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Device and method for preparing tissue engineering supporting materials by electric spinning

A tissue engineering scaffold and electrospinning technology, which is applied in the field of biomedical material preparation, can solve the problems of large-scale industrial application of equipment and complex structure of equipment, and achieve the effect of high porosity, simple equipment and good biocompatibility

Inactive Publication Date: 2003-11-19
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been many reports on the research on electrospinning equipment, but most of the equipment is focused on large-scale industrial applications, the equipment structure is complex, and the miniaturized equipment suitable for laboratory research and preparation of tissue engineering scaffolds has not been reported yet.

Method used

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  • Device and method for preparing tissue engineering supporting materials by electric spinning
  • Device and method for preparing tissue engineering supporting materials by electric spinning
  • Device and method for preparing tissue engineering supporting materials by electric spinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Prepare a chloroform solution with a mass concentration of 1% PHBV and place it in a liquid storage device;

[0044] 2. Install a metal plate as a collection device;

[0045] 3. Install the pneumatic feeding device, adjust the air pressure so that the liquid droplets appear at the nozzle without dripping;

[0046] 4. Adjust the distance from the nozzle to the collection device to 10cm;

[0047] 5. Turn on the high-voltage power supply, adjust the voltage to 10kV, and start spinning.

Embodiment 2

[0049] 1. Prepare a chloroform solution with a mass concentration of 10% PHBV and place it in a liquid storage device;

[0050] 2. Install a conductive roller as a collection device, and set the speed at 10 rpm;

[0051] 3. Install pump feeding device;

[0052] 4. Adjust the distance from the nozzle to the collection device to 20cm;

[0053] 5. Turn on the high-voltage power supply, adjust the voltage to 20kV, and start spinning.

Embodiment 3

[0055] 1. Prepare a chloroform solution with a mass concentration of 5% PHBH and place it in a liquid storage device;

[0056] 2. Install liquid surface collection device;

[0057] 3. Install a high-level trough-type feeding device, and adjust the air pressure so that droplets appear at the nozzle without dripping;

[0058] 4. Adjust the distance from the nozzle to the collection device to 5cm;

[0059] 5. Turn on the high-voltage power supply, adjust the voltage to 15kV, and start spinning.

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Abstract

A scaffold material for tissue engineering is disclosed, which is a non-woven cloth prepared from the electrically spoun fibres which are prepared by jet spinning of charged liquid under the action of electric field force. Its advantages are high uniformity and porosity, adjustable pore diameter, and good biologic compatibility. Its apparatus is composed of high voltage power supply, feeder, jetter and collector. Said electrically spun fibre features small diameter (3 nm-5 microns).

Description

technical field [0001] The invention belongs to the field of preparation of biomedical materials, in particular to a method and device for preparing tissue engineering scaffold materials by electrospinning Background technique [0002] The traditional spinning process is currently used in the following five main processes for the preparation of tissue engineering scaffolds: 1) solution casting, pore-forming agent filtration method. The used pore-forming agent content of this method is low, owing to adopting solution to cast in vessel, thereby cause pore-forming agent to sink, pore distribution is uneven and upper and lower surface form difference appears; 2) three-dimensional layering method. A three-dimensional scaffold is formed by preparing a porous membrane and then bonding the layers together with a solvent. The process of this method is complex, and in the bonding process, the holes of the bonding part are closed, thereby forming an interface and making the internal s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/14D01D5/00D04H13/00
Inventor 胡平张璐方状熙韩涛
Owner TSINGHUA UNIV
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