3D printing biphase calcium phosphate stent and preparation method thereof

A biphasic calcium phosphate, 3D printing technology, applied in medical science, surgery, coating and other directions, can solve the problems of poor osseointegration of scaffolds, poor promotion of osteogenic differentiation, and unfavorable osteocytes, and achieve the coating preparation method. Simple, effective in improving osseointegration and compressive strength

Active Publication Date: 2022-08-02
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the traditional preparation methods of ceramic bone scaffolds include foam impregnation method, pore-forming agent method, and foaming method. The prepared block ceramic bone scaffolds do not have three-dimensional through pores, which is not conducive to the growth o...

Method used

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  • 3D printing biphase calcium phosphate stent and preparation method thereof
  • 3D printing biphase calcium phosphate stent and preparation method thereof
  • 3D printing biphase calcium phosphate stent and preparation method thereof

Examples

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preparation example Construction

[0031] In a first aspect, the present invention provides a method for preparing a 3D printed biphasic calcium phosphate scaffold, comprising the following steps:

[0032] Prepare a slurry with hydroxyapatite, β-tricalcium phosphate, hydroxypropyl methylcellulose and deionized water according to the set mass ratio, and the solid-liquid ratio of the slurry is 1:0.96-1.01;

[0033] Using 3D printing technology to print the biphasic calcium phosphate scaffold with the prepared slurry, and sintering the printed biphasic calcium phosphate scaffold;

[0034] The sintered scaffolds are soaked in chitosan solution in vacuum to obtain biphasic calcium phosphate scaffolds modified on the surface of chitosan;

[0035] The biphasic calcium phosphate scaffold modified on the surface of the dried chitosan is placed in a polydopamine solution, coated, dried, washed and dried again to obtain a chitosan / polydopamine composite surface-modified biphasic phosphate calcium scaffold.

[0036] In s...

Embodiment 1

[0049] (1) Preparation of biphasic calcium phosphate ceramic slurry

[0050] Weigh 3g hydroxyapatite, 2g β-tricalcium phosphate and 0.2g hydroxypropyl methylcellulose, measure 5.2mL deionized water, and mix them to prepare biphasic calcium phosphate ceramic slurry;

[0051] (2) 3D printed porous biphasic calcium phosphate scaffolds

[0052]Use a direct-write molding printer, put the ceramic slurry into the printer barrel, select a needle with an inner diameter of 0.6mm, set the air pressure of the air pressure valve to 0.3MPa, the printing speed is 10mm / s, and the printing size is 14mm×14mm×2.5mm and 14mm×14mm×10mm porous biphasic calcium phosphate scaffold with a filling rate of 60%;

[0053] (3) Sintering bracket

[0054] Put the printed and dried brackets into the muffle furnace, and use the original sintering procedure of the muffle furnace for sintering, where the maximum temperature is 1245°C;

[0055] (4) Surface modification of chitosan

[0056] Prepare 5 mg / mL chi...

Embodiment 2

[0060] The sintering process of setting the muffle furnace in step (3) of this embodiment is to heat up at a rate of 5°C / min, then keep the temperature at 1200°C for 2 hours, and then cool with the furnace;

[0061] In step (4) of this example, a 5 mg / mL chitosan solution was prepared with 1% (v / v) acetic acid as a solvent, and the stent was soaked in a vacuum environment for 2 hours;

[0062] 10mmol·L was used in the step (5) of this example -1 , pH 10 Tris-HCl solution to prepare 5mg / mL polydopamine solution; set the temperature of the shaker to 37°C, the rotation speed to 160r / min, and the coating time to 2h.

[0063] Others are the same as in Example 1.

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Abstract

The invention belongs to the technical field of ceramic bone scaffold preparation and surface modification, and discloses a 3D printing biphase calcium phosphate scaffold and a preparation method thereof.The preparation method comprises the following steps that hydroxyapatite, beta-tricalcium phosphate, hydroxypropyl methyl cellulose and deionized water are prepared into slurry according to the set mass ratio, and the solid-to-liquid ratio of the slurry is 1: (0.96-1.01); printing a biphase calcium phosphate stent from the prepared slurry by adopting a 3D printing technology, and sintering the printed biphase calcium phosphate stent; performing vacuum soaking on the sintered stent in a chitosan solution to obtain a chitosan surface modified biphase calcium phosphate stent; and placing the dried chitosan surface modified biphase calcium phosphate scaffold in a polydopamine solution, coating, drying, cleaning, and drying again to obtain the chitosan/polydopamine composite surface modified biphase calcium phosphate scaffold.

Description

technical field [0001] The invention belongs to the technical field of preparation and surface modification of a ceramic bone scaffold, and particularly relates to a 3D printed biphasic calcium phosphate scaffold and a preparation method thereof. Background technique [0002] The statements herein merely provide background related to the present invention and do not necessarily constitute prior art. [0003] At present, the traditional preparation methods of ceramic bone scaffolds include foam impregnation method, pore-forming agent method and foaming method. Therefore, the osseointegration ability of the scaffold is poor. In addition, the existing scaffolds have poor promotion effects on cell adhesion, proliferation and osteogenic differentiation, and the mechanical properties are difficult to guarantee. SUMMARY OF THE INVENTION [0004] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a 3D printed biphasic calcium phospha...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/10A61L31/14B33Y10/00B33Y70/10B33Y80/00
CPCA61L31/028A61L31/10A61L31/14A61L31/148A61L31/146B33Y10/00B33Y80/00B33Y70/10A61L2420/08C08L5/08C08L79/04Y02P10/25
Inventor 万熠范世缘赵梓贺王宏卫纪振冰
Owner SHANDONG UNIV
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