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Sodium acetate anhydrous and preparation method and usage thereof

A technology of anhydrous sodium acetate and sodium acetate trihydrate, which is applied in the fields of carboxylate preparation, active ingredients of anhydride/acid/halide, metabolic diseases, etc., can solve the problem of harmfulness to the human body, unsuitable for pharmaceutical preparations, and inapplicable to the human body, etc. problems, to achieve the effect of easy storage, low production cost and good product quality

Active Publication Date: 2008-03-12
HUBEI DUORUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Sodium acetate is a pH regulator. At present, there is no medicinal anhydrous sodium acetate in the market. Commercially available products are all chemical reagents containing 3 crystal waters. This reagent cannot be used for human body
In addition, most of the existing preparation methods of sodium acetate use organic solvents as solvents or adopt techniques such as organic solvent extraction to remove impurities, so that the chemical reaction is more intuitive, but organic solvents are often harmful to the human body and are not suitable for pharmaceutical preparations.

Method used

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  • Sodium acetate anhydrous and preparation method and usage thereof
  • Sodium acetate anhydrous and preparation method and usage thereof
  • Sodium acetate anhydrous and preparation method and usage thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Take calcium acetate and sodium carbonate according to the molar ratio of 1:1~1:1.2, dissolve calcium acetate and sodium carbonate in water respectively, and the weight ratios of calcium acetate, sodium carbonate and water are 1:2~1:3 and 1:2 respectively 7~1:8, and then mixed for metathesis reaction, the reaction temperature is 90~110°C, the reaction time is 10~60 minutes, remove impurities and decolorize with activated carbon to obtain sodium acetate trihydrate; heat the sodium acetate trihydrate to 120-130°C, concentrated under reduced pressure, cooled to precipitate crystals, dried to obtain anhydrous sodium acetate, the molecular weight of the anhydrous sodium acetate is 82.03, and has the following chemical structure:

[0015]

[0016] The anhydrous sodium acetate is clinically used in supplementation of circulating blood volume and extracellular fluid and metabolic acidosis when interstitial fluid is reduced.

[0017] The anhydrous sodium acetate is clinically...

Embodiment 2

[0019] Dissolve 500 grams of calcium acetate in 1000 ml of water, add 335.1 grams of sodium carbonate dissolved in 2500 ml of water, heat until the water boils, cool to room temperature, filter with suction, concentrate the mother liquor to 1000 ml, add 50 grams of activated carbon and heat to boiling for 15~ After 25 minutes, filter, concentrate the filtrate to 400ml, cool and precipitate crystals to obtain sodium acetate trihydrate, heat the sodium acetate trihydrate to 120-130°C and concentrate under reduced pressure, cool to precipitate crystals, dry at 120°C to obtain anhydrous Sodium acetate has a molecular weight of 82.03 and has the following chemical structure:

[0020]

[0021] The anhydrous sodium acetate is clinically used in supplementation of circulating blood volume and extracellular fluid when interstitial fluid is reduced and metabolic acidosis, and is used as the main component of oral tablets, capsules, freeze-dried injections and injections.

Embodiment 3

[0023] Take acetic acid and sodium hydroxide according to the molar ratio of 1:1.2~1:1.5, add acetic acid to the reaction flask, then add sodium hydroxide and water to the reaction flask, the weight ratio of sodium hydroxide and water is 1:2~1:3 , react at room temperature for 0.5-1.5 hours, concentrate to dryness at 120-130°C under reduced pressure; add 1000ml of water and activated carbon, reflux for 15-20 minutes, filter out the activated carbon to obtain sodium acetate trihydrate. This sodium acetate trihydrate is heated to 120~130 ℃, and concentrated under reduced pressure, cools and precipitates crystallization, obtains anhydrous sodium acetate, and its molecular formula, molecular weight and chemical structural formula are the same as embodiment 1.

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Abstract

The molecular formula of an anhydrous sodium acetate is C2H3NaO2; the molecular weight is 82.03; and the anhydrous sodium acetate has the following chemical structure. The preparation method is: the sodium acetate trihydrate is got and heated to be between 120 and 130 DEG C; then the sodium acetate trihydrate is decompressed and concentrated, cooled and crystallized, and dried to get the anhydrous sodium acetate. The anhydrous sodium acetate is clinically applied in the circulating blood volume, the supplement of the outer liquid of the cell when the issue liquid is reduced, and the metabolic acidosis. The advantages are: the anhydrous sodium acetate has the good solubility in water; the chemical stability is good, suitable for the human medication requirements; the anhydrous sodium acetate is easy to be stored. Because the anhydrous sodium acetate can be dissolved in water; the anhydrous sodium acetate is more suitable for the pharmaceutical preparation, in particular for the preparation of the injection. The preparation method is characterized in the high collection rate, the good product quality, the low production cost, no environmental pollution, and so on. The anhydrous sodium acetate is clinically applied in the circulating blood volume, the supplement of the outer liquid of the cell when the issue liquid is reduced, and the metabolic acidosis.

Description

technical field [0001] The invention relates to anhydrous sodium acetate and its preparation method and application. Background technique [0002] Sodium acetate is a kind of pH regulator. There is no medicinal anhydrous sodium acetate in the market at present. The commercially available products are all chemical reagents containing 3 crystal waters, which cannot be used for human body. In addition, most of the existing sodium acetate preparation methods use organic solvents as solvents or adopt techniques such as organic solvent extraction to remove impurities, so that the chemical reaction is more intuitive, but organic solvents are often harmful to the human body and are not suitable for pharmaceutical preparations. Contents of the invention [0003] The purpose of the present invention is to overcome the deficiencies in the prior art, to provide a kind of water-soluble, good solubility in water, good chemical stability, anhydrous sodium acetate more suitable for pharma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C53/10C07C51/41A61K31/19A61P3/12
Inventor 宋桂兰邓勇
Owner HUBEI DUORUI PHARMA
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