Silk fibroin micro-needle patch and preparation method thereof

Abstract

The invention belongs to the field of medical beauty micro-needles, and in particular relates to a silk fibroin micro-needle patch and a preparation method thereof. The silk fibroin micro-needle patch comprises a backing layer, a micro-needle layer and a pressure-sensitive adhesive coating by which the backing layer and the micro-needle layer are stuck, wherein a plurality of needle-shaped bumps, which are uniformly distributed, are arranged on the micro-needle layer; needle-shaped cavities are formed in the needle-shaped bumps; the volume of the needle-shaped cavities is 40-90% of the volume of the needle-shaped bumps; medicines are kept in the needle-shaped cavities; the micro-needle layer is made from silk fibroin, and the molecular weight of the silk fibroin is lower than 100,000; the silk fibroin micro-needle patch is excellent in mechanical performance under a dry state, the silk fibroin micro-needle patch is sufficient in strength to penetrate into skin, and since the molecular weight of the silk fibroin is lower than 100,000, the micro-needle patch is high in dissolving rate, and as the micro-needle patch penetrates into the skin and gets into contact with body liquid, the micro-needle layer can rapidly dissolve, and subsequently, the medicines can get into contact with the body liquid and can dissolve in and disperse to the inner side of epidermis; therefore, the silk fibroin micro-needle patch is applicable to symptoms which require the rapid release of the medicines and have a relatively high requirement on a blood medicine dose.

Description

technical field [0001] The invention belongs to the field of medical cosmetic microneedles, in particular to a silk fibroin microneedle patch and a preparation method thereof. Background technique [0002] Nowadays, people pay more and more attention to skin care, especially the skin around the eyes. The skin around the eyes is thin and prone to aging and problems. The commonly used eye skin maintenance drugs are mostly macromolecular drugs, which are difficult to penetrate the eye skin and enter the subcutaneous area, so the utilization rate is low. [0003] A microneedle is a micron-sized hollow or solid needle similar to an injection needle. It is made by a micro-fabrication process, with a diameter of 30-80 μm and a length of about several hundred microns. It can just pass through the stratum corneum without touching the pain nerves. It can promote penetration without causing pain and skin damage. It opens a vertical and visible channel on the stratum corneum of the ski...

AI Technical Summary

Problems solved by technology

[0004] Although traditional metal, glass, silicon and other solid microneedles have good penetration ability to change the skin permeability, the drug is generally applied to the surface of the microneedle, and the drug loading is small, so it is difficult to achieve the therapeutic effect

Traditional metal, glass, silica, silicon and polymer hollow microneedles can improve the defects of low drug loading rate and poor drug release control of solid microneedles by adding drug storage, but it requires complicated electroplating, Complex processes such as photolithography, wet etching, microchannel casting technology, and insert mold preparation and use are high in cost and not suitable for mass production

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