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Method for nano plant Chinese medicine

A nanotechnology and traditional Chinese medicine technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of nano-plant traditional Chinese medicines that have not yet been discovered, and achieve great pharmaceutical application value, no loss of active ingredients, Effect of Improving Dissolution Rate

Inactive Publication Date: 2005-03-02
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] After extensive review of literature and patents, no relevant reports have been found to prepare nano-plant traditional Chinese medicine with a particle size of 50-200nm by ultra-fine pulverization

Method used

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  • Method for nano plant Chinese medicine
  • Method for nano plant Chinese medicine
  • Method for nano plant Chinese medicine

Examples

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Effect test

Embodiment 1

[0028] Example 1: Preparation of nano Liuweidihuang powder by wet method. According to the provisions of the Chinese Pharmacopoeia, the original medicine of Liuwei Dihuang is formulated: Rehmannia glutinosa 160g, Cornus officinalis 80g, Chinese yam 80g, Poria cocos 60g, Moutan cortex 60g, Alisma 60g. evenly distributed.

[0029] Add distilled water as a dispersant to Liuweidihuang fine powder, the weight ratio of traditional Chinese medicine fine powder to distilled water is 1:20, after dispersing evenly, soak for 24 hours, and then transfer to a fully enclosed high-speed centrifugal shear ultrafine pulverizer for pulverization In the barrel, the knob is used to control the rising of the crushing barrel and the main shaft is sealed, and the dispersion of distilled water makes the raw material powder distribute in the gap of the ceramic crushing ring. The jacket of the crushing cylinder is connected with cooling water to control the working temperature at room temperature. Af...

Embodiment 2

[0037]Example 2: Preparation of nano Liuweidihuang powder by wet method. Add distilled water as a dispersant to Liuweidihuang fine powder, the weight ratio of traditional Chinese medicine fine powder to distilled water is 1:25, after dispersing evenly, soak for 12 hours, and then transfer to a fully enclosed high-speed centrifugal shear ultrafine pulverizer for pulverization In the cylinder, the jacket of the crushing cylinder is connected with cooling water to control the working temperature at room temperature. After sealing the crushing cylinder, carry out continuous crushing, the spindle speed is 800 rpm, and the crushing time is 90 minutes. The particle size of the ultra-finely pulverized powder is 200nm as measured by a ZetaPALS light scattering particle size distribution analyzer.

Embodiment 3

[0038] Example 3: Preparation of nano Liuweidihuang powder by wet method. Add distilled water as a dispersant to Liuweidihuang fine powder, the weight ratio of traditional Chinese medicine fine powder to distilled water is 1:30, after dispersing evenly, soak for 1 hour, and then transfer to a fully enclosed high-speed centrifugal shear ultrafine pulverizer for pulverization In the cylinder, the jacket of the crushing cylinder is connected with cooling water to control the working temperature at room temperature. After sealing the crushing cylinder, carry out continuous crushing, the spindle speed is 2400rpm, and the crushing time is 30 minutes. The particle size of the powder after ultrafine pulverization is 134nm as measured by a ZetaPALS light scattering particle size distribution analyzer.

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Abstract

The present invention provides nanometerizing plant Chinese medicinal materials. Single or compound Chinese medicinal material is crushed in a closed high speed centrifugal shearing and smashing machine at normal temperature to form solid particle of 50-200 nm average size. During the crushing, the main shaft rotating at high speed provides powerful centrifugal force and high frequency shearing force in the ceramic crushing rings symmetrically distributed in the subsidiary shaft, and through cutting and crushing material grains in short time, the plant cell wall is broken and the effective components are released directly to improve the medicine leaching rate and raise the medicine bioavailability. The operation may be continuous, semi-continuous or intermittent and may be a dry or wet process. The present invention has no pollution, no loss in effective components, short time and simple operation.

Description

technical field [0001] The invention relates to a method for nanometerizing plant traditional Chinese medicine. Background technique [0002] Traditional Chinese medicine has a long history and has the advantages of unique medicinal effects and few side effects. However, it is difficult to be accepted by patients due to troublesome decoction, bitter taste and large dosage. Most of the active ingredients of traditional Chinese medicine exist in the cell fluid, and the release of the active ingredients needs to go through the diffusion and osmosis of the cell wall and cell membrane. The existing traditional Chinese medicine crushing methods are difficult to completely break up the cells and cannot fully extract the active ingredients. The Chinese patent medicines prepared by the original drug also generally have the disadvantages of reduced dissolution rate and poor efficacy. The active ingredients of traditional Chinese medicine are often extrac...

Claims

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Application Information

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IPC IPC(8): A61K9/14
Inventor 傅正义马培艳苏艳丽王为民王玉成张金咏张清杰
Owner WUHAN UNIV OF TECH
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