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771 results about "Disease progression" patented technology
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Disease Progression. The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Treating Dysfunctional Cardiac Tissue
ActiveUS20090093670A1Reduce distanceBeneficial heart geometrySuture equipmentsSurgical furnitureCongestive heart failure chfDisease progression
Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and / or slowed.
Owner:BIOVENTRIX A CHF TECH
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
InactiveUS6710040B1Easy to prepareEase of detectabilityBiocideOrganic chemistryAcute coronary syndromeDisease progression
The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, hyperglycemia, impaired glucose tolerance, metabolic syndrome (Syndrome X or insulin resistance syndrome), glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome, anxiety, depression, insomnia, chronic fatigue, epilepsy, eating disorders, chronic pain, alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of identifying an insulin secretagogue agent for diabetes.
Owner:PFIZER INC
Automatic orientation determination for ECG measurements using multiple electrodes
InactiveUS20050288600A1ElectrocardiographyCharacter and pattern recognitionDefibrillationDisease progression
Cardiac monitoring and / or stimulation methods and systems provide monitoring, defibrillation and / or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and / or an independent component analysis. Vectors may be selected and updated based on changes of position and / or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
Owner:CARDIAC PACEMAKERS INC
Combination therapy for depression, prevention of suicide, and various medical and psychiatric conditions
InactiveUS7973043B2Preventing disease progression/modifyingDelaying/preventing relapseBiocideNervous disorderInitial treatmentTherapy resistant
The present invention relates to a new method of treatment for persons meeting diagnoses for major depressive disorder, or other unipolar (non-bipolar, non-psychotic and non-treatment resistant) depression. The method comprises administering a combination of two categories of drugs, antipsychotics or dopamine system stabilizers, in combination with a newer antidepressant such as a selective serotonin reuptake inhibitor, as initial treatment or as soon as possible. The method targets the prevention of suicide, and provides other benefits including preventing disease progression development of tolerance toward the antidepressants. Another aspect of the invention relates to using the method for alleviating cognitive distortion and related functional impairment or health risks, and / or using the method for smoking cessation or nicotine withdrawal.
Owner:MIGALY PETER
Method and System for Computational Modeling of the Aorta and Heart
A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.
Owner:SIEMENS HEALTHCARE GMBH
Method and apparatus to diagnose the metastatic or progressive potential of cancer, fibrosis and other diseases
Owner:UNIVERSITY OF ROCHESTER
Continuous noninvasive glucose monitoring in diabetic, non-diabetic, and critically ill patients with oct
InactiveUS20070232872A1Efficient removalIncrease contrastDiagnostic recording/measuringSensorsCritically illAnalyte
New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Dipeptidyl peptidase IV inhibiting fluorinated cyclic amides
InactiveUS20040110817A1Ease of preparation and detectabilityGood metabolic stabilityBiocideSenses disorderDiabetic retinopathyDisease progression
The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for treating diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, hyperglycemia, impaired glucose tolerance, metabolic syndrome (Syndrome X or insulin resistance syndrome), glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome, anxiety, depression, insomnia, chronic fatigue, epilepsy, eating disorders, chronic pain, alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of identifying an insulin secretagogue agent for diabetes.
Owner:PFIZER INC
Cardiac Anchor Structures, Methods, and Systems for Treatment of Congestive Heart Failure and Other Conditions
ActiveUS20100016655A1Reduce distanceBeneficial heart geometrySuture equipmentsSurgical furnitureCongestive heart failure chfMedical device
Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and / or slowed.
Owner:BIOVENTRIX A CHF TECH
Method For Monitoring Disease Progression or Recurrence
ActiveUS20080161420A1BiocideMicrobiological testing/measurementDisease progressionGENETIC ABNORMALITY
Owner:ESOTERIX GENETIC LAB
Conjunctive analysis of biological marker expression for diagnosing organ failure
InactiveUS6461828B1Easy to useHigh riskAnalysis using chemical indicatorsEnzymologyOrgan systemOrganism
A diagnostic tool is disclosed for accurately and rapidly diagnosing the condition of an ailing organ. Although applicable to numerous organ and organ systems, this application particularly illustrates the concept of conjunctive marker utilization as it relates to diagnosing and distinguishing congestive heart failure. The invention particularly relates to the conjunctive utilization of cardiac Troponin I (cTn-I) and natriuretic peptide, e.g. ANP, pro-ANP, BNP, pro-BNP and CNP as a retrospective tool for diagnosing the underlying mechanism of heart failure and as a prospective analytical device for monitoring disease progression and efficacy of therapeutic agents.
Owner:SYN X PHARMA
System and method for monitoring disease progression or response to therapy using multi-modal visualization
Owner:SIEMENS HEALTHCARE GMBH
Chimeric proteins for diagnosis and treatment of diabetes
InactiveUS6982323B1Enhance the beneficial effectEasy diagnosisSugar derivativesPeptide/protein ingredientsImmunodominant EpitopesPancreas
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of Type 1 diabetes, determining prognosis of Type 1 diabetes patients early in disease progression, and in evaluating patients for suitability as recipients of transplants of pancreatic cells or tissues. The administration of the proteins of the invention in accordance with the immunomodulatory methods of the invention results in beneficial effects on disease development and severity in patients suffering from or predicted to be at risk of developing Type 1 diabetes, as well as on the outcome of transplants of pancreatic cells or tissues in Type 1 diabetes patients.
Owner:ALEXION PHARMA INC
Extending time to disease progression or survival in cancer patients
InactiveUS20060188509A1Extension of timeExtends TTPOrganic active ingredientsDigestive systemBiological activationSurgery
The present application describes extending time to disease progression or survival in a cancer patient, where the patient's cancer displays HER activation, by treating the patient with a HER dimerization inhibitor, such as pertuzumab.
Owner:GENENTECH INC
TP53 gene expression and uses thereof
InactiveUS20080234138A1Microbiological testing/measurementLibrary screeningDisease progressionCancer research
The present invention is drawn to diagnosis, prognosis and treatment of multiple myeloma. In this regard, the present invention discloses importance of down-regulation of TP3 gene in multiple myeloma and its use as an independent progostic indicator of multiple myeloma. Additionally, the present invention also discloses novel-TP53 associated genes and demonstrates the clinical relevance of these alterations to disease progression.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSAS
Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds
The present invention relates to a method of making novel dipeptidyl peptidase-IV ("DPP-IV') inhibitor compounds useful for treating, inter alia, diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, metabolic syndrome (Syndrome X or insulin resistance syndrome), hyperglycemia, impaired glucose tolerance, glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.
Owner:PFIZER INC
Integrated wireless patch for physiological monitoring
A sensor system in accordance with the present invention comprises a plane member, a plurality of electrodes within the plane member, adapted to contact a human body to detect and monitor human generated voltages. The sensor can be applied to monitor a variety of applications relating to health, disease progression, fitness and wellness. Some of the specific applications include the monitoring of ECG, EEG, EMG, glucose, electrolytes, body hydration, dehydration, tissue state and wounds. Various aspects of the invention are shown by illustrating certain embodiments. Many other embodiments can be used to implement the invented schemes.
Owner:LIFESIGNALS INC
Anti-CD38 human antibodies and uses thereof
ActiveUS20100285004A1Effectively mediate killing of CD38-overexpressingBacteriaPeptide/protein ingredientsAntiendomysial antibodiesAntigen binding
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore
Owner:MORFOZIS AG
Multi-format, multi-domain and multi-algorithm metalearner system and method for monitoring human health, and deriving health status and trajectory
InactiveUS20170249434A1Effective therapyAccurate trackingDigital data information retrievalTelemedicinePersonalizationDisease monitoring
Real-time and individualized disease monitoring is central to rapidly evolving medical sciences and technologies, but for the vast majority of patients, disease progression and treatment are monitored only in an irregular and discontinuous fashion. Consequently, disease progression and relapse are often allowed to proceed too far before they are detected, compromising the possibility of any effective treatment. For one patient, this can mean becoming refractory to the few early drug treatments that are available; for another, missing early detection may be deadly. This invention provides a method for the detection of early signals of disease and recovery thereof comprising a universal yet personalized health-monitoring solution using cell phones or other wearable smart device data that generate extensive real-time data. The invention further provides a system and method to provide answers to a variety of questions related to the patient health status and health trajectory. Its flexibility and generality is designed for a preferred application to rare disorders and rare questions for which other analytical system are lacking.
Owner:EARLY SIGNAL LLC
Circulating tumor cells (CTC's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients
InactiveUS20070037173A1Less side effectsImprove the quality of lifeMicrobiological testing/measurementBiological testingClinical trialOncology
A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies CTC's. The absolute number of CTC's detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. The mean time to survival of patients depended upon a threshold number of 5 CTC's per 7.5 ml of blood. Detection of CTC's in metastatic cancer represents a novel prognostic factor in patients with metastatic cancers, suggests a biological role for the presence of tumor cells in the blood, and indicates that the detection of CTC's could be considered an appropriate surrogate marker for prospective therapeutic clinical trials.
Owner:JANSSEN DIAGNOSTICS LLC
Extending time to disease progression or survival in cancer patients
InactiveUS20090155259A1Extension of timeExtends TTPOrganic active ingredientsDigestive systemBiological activationSurgery
The present application describes extending time to disease progression or survival in a cancer patient, where the patient's cancer displays HER activation, by treating the patient with a HER dimerization inhibitor, such as pertuzumab.
Owner:GENENTECH INC
Techniques for positioning therapy delivery elements within a spinal cord or brain
Owner:MEDTRONIC INC
Biological profiles and methods of use
InactiveUS20070087448A1Avoid overestimation and underestimationUnderestimation of the illness levelBiological testingMaterial analysis by using resonanceProtein profilingBiological profile
The invention provides methods to diagnose and follow the progression of disease through use of protein profile analysis.
Owner:NELSESTUEN GARY L
Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND
Cardiac anchor structures, methods, and systems for treatment of congestive heart failure and other conditions
ActiveUS8425402B2Reduce distanceLess and minimally invasiveSuture equipmentsSurgical furnitureCongestive heart failure chfDisease progression
Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension to the anchor may draw the first and second walls of the heart into contact along a desired contour so as to effect a desired change in the geometry of the heart. Additional anchors may be inserted and aligned with the first anchor to close off a portion of a ventricle such that the ventricle is geometrically remodeled and disease progression is reversed, halted, and / or slowed.
Owner:BIOVENTRIX A CHF TECH
Inflammatory bowel disease biomarkers and related methods of treatment
Biomarkers associated with inflammatory bowel disease (IBD) are provided, as well as methods of using such biomarkers for diagnosing, assessing and monitoring disease progression. The biomarkers may be measured at the protein level or the gene expression level Biomarkers may be tracked individually or in groups of two or more. The disclosed biomarkers may find particular utility in monitoring a course of therapy, such as treatment with an IL-23 antagonist. Changes in biomarker levels can also be used to confirm target engagement and therapeutic efficacy. Changes in biomarkers can also be used inform modification of a therapeutic regimen, for example to increase or decrease dosing of a therapeutic agent, such as an anti-IL-23 or anti-IL-23R anti-body.
Owner:MERCK SHARP & DOHME CORP
Method for the detection of gene transcripts in blood and uses thereof
InactiveUS20070054282A1Microbiological testing/measurementICT adaptationGene transcriptDisease progression
Owner:GENENEWS
Self-improving method of using online communities to predict health-related outcomes
ActiveUS20090131758A1Great empowermentAddress bad outcomesMechanical/radiation/invasive therapiesDrug and medicationsPersonalizationDisease progression
The invention is directed, in part, to method of using self-reported health data in online communities to predict significant health events in life-changing illnesses to improve the lives of individuals and to improve patient self-management. The invention provides a method for providing real-time personalized medical predictions for an individual patient. The method includes: providing a database containing patient information for a plurality of other patients including one or more attributes for each patient in the database; constructing a model of a disease based on disease progressions for the plurality of patients; receiving a request from the individual patient, the patient associated with one or more attributes; and making a real-time prediction for the individual patient based on the mode and the individual patient's attributes.
Owner:PATIENTSLIKEME
Antibodies specific for toxic amyloid beta protein oligomers
InactiveUS20050124016A1Animal cellsImmunoglobulins against animals/humansOligomerMonoclonal antibody
The present invention provides compositions and methods for diagnosing Alzheimer's disease (AD). In particular, the present invention provides monoclonal antibodies that specifically bind to soluble, non-fibrillar oligomeric amyloid β protein assemblies proteolytically derived from the transmembrane amyloid precursor protein (APP) while not reacting with fibrillar amyloid β protein assemblies, monoclonal antibodies that specifically bind to fibrillar amyloid β protein assemblies that do not react with soluble, non-fibrillar oligomeric amyloid β protein assemblies, and methods of use of these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and / or disease progression of AD in patients.
Owner:NORTHWESTERN UNIV +1
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