38results about How to "Degradation rate adjustable" patented technology

The invention relates to a degradable drug loading stent and a preparation method of the degradable drug loading stent. The degradable drug loading stent is characterized by comprising a skeleton structure made of a medical degradable metal or an alloy of the metal, a degradable macromolecular transition layer adhered to the surface of the skeleton structure and a drug loading layer. The degradable metal / macromolecular / drug multilayer composite stent provided by the invention has excellent mechanical property, degradable property and biocompatibility, and such drugs as taxol, taxol derivative, actinomycin D, 5-fluorouracil and sirolimus are loaded to the stent to perform active directional treatment on the focus position, so the stent is a functional degradable stent. The degradable multifunctional drug loading stent provided by the invention is suitable for interventional therapy in the blood vessel field and non-blood vessel fields and is especially suitable for interventional therapy of stenosis, obstruction or tumor of such non-blood vessel cavities as esophagus, bile duct, ductus pancreaticus, intestinal tract, urethral canal, trachea and bronchus, etc.

The invention adopts a melt polycondensation method. A few of monomers of C2-5 aliphatic dibasic alcohol, diethylene glycol, polyglycol, fumaric acid, maleic anhydride, lactic acid, glycolic acid, ethanolamine, C2 to C12 aliphatic diamine, glutamic acid, lysine, glycine, etc. are taken as basic materials to be synthesized to obtain non toxic unsaturated polyester-amide resin with adjustable degradation rate and lower cost; wherein, the partial fumaric acid or maleic anhydride can be replaced with phthalic anhydride, isophthalic acid, or adipic acid. The resin yearns for being used as matrix resin of medical bone internal fixation material, tissue engineering scaffold material, bone tissue temporary substitutes, environmental protection type bonding agent, environmental protection type fiberglass reinforced plastics, environmental protection type coating material, disposable tableware, packing material, shopping bags, disposable bags, drug coating or capsule, drug delivery (controlled-release) material, agricultural mulching films, etc., and can be recovered to be utilized.

The invention discloses a porous support material in the tissue engineering of konjac glucan-mannan / hydroxyapatite / chitosan combined bone, and a preparation thereof, pertaining to the technical field of bioengineering materials. Degradable biomaterials with good biocompatibility, such as konjac glucan-mannan, hydroxyapatite and chitosan, are adopted as basic raw materials and respectively prepared into konjac glucan-mannan solution and hydroxyapatite / chitosan composite powder suspension which are then mixed to prepare mixture gel. After aging, alkali elimination, freeze-drying of the mixturegel, the degradable porous support with regenerated and reparative konjac glucan-mannan / hydroxyapatite / chitosan combined bone tissues. Not only does the support material have simple preparation technology and low cost, but also the prepared degradable porous support has good compatibility with trauma parts. Cell tests and animal tests show that the support can be universally used in vivo (bone defect diseased region, etc.) and is multifunctional and antibacterial composite material with adjustable degradation rate in vivo and can promote and induce the repair of the bone defect.

The invention discloses a cellular silk fibroin porous scaffold, and a preparation method thereof. The method comprises the following steps of: degumming silkworm cocoon serving as a raw material, dissolving, dialyzing, and freeze-drying to obtain silk fibroin; and immersing a negative norm sodium chloride porous body which has a plant tissue structure and serves as a template in a silk fibroin solution, vacuum-drying at room temperature, performing beta treatment, and desalting to obtain the silk fibroin porous scaffold which has a bionic plant tissue cellular pore structure. The porosity of the prepared cellar silk fibroin porous scaffold is more than 80 percent, and the apertures of cellular pores are 50 to 300 mu m; and the cellular silk fibroin porous scaffold is high in biocompatibility, and matter permeability, and good in mechanical property and degradation property and the like. The scaffold is particularly suitable for a tissue engineering technology of peripheral nerve, tendon, ligament and the like which have longitudinal structural tissues, and can be widely applied to in-vitro three-dimension cell culture.

The invention discloses a high-strength degradable strontium phosphate dual-phase ceramic bone skeleton and relative preparation, wherein the initial material is calciprivia fermorite bone cement, whose solid phase powder is the mixture of Ca4(PO4)2O, SrHPO4, CaHPO4, and the liquid phase is 0.1mol / L-1mol / L H3PO4 water solution. The invention uses skeleton structure to controllably quickly print and shape RP optical sensitive resin as concave mold, to irrigate slurry, solidify, and thermally remove mold and following sinter to obtain the strontium phosphate dual-phase ceramic bone support with adjustable phases. The total porous rate of skeleton is 42.5-75%, the size of macro hole is 300mum-600mum, the volume of macro hole is 0-50%, the size of micro hole is 2-10mum, and the compression strength is 3.15MPa-21.53MPa, with wide application.

The invention belongs to the fields of packaging materials and packaging products, and relates to a biodegradable high-barrier liquid packaging film. The packaging film concretely sequentially comprises a biodegradable heat seal layer, a barrier layer and a protective layer. The invention also relates to a method for preparing the packaging film, a use of the packaging film, and a packaging product comprising the packaging film.

The invention belongs to the field of packaging materials and packaging products, and relates to a biological degradable compound packaging film and a packaging bag. Particularly, the invention relates to the packaging film which sequentially comprises a biological degradable heat seal layer, a blocking layer and a protection layer. The invention further relates to a method for preparing the packaging film, application of the packaging film, and a packaging product (such as the packaging bag) with the packaging film.

The invention discloses a medical degradable polyester asymmetric membrane and a preparation method thereof. The asymmetric membrane uses degradable polyester as a membrane material, one surface of the asymmetric membrane is a compact layer, the other surface of the asymmetric membrane is a porous layer, the compact layer and the porous layer are molded integrally once, the aperture of micropores in the compact layer is 0.5 to 5 mu m, the aperture in the porous layer is 50 to 600 mu m, and the pores are intercommunicated. The preparation method for the asymmetric membrane mainly comprises the following steps: dissolving polymers such as PLA and the like into solvents such as methylene dichloride and the like to prepare solution, adding a powdery pore-forming agent into the polymer solution, stirring, fully mixing and defoaming the solution and then pouring the solution into a die, then soaking the die into neutral or acid distilled water at the temperature of between 4 and 100 DEG C to perform membrane forming, removing the die in water and taking the formed membrane out, flushing the formed membrane by running water or / and soaking the formed membrane into running water to remove residual inorganic salt, and drying the formed membrane to obtain the medical degradable polyester asymmetric membrane. The asymmetric membrane provided by the invention has the characteristics of biodegradability and adjustable performance such as degrading rate, thickness, aperture, pore communication, tensile strength and the like.

A degradable unsaturated polyester-amidourea resin used for disposable food container, packing material, plastic bag, medicinal coating, capsule and slow-releasing material, etc is prepared from C2-C4 binary alcohol, anti-butenedioic acid or maleic anhydride, and urea through fusing and polycondensating. It can be modified by starch or calcium carbonate powder.

The invention relates to a melt polycondensation method for the synthesis of unsaturated polyester amide urea resin from dipropylene glycol or neopentyl glycol or polyethylene glycol, transbutene dioic acid or maleic anhydride and urea as raw materials. The synthesized unsaturated polyester amide urea resin has the advantages of controllable degradation rate, no toxicity and low cost. The transbutene dioic acid or maleic anhydride can be partially replaced by benzene anhydride, isophthalic acid or adipic acid. The dipropylene glycol or neopentyl glycol or polyethylene glycol can be partially replaced by ethylene glycol or propylene glycol. The resin is used as matrix of fracture internal fixation material, tissue engineering scaffold, bone graft substitute, environment-friendly binder, environment-friendly glass-reinforced plastics, environment-friendly painting, disposable tableware, packaging material, shopping bag, garbage bag, pharmaceutical coating or capsule, pharmaceutical slow- / controlled-release material, agricultural mulch film, etc. furthermore, the resin is recoverable.

The invention relates to a calcium polyphosphate / calcium sulfate complex phase biologic ceramic material and a preparation method thereof. The main phase of the ceramic material consists of calcium sulfate and amorphous calcium polyphosphate or beta calcium polyphosphate. The preparation method comprising the following steps of: selecting the calcium sulfate and amorphous calcium polyphosphate as ingredients, wherein the content of the calcium sulfate is 5 to 45 volume percent; weighing calcium sulfate and amorphous calcium polyphosphate according to a proportion, mixing the materials uniformly, using absolute ethyl alcohol as the medium, ball milling and mixing the materials to slurry materials, drying the mixed slurry materials at 60 to 80 DEG C, pelleting the dried powder by polyving alcohol solution and passing a 40-60 mesh screen, and then dry pressing and forming, wherein the forming pressure is 100 to 200 MPa; calcining a formed sample at 550 to 700 DEG C, keeping the temperature for 2 to 8 hours and then furnace cooling the sample. The method disclosed by the invention composes the calcium polyphosphate and calcium sulfate and ensures the aim of regulating degradation rate possibly in the degradation process of the complex phase ceramics through regulating Ca / P rate. The biologic ceramic can be used as a bone to replace repairing materials.

The invention discloses a tissue engineering bracket imitating intima-media structures and functions of natural blood vessels, and a preparation method of the bracket. The bracket is a porous membranoid substance which is prepared from degradable macromolecules, loaded with growth factors, provided with micron-order grooves in parallel in the surface and is of a nano topological structure on the outer surface. The preparation method comprises the following steps: uniformly stirring nano grains with growth factors and a biologic degradable polymer solution, subsequently casting on a mold surface with the grooves in parallel, freezing and drying to eliminate the solvent, further performing surface treatment and loading the growth factors so as to obtain the tissue engineering bracket. Due to the parallel micron-order groove structure, the surface nano topological structure and the loaded growth factors of the tissue engineering bracket disclosed by the invention, induction and prompting functions on growth and breading of vascular smooth muscle cells, which are similar to those of extracellular matrix of intima-media cells of the natural blood vessels, can be achieved, and the vascular smooth muscle cells are enabled to grow and breed in ordered orientation on the artificial bracket like the intima-media of the natural blood vessels.

The invention belongs to the technical field of bio-based materials, and especially relates to a 3D printing artificial biodegradable cerebral dura mater and a preparation method thereof. The invention provides a three-layer composite structure cerebral dura mater repair material, an artificially synthesized degradable material is utilized as a base material, a bacterial cellulose / . polylactic acid composite membrane is used as a reinforcing layer, a collagen sponge membrane layer is used as a biological membrane, an internal structure of the artificial cerebral dura mater prepared by a 3D printing technique is highly similar to human meninges, and the artificial cerebral dura mater can be directly attached to damaged meninges of a patient to achieve the effect of stitching a wound. Compared with a traditional method, the 3D printing artificial biodegradable cerebral dura mater and the preparation method thereof are more beneficial to growth of dura mater cells, enable the probabilityof adhesion to calvarium skull, and provide a powerful guarantee for repair of the cerebral dura mater and prevention of occurrence of epilepsy.

The invention provides a biodegradable poly-caprolactone artificial breast wall material and preparation method thereof, wherein the material comprises 10-70% of chitosan fiber and balancing ploycaprolactone. When short chitosan fiber is employed, the short chitosan fiber is weighed and mixed with ploycaprolactone and stirred in high speed mixing machine, the premix is compounded, squeezed and granulated with a double bolt extrusion machine, or compounded and squashed with a closed-smelting machine, then is subject to compression moulding on vulcanizing press and cut into samples. The invention also provides the preparing method for the situation when long chitosan fiber is employed.

The invention discloses a composite multilayer and porous scaffold and a preparation method of the scaffold. The konjac glucomannan / artificially synthesized high polymer / hydroxyapatite whisker composite multilayer and porous scaffold is prepared by taking konjac glucomannan, an artificially synthesized high polymer and a hydroxyapatite whisker as raw materials, performing film formation in a layer-by-layer composite superposition manner via flow casting and freezing technologies, and finally performing technologies of freeze-drying, cross linking, cleaning and the like. The method is simple in technology, convenient to operate and stable in yield; the prepared multilayer and porous composite scaffold has the characteristics of good biocompatibility, stability, appropriate aperture and the like; since the scaffold is crosswise composited in a layer-by-layer manner by a konjac glucomannan film, and an artificially synthesized high polymer / hydroxyapatite whisker film; the films of different layers have different ingredients and different degradation rates; further, the degradation rates can be regulated to be matched with a growth rate of a new bone; and therefore, the scaffold has good application prospects in an aspect of cartilaginous tissue implantation.

The invention discloses a biodegradable adhesive prepared by copolymerizing protolysate and urea and formaldehyde. In a preparation process of the adhesive, the bonding strength between the bonding material and a seedling culture substrate as well as the nutrient release speed can be controlled by controlling the urea-formaldehyde molar ratio and the hydrolysis degree and addition amount of the protolysate in the copolymerizing process; the adhesive can be used for bonding and moulding the seedling culture substrate to avoid scattering and root injury of the seedlings in a mechanical transplanting process; and after being compounded with the substrate, the adhesive can be degraded to provide nutrients during the seedling growth and also can serve as a coating slow-release material of nutrient elements to promote the seedling growth.

The invention discloses a preparation method of a fibrous ring inter-vertebral disk tissue engineering scaffold, and belongs to the application field of biomedical material technologies. The preparation method comprises the following steps: taking KGM, gelatin and nano-hap as basic raw materials; taking ethanol and glycerine as curing agents for curing according to the wet spinning technology; after curing, adopting a cross-linking agent comprising ethanol and ammonia water for preliminary cross-linking; then adopting an alkali liquor for further cross-linking; carrying out freeze drying, so as to obtain the non-isotropic fibrous ring inter-vertebral disk tissue engineering scaffold. The preparation method has the advantage that the product is high in structural simulation, anisotropy and porosity rate, optional in design of size and shape, and adjustable in degradation rate. The ring inter-vertebral disk tissue engineering scaffold prepared according to the method has a favorable application prospect.

The invention relates to a biodegradable stent composite material and a preparation method thereof. The degradable material has a multi-gradient composite structure, and comprises a matrix made of a medical metal or an alloy thereof, a chemical coupling layer attached to the surface of the matrix, a high polymer transition layer attached to the surface of the chemical coupling layer and a degradable high polymer functional layer fixed on the surface of the high polymer transition layer. The stent composite material has high mechanical property, degradation property and biocompatibility, also can absorb and carry needed therapeutic medicaments, and meets the requirement on clinical treatment. The degradable composite material can be used as stent materials of esophagi, biliary ducts, intestinal tracts, urethrae, tracheae and other non-vessel lumens and blood vessels, and also can be used for manufacturing artificial bones, bone nails, bone connectors, bone sutures, anchors for suture, intervertebral discs, hemostatic clamps, hemostatic forceps, hemostatic plates, hemostatic screws, tissue adhesives, sealants and other medical devices and products.

The invention discloses a skin tissue engineering double-layer film material and a preparation method thereof. The preparation method comprises the steps that degradable materials including chitosan and konjac glucomannan which have the good biocompatibility are adopted as raw materials and prepared into mixed solutions separately, film forming is conducted on the mixed solutions through a tape casting method separately, two layers of films are bonded together by adopting a konjac glucomannan solution with the certain concentration as a bonding agent, and then the chitosan-konjac glucomannan double-layer film material is prepared. The material has the advantages of being simple in preparation process, low in cost, adjustable in degradation rate, good in biocompatibility and the like; early cell experiments and animal experiments show that the double-layer film material can be suitable for organisms and is a degradable multifunctional composite material capable of promoting skin repairing.

The invention discloses degradable polyester rubber as well as a preparation method and application thereof. The preparation method comprises the steps of carrying out primary esterification reaction on a first mixed reaction system containing dimer acid, polyethylene glycol, an esterification catalyst and a polycondensation catalyst under a vacuum condition; adding itaconic acid, ethylene glycol and a degradation regulator into the first mixed system to form a second mixed reaction system, and carrying out secondary esterification reaction at the temperature of 130-150 DEG C for 2-4 hours; and reducing the vacuum degree of the reaction system obtained after the secondary esterification reaction to be lower than 200Pa, and then carrying out condensation polymerization at the temperature of 200-230 DEG C for 4-6 hours to obtain the degradable polyester rubber. The process flow is short, the prepared degradable polyester rubber has good degradation performance and processing performance, and a rubber compound prepared from the polyester rubber has excellent mechanical performance and good degradation performance; and meanwhile, the degradable polyester rubber prepared by the method has a wide application prospect.

The invention relates to a double-layer composite regeneration film and a making method thereof. The regeneration film comprises a compact layer and a loose layer, the compact layer is formed through compounding a degradable high-molecular fiber web with a collagen film, or with collagen and nano-silver particles, or with collagen and a medicine having a treatment effect, and the loose layer is formed by treating one or more selected from chitosan, silk fibroins, keratoprotein and collagens as a matrix material. The preparation method mainly comprises a step of preparing the fiber strengthened compact layer, a step of preparing the loose layer, and a step of preparing a guide film through compounding. The regeneration film has the advantages of good biocompatibility and mechanical performances, biodegradability, low immune rejection response, simple operation and the like, and can be widely used for restoring tissues, especially bone tissues and periodontal tissues.

The invention discloses a biodegradable adhesive prepared by copolymerizing protolysate and urea and formaldehyde. In a preparation process of the adhesive, the bonding strength between the bonding material and a seedling culture substrate as well as the nutrient release speed can be controlled by controlling the urea-formaldehyde molar ratio and the hydrolysis degree and addition amount of the protolysate in the copolymerizing process; the adhesive can be used for bonding and moulding the seedling culture substrate to avoid scattering and root injury of the seedlings in a mechanical transplanting process; and after being compounded with the substrate, the adhesive can be degraded to provide nutrients during the seedling growth and also can serve as a coating slow-release material of nutrient elements to promote the seedling growth.

The invention discloses a cartilage tissue engineering scaffold, a preparation method and application thereof. It includes the following steps of preparation: loading growth factors on nanoparticles to obtain growth factor-loaded nanoparticles; then surface-treating them to make their surfaces have reactive active groups; Diol aqueous solution is mixed with the following 1) and / or 2) to obtain hydrogels loaded with growth factors A and B; 1) nanoparticles loaded with growth factor A and nanoparticles loaded with growth factor B; 2) growth factor A loaded and growth factor B nanoparticles; growth factor C is loaded on the hydrogel loaded with growth factors A and B to obtain a cartilage tissue engineering scaffold; wherein, growth factor A, growth factor B and growth factor C all promote cartilage regeneration different growth factors. The scaffold of the invention simulates the structure and function of natural cartilage tissue, and carries multiple growth factors to express synergistically and act on cartilage repair and regeneration.

Belonging to the application field of biomedical material technologies, the invention discloses a preparation method of an intervertebral disc fibrous ring tissue engineering scaffold. The method provided by the invention adopts degradable biomaterial konjac glucomannan (KGM), gelatin (Gelatin) and nano-hydroxyapatite (Nano HAP) with good biocompatibility as the basic raw materials, utilizes film coiling technique to perform crosslinking with ammonia water or glutaraldehyde as the crosslinking agent, and then conduct freeze drying to obtain an anisotropic intervertebral disc fibrous ring tissue engineering scaffold. According to the preparation method of the scaffold, the product has the advantages of high simulation structure, anisotropy, high porosity, arbitrarily designable shape and size, and adjustable degradation rate, etc. As an intervertebral disc fibrous ring repair material, the intervertebral disc fibrous ring tissue engineering scaffold prepared by the method can have good application prospect.

The invention discloses a corrosion-resistant medical wrought magnesium alloy, and belongs to the field of biomedical metal materials. The corrosion-resistant medical wrought magnesium alloy comprises, by mass, 1 to 4% of Sn, 0.01 to 1% of Mn, 0.05 to 1% of Zn, and the balance Mg. The invention also discloses a method used for preparing the corrosion-resistant medical wrought magnesium alloy. The preparation method comprises following steps: raw materials are weighed at the above ratio, are subjected to polishing, and are delivered into a high purity graphite crucible; a mixed gas of SF6 and N2 is taken as a protective gas, and alloy smelting is carried out in a well-type resistance furnace; an obtained melt is stirred, is allowed to stand, and is subjected to casting so as to obtain a cast ingot; and extrusion alloy rods with excellent performance are obtained via extrusion. According to the preparation method, microalloying is adopted to prepare the rare earth element-free corrosion-resistant medical magnesium alloy, the rare earth element-free corrosion-resistant medical magnesium alloy possesses excellent biocompatibility and mechanical properties, and a problem that degradation rate of medical magnesium alloy in application process is too high is solved.

The invention belongs to the technical field of ceramic bone scaffold preparation and surface modification, and discloses a 3D printing biphase calcium phosphate scaffold and a preparation method thereof.The preparation method comprises the following steps that hydroxyapatite, beta-tricalcium phosphate, hydroxypropyl methyl cellulose and deionized water are prepared into slurry according to the set mass ratio, and the solid-to-liquid ratio of the slurry is 1: (0.96-1.01); printing a biphase calcium phosphate stent from the prepared slurry by adopting a 3D printing technology, and sintering the printed biphase calcium phosphate stent; performing vacuum soaking on the sintered stent in a chitosan solution to obtain a chitosan surface modified biphase calcium phosphate stent; and placing the dried chitosan surface modified biphase calcium phosphate scaffold in a polydopamine solution, coating, drying, cleaning, and drying again to obtain the chitosan / polydopamine composite surface modified biphase calcium phosphate scaffold.

The invention discloses a porous support material in the tissue engineering of konjac glucan-mannan / hydroxyapatite / chitosan combined bone, and a preparation thereof, pertaining to the technical field of bioengineering materials. Degradable biomaterials with good biocompatibility, such as konjac glucan-mannan, hydroxyapatite and chitosan, are adopted as basic raw materials and respectively prepared into konjac glucan-mannan solution and hydroxyapatite / chitosan composite powder suspension which are then mixed to prepare mixture gel. After aging, alkali elimination, freeze-drying of the mixturegel, the degradable porous support with regenerated and reparative konjac glucan-mannan / hydroxyapatite / chitosan combined bone tissues. Not only does the support material have simple preparation technology and low cost, but also the prepared degradable porous support has good compatibility with trauma parts. Cell tests and animal tests show that the support can be universally used in vivo (bone defect diseased region, etc.) and is multifunctional and antibacterial composite material with adjustable degradation rate in vivo and can promote and induce the repair of the bone defect.

The invention discloses an encircling-type fracture internal fixation device and a making method. The encircling-type fracture internal fixation device is made of a degradable polymer with a shape memory characteristic and comprises a center ridge beam plate and lateral encircling claws; the lateral encircling claws are arranged on the two sides of the center ridge beam plate and integrally formed with the center ridge beam plate, and the degradable polymer is one or a combination of a linear polymer and a crosslinked polymer. The encircling-type fracture internal fixation device has the shape memory function and is integrally formed by the degradable polymer with the shape memory function, the degradable polymer replaces an existing memory alloy or degradable polymer material and can rapidly restore to an initial shape when heated, the degradable polymer has a continuous self-pressurization function at body temperature, is high in fit degree with a fracture part and has excellent biocompatibility, degradation controllability and high mechanical strength, and the influence on observation and treatment of other organs is avoided.

The invention discloses a hierarchical porous chitosan / polylactic acid composite material and a preparation method and application thereof. The aximum wet compression modulus of the hierarchical porous chitosan / polylactic acid composite material is 0.20-0.52MPa and dry compression modules is 2.27-6.76MPap; the hierarchical porous chitosan / polylactic acid composite material has an artificially constructed longitudinal macro-pore of which the diameter is more than 500microns, and micro-pores of which the diameter is 2-500microns are distributed around the longitudinal macro-pore in all directions. The composite material disclosed by the invention has the advantages of relatively high crystallinity, good biological performance, adjustable degradation rate and proper mechanical property; the composite material has an internal porous structure similar to human bones and has a function of promoting bone tissue regeneration; moreover, due to the macro-porous structure, the composite material is more beneficial to growth of nerves and blood vessels and delivery of nutrient substances.