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Pharmaceutical composition of compound amino acid injection 18AA and application thereof

A compound amino acid and composition technology, applied in the field of medicine, can solve problems such as unusable disease, acid-base imbalance, adverse problems and the like

Inactive Publication Date: 2014-09-24
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compound Amino Acid Injection (18AA) is an amino acid drug (the second supplement of the Chinese Pharmacopoeia 2010 edition, p270), which is used for patients with insufficient protein intake, malabsorption and other amino acids that cannot meet the metabolic needs of the body, and is also used to improve postoperative patients. nutritional status, but in some cases, the existing preparations may lead to acid-base imbalance or other adverse reactions or restrictions on indications, which may lead to the inability to use some diseases or unexpected adverse problems after use, or make the clinical The selectivity of the drug or the drug is so limited that it is the focus of or object of study in pharmacy or pharmacology or related disciplines

Method used

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  • Pharmaceutical composition of compound amino acid injection 18AA and application thereof
  • Pharmaceutical composition of compound amino acid injection 18AA and application thereof
  • Pharmaceutical composition of compound amino acid injection 18AA and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0288] Embodiment 1, the preparation of compound amino acid injection (18AA), prescription:

[0289] L-proline 10.00 grams; L-serine 10.00 grams; L-alanine 20.00 grams; L-isoleucine 35.2 grams;

[0290] L-leucine 49.0 grams; L-aspartic acid 25.0 grams; L-tyrosine 2.50 grams; L-glutamic acid 7.5 grams; L-phenylalanine 53.30 grams; L-arginine 41.35 grams; L-Lysine acetate 48.55 grams; L-valine 36.0 grams; L-threonine 25.0 grams; L-histidine 18.5 grams; L-tryptophan 9.0 grams; L-methionine 22.5 grams;

[0291] L-cystine 1.0g; Glycine 76.0g; Sorbitol 500.0g; Sodium bisulfite 5.0g;

[0292]

[0293] Preparation Process:

[0294] Weigh each raw material and auxiliary material according to the prescription; add 8000ml of water for injection into the dispensing tank, heat to boil, repeatedly vacuumize and replace with nitrogen to reduce the oxygen content in the dispensing tank, and then fill the tank with nitrogen during the whole process. Between 96°C and 85°C, raw and auxilia...

Embodiment 2

[0296] Embodiment 2, the preparation of compound amino acid injection (18AA), prescription:

[0297] L-proline 10.00 g;

[0298] L-serine 10.00 g;

[0299] L-alanine 20.00 grams;

[0300] L-isoleucine 35.2 grams;

[0301] L-leucine 49.0 grams;

[0302] L-aspartic acid 25.0 grams;

[0303] L-tyrosine 2.5 grams;

[0304] L-glutamic acid 7.5 grams;

[0305] L-phenylalanine 53.3 grams;

[0306] L-arginine 41.35 grams;

[0307] L-Lysine acetate 48.55 grams;

[0308] L-valine 36.0 grams;

[0309] L-threonine 25.0 grams;

[0310] L-histidine 18.5 grams;

[0311] L-tryptophan 9.0 grams;

[0312] L-methionine 22.5 grams;

[0313] L-cystine 1.0 g;

[0314] Glycine 76.0 grams;

[0315] Sorbitol 500.0 grams;

[0316] Edetate calcium sodium 0.5 g (antioxidant);

[0317] Tartaric acid 2.0g (antioxidant)

[0318]

[0319] Preparation Process:

[0320] Weigh each raw material and auxiliary material according to the prescription; add 7500ml of water for injection into the...

Embodiment 3

[0322] Embodiment 3, the preparation of compound amino acid injection (18AA), prescription:

[0323] L-proline 11.00 grams; L-serine 10.00 grams; L-alanine 20.00 grams; L-isoleucine 35.2 grams;

[0324] L-leucine 49.0 grams; L-aspartic acid 25.0 grams; L-tyrosine 2.50 grams; L-glutamic acid 7.5 grams; L-phenylalanine 53.30 grams; L-arginine 48.35 grams; L-Lysine acetate 48.55 grams; L-valine 36.0 grams; L-threonine 25.0 grams; L-histidine 18.5 grams; L-tryptophan 9.0 grams; Methionine 25.2 grams;

[0325] L-cystine 1.0g; glycine 76.0g; xylitol 500.00g; edetate calcium sodium 0.5g, citric acid 5g;

[0326]

[0327] Preparation Process:

[0328]Weigh each raw material and auxiliary material according to the prescription; 1), add xylitol of the prescription amount in a batching bucket, add 1000ml of water for injection, stir to dissolve, add 0.3 g of activated carbon, stir, heat and boil for 20 minutes, cool to 65-80 2), add 7000ml of water for injection into the concentrat...

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Abstract

The invention provides a pharmaceutical composition of compound amino acid injection 18AA. The pharmaceutical composition disclosed by the invention can be used for preparing drug for treating patients with body metabolism needs on amino acid being not unsatisfied due to protein intake deficiency, absorbing barrier, and the like, drug for improving the nutrition status of a postoperative patient, and drug for preventing or treating metabolic acidosis and the like, so that the prepared product has widened application people or better targeting performance and better clinical safety during clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, it is provided for patients whose amino acids cannot meet the metabolic needs of the body, such as insufficient protein intake and malabsorption. The pharmaceutical composition of compound amino acid injection (18AA), which is also used to improve the nutritional status of patients after surgery, and its preparation and application. The product of the present invention is more suitable for patients who need to supplement 18AA amino acid injection under many diseases or symptoms such as metabolic acidosis or hyperchloremic metabolic acidosis, and the product of the present invention has wider safety or better More or newer indications or adapted populations, etc. Background technique [0002] Protein is the main component of cell structure. The basic unit of protein structure is amino acid. The human body needs to take in a certain amount of protein every day to meet the needs of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61K9/08A61K47/26A61P3/02A61K31/198A61K31/401A61K31/405
Inventor 刘力
Owner 刘力
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