819 results about "Entrapment" patented technology

This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.

A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic solvent, followed by removing the organic solvent; which provides a sustained-release preparation showing a high entrapment ratio of the physiologically active polypeptide and its constant high blood concentration levels over a long period of time.

Apparatus for filtering and entrapping debris in the vascular system of a patient, the apparatus including a filter to allow blood to flow therethrough and to restrict passage of debris, wherein the filter captures debris carried in a first direction of blood flow. The apparatus further includes an entrapment mechanism which allows passage of debris and blood therethrough, in the first direction of blood flow and prevents debris passage in a second direction. The entrapment mechanism and filter allow blood and debris therethrough in the first direction of blood flow. The entrapment mechanism prevents debris flow in the second direction of blood flow. A method for filtering and entrapping debris in the vascular system includes inserting the apparatus into the vascular system, allowing blood and debris carried therein to flow through the entrapment mechanism, and removing the apparatus and accumulated debris from the vascular system.

Safety systems for vehicles, primarily passenger vehicles, comprising automated systems and methods for preventing entrapment of children, disabled, aged or infirm persons, or pets from being trapped in closed vehicles left in the sun, so that they will not suffocate from the heat. The invention is characterized by use of one or more systems to sense the occupancy state and temperature inside the vehicle passenger or load space, and provide one or more outputs which can selectively be employed to provide interior and exterior warning of a trapped passenger in a dangerously hot car to permit rescue, and / or to activate vehicle electro-mechanical systems to relieve the heat, such as rolling down windows, unlatching seat belts, unlocking doors, starting the car and / or fans or air conditioning systems and the like. The exterior warnings may be any suitable warning, such as sounding the car horn or alarm siren, flashing head, tail or special lights, placing an emergency call via a vehicle dedicated cell phone, CB radio, GPS system, or the like.

A marine seismic exploration method and system comprised of continuous recording, self-contained ocean bottom pods characterized by low profile casings. An external bumper is provided to promote ocean bottom coupling and prevent fishing net entrapment. Pods are tethered together with flexible, non-rigid, non-conducting cable used to control pod deployment. Pods are deployed and retrieved from a boat deck configured to have a storage system and a handling system to attach pods to cable on-the-fly. The storage system is a juke box configuration of slots wherein individual pods are randomly stored in the slots to permit data extraction, charging, testing and synchronizing without opening the pods. A pod may include an inertial navigation system to determine ocean floor location and a rubidium clock for timing. The system includes mathematical gimballing. The cable may include shear couplings designed to automatically shear apart if a certain level of cable tension is reached.

The invention provides multi-arm block copolymers useful as drug delivery vehicles comprising a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, methods of making such copolymers and pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.

A pumping system includes a water pump for moving water. The pumping system includes means for determining a value indicative of a blockage that inhibits the movement of water through the pumping system, and means for determining a performance value of the pumping system. In one example, the pumping system includes means for comparing the performance value to the value indicative of a blockage and means for controlling the pump in response to the comparison. In another example, the system includes means for determining a change in power consumption of the water pump. In another example, the system includes means for determining a threshold value and means for controlling the pump when the performance value exceeds the threshold value. In another example, the system includes means for determining a difference value based upon a plurality of performance valves during a first time period and a second time period. A method of controlling the pumping system is also included.

The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.

A drain for swimming pools, spas, whirlpool baths, etc., includes a plurality of first orifices in communication with corresponding serpentine passageways to minimize hair or a body part from covering and entering the first orifices to a degree sufficient to entrap a bather. A plurality of second orifices independent of the first orifices and in fluid communication with one another through a peripheral passageway provide a flow of water from the peripheral passageway into the serpentine passageways to create an alternate water inflow path and reduce the pressure differential and possible entrapment that might occur should a body part or hair come in contact with or enter the first orifices. Moreover, a plurality of ridges are attendant the first orifices to reduce the likelihood of direct contact with the first orifices by a body part or hair.

A machine for anticipatory sensing and intervention to avoid swimmer entrapment, with an active pre-entrapment sensor (e.g. ultrasonic) that assesses the relative hazard based on swimmer proximity to the drain cover. An Ultrasonic Transducer launches waves into the suction piping and / or drain system, and to receive echoes from the drain cover, swimmer limbs, hair or body, and the water surface parellel to the drain cover. A Transmitter / Pulser electrically energizes the ultrasonic transducer to launch waves into the suction piping and / or drain system, A Receiver / Processor detects the echoes electrical signals from the the ultrasonic transducer and to receive echoes from objects of interest beyond the pool drain. A Logic and Control element converts the detected signals into reliable information regarding a swimmer safety / hazard status. An Output provides a pump shutdown command when required. Solutions for both new construction and retrofit are described.

An anti-entrapment system for preventing an object from being entrapped by a translating device includes a capacitance sensor positioned adjacent to the translating device. The sensor has first and second conductors separated by a separation distance, a compressible dielectric element interposed between the conductors, and a non-conductive elastomer outer jacket encasing the conductors and the dielectric element. The sensor having a capacitance dependent upon the separation distance between the conductors. The capacitance changes in response to the separation distance changing as a result of the dielectric element compressing in response to a first object touching the outer jacket, and in response to a second conductive object coming into proximity with at least one of the conductors. A controller controls the translating device as a function of the capacitance in order to prevent the translating device from entrapping either object.

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

In laser welding of metallic workpieces, the energetic beam is moved over the workpiece surface to form a pool of molten weld metal that quickly solidifies behind the advance of the laser into a weld nugget. The laser beam produces a keyhole of plasma-containing vapor within the molten pool. Weld nugget porosity, due to entrapment of the vapor, is minimized by continually sensing radiation from the molten metal pool to determine pool depth and width and then controlling laser power and speed to continually produce a weld metal pool wide enough for the liquid to fully expel the vapor and solidify into a pore free nugget.

A method of preparing a liposomal bioactive agent comprising infusing an lipid-ethanol mixture with an aqueous or ethanolic solution of the bioactive agent at a temperature below the phase transition of at least one of the lipid components of the lipid and compositions produced by the method of the invention.

An anti-entrapment system for preventing an object from being entrapped by a translating device includes a capacitance sensor positioned adjacent to the translating device. The sensor has first and second conductors separated by a separation distance, a compressible dielectric element interposed between the conductors, and a non-conductive elastomer outer jacket encasing the conductors and the dielectric element. The sensor having a capacitance dependent upon the separation distance between the conductors. The capacitance changes in response to the separation distance changing as a result of the dielectric element compressing in response to a first object touching the outer jacket, and in response to a second conductive object coming into proximity with at least one of the conductors. A controller controls the translating device as a function of the capacitance in order to prevent the translating device from entrapping either object.

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Apparatus for filtering and entrapping debris in the vascular system of a patient, the apparatus including a filter to allow blood to flow therethrough and to restrict passage of debris, wherein the filter captures debris carried in a first direction of blood flow. The apparatus further includes an entrapment mechanism which allows passage of debris and blood therethrough, in the first direction of blood flow and prevents debris passage in a second direction. The entrapment mechanism and filter allow blood and debris therethrough in the first direction of blood flow. The entrapment mechanism prevents debris flow in the second direction of blood flow. A method for filtering and entrapping debris in the vascular system includes inserting the apparatus into the vascular system, allowing blood and debris carried therein to flow through the entrapment mechanism, and removing the apparatus and accumulated debris from the vascular system.

The invention relates to a method for predicting and controlling slab continuous casting breakout, in particular to a method for preventing sticking breakout according to the temperature variation condition of a thermocouple in a crystallizer in the process of slab continuous casting. The method mainly aims at solving the technical problems that the existing various breakout prediction methods can not compressively consider interference factors and can not predict small-scale sticking and slag entrapment in time. The technical proposal of the invention is that the method for predicting and controlling the slab continuous casting breakout comprises the step that lines of thermocouples are arranged on the crystallizer, and the method is characterized by comprising the following steps: a. capture of typical temperature characteristics: the typical temperature characteristics of each thermocouple is determined according to the crystallizer parameters and the installment location of the crystallizer on the thermocouple; b. determination of breakout probability: the breakout probability of each thermocouple is determined according to the typical temperature characteristics of the adjacent thermocouples as well as the characteristics of the breakout thermal conductance and abnormal temperature distribution; c. control of casting speed: when the breakout probability of the thermocouples is up to 95%, the casting is stopped. The method is mainly used for warning continuous casting breakout.

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

To overcome 1) the high levels of porosity due to coating material vaporization and entrapment into the weld, 2) spewing of molten base metal from the weld leaving holes and pits in the weld, and 3) humping effects when oblong beam configurations are used at higher weld speeds to weld coated materials, the present invention features an energy source (10) with multiple separated energy beams (24, 26) (formed by using multiple separate beam sources or manipulation of a single beam (14) into separated multiple energy beams (44, 46) using wedge mirror (18) and parabolic focusing mirror (20)) that produces high quality (porosity free) lap welds in a weld stack (50) of layered materials (30, 32) coated with coating material (28, 28', 34, 34') with zero gap at interface (38) during the welding process. An energy source (12) with multiple, separated energy beams (24, 26) extends the beam keyhole and increases the time and conditions available for vapor / gas to diffuse less violently through the molten weld pool.

Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the following: an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles; an effective amount of a cooling component; an effective amount of a heat minimizing or blocking component; an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves; and an effective amount of a soothing and anti-inflammatory complex for the joints and / or muscles comprising Glucosamine sulfate or HCl, Zingiber officiniale (Ginger Root) extract, Methyl sulfonylmethane (MSM), Polygonum cuspidatum (Mexican Bamboo) extract, Aloe barbadensis leaf, and Salix alba (white willow) bark extract. Additionally, the composition includes an encapsulation or entrapment system for a timed release delivery.