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Medicinal composition

A composition and drug technology, applied in the direction of drug combination, active ingredients of alkali/alkaline earth metal chlorides, metabolic diseases, etc., can solve the problems of clinical blood volume expansion, low expansion strength of hydroxyethyl starch, short expansion time, etc. problems, to achieve convenient clinical application, stable properties, and good results

Inactive Publication Date: 2006-08-09
SHANDONG CHENGCHUANG PHARMA R&D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the expansion strength of hydroxyethyl starch with this molecular weight is small and the expansion time is short, which cannot effectively meet the needs of clinical blood volume expansion.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of Hydroxyethyl Starch 130 / 0.4 Sodium Lactated Ringer Injection:

[0020] Prepare according to the following proportions:

[0021] Hydroxyethyl starch 130 / 0.4 55.0g

[0022] Sodium chloride 5.5 g

[0023] Sodium Lactate 2.9g

[0024] Potassium chloride 0.28 g

[0025] Calcium Chloride (CaCl 2 2H 2 O) 0.19 g

[0026] Add water for injection to 1000ml

[0027] Put the above raw materials into a container with a stirrer in proportion, add water for injection and stir to dissolve, adjust the pH to 5.0-7.0, add water for injection to 1000 ml, add 1.0 g of activated carbon, stir, and boil for 20 minutes. Then use a medium-speed sand filter stick to filter, and then filter with a 0.45 micron microporous membrane. Filling, 100-1000ml per bag, stoppered and capped. 115 degrees circulating steam sterilization for 30 minutes. The pharmaceutical composition of the present invention is obtained after sterilization. Through content determination, the content of...

Embodiment 2

[0029] Preparation of Hydroxyethyl Starch 130 / 0.4 Sodium Lactated Ringer Injection:

[0030] Prepare according to the following proportions:

[0031] Hydroxyethyl starch 130 / 0.4 65.0g

[0032] Sodium chloride 6.5 grams

[0033] Sodium Lactate 3.3g

[0034] Potassium chloride 0.32 g

[0035] Calcium Chloride (CaCl 2 2H 2 O) 0.21 g

[0036] Add water for injection to 1000ml

[0037] Put the above raw materials into a container with a stirrer in proportion, add 70% water for injection, stir to dissolve, adjust the pH to 5.0-7.0, add water for injection to the full amount, add 2.0g of activated carbon, stir, boil and keep for 30 minutes . Then filter with a titanium filter, and then filter with a 0.45 micron microporous membrane. Filling, 100-1000ml per bottle, stoppered and capped. Autoclave at 121°C for 20 minutes. The pharmaceutical composition of the present invention is obtained after sterilization. Through content determination, the content of each main drug is c...

Embodiment 3

[0039] Preparation of hydroxyethyl starch 130 / 0.4 compound electrolyte injection:

[0040] Prepare according to the following proportions:

[0041] Hydroxyethyl starch 130 / 0.4 55.0g

[0042] Sodium chloride 4.8 grams

[0043] Sodium Gluconate 4.6g

[0044] Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O) 3.4 g

[0045] Potassium chloride 0.34 g

[0046] Magnesium Chloride (MgCl 2 ·6H 2 o) 0.28 g

[0047] Add water for injection to 1000ml

[0048]The above-mentioned raw materials are put into a container with a stirrer in proportion, dissolved according to the method described in Example 1, pH is adjusted to 6.0-8.0, activated carbon is adsorbed, filtered, filled and sterilized to obtain the product of the present invention. Through content determination, the content of each main drug is close to the lower limit of the standard prescription.

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PUM

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Abstract

The present invention relates to a medicine composition. It is composed of hydroxyethyl starch 130 / 0.4 and electrolyte balancing solution, in which the molecular weight of hydroxyethyl starch is 100000-150000, its content in every 100 ml of said composition is 5.4-6.6 g, and the electrolyte balancing solution is sodium lactate Ringer's injection or compound electrolyte injection. Its production process is simple and its product quality is stable.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to the pharmaceutical composition of hydroxyethyl starch 130 / 0.4 and electrolyte balance liquid, and belongs to the field of pharmaceutical preparations. Background technique [0002] Hypovolemia is a common perioperative problem in surgical patients. The causes of hypovolaemia include fluid loss caused by surgical diseases and preoperative bowel preparations (such as enemas, preoperative fasting, etc.), cardiovascular effects of anesthetic drugs, and intraoperative blood loss and fluid loss. In the case of decompensated cardiovascular function, hypovolemia will cause blood pressure to drop or even shock, which will lead to a drop in organ tissue perfusion pressure, especially visceral perfusion failure. In severe cases, it can lead to damage to the visceral mucosal barrier, causing bacterial translocation and systemic inflammatory response and multiple organ dysfunction syndrome. ...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K31/191A61K31/718A61P3/12
Inventor 王志刚左力
Owner SHANDONG CHENGCHUANG PHARMA R&D
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