The present invention relates to a membrane for guided
bone tissue regeneration and, more particularly, to a membrane for guided
bone tissue regeneration having a structure that silk
fibroin nanofibers obtained by removing
sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof. A membrane for guided
bone tissue regeneration according to the present invention has a predetermined strength,
biocompatibility, and biodegradability, and may maintain a sustained
drug release
system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling
fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A
nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly,
drying a silk
fibroin solution obtained by removing
sericin from silk fibers, and by
electrospinning after dissolving the dried silk
fibroin in an
electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.