907 results about "Chinese pharmacopoeia" patented technology

The invention relates to the field of a pharmaceutical preparation, and in particular discloses an olaparib solid dispersion preparation and a preparation method thereof. The olaparib solid dispersion preparation consists of olaparib, povidone, a special lubricating agent, a special disintegrating agent and a thinner. According to the olaparib solid dispersion preparation disclosed by the invention, povidone, replacing the existing copovidone, is used as a matrix polymer, and appropriate auxiliary materials are added, so that the povidone, as the matrix polymer of the olaparib solid dispersion preparation, is wide in source, low in cost and clear in quality standard in accordance with Chinese Pharmacopoeia; meanwhile, the dissolution effect, bioavailability and stability of the preparation are guaranteed; and the industrial production of the olaparib solid dispersion preparation is facilitated.

The invention discloses an ecological cultivation method for paris polyphylla, and relates to the technical field of planting industry. The cultivation method mainly includes the steps of land selecting, cultivating, managing, insect controlling, harvesting and the like. By the adoption of the method, standardized planting of the paris polyphylla is achieved, moreover, the growth period is short, and the yield can be improved by over 30%; due to the facts that organic fertilizer is mainly adopted, and usage of pesticides is limited, the rootstock used as medicine meets all provisions in the item of paris polyphylla in the first part of < Chinese pharmacopoeia > (2010 edition), and pesticide residue, heavy metal and other harmful substances are all lower than standard provisions; the cost is reduced, and the medicinal quality is ensured. Because planting and processing of the paris polyphylla have strict requirements for various chemical contamination, and while society and economy benefits are created, good ecological environment benefits are brought about.

The invention discloses a process for refining valsartan, which includes the following steps: dissolving crude products of the valsartan with an alcoholic solvent or an ester solvent; adding inorganic base to form salt, so that salt of valsartan is obtained through centrifugation; adding the obtained salt of the valsartan into the ester solvent; adding an aqueous solution of an inorganic acid for acidification; delaminating; recovering a drying solvent after the ester solvent layer is washed with water; adding the ester solvent to dissolve materials; and obtaining the valsartan through stirring, cooling crystallization, centrifugation and drying after dissolution. The process is simple in operation, high in yield, low in cost and good in quality of the obtained valsartan, all the reagents are common, cheap and easy to obtain, and simultaneously, the process is beneficial to environmental protection and suitable for industrial production. The quality of the obtained valsartan conforms to a standard of Chinese Pharmacopoeia 2010, and the refining mass yield exceeds 75%.

The invention discloses a purification method of tryptophan; wherein, the tryptophan to be purified is dissolved in water; filtrate which is absorbed after being added with surface oxidative activated carbon is treated with vacuum condensation into a volumn which is 6 to 10 percent of the original volume at the temperature of 40 to 65 DEG C, and the temperature is reduced to 3 to 5 DEG C to carry out stirring and crystallization to obtain pure products; an intermittent concentration cooling crystallization mode is preferably chosen in the concentration process. The purification method basically has no three wastes; the mother liquor can be recycled and used for a plurality of times; the purification method is low in cost, simple in technical control, high in the purity of the obtained products and low in impurity content; and the purification method more conveniently obtains the tryptophan products which meet the requirements of the version 2005 of Chinese pharmacopoeia and the 29th version of American pharmacopoeia.

The invention discloses a traditional Chinese medicine composition for treating acute enteritis and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: medicated leaven, malt, Alisma orientale, Poria, Rhizoma atractylodiss, Magnolia officinalis, Atractylodes macrocephaia, Chinese yam, coix seed, Amomum villosum, honeysuckle, dandelion, Chinese violet, plantain seed, gordon euryale seed, Limonitum, blighted wheat, Amomum cardamomum, cinnamon, nutgall, angelica, Ligustrum lucidum, cherokee rose and the like. The traditional Chinese medicine composition can be prepared into any one commonly used oral preparation according to the conventional method of traditional Chinese medicine preparations. The invention can obviously improve the symptoms of excessive diarrhea, loose stool, watery stool, abdominal pain, nausea, vomiting, dyspepsia, fever, body pain, limb weakness and the like, and has obvious clinical curative effect, significant curative effect and rapid effect. Since the traditional Chinese medicine composition adopts medicinal and edible medicines stipulated in the Chinese Pharmacopoeia to compound, the composition has the advantages of low cost, basically no toxicity and side effects and the like.

The invention discloses a method for propagating bilateral trichosanthes kirilowii maxim seeds, seeds are stored in aired fruit, peeled out from the fruit during pregermination and also soaked by 20% biogas slurry for 24 hours, seeding and seedling culturing are completed in a nutrition pot and row cover seedling culture manner, nutrition soils in nutrition pots are the mixed soils of 60% decomposed organic fertilizer and 40% topsoil, the temperature of a row cover before the seedling emergence of the seeds is between 30-32 DEG C, the bed temperature after the seedling emergence is about 25 DEG C, and seedlings are transplanted to a land when reaching above 10 centimeter; and enough base fertilizer can be applied in the land in advance, furrows with the width of 1.5 centimeters are formed, the transplanting spacing is 1.5 meters multiplied by 1 meter, a leaf fertilizer and an additional fertilizer are sprayed timely during the field management period, and hand pollination is carried out during the flowering periods of the second year and the third year. The germination rate of the seeds reaches 90%, the yield can be improved by about 20%, the extract content of the medical bilateral trichosanthes kirilowii maxim is the highest, the extract content of the all tichosanthes kirilowii maxim accounts for 39.8%, the extract content of Mongolian snake gourd root accounts for 15.6%, and the extract contents of both the all tichosanthes kirilowii maxim and the Mongolian snake gourd root are higher than the quality standards which are stipulated in Chinese Pharmacopoeia.

The invention relates to an orally taken traditional Chinese medicine capsule special for treating neck, waist and leg pains caused by various causes, which comprises the following formulation by weight (in terms of preparing 1,000 granules of orally taken capsules as standard): 9 to 90 grams of wild celery, 9 to 90 grams of radix gentianae macrophyllae, 9 to 90 grams of parsnip, 3 to 30 grams of wild ginger, 12 to 120 grams of loranthus parasiticus, 9 to 90 grams of angelica, 9 to 90 grams of white paeony root, 8 to 80 grams of Szechuan lovage rhizome, 9 to 90 grams of prepared rhizome of rehmannia, 10 to 100 grams of eucommia bark, 10 to 100 grams of achyranthis root, 9 to 90 grams of desertliving cistanche, 12 to 120 grams of teasel root, 5 to 50 grams of cinnamon core, 12 to 120 grams of radix codonopsitis, 12 to 120 grams of hoantchy root, 6 to 60 grams of rhizoma gastrodiae, 12 to 120 grams of Chinese wolfberry, 10 to 100 grams of kudzuvine root, 10 to 100 grams of akebia stem, 10 to 100 grams of Atractylis ovata, 10 to 100 grams of clematis root, 6 to 60 grams of safflower, 6 to 60 grams of cortex moutan, 6 to 60 grams of libanotus, 6 to 60 grams of myrrh, 10 to 100 grams of papaya, 12 to 120 grams of rhizoma drynariae, 12 to 120 grams of caulis milletiae, 10 to 100 grams of notoginseng, 10 to 100 grams of ophidian, 9 to 90 grams of scorpion, 2 to 15 chilopod, 10 to 100 grams of daemonorops draco, 12 to 120 grams of eupolyphaga, and 0 to 30 grams of radix glycyrrhizae preparata; and the quality of the 36 gouts of traditional Chinese medicine accords with prescription of Chinese pharmacopoeia, and the components are prepared into powder according to a preparation method for the traditional Chinese medicine, and canned into capsules.

The invention discloses an artificial cultivation method for savatier monochasma herb. The method comprises the aspects of planting base establishing, breeding, planting, field managing, harvesting, processing, storing and seed reserving. By adopting the cultivation method, the survival rate of medicine materials is high, the per unit area yield is high, the content of the flavonoid and other effective components is high, the quality of the medicine materials is stable, the pesticide residue does not exist, the pollution does not exist, the heave metal content is low, the quality control is easy to carry out during large-area generalizing and planting, the environmentally-friendly Chinese medicine materials are achieved, the medicine material products are accordant with the standard in the Chinese pharmacopoeia in the 2010 edition.

The invention discloses a method for determining a radix notoginseng extract and contents of five types of ginsenosides in a preparation of the radix notoginseng extract by a Fourier transform near-infrared spectrograph. The method comprises the steps that a sample is detected by an ultra-high performance liquid chromatography, moving phase builds acetonitrile and water gradient elution parameters with separation degrees higher than 1.7 in chromatographic peaks of Rg1 and Re, and the spectrum preprocessing adopts the combination of 2 to 3 methods in Savitzky-Golay polynomial smoothing, second-order differential, Noriis derivative filtering and data normalization; and three preferred wave bands of the five types of ginsenosides are modeled, and a calibration model is built by any one of a partial least squares regression method, a principal component regression method and a multiple linear regression method. The method is used for determining the contents of the five types of ginsenosides in the sample to be detected, the determining result is consistent with a result determined by the ultra-high performance liquid chromatograph basically, the requirements of 'Chinese pharmacopoeia' are met, the accuracy is high, and the determination speed is increased substantially.

The invention provides cefuroxime sodium and a preparation method thereof. The preparation method comprises the following steps that: (1) 7-aminocephalosporanic acid reacts with 2-(furan-2-base)-2-(methoxyimino) acetyl chloride to produce 3-deacety-7-aminocephalosporanic acid; (2) crystallization is conducted after the 3-deacety-7-aminocephalosporanic acid reacts with chlorosulfonyl isocyanate to produce cefuroxime acid; and (3) the cefuroxime acid is salified to obtain the cefuroxime sodium, wherein solvent for crystallization is selected from one or more of petroleum ether, normal hexane, cyclohexane, solvent oil and tetrahydrofuran. Since the preparation method adopts solvents such as petroleum ether for crystallization in the process of the preparation of the cefuroxime acid, the invention has the advantages that the yield of the product is effectively improved, the product purity is further improved, the impurity content is reduced, the product quality is compliant with Chinese Pharmacopoeia of version 2005, the operation of the method is simple, the raw materials can be easily obtained, the cost is relatively low and the industrial production can be realized easily.

The invention discloses coptis chinensis drying and tassel removing method and equipment. A drying chamber is formed by an inverted U-shaped heating cover fixed on a framework and a V-shaped deslagging screw conveyer; a roller is erected on a front frame and a rear frame of the framework and can slide in / out of the drying chamber through the front frame and the rear frame; the roller wall on the lower part of the roller consists of a screen mesh; and the roller can rotate. The invention has the advantages that coptis chinensis is dried under a temperature control condition, thereby avoiding that coptis chinensis alkaloid is heated and decomposed and ensuring that the quality of the coptis chinensis conforms to the requirement of the Chinese pharmacopoeia; meanwhile, the primary processing of the coptis chinensis is carried out in a hermetic system, thereby improving the energy utilization rate and the drying efficiency and reducing influences of smoke and silt on the working environment; and the automatic sample inlet (outlet) improves the working efficiency.

The invention discloses a novel traditional Chinese medicine composition for treating gum bleeding and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: rhizoma coptidis, snakegourd root, gypsum, common anemarrhena rhizome, reed rhizome, lophatherum herb, cape jasmine fruit, Chinese eaglewood wood, rosewood, rhubarb, radish seed, rehmannia root, dandelion, figwort root, tree peony bark, red peony root, honeysuckle flower, Chinese wolfberry root-bark, officinal magnolia bark, medicated leaven, Chinese dwarf cherry seed, dried tangerine peel, nutgrass galingale rhizome, carbonized cacumen platycladi, carbonized garden burnet root and the like. The traditional Chinese medicine composition can be prepared into any one commonly used oral preparation according to the conventional method of traditional Chinese medicine preparations. The invention can obviously improve the symptoms of gum and tooth seam bleeding, flaring up of stomach fire, burning of blood collateral vessels, deficiency of kidney-yin, deficient fire stirring up internally, extravasation of forcing blood and the like, and has obvious clinical curative effect, significant curative effect and rapid effect. Since the traditional Chinese medicine composition adopts medicinal and edible medicines stipulated in the Chinese Pharmacopoeia to compound, the composition has the advantages of low cost, basically non-toxic side effects and the like.

The invention discloses a headspace gas chromatography detection method of residual solvents in a macroporous resin extract, which can be used for simultaneously measuring normal hexane, benzene, methylbenzene, methylcyclohexane, dimethylbenzene, styrene and divinylbenzene in the macroporous resin extract. The method comprises the following steps of: (1) carrying out tests of chromatographic conditions and system suitability; (2) preparing a comparison product solution; (3) preparing a test product solution; and (4) measuring. The specificity, the system suitability, the linearity, the precision, the minimum detection limit, the recovery rate, and the like of the method all meet the requirements of drug quality standard analysis method verification and guiding principles in the first appendix of the Chinese pharmacopoeia (Version 2005).

The invention provides an oral capsule used to cure the pains in neck, waist and legs, as well as the preparation method thereof. The oral capsule is composed of 36 species of traditional Chinese medicines by the weight ratios and the formula as follows (takes preparing 1000 oral capsules as the standard): heracleum hemsleyanum michaux 9 to 90 gram, gentian root 9 to 90 gram, ledebouriella seseloides 9 to 90 gram, asarum herb 3 to 30 gram, viscum album 12 to 120 gram, angelica 9 to 90 gram, white peony root 9 to 90 gram, ligusticus wallichii franchet 8 to 80 gram, arable land 9 to 90 gram, cortex eucommiae 10 to 100 gram, butter 10 to 100 gram, butcher shop 9 to 90 gram, Japanese teasel 12 to 120 gram, cassia bark 5 to 50 gram, codonopsis pilosula 12 to 120 gram, astragalus root 12 to 120 gram, rhizoma gastrodiae 6 to 60 gram, Chinese wolfberry 12 to 120, kudzu root 10 to 100 gram, akebiaquinata 10 to 100 gram, atractylis ovata 10 to 100 gram, clematis chinensis 10 to 100 gram, safflower 6 to 60 gram, cortex moutan 6 to 60 gram, mastic 6 to 60 gram, common myrrh 6 to 60 gram, Chinese flowering quince 10 to 100 gram, drynaria 12 to 120 gram, caulis spatholobi 12 to 120 gram, panax notoginseng 10 to 100 gram, crow 10 to 100 gram, dried body of scorpion 9 to 90 gram, centipedes 2 to 15, dragon blood 10 to 100 gram, eupolyphaga 12 to 120 gram and broiled licorice root 0 to 30 gram; the quality of all traditional Chinese medicines satisfies the standard of the Chinese Pharmacopoeia, and the traditional Chinese medicines are made into powder according to the Chinese traditional medicine preparation method, and are then canned into capsules.

The invention discloses several fresh rhizoma gastrodiae drying methods, in which the rhizoma gastrodiae is put into one or sequentially two or more different equipment to be dried. In a complex drying method, the rhizoma gastrodiae is put into equipment for easily removing moisture on the surface of the rhizoma gastrodiae first and then is put into equipment for easily removing moisture inside the rhizoma gastrodiae, so that active components in the rhizoma gastrodiae can be prevented from being destroyed, and the moisture content of the rhizoma gastrodiae can quickly reach a standard required in Chinese Pharmacopoeia; harm caused by sulfur fumigation in the processing process is avoided; through content comparison and efficacy comparison among five active components in the rhizoma gastrodiae in different processing groups, an optimal processing method is selected, and the accuracy and reliability of the method can be reflected better.

The invention discloses a novel traditional Chinese medicine composition for treating toothache and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: pricklyash peel, clove, storax, venenum bufonis, borneol, camphor, grassleaf sweetflag rhizome, cornu saigae tatariace powder, tall gastrodia tuber, the larva of silkworm with botrytis, nidus vespae, catechu, dragon blood, unbracteolated spurge root, Chinese eaglewood wood, rosewood, rhubarb, officinal magnolia bark, villous amomum fruit, atractylodes rhizome, fineleaf schizonepeta herb, divaricate saposhnikovia root, frankincense and myrrh. The traditional Chinese medicine composition can be prepared into any one commonly used oral preparation according to the conventional method of traditional Chinese medicine preparations. The invention can obviously improve the symptoms of toothache, gingival swelling, pain in case of hot and cold stimulation, cheek swelling and the like, and has obvious clinical curative effect, significant curative effect and rapid effect. Since the traditional Chinese medicine composition adopts medicinal and edible medicines stipulated in the Chinese Pharmacopoeia to compound, the composition has the advantages of low cost, basically non-toxic side effects and the like.

The invention provides a pantoprazole sodium enteric-coated tablet, which consists of the following components in parts by weight: 1 part of a pantoprazole sodium plain film, 0.1-0.5 part of an isolating layer and 0.5-1 part of an enteric-coated layer, wherein the isolating layer consists of hydroxypropyl methylcellulose and an alkali in the weight part ratio of 1:5-5:1; and the enteric-coated layer is prepared from 0.5-1 part of acrylic resin. The invention provides a preparation method of the pantoprazole sodium enteric-coated tablet. Parameters such as spray speed, spray pressure, the rotating speed of a coating pan and the like are improved through process parameters of the isolating layer, an enteric liquid and a coating, so that the prepared pantoprazole sodium enteric-coated tablet has high acid tolerance and dissolution rate, the acid tolerance of a finished product is over 90 percent, the dissolution rate is over 75 percent, and the pantoprazole sodium enteric-coated tablet is accordant with and superior to the requirements of the Chinese Pharmacopoeia on the enteric tablet. The product has the advantages of stable quality, convenience for storing and transporting and contribution to clinical application. The method is simple, is suitable for industrial production, and has high application value.

The invention discloses a method for industrially cultivating dendrobium candidum. The method is suitable for cultivating dendrobium candidum, and belongs to the technical field of traditional Chinese medicinal material cultivation. In According to the method, a bottle seedling which is domesticated together with a bottle in a greenhouse for 30 days is taken as an original cultivating seedling, and a set of equation planting and cultivating technology including bottling out, transplanting, domesticating, fertilizer and water management and the like is adopted, so that the problems of low survival rate, long planting period and low active ingredient content during cultivation caused by different seedling sources in the cultivating process of dendrobium candidum seedlings are effectively solved; compared with the conventional cultivating way, the cultivating method has the advantages that: the conventional cultivating technology is broken through, the method is suitable for seed source cultivation in regions where wild dendrobium candidum exists, the transplanting survival rate is raised to over 95 percent, and the yield is increased by over 30 percent; and the polysaccharide content of the dendrobium candidum cultivated by using the method surpasses a dendrobium candidum polysaccharide content standard specified by the Chinese pharmacopoeia.

The invention provides a starch hollow capsule and a preparation method thereof. The starch hollow capsule comprises components in parts by weight as follows: 60 parts to 90 parts of cross-linking high amylose, 3 parts to 15 parts of tributyl citrate, 5 parts to 15 parts of guar gum, 1 part to 5 parts of span-80 and 1 part to 5 parts of inulin. The cross-linking high amylose is prepared by cross-linking natural high direct connection starch through a cross-linking agent consisting of sodium metaphosphate and adipic acid. The starch hollow capsule has the advantages that the price is low, the quality is good, and the strength is high, standards of Chinese Pharmacopoeia are achieved, the friability is 5%, the disintegration time is five minutes, and obvious effects are achieved in practical application.

The invention relates to the related ingredient combination with the function of relaxing vessels in traditional Chinese medicine for reducing blood pressure which is commonly used clinically. The invention utilizes modern traditional Chinese medicine theory and provides a related ingredient combination with definite ingredient, controllable quality and precise curative effect by animal model tests for reducing blood pressure. The related ingredient combination can be used for relaxing vessels, treating hypertension and improving hypertension complication. The commonly used traditional Chinese medicine relates to eucommia ulmoides, rhizoma gastrodiae, rhizoma chuanxiong, salviae miltiorrhizae, Astragalus mongholicus, root of kudzu vine, uncaria, radix stephaniae tetrandrae, red flower, radix scutellariae, selfheal, semen cassiae, dogbane leaf, hawthorn, radix achyranthis bidentatae, sophora flower, pseudo-ginseng, motherwort, chrysanthemum, lotus plumule, evodia, cape jasmine fruit, epimedium and caltrop which are included in Chinese Pharmacopoeia (2010 edition). The related ingredients are active ingredients which are extracted from single traditional Chinese medicine. Each traditional Chinese medicine provides one or several active ingredients. The combination study comprises the following steps of combining 2-6 active ingredients with different mechanisms in proportion, screening by utilizing rat thoracic aorta vascular rings and spontaneous hypertension rat models and determining the optimum combination proportion.

The invention discloses a lyophilized viper antivenin and a preparation method thereof, belonging to biochemical products, more particularly relating to an antivenin and a preparation technology thereof. The mass ratio of the antivenin and viper venom is 15:1, which can specifically neutralize the viper venom injected to mouse; as determined by immunodiffusion, the immunoprecipitation line appears in case that the ratio of viper antivenin F(ab')2 in lyophilized form to viper venom is 8:1; and other detected items conform to the quality standard of antivenin in Chinese Pharmacopoeia 2010. The detection of Phenyl-Sepharose (low-sub) FF column chromatography result shows that: activity is centralized at eluting peak 1, micromolecule impurity proteins are centralized at penetration peal, eluting peak 2 and eluting peak 3. According to the technology of the invention, immune blood plasma is resulted from viper venom immune horse, IgG is prepared by salting out the immune blood plasma, and F(ab')2 active fragment is obtained after the IgG is subject to enzymolysis and purification by a hydrophobic column. The lyophilized viper antivenin has strong specificity, high potency and more than 85% of the purity of antivenin F(ab')2 in lyophilized form.

The present invention provides nanometerizing plant Chinese medicinal materials. Single or compound Chinese medicinal material is crushed in a closed high speed centrifugal shearing and smashing machine at normal temperature to form solid particle of 50-200 nm average size. During the crushing, the main shaft rotating at high speed provides powerful centrifugal force and high frequency shearing force in the ceramic crushing rings symmetrically distributed in the subsidiary shaft, and through cutting and crushing material grains in short time, the plant cell wall is broken and the effective components are released directly to improve the medicine leaching rate and raise the medicine bioavailability. The operation may be continuous, semi-continuous or intermittent and may be a dry or wet process. The present invention has no pollution, no loss in effective components, short time and simple operation.

The invention discloses an iron-protein succinylate solubilizing method and an oral solution preparation thereof, which are used for solving the problems of difficulty in dissolving iron-protein succinylate into water, unstable solution and the like. In the method, lauryl sodium sulfate or poloxamer or PEG-400 or beta-cyclodextrin is taken as a solubilizing solvent, and 1,2-propylene glycol and the like are taken as latent solvents, so that the water solubility of the iron protein succinylate are increased, and the free iron content is less than 0.1 percent. An iron protein succinylate oral solution prepared by using a process disclosed by the invention is accordant with relevant regulations in the Imported Medicine Registration Standard JX20000298 and oral liquid dosage form items in the second version of the Chinese Pharmacopeia, edition 2010.

The invention provides a method of preparing a quick-acting jiuxin orally disintegrating tablet through 3D printing. The disintegrating tablet is formed by spraying a bonder through a nozzle of a 3D printer to bond medicinal powder, the medicinal powder comprises, by mass, 76-85% of, 12-18% of and 2-6% of, and 3D printing parameters include spraying radius of 2.5-10mm, spraying layer height of 0.1-0.5mm and spraying layer number of 10-50 layers. Heating is not needed in the preparation process, so that loss of active ingredients, such as borneol, which are unstable when being heated in conventional preparation methods is avoided; the disintegrating tablet prepared is high in medicine release speed, content of active ingredients meets requirements of the Chinese Pharmacopoeia, and the disintegrating tablet is especially suitable for acute diseases such as coronary heart disease and angina.

The present invention relates to a sodium chondroitin sulfate extraction method, wherein sodium chondroitin sulfate is a mucopolysaccharide substance extracted from swine nasal bone and other animal cartilages. The traditional process method adopts alkaline hydrolysis, enzymolysis, salt hydrolysis, an ion exchange resin or a combination method thereof to extract, and the extraction solution contains a large amount of proteins, nucleic acids and other impurities so as to cause a certain difficult problem to further purification. According to the invention, the alkaline hydrolysis-enzymolysis method and the flocculation precipitation method are combined to remove impurities remained in the sodium chondroitin sulfate extraction solution, such that the process is reasonable, the removing efficiency is high, the subsequent refinement working hour is shortened, the product yield is improved, and the drug meets standards of the Chinese pharmacopoeia (2000 edition).

The invention provides a preparation method for a pharmaceutic adjuvant--magnesium stearate. The preparation method comprises the following two steps: step 1, subjecting stearic acid and sodium hydroxide to a saponification reaction; and step 2, reacting sodium stearate produced by stearic acid and sodium hydroxide with magnesium sulfate so as to produce the magnesium stearate. The pharmaceutic adjuvant magnesium stearate produced by using the method provided by the invention has stable quality indexes, and in particular, the content of MgO accords with requirements prescribed in Chinese Pharmacopoeia (2010 edition); production process conditions are easily controllable, and the produced magnesium stearate has a good color.

The invention relates to a preparation method of a tissue suitable type composite material dental implant. The preparation method comprises the steps of performing micro-arc oxidation treatment on a surface part, in contact with a bone tissue, of a titanium or titanium alloy implant to generate a layer of porous composite ceramic membrane which contains calcium phosphate and has biological activity; performing surface etching treatment on a surface part, in contact with a soft tissue, of the implant in a mixed acid etching agent consisting of hydrofluoric acid and hydrochloric acid; soaking the dental implant subjected to the micro-arc oxidation and surface etching treatment into composite simulated body fluid containing minocycline hydrochloride and bone morphogenetic protein to ensure that an anti-inflammatory drug namely minocycline hydrochloride and the bone morphogenetic protein are simultaneously loaded in surface holes of the implant. The bonding strength between the ceramic membrane on the surface of the implant and a titanium or titanium alloy matrix is improved to 20-30MPa from 10-20Mpa; the bone interface maturation period is shortened to be within 3 months from 3-6 months of the current titanium dental implant; the biological properties of the composite material dental implant accord with relevant regulations of ISO (International Standardization Organization), Chinese Pharmacopoeia and United States Pharmacopoeia.