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Alveolar bone repairing material, preparation method and uses thereof

A repair material and alveolar bone technology, applied in the field of medical materials, can solve the problems of affecting bone function, not being able to effectively exert bone regeneration activity for a long time, and not having a scaffolding effect, so as to achieve the effect of promoting regeneration and reconstruction

Active Publication Date: 2009-02-18
TIANJIN ZHONGJIN BIOLOGICAL DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although osteoinductive materials such as bone morphogenic protein (BMP) are osteoinductive, they are easily decomposed by proteases in the body and cannot effectively exert bone regeneration activity for a long time
At the same time, due to the lack of scaffolding, it is difficult to obtain ideal new bone tissue in the implanted area for larger defects, which affects the performance of bone function.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The allograft bone was taken, the soft tissue was removed, rinsed with running water for 4 hours, cut into pieces with a diameter of 1.5 cm, and completely deproteinized allograft bone was prepared by soaking in solution according to conventional methods. Pulverize with pulverizer, make 120 mesh bone meal. According to the mass volume ratio of bone powder and growth factor solution of 1:20, the bone powder was soaked in the bone growth inducing factor BMP aqueous solution with a concentration of 600 μg / ml for 5 hours to prepare composite bone powder, which was dried at room temperature and stored for later use.

[0032] Accurately weigh sodium hyaluronate to form a 0.8% aqueous solution, configure a 0.4% chitosan solution, and add an appropriate amount of 1M HCl solution to promote its dissolution. Use EDC.HCl as an activator to cross-link to form a biogel. The weight ratio of EDC.HCl to chitosan is 2:1, and then sodium hyaluronate and chitosan are mixed in a weight rat...

Embodiment 2

[0036] The allograft bone was taken, the soft tissue was removed, rinsed with running water for 5 hours, cut into pieces with a diameter of 1 cm, and completely deproteinized allograft bone was prepared. Pulverize with pulverizer, make 60 mesh bone meal.

[0037] According to the mass volume ratio of bone powder and growth factor solution of 1:10, the bone powder was soaked in the aqueous solution of bone growth-inducing factor bFGF with a concentration of 620 μg / ml for 6 hours to prepare composite bone powder, which was dried at room temperature and stored for later use. Accurately weigh carboxymethyl cellulose to form a 1.0% aqueous solution, prepare a 0.4% collagen solution, use dimethylaminopropyl ethyl carbodiimide as an activator to cross-link to form a biogel, and dimethylamine The weight ratio of propylethylcarbodiimide to collagen is 1:2. Mix carboxymethyl cellulose and collagen at a weight ratio of 10:1, and adjust the pH value to 5. Wash the gel to neutral with pu...

Embodiment 3

[0040] The xenograft bone was taken, the soft tissue was removed, rinsed with running water for 4 hours, cut into pieces with a diameter of 1.2 cm, and completely deproteinized allograft bone was prepared. Pulverize with pulverizer, make 400 mesh bone meal.

[0041] According to the mass volume ratio of bone powder and growth factor solution of 1:30, the bone powder was soaked in the bone growth inducing factor BMP aqueous solution with a concentration of 60 μg / ml (until it was completely submerged) for 48 hours to prepare composite bone powder, and dried at room temperature and stored for later use .

[0042] Accurately weigh sodium alginate to make 0.8% aqueous solution, configure 0.4% amino-oligosaccharide solution, use phenylene ethyl carbodiimide as activator to cross-link to make biogel, phenylene ethyl carbon The weight ratio of diimine and amino oligosaccharide is 1:1, and the weight ratio of sodium alginate and amino oligosaccharide is 1:2 for mixing, and the pH valu...

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Abstract

The invention provides an alveolar bone restorative material which comprises compound bone powder and a scaffold material, wherein the compound bone powder is formed by soaking bone powder in solution of an osteoinduction material, and the ratio of the bone powder to the solution of the osteoinduction material is between 1to1 and 1to100 (mass / volume ratio); the scaffold material consists of a macromolecular substance containing carboxyl and a macromolecular substance containing amino group which crosslink and form gel upon the function of an activator, and the weight ratio of the compound bone powder and the scaffold material is between 10< -3 > to1 and 1to1. The invention also provides a preparation method and application of the alveolar bone restorative material. The material has the biological hemostasis function and bone guiding function, has certain osteoinduction activity for bone growth, and can promote the growing and reconstruction of bone tissue at the surrounding defect area of a dental implant so as to obtain an ideal interface where the implant combines with the bone; and when used for alveolar bone restoration, dental implantation and the like, the material plays a role in inducing bone restoration, hemostasis and anti-adhesion.

Description

technical field [0001] The invention relates to an alveolar bone repair material, in particular to a bone powder composite osteoinductive material combined with a degradable bracket to form an alveolar bone repair material, a preparation method and an application thereof, belonging to the field of medical materials. Background technique [0002] In recent years, dental implants have been widely used clinically to restore missing teeth, but insufficient alveolar bone in the implanted area has become a common problem faced by dental implant surgery. In the treatment of periodontal disease, how to repair and regenerate the damaged alveolar bone is a major problem at present. In order to solve these problems, people have studied a variety of bone repair methods, among which bone materials are widely used in oral surgery and have achieved good repair results. [0003] At present, there are many kinds of bone graft materials that can be used to repair bone defects in dental impla...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/44
Inventor 李次会
Owner TIANJIN ZHONGJIN BIOLOGICAL DEV CO LTD
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