combines medicaments having homology of medicament and food specified in national formulary.