713 results about "Scaffold material" patented technology

The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.

An artificial tissue including an internal mass transport network having a plurality of channels, wherein the channels are designed to substantially mimic naturally occurring vascular network and a method for creating an internal transport system within a tissue scaffold to improve circulation, diffusion, and mass transport properties by utilizing computer-aided tissue engineering (CATE). The artificial tissue has the internal mass transport network of channels embedded, deposited, or molded within a scaffold, wherein the channels are made from a biodegradable transporting material and the scaffold is made from a scaffold material. The artificial tissue of the invention includes a basic circulatory system embedded within the tissue scaffold. This system provides mass transport throughout the entire scaffold and degrades after the new circulatory system develops.

This invention related to a tissue-adhesive sheet comprising a homogeneous, preformed and cross-linked matrix formed from one or more polymers, and having at least one surface that, in use, is exposed, at least one of said one or more polymers being a synthetic polymer and having appendant functional groups of a first form, cross-linking of said matrix being via a proportion of said functional groups of the first form, and the remainder of said functional groups of the first form being free. The sheet is particularly useful as a tissue adhesive and sealant, and is intended for topical application to internal and external surfaces of the body for therapeutic reasons. The invention further relates to sheets comprising a scaffold material, three-dimensional articles formed from similar material to that of the sheet and to implantable medical devices coated with such material.

A method for preparing a scaffold material for use in the prosthesis therapy is disclosed. The method comprises (a) lyophilizing a segment of native soft tissue of mammalian origin, heating the lyophilized tissue at a temperature of 100-200° C., and incubating the tissue with elastase to selectively remove elastin leaving the extracellular components mainly comprised of collagen.

A solid freeform fabrication method of creating a three-dimensional article built at least in part from scaffolding layers, the method includes providing a scaffolding material, providing a supporting material in a shape of a foamy layer, and contacting the scaffolding material with the foamy layer to form at least one scaffolding layer and thereby creating the three dimensional article.

Thin-film multi-electrode arrays (MEA) having one or more electrically conductive beams conformally encapsulated in a seamless block of electrically insulating material, and methods of fabricating such MEAs using reproducible, microfabrication processes. One or more electrically conductive traces are formed on scaffold material that is subsequently removed to suspend the traces over a substrate by support portions of the trace beam in contact with the substrate. By encapsulating the suspended traces, either individually or together, with a single continuous layer of an electrically insulating material, a seamless block of electrically insulating material is formed that conforms to the shape of the trace beam structure, including any trace backings which provide suspension support. Electrical contacts, electrodes, or leads of the traces are exposed from the encapsulated trace beam structure by removing the substrate.

The presently claimed and disclosed invention relates, in general, to three dimensional micro-environments and, in particular, to three dimensional (“3D”) micro-environments found in inverted-opal scaffolds made from hydrogel therein for controlled release of nutrients. Specifically, the scaffolds have exceptionally ordered, three-dimensional organization that provides excellent porosity, permeability, and transportation properties can that are especially well suited for use as a nutrient carrier in the emerging technologies of drug delivery and cell culture. Methods for incorporation of or to control the release of nutrients and other substances from such scaffold materials are also herein disclosed and claimed.

<heading lvl="0">Abstract of Disclosure</heading> A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The process includes, but is not limited t, harvesting the tissue, optionally extracting growth and differentiation factors from the tissue, inactivating infective agents of the tissue, mechanically expressig undesirable components frm the tissue, delipidizing the tissue, washing the tissue, optionally drying the tissue, and optionally cross-linking the tissue not necessarily in the order described. The resulting product, EBM, is characterized by its microbial, fungal, viral and prion inactivated state. EBM is storng, bioremodelable, drapable and does not undergo calicification. EBM supplants previous inventions because of its unique method of preparation and broad applicability in tissue reengineering

The invention belongs to the field of researching and application of biomedicine and particularly relates to human pluripotent stem cell-hereditary cardiomyopathy cardiac muscle cells and a preparation method thereof. The invention provides a human hereditary cardiomyopathy-pluripotent stem cell, which is constructed by means of TALEN or CRISPR/CAS9 genome editing technology. The human hereditary cardiomyopathy cardiac muscle cell can be combined with any scaffold materials to culture various in-vitro human hereditary cardiomyopathy cardiac muscle tissues. The human hereditary cardiomyopathy cardiac muscle cells in the invention have disease phenotypes and electrophysiology change being similar as the cardiac muscle cells of human hereditary cardiomyopathy patients. The human hereditary cardiomyopathy cardiac muscle cells are wide in sources and can be cultured in-vitro for a long time. The invention provides excellent tools and platforms for researching an effective new therapy means and researching an effective corresponding treatment medicine.

The invention discloses a multiplex composite engineering scaffold material capable of gradually decomposing bone tissue and a preparation method thereof. The composite scaffold material consists of calcium phosphate bone cement, biological compatible degradable synthetic high polymer and biological compatible degradable natural high polymer, has better mechanical property and gradient degradation characteristic, and can achieve the aim of regenerating and repairing bone tissue defect by implanting a bone growth factor to induce in-vivo stem cells to be differentiated into bone cells, thereby obviously improving initial strength and toughness of the scaffold material, and ensuring enough strength and toughness of the scaffold material during operating and implanting. After compounded with the high polymer material, the scaffold has excellent flexibility, so that the scaffold can be subjected to certain machining, such as cutting and the like.

A method of manufacturing a carbon macrotube includes providing at least one layer of graphene and wrapping the at least one layer of graphene around a scaffold material to form a carbon macrotube is disclosed. In other words the carbon macrotube includes at least one layer of graphene having opposed lateral edges that are spirally wrapped around itself so as to form the macrotube.

Disclosed is a method for production of a bio-derived scaffold for use in regenerative medicine, which has a bio-compatibility and biodegradability and can self-organize and grow without causing calcification. The method comprises the steps of partially fixing a biological soft tissue with glutaraldehyde by cross-linking and incubating the partially fixed tissue together with an elastase.

The invention discloses a novel high-strength hydrogel which is prepared by the following steps: synthesizing a first network hydrogel from a polyelectrolyte (such as hyaluronate, polyglutamic acid, chondroitin sulfate or polylysine); and after soaking the hydrogel in a double-bond functional polyethyleneglycol water solution for some time, taking out, and crosslinking to obtain the high-strength double-network hydrogel. The synthesized high-strength hydrogel has favorable biocompatibility, can be used as a tissue engineering/repair scaffold material or the like, and has wide applicability in the field of biomedical materials.

The invention discloses a method for preparing three-dimensionally sequentially porous chitosan bone repair scaffold material. The method comprises the steps of dissolving chitosan powder in dilute acetic acid and standing to defoam; coating the prepared chitosan solution on the surface of a mold evenly, placing in a solidification solution at room temperature to solid and form a membrane, demoulding and obtaining a chitosan membrane moulding plate; pouring the prepared chitosan solution into the chitosan membrane moulding plate, sealing and soaking in the solidification solution to solid and demould to obtain chitosan gel; and washing the chitosan gel to be neutral by distilled water and drying. The method is simple in preparation technology; the three-dimensionally sequentially porous chitosan bone repair scaffold material prepared is good in regularity and high in strength and porosity, and can meet the requirements of tissue engineering scaffold material.

The invention provides a repair material for biological derivative tendon. The material takes homogeneous or heterogeneous tendon as a raw material and is formed through disinfection, degreasing, deproteinization, decellularization, freeze drying, depolymerization, devillication recombination and secondary disinfection. A method for preparing a tendon scaffold material comprises the following steps that: on one hand, a periphery structure of a tendon tissue is destructed through treatment processes of removing soft tissues, the disinfecting, the degreasing and the decellularization, and the repellency of a transplantation receipt to the tendon is reduced; on the other hand, a basic mechanism, partial enzyme activity of the tendon tissue and the continuity of the tendon tissue are further maintained through a freeze drying process so as to provide a good scaffold structure for the revascularization and cell tissue of the tendon.

The invention provides an alveolar bone restorative material which comprises compound bone powder and a scaffold material, wherein the compound bone powder is formed by soaking bone powder in solution of an osteoinduction material, and the ratio of the bone powder to the solution of the osteoinduction material is between 1to1 and 1to100 (mass/volume ratio); the scaffold material consists of a macromolecular substance containing carboxyl and a macromolecular substance containing amino group which crosslink and form gel upon the function of an activator, and the weight ratio of the compound bone powder and the scaffold material is between 10< -3 > to1 and 1to1. The invention also provides a preparation method and application of the alveolar bone restorative material. The material has the biological hemostasis function and bone guiding function, has certain osteoinduction activity for bone growth, and can promote the growing and reconstruction of bone tissue at the surrounding defect area of a dental implant so as to obtain an ideal interface where the implant combines with the bone; and when used for alveolar bone restoration, dental implantation and the like, the material plays a role in inducing bone restoration, hemostasis and anti-adhesion.

The invention relates to a preparation method and application of a silicon rubber/collagen-based porous skin scaffold material. The preparation method comprises the following steps of: (1) putting an organic silicon film into a plasma treatment instrument, and introducing a polar group into the surface of silicon rubber; (2) preparing collagen solution or mixed solution of collagen and other biomacromolecules at certain concentration, coating the solution on the surface of a silicon rubber film obtained in the step (1), and extracting a solvent by using a freeze dryer; (3) soaking a silicon rubber/collagen-based composite scaffold obtained in the step (2) in a dehydrating agent-containing mixed solvent of ethanol and water, reacting for 6 to 12 hours at room temperature, and soaking and washing by using a large amount of deionized water; and (4) putting a scaffold obtained in the step (3) into the freeze dryer again to extract absorbed water. The silicon rubber/collagen-based composite porous material prepared by the method has high biocompatibility and appropriate pore diameter, is stable, and can be used for a skin scaffold, or a temporary dressing favorable for repairing wound parts.

The invention provides a tissue engineering scaffold material of a chemical bonding active material and a preparation method of the tissue engineering scaffold material. The tissue engineering scaffold material of the chemical bonding active material is prepared by a biodegradable macromolecular substance and an active material, wherein the macromolecular substance is counted by 100 parts by weight, and the active material is 0-15 part(s) by weight but is not zero; the 100 parts by weight of the macromolecular substance consists of 50-100 parts by weight of the synthesized macromolecular substance and 0-50 part(s) by weight of natural macromolecular substance; and a macromolecular nano-fiber film or a composite macromolecular nano-fiber film is formed by the macromolecular substance by means of electrostatic spinning, and the active material is evenly bonded on the surface of the fiber film. The tissue engineering scaffold material of the chemical bonding active material provided by the invention is good in biocompatibility, enough in mechanical strength, biodegradable, and suitable for stem cell proliferation and directed differentiation, and has the functions of cell migration adhesion promotion and stem cell capture to induce the regeneration of tissues such as bone, cartilage, nerve, skin, etc.