The invention relates to the compound fertilizer field, and more specifically relates to a high efficiency slow release compound fertilizer containing grape skin, and comprises the following raw materials by weight: 10-15 parts of 1250-2000 meshes diatomite, 25-30 parts of biogas slurry, 2-4 parts of zinc sulfate, 20-25 parts of monoammonium phosphate, 1-2 parts of ammonium molybdate, 15-18 parts of urea, 16-18 parts of potassium chloride, 4-5 parts of dry grape, 2-5 parts of animal crushed bone meal, 2-4 parts of zinc gluconate, 6-8 parts of edible vinegar, 10-12 parts of water hyacinth fresh slurry, 30-35 parts of decomposed rapeseed cake, 10-12 parts of non-ionic polyurethane dispersion liquid, 1-2 parts of polyethylene glycol, 18-20 parts of brewer's grain and 4-5 parts of auxiliary agent. The composite fertilizer has the advantages that production cost is low, raw materials such as waste grape skin can be used, technology is simple, nutrient is rich, duration time of the fertilizer efficiency is long, nontoxicity and innocuousness can be generated to soil, certain sterilization anticorrosion effect is provided, crop insect disease condition can be mitigated, and increasing yield and income effect is obvious.